EC                 Enzyme                                 

[heparan sulfate]-glucosamine 3-sulfotransferase 3;
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
Transferring sulfur-containing groups;
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfonotransferase
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate [RN:R05798]
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-glucosamine 3-sulfate [CPD:C11553]
Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN*-> and -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN6S*-> (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells [2]. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes [3]. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC ([heparan sulfate]-glucosamine 3-sulfotransferase 2)].
EC created 2001
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
K07809  [heparan sulfate]-glucosamine 3-sulfotransferase 3
HSA: 9953(HS3ST3B1) 9955(HS3ST3A1)
PTR: 455061(HS3ST3A1) 468393(HS3ST3B1)
PPS: 100974193(HS3ST3A1) 100988267(HS3ST3B1)
GGO: 101145926(HS3ST3A1) 101151182
PON: 100441136(HS3ST3A1) 100442248
NLE: 100586137(HS3ST3A1) 100589938
MCC: 114673061 718232(HS3ST3A1)
MCF: 102131170(HS3ST3A1)
CSAB: 103242411(HS3ST3A1) 103242418(HS3ST3B1)
RRO: 104667951(HS3ST3A1) 104667957(HS3ST3B1)
RBB: 108525424
CJC: 100413776(HS3ST3B1) 100414502(HS3ST3A1)
SBQ: 101037911 101038227(HS3ST3B1)
MMU: 15478(Hs3st3a1) 54710(Hs3st3b1)
MCAL: 110305378 110305871(Hs3st3a1)
MPAH: 110331784(Hs3st3b1) 110331917(Hs3st3a1)
RNO: 303218(Hs3st3b1) 363618(Hs3st3a1)
NGI: 103752044(Hs3st3b1) 103752048(Hs3st3a1)
HGL: 101696746(Hs3st3b1)
CCAN: 109680480 109684974(Hs3st3b1)
OCU: 100352865(HS3ST3B1) 100355575(HS3ST3A1)
TUP: 102487594(HS3ST3A1) 102489387(HS3ST3B1)
CFA: 489512(HS3ST3A1) 489516
VVP: 112924911 112925005(HS3ST3A1)
UAH: 113271229(HS3ST3A1) 113271232
ORO: 101366769(HS3ST3A1) 101375153(HS3ST3B1)
FCA: 101087432(HS3ST3A1) 101091978
PTG: 102967959(HS3ST3A1) 102968545
PPAD: 109245836
AJU: 106989807(HS3ST3A1) 113595910
BTA: 521959(HS3ST3A1) 617069(HS3ST3B1)
BOM: 102264332(HS3ST3A1) 102264905(HS3ST3B1)
BIU: 109574448(HS3ST3B1) 109574478(HS3ST3A1)
BBUB: 102394062(HS3ST3A1) 102398535(HS3ST3B1)
CHX: 102176640(HS3ST3A1) 102184089(HS3ST3B1)
OAS: 101105173(HS3ST3A1) 101115554
SSC: 100625836(HS3ST3A1) 100737777(HS3ST3B1)
CFR: 102512802(HS3ST3A1)
CDK: 105085069(HS3ST3B1) 105085097(HS3ST3A1)
BACU: 103016406(HS3ST3A1)
LVE: 103071775(HS3ST3A1) 103072323(HS3ST3B1) 103080038
OOR: 101269529(HS3ST3A1) 101290366(HS3ST3B1)
DLE: 111167705(HS3ST3A1) 111167707
ECB: 100063069(HS3ST3B1) 100073112(HS3ST3A1)
EAI: 106845777(HS3ST3A1) 106845781(HS3ST3B1)
MYB: 102261026(HS3ST3B1) 102261616(HS3ST3A1)
MNA: 107528076 107544569(HS3ST3A1)
HAI: 109382157(HS3ST3B1) 109382182
