KEGG   ENZYME: 2.8.2.8Help
Entry
EC 2.8.2.8                  Enzyme                                 

Name
[heparan sulfate]-glucosamine N-sulfotransferase;
heparin N-sulfotransferase;
3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase;
PAPS:N-desulfoheparin sulfotransferase;
PAPS:DSH sulfotransferase;
N-HSST;
N-heparan sulfate sulfotransferase;
heparan sulfate N-deacetylase/N-sulfotransferase;
heparan sulfate 2-N-sulfotransferase;
heparan sulfate N-sulfotransferase;
heparan sulfate sulfotransferase;
N-desulfoheparin sulfotransferase;
desulfoheparin sulfotransferase;
3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase;
heparitin sulfotransferase;
3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase;
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfonotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
Reaction(KEGG)
(other) R02122
Show
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-N-sulfoglucosamine [CPD:C17142]
Comment
The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.
History
EC 2.8.2.8 created 1972, modified 2001 (EC 2.8.2.12 created 1972, incorporated 2001)
Reference
1
  Authors
Suzuki, S., Trenn, R.H. and Strominger, J.L.
  Title
Separation of specific mucopolysaccharide sulfotransferases.
  Journal
Biochim Biophys Acta 50:169-174 (1961)
Reference
2  [PMID:4964017]
  Authors
Eisenman RA, Balasubramanian AS, Marx W.
  Title
3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction.
  Journal
Arch Biochem Biophys 119:387-97 (1967)
Reference
3  [PMID:4270798]
  Authors
Johnson AH, Baker JR.
  Title
The enzymatic sulphation of heparan sulphate by hen's uterus.
  Journal
Biochim Biophys Acta 320:341-51 (1973)
DOI:10.1016/0304-4165(73)90314-0
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.8
IUBMB Enzyme Nomenclature: 2.8.2.8
ExPASy - ENZYME nomenclature database: 2.8.2.8
BRENDA, the Enzyme Database: 2.8.2.8
CAS: 9026-75-9

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (88)   
   UniProt (30)   
   SWISS-PROT (15)   
   RefSeq(pep) (43)   
DNA sequence (71)   
   RefSeq(nuc) (54)   
   GenBank (13)   
   EMBL (4)   
Protein domain (1)   
   InterPro (1)   
All databases (167)   

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