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Entry
EC 2.8.3.22                 Enzyme                                 

Name
succinyl-CoA---L-malate CoA-transferase;
SmtAB
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
succinyl-CoA:(S)-malate CoA-transferase
Reaction(IUBMB)
(1) succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA [RN:R00406];
(2) succinyl-CoA + (S)-citramalate = succinate + (S)-citramalyl-CoA [RN:R03154]
Reaction(KEGG)
Substrate
succinyl-CoA [CPD:C00091];
(S)-malate [CPD:C00149];
(S)-citramalate [CPD:C02614]
Product
succinate [CPD:C00042];
(S)-malyl-CoA [CPD:C04348];
(S)-citramalyl-CoA [CPD:C01011]
Comment
The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 2.8.3.22 created 2014
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14471  succinyl-CoA:(S)-malate CoA-transferase subunit A
K14472  succinyl-CoA:(S)-malate CoA-transferase subunit B
K18289  itaconate CoA-transferase
Genes
PAE: PA0882
PAEV: N297_910
PAEI: N296_910
PAU: PA14_52870
PAP: PSPA7_4632
PAG: PLES_44341
PAF: PAM18_4157
PNC: NCGM2_1660
PAEB: NCGM1900_1840
PDK: PADK2_21290
PAEP: PA1S_22030
PAEM: U769_21400
PAEL: T223_22665
PAEG: AI22_11910
PAEC: M802_906
PAEO: M801_910
PMK: MDS_3404
PPSE: BN5_1316
PCQ: PcP3B5_31090(frc_3)
PPUN: PP4_26590
PSB: Psyr_2175
PFL: PFL_2650
PPRO: PPC_2699
PFS: PFLU_3473
PFB: VO64_0586
PSA: PST_1697
PSTT: CH92_08225
PSES: PSCI_4461
PSEM: TO66_12955
PSIL: PMA3_18310
ADI: B5T_02015
APAC: S7S_06585
AXE: P40_09635
PLG: NCTC10937_02758(frc_1)
BPA: BPP3644
BBR: BB4079
BPT: Bpet0819
BHO: D560_1019
BHM: D558_1005
BHZ: ACR54_03834(frc_9)
BTRM: SAMEA390648700435(frc_4)
AXX: ERS451415_00903(frc_3)
TEA: KUI_1573
TEG: KUK_0904
TAS: TASI_1544
TAT: KUM_1149
PUT: PT7_0056
AMIM: MIM_c40130
CCQ: N149_0441
CCF: YSQ_07645
CCY: YSS_02010
CCOI: YSU_06655
CCOF: VC76_02325(frc)
CCOO: ATE51_03326(frc)
 » show all
Taxonomy
Reference
1  [PMID:16547052]
  Authors
Friedmann S, Steindorf A, Alber BE, Fuchs G.
  Title
Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 188:2646-55 (2006)
DOI:10.1128/JB.188.7.2646-2655.2006
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.22
IUBMB Enzyme Nomenclature: 2.8.3.22
ExPASy - ENZYME nomenclature database: 2.8.3.22
BRENDA, the Enzyme Database: 2.8.3.22

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