KEGG   ENZYME: 2.8.2.40
Entry
EC 2.8.2.40                 Enzyme                                 
Name
omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase;
stf3 (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
Sysname
3'-phosphoadenylyl-sulfate:omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + omega-sulfo-beta-dihydromenaquinone-9 [RN:R12794]
Reaction(KEGG)
R12794
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
omega-hydroxy-beta-dihydromenaquinone-9 [CPD:C21885]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
omega-sulfo-beta-dihydromenaquinone-9 [CPD:C22399]
Comment
The enzyme catalyses the last step in the production of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.
History
EC 2.8.2.40 created 2021
Orthology
K22905  omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase
Genes
PPHABVH74_17800
MICCAUP74_01771
MCAMCA2756
METUGNH96_00035 GNH96_00395
MMAIsS8_4162
MEINmethR_P0932
NOCNoc_1729
NHLNhal_0284
TVIThivi_2192
TTPE6P07_04950
THIPN838_15095 N838_32060
THIMKFB96_18580 KFB96_19550
TBOGLT988_06510
ABOABO_1043
ADIB5T_01851
ALNAS19_11090
AXEP40_08825
GSNYC6258_03339
SDFACG33_03610
ENMEBS_0951
DOEDENOEST_0413
ABREpbN1_33280
THUAC731_008690
SUNSUN_1532
DAFDesaf_0194
DTIDesti_0521
PCAYFRD00_23090
PMOBHG718_04870
MCGGL4_1680
METGHT051_10670
MAADAZF01_09220
RBMTEF_20330
CEHCEW89_09445
SMEDJNX03_18500
RHPLPB142_16215
PSEBEOK75_04360
HGNE6W36_08420
ABSAZOBR_p150006
ABQABAZ39_20235
ABFAMK58_14570
AZTTSH58p_24410
AOZHUE56_02780
SKTIGS68_13670 IGS68_17780
SMUCJL100_008230 JL100_014915
SROEJL101_008110 JL101_010375
CLSCXIVA_00400
CSSCst_c20830
CSDClst_1990
MTURv2267c
MTVRVBD_2267c
MTCMT2329
MRAMRA_2287
MTFTBFG_12294
MTBTBMG_01715
MTKTBSG_01725
MTZTBXG_001697
MTGMRGA327_13980
MTIMRGA423_14105
MTECCDC5079_2103
MTURCFBS_2400
MTLCCDC5180_2075
MTOMTCTRI2_2302
MTDUDA_2267c
MTNERDMAN_2491
MTJJ112_12170
MTUBMT7199_2298
MTUCJ113_15805
MTUEJ114_12160
MTXM943_11735
MTULTBHG_02217
MTUTHKBT1_2391
MTUUHKBT2_2393
MTQHKBS1_2397
MBOBQ2027_MB2290C
MBBBCG_2284c
MBTJTY_2278
MBMBCGMEX_2272c
MBKK60_023520
MBXBCGT_2090
MAFMAF_22770
MMICRN08_2515
MCEMCAN_05811 MCAN_22911
MCQBN44_50213
MCVBN43_31509
MCXBN42_20319 BN42_40189
MCZBN45_10647 BN45_50599
MULMUL_0658
MMIMMAR_0905
MMAEMMARE11_08550
MLIMULP_00933
MKNMKAN_03515 MKAN_08310
MYEAB431_15275
MSHGMSG_00556(stf3)
MFJMFLOJ_29390(stf3)
MSTOMSTO_33340(stf3)
MSIMMSIM_19190(stf3)
MSAKMSAS_51810
MPAGC0J29_08280 C0J29_24340
MCOOMCOO_03730
MBAIMB901379_00775
MPSEMPSD_10360
MSHOMSHO_26650
MGAUMGALJ_24660
MLJMLAC_22880(stf3)
MSHJMSHI_09970(stf3)
MMAMK3U93_19820
MPAEK0O64_00520 K0O64_14740
MOTLTS72_03075
MCBMycch_1747
MFTXA26_45540
MRHMycrhN_4094
MAICMAIC_27010
MANYMANY_22930
MPHUMPHO_24890
MBOKMBOE_28160
MAUMicau_0536
MILML5_0732
MICBMicB006_0549
MTUACSH63_22545
MTEMGCE86_08255
RXYRxyl_1946
RUBGBA63_11270
SYDSyncc9605_0918
SYESyncc9902_1491
SYGsync_0812
SYXSynWH7803_1701
SYNRKR49_13905
SYNDKR52_12360
SYNWSynWH8103_01806
PMHP9215_00441
HHGXM38_041650(stf3)
GLPGlo7428_1510
MARMAE_31770
MPKVL20_1757
MIQB5D77_02895
MVZmyaer102_07180
CYJCyan7822_5853
PHORJWS08_16910
STANSTA3757_48970
PBFCFX0092_A1535
CAACaka_2387
LUOHHL09_08300
SOAG3M56_002050
RBARB7157
PSLPsta_4359
PIRVN12_12430
RULUC8_02040 UC8_53490
RMLFF011L_47510
MFFMFFC18_41010
ROLCA51_06410
AHELQ31a_55000
LCREPla8534_63940
AAGGETAA8_30890
BVOPan97_14450
RLCK227x_09690
TTFTHTE_1115
LPAVPLANPX_4132
AMUCPan181_14740
PNDPla175_15880 Pla175_45830
AMOBHG15A2_33700
PLMPlim_0831
PEHSpb1_15890
PBSPlabr_0431 Plabr_1084
PLSVT03_20370
FMRFuma_02395 Fuma_03636 Fuma_05923
GMRGmarT_50380
GIMF1728_20290
GPNPan110_50120
MRIMal4_44530 Mal4_45320
SDYNMal52_07500
GESVT84_18745
GOGC1280_16330
GMSSOIL9_15250 SOIL9_28300
TIMGMBLW1_07820
LRSPX52LOC_02136
FTJFTUN_7086
ULIETAA1_26670
TSPHKIH39_11780
SACISinac_5512
AGVOJF2_54860
PGINFRZ67_20620
LACSH4075_18220
FPFDCC35_04185
CABYCabys_1314 Cabys_1386
NGANgar_c32880
 » show all
Reference
1  [PMID:16537518]
  Authors
Mougous JD, Senaratne RH, Petzold CJ, Jain M, Lee DH, Schelle MW, Leavell MD, Cox JS, Leary JA, Riley LW, Bertozzi CR.
  Title
A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 103:4258-63 (2006)
DOI:10.1073/pnas.0510861103
Reference
2  [PMID:18928249]
  Authors
Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi CR, Leary JA
  Title
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.
  Journal
ACS Chem Biol 3:619-24 (2008)
DOI:10.1021/cb800145r
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.40
IUBMB Enzyme Nomenclature: 2.8.2.40
ExPASy - ENZYME nomenclature database: 2.8.2.40
BRENDA, the Enzyme Database: 2.8.2.40

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