| Entry |
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| Name |
3-oxoacid CoA-transferase;
3-oxoacid coenzyme A-transferase;
3-ketoacid CoA-transferase;
3-ketoacid coenzyme A transferase;
3-oxo-CoA transferase;
3-oxoacid CoA dehydrogenase;
acetoacetate succinyl-CoA transferase;
acetoacetyl coenzyme A-succinic thiophorase;
succinyl coenzyme A-acetoacetyl coenzyme A-transferase;
succinyl-CoA transferase
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| Class |
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
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| Sysname |
succinyl-CoA:3-oxo-acid CoA-transferase
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| Reaction(IUBMB) |
succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA [RN: R01780]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
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| History |
EC 2.8.3.5 created 1961, modified 1980
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| Pathway |
| ec00072 | Synthesis and degradation of ketone bodies |
| ec00280 | Valine, leucine and isoleucine degradation |
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| Orthology |
| K01027 | 3-oxoacid CoA-transferase |
| K01028 | 3-oxoacid CoA-transferase subunit A |
| K01029 | 3-oxoacid CoA-transferase subunit B |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Hersh, L.B. and Jencks, W.P. |
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| Title |
Coenzyme A transferase. Kinetics and exchange reactions. |
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| Journal |
J Biol Chem 242:3468-3480 (1967) |
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| Reference |
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| Authors |
LYNEN F, OCHOA S. |
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| Title |
Enzymes of fatty acid metabolism. |
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| Journal |
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| Reference |
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| Authors |
MENON GK, STERN JR. |
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| Title |
Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A. |
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| Journal |
J Biol Chem 235:3393-8 (1960) |
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| Reference |
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| Authors |
STERN JR, COON MJ, DEL CAMPILLO A, SCHNEIDER MC. |
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| Title |
Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase. |
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| Journal |
J Biol Chem 221:15-31 (1956) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.8.3.5 |
| ExPASy - ENZYME nomenclature database: | 2.8.3.5 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 2.8.3.5 |
| BRENDA, the Enzyme Database: | 2.8.3.5 |
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