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Entry
EC 2.8.2.37                 Enzyme                                 

Name
trehalose 2-sulfotransferase;
Stf0 sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:alpha,alpha-trehalose 2-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = adenosine 3',5'-bisphosphate + 2-O-sulfo-alpha,alpha-trehalose [RN:R10971]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
alpha,alpha-trehalose [CPD:C01083]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
2-O-sulfo-alpha,alpha-trehalose [CPD:C20985]
Comment
The sulfation of trehalose in the bacterium Mycobacterium tuberculosis is required for the biosynthesis of sulfolipid-1.
History
EC 2.8.2.37 created 2014
Orthology
K21014  trehalose 2-sulfotransferase
Genes
LEZ: GLE_2492
LEM: LEN_2518
SBL: Sbal_1699
SBS: Sbal117_1812
SBB: Sbal175_2640
AMG: AMEC673_07475
MPSY: CEK71_13120 CEK71_14265
BCED: DM42_947
BTEI: WS51_14685
BFN: OI25_820
GEB: GM18_0971
MLO: mll3788
SME: SMc01744
SMER: DU99_12855
AVI: Avi_3258
MNO: Mnod_7038
MMED: Mame_00018
SIL: SPO3420
JAN: Jann_2787
RRU: Rru_A1625
RRF: F11_08385
MTU: Rv0295c
MTC: MT0308
MRA: MRA_0304
MTUR: CFBS_0313
MTD: UDA_0295c
MTUE: J114_01615
MTUH: I917_02110
MTUL: TBHG_00294
MTUT: HKBT1_0313
MTUU: HKBT2_0313
MBB: BCG_0335c
MBT: JTY_0305
MBX: BCGT_0065
MAF: MAF_02970
MMIC: RN08_0337
MPA: MAP_2118
MAO: MAP4_1705
MAVI: RC58_08520
MAVU: RE97_08520
MAV: MAV_2058
MAVD: NF84_09255
MAVR: LA63_09445
MAVA: LA64_09465
MIT: OCO_20370
MIA: OCU_20470
MID: MIP_02867
MYO: OEM_18200
MIR: OCQ_19040
MMC: Mmcs_0389
MKM: Mkms_0398
MJL: Mjls_0377
MMI: MMAR_4255
MMM: W7S_09550
MHAD: B586_00830
MVQ: MYVA_0396
MAB: MAB_1546c
MABB: MASS_1642
MABO: NF82_07820
MCHE: BB28_08395
MSTE: MSTE_01538
RER: RER_01280
REY: O5Y_00645
ROP: ROP_09850
GBR: Gbro_1563
GOR: KTR9_1484
TPR: Tpau_3332
CFL: Cfla_3588
AFS: AFR_20265
RXY: Rxyl_2350
TRA: Trad_0294
 » show all
Taxonomy
Reference
1  [PMID:15258569]
  Authors
Mougous JD, Petzold CJ, Senaratne RH, Lee DH, Akey DL, Lin FL, Munchel SE, Pratt MR, Riley LW, Leary JA, Berger JM, Bertozzi CR
  Title
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis.
  Journal
Nat Struct Mol Biol 11:721-9 (2004)
DOI:10.1038/nsmb802
  Sequence
Reference
2  [PMID:15866533]
  Authors
Pi N, Hoang MB, Gao H, Mougous JD, Bertozzi CR, Leary JA
  Title
Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry.
  Journal
Anal Biochem 341:94-104 (2005)
DOI:10.1016/j.ab.2005.02.004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.37
IUBMB Enzyme Nomenclature: 2.8.2.37
ExPASy - ENZYME nomenclature database: 2.8.2.37
BRENDA, the Enzyme Database: 2.8.2.37

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