KEGG   ENZYME: 2.8.3.27
Entry
EC 2.8.3.27                 Enzyme                                 
Name
propanoyl-CoA:succinate CoA transferase;
succinyl-CoA:propionate CoA-transferase;
propionyl-CoA:succinyl-CoA transferase;
ASCT;
scpC (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
propanoyl-CoA:succinate CoA transferase
Reaction(IUBMB)
propanoyl-CoA + succinate = propanoate + succinyl-CoA [RN:R11773]
Reaction(KEGG)
R11773
Substrate
propanoyl-CoA [CPD:C00100];
succinate [CPD:C00042]
Product
propanoate [CPD:C00163];
succinyl-CoA [CPD:C00091]
Comment
The enzyme is most specific in Escherichia coli, where the preferred substrates are propanoyl-CoA and succinate. In other organisms, the enzyme uses acetyl-CoA at the same rate as propanoyl-CoA (cf. EC 2.8.3.18, succinyl-CoA:acetate CoA-transferase).
History
EC 2.8.3.27 created 2022
Pathway
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K22214  propionyl-CoA:succinyl-CoA transferase
Genes
ECOb2920(scpC)
ECJJW2887(ygfH)
EBWBWG_2643(scpC)
ECOKECMDS42_2420(ygfH)
ECEZ4257(ygfH)
ECSECs_3790(scpC)
ECFECH74115_4217
ETWECSP_3886(ygfH)
ELXCDCO157_3543
EOIECO111_3656(scpC)
EOJECO26_4007(scpC)
ECOOECRM13514_3780(ygfH)
ECOHECRM13516_3641(ygfH)
ESLO3K_04870
ESOO3O_20780
ESMO3M_04915
ECKEC55989_3208(ygfH)
EOKG2583_3574(scpC)
ELRECO55CA74_17030
ELHETEC_3112
EUNUMNK88_3616
ECOAAPECO78_18310
ECXEcHS_A3078
ECMEcSMS35_3057
ECYECSE_3182
ECRECIAI1_3040(ygfH)
EUMECUMN_3264(ygfH)
ECTECIAI39_3334(ygfH)
EOCCE10_3356(scpC)
EBRECB_02751(ygfH)
EBLECD_02751(scpC)
EBEB21_02714(scpC)
EBDECBD_0818
ELOEC042_3129
ECLEcolC_0790
EKOEKO11_0812
EKFKO11_08170(scpC)
EDHEcDH1_0773
EDJECDH1ME8569_2821(scpC)
ELWECW_m3175(scpC)
ELLWFL_15500(scpC)
ELPP12B_c3012
ECOLLY180_15025
EALEAKF1_ch3075c
EMAC1192_21020
SESSARI_04582
SBGSBG_2661(scpC)
SBZA464_3078
SBVN643_13055
SFVSFV_2966(ygfH)
SFNSFy_4136 SFy_4137
SFSSFyv_4212 SFyv_4213
SFTNCTC1_03196(ygfH_1) NCTC1_03197(ygfH_2)
SSNSSON_3071(ygfH)
SBOSBO_3074(ygfH)
SHQA0259_18165
ENRH650_21255
KOXKOX_02555
KOEA225_4951
KOYJ415_07225
KOMHR38_00925
KOKKONIH1_24890
KOCAB185_11570
KLLBJF97_24745
KLWDA718_04585
KGRJJJ10_04620
KPASLUW96_02440
CFDCFNIH1_01580
CBRAA6J81_21465
CWECO701_02600
CYOCD187_04190
CPOTFOB25_15655
CFQC2U38_20770
CAMAF384_03450
CAFAL524_18805
CIFAL515_19135
CIRC2U53_17420
CIEAN232_08745
CPARCUC49_14995
CTELGBC03_21810
CITZE4Z61_20970
CARSE1B03_21865
ESCEntcl_0834
KLEAO703_17405
KSAC813_09230
KORAWR26_18735
KRDA3780_05560
KPSEIP581_05700
YREHEC60_14090
PVJLMA04_15785
YENYE1893
YEPYE105_C1973
YEYY11_07651
YELLC20_02998
YEWCH47_1326
YETCH48_3599
YEFFORC2_2243
YEEYE5303_20611 YE5303_34011
YALAT01_232
YINCH53_4256
YROCH64_769
YHID5F51_07710
YCAF0T03_09925
YMOHRD69_14725
YASN0H69_13135
SLIGGTU79_09875
MESLKKZ03_10255
DALKDSCA_25020
SFUSfum_0389
PMASNCF86_16670
ANMGFC28_2173
ANLGFC29_3263
PNDPla175_02420(scpC)
AGVOJF2_32450(scpC)
PCORKS4_34640(scpC)
MCADPan265_26710(scpC)
BZGC4H11_09755
BHFC3V43_08710
BISDXK01_005115
BUNBun01g_07710
PBTING2E5B_1717(scpC)
PMUCING2E5A_1407(scpC)
PETPEIBARAKI_5274
PSACPSM36_2435(scpC)
DYSG7050_17405
PRUPRU_2762
PDTPrede_1444
POCNCTC13071_00558(scpC)
 » show all
Reference
1  [PMID:14102852]
  Authors
ALLEN SH, KELLERMEYER RW, STJERNHOLM RL, WOOD HG.
  Title
PURIFICATION AND PROPERTIES OF ENZYMES INVOLVED IN THE PROPIONIC ACID FERMENTATION.
  Journal
J Bacteriol 87:171-87 (1964)
DOI:10.1128/jb.87.1.171-187.1964
Reference
2
  Authors
Schulz, T.KF. and Kluytmans, J.H.
  Title
Pathway of propionate synthesis in the sea mussel Mytilus edulis L.
  Journal
Comp Biochem Physiol B Comp Biochem 75:365-372 (1983)
Reference
3  [PMID:10769117]
  Authors
Haller T, Buckel T, Retey J, Gerlt JA
  Title
Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.
  Journal
Biochemistry 39:4622-9 (2000)
DOI:10.1021/bi992888d
Reference
4  [PMID:19103231]
  Authors
van Grinsven KW, van Hellemond JJ, Tielens AG.
  Title
Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica.
  Journal
Mol Biochem Parasitol 164:74-9 (2009)
DOI:10.1016/j.molbiopara.2008.11.008
  Sequence
Reference
5  [PMID:33931420]
  Authors
Zhang B, Lingga C, Bowman C, Hackmann TJ.
  Title
A New Pathway for Forming Acetate and Synthesizing ATP during Fermentation in Bacteria.
  Journal
Appl Environ Microbiol 87:e0295920 (2021)
DOI:10.1128/AEM.02959-20
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.27
IUBMB Enzyme Nomenclature: 2.8.3.27
ExPASy - ENZYME nomenclature database: 2.8.3.27
BRENDA, the Enzyme Database: 2.8.3.27

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