DRO: 112308627(HS3ST3B1) 112308863(HS3ST3A1)
PALE: 102889218(HS3ST3A1) 102889972(HS3ST3B1)
RAY: 107518996(HS3ST3A1) 107519021(HS3ST3B1)
MJV: 108385365(HS3ST3B1) 108392273
LAV: 100667730 100668015(HS3ST3B1)
PCW: 110193924
OAA: 100078354
GGA: 769421(HS3ST3B1L) 769490(HS3ST3B1)
CJO: 107322099 107322259(HS3ST3A1)
NMEL: 110407400(HS3ST3A1) 110407480
APLA: 101793969(HS3ST3B1) 113845533
ACYG: 106029692
SCAN: 103820028
GFR: 102043657
PHI: 102104421(HS3ST3B1) 102112304(HS3ST3A1)
CCW: 104695619(HS3ST3B1) 104695646
ETL: 114064753 114064755(HS3ST3A1)
NNI: 104021321(HS3ST3B1)
PADL: 103918988
CMY: 102932558 102933158(HS3ST3B1)
CPIC: 101934697(HS3ST3A1) 101934991(HS3ST3B1)
ACS: 100555056 100555456(hs3st3a1)
PVT: 110075060 110084026(HS3ST3B1)
XLA: 100037135(hs3st3a1.L) 108701173 108702850(hs3st3a1.S)
XTR: 100380167(hs3st3a1) 116408044
DRE: 100008592(hs3st3l) 100329339(si:ch211-216b21.2) 558084(hs3st3b1b)
IPU: 108260710(Hs3st3b1) 108273439 108273751 108274355(HS3ST3B1)
KMR: 108235828(hs3st3l) 108241265(hs3st3b1a) 108246656(si:ch211-216b21.2) 108248841(hs3st3b1b)
LCM: 102359925(HS3ST3B1) 102360615(HS3ST3A1)
BFO: 118428870
CIN: 101242339
DME: Dmel_CG7890(Hs3st-B)
DER: 6550304
DSE: 6614973
DSI: Dsimw501_GD24871(Dsim_GD24871)
DAN: 6498794
DSR: 110180633
DPE: 6597442
DMN: 108165050
DWI: 6644473
DAZ: 108619425
DNV: 108656537
DHE: 111600214
DVI: 6635609
MDE: 101892345
LCQ: 111678947
AAG: 5577441
AME: 413133
BIM: 100746082
BTER: 100642292
CCAL: 108624329
OBB: 114880730
SOC: 105195630
MPHA: 105833281
AEC: 105144583
ACEP: 105618373
PBAR: 105431729
VEM: 105567744
HST: 105185983
DQU: 106747028
CFO: 105259454
LHU: 105678665
PGC: 109854140
OBO: 113563416
NVI: 100120076
CSOL: 105361129
MDL: 103576536
TCA: 662715
DPA: 109539423
ATD: 109601856
NVL: 108562372
BMOR: 101745633
BMAN: 114240646
PMAC: 106717481
PRAP: 110996735
HAW: 110372069
TNL: 113494854
PXY: 105384979
CLEC: 106669891
ZNE: 110837600
CEL: CELE_F52B10.2(hst-3.2)
CBR: CBG02023
CRG: 105322387
MYI: 110443208
LAK: 106168414
PDAM: 113667730
SPIS: 111325429
 » show all
1  [PMID:10608887]
Liu J, Shriver Z, Blaiklock P, Yoshida K, Sasisekharan R, Rosenberg RD
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues.
J Biol Chem 274:38155-62 (1999)
2  [PMID:10520990]
Shukla D, Liu J, Blaiklock P, Shworak NW, Bai X, Esko JD, Cohen GH, Eisenberg RJ, Rosenberg RD, Spear PG
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry.
Cell 99:13-22 (1999)
[hsa:9955 9953][mmu:54710]
3  [PMID:9988767]
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD.
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.
J Biol Chem 274:5170-84 (1999)
[hsa:9955 9953]
4  [PMID:9988768]
Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.
J Biol Chem 274:5185-92 (1999)
[hsa:9955 9953]
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