KEGG ENZYME: 2.8.3.17

ENZYME: 2.8.3.17

Entry

EC 2.8.3.17                 Enzyme

Name

3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase;
FldA;
cinnamoyl-CoA:phenyllactate CoA-transferase

Class

Transferases;
Transferring sulfur-containing groups;
CoA-transferases

Sysname

3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase

Reaction(IUBMB)

(1) (E)-cinnamoyl-CoA + (R)-(phenyl)lactate = (E)-cinnamate + (R)-(phenyl)lactoyl-CoA [RN:R07796];
(2) (E)-4-coumaroyl-CoA + (R)-3-(4-hydroxyphenyl)lactate = 4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA [RN:R12492];
(3) 3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA [RN:R12493]

Reaction(KEGG)

R07796 R12492 R12493

Substrate

(E)-cinnamoyl-CoA [CPD:C16256];
(R)-(phenyl)lactate;
(E)-4-coumaroyl-CoA [CPD:C00223];
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
3-(indol-3-yl)acryloyl-CoA [CPD:C22207];
(R)-3-(indol-3-yl)lactate [CPD:C22006]

Product

(E)-cinnamate [CPD:C00423];
(R)-(phenyl)lactoyl-CoA;
4-coumarate [CPD:C00811];
(R)-3-(4-hydroxyphenyl)lactoyl-CoA [CPD:C22205];
3-(indol-3-yl)acrylate [CPD:C21283];
(R)-3-(indol-3-yl)lactoyl-CoA [CPD:C22206]

Comment

The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It forms a complex with EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase.

History

EC 2.8.3.17 created 2003, modified 2019

Pathway

ec00960

Tropane, piperidine and pyridine alkaloid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K13607

cinnamoyl-CoA:phenyllactate CoA-transferase

Genes

SYM:	K6K13_14550

PCOL:

F1325_16665

PPEE:

I6G31_11940

PAPP:

QQS39_16300

LGB:	V8L73_17155

CBO:	CBO3292(fldA)

CBA:	CLB_3348(fldA)

CBH:	CLC_3234(fldA)

CBY:	CLM_3725(fldA)

CBL:	CLK_2708(fldA)

CBB:	CLD_1231(fldA)

CBI:	CLJ_B3572(fldA)

CBF:	CLI_3462(fldA)

CBM:	CBF_3444(fldA)

CBJ:	H04402_03377

CLD:	CLSPO_c34120(fldA)

CFER:

D4Z93_06645

CCAA:

KQH81_14360

CFEM:

HCR03_03830

LGG:	QJR73_06875

MNL:	QU661_02670

PEB:	O0R46_02445

PIV:	NCTC13079_00074(frc)

» show all

Reference

1 [PMID:10849007]

Authors

Dickert S, Pierik AJ, Linder D, Buckel W

Title

The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes.

Journal

Eur J Biochem 267:3874-84 (2000)
DOI:10.1046/j.1432-1327.2000.01427.x

Sequence

[ag:AAL18808]

Reference

2 [PMID:29168502]

Authors

Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL

Title

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.

Journal

Nature 551:648-652 (2017)
DOI:10.1038/nature24661

Other DBs

ExplorEnz - The Enzyme Database:

2.8.3.17

IUBMB Enzyme Nomenclature:

2.8.3.17

ExPASy - ENZYME nomenclature database:

2.8.3.17

BRENDA, the Enzyme Database:

2.8.3.17

CAS:	289682-21-9

DBGET integrated database retrieval system