KEGG   ENZYME: 2.8.4.2
Entry
EC 2.8.4.2                  Enzyme                                 
Name
arsenate-mycothiol transferase;
ArsC1;
ArsC2;
mycothiol:arsenate transferase
Class
Transferases;
Transferring sulfur-containing groups;
Transferring alkylthio groups
Sysname
mycothiol:arsenate S-arsenotransferase
Reaction(IUBMB)
arsenate + mycothiol = arseno-mycothiol + H2O
Substrate
arsenate [CPD:C11215];
mycothiol [CPD:C06717]
Product
arseno-mycothiol;
H2O [CPD:C00001]
Comment
Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione.
History
EC 2.8.4.2 created 2010
Orthology
K18701  arsenate-mycothiol transferase
Genes
SKS: FCN78_07980
NOH: G5V57_14365
MAV: MAV_1497
MJL: Mjls_1444
MDX: BTO20_20570
MKU: I2456_17785
MLW: MJO58_28370
MPAG: C0J29_32075
MBRD: MBRA_47590
MSPG: F6B93_09465
MVA: Mvan_3220
MGI: Mflv_1656
MSP: Mspyr1_53720
MCB: Mycch_4038 Mycch_5680
MFT: XA26_02280
MRH: MycrhN_2862 MycrhN_4470
MAUU: NCTC10437_04855(arsC_4)
MMAG: MMAD_27920
MFX: MFAL_17510 MFAL_31790
MALV: MALV_01950
MTY: MTOK_20570
MPSC: MPSYJ_13340 MPSYJ_17680
MARZ: MARA_04190 MARA_39360 MARA_62170
MHEV: MHEL_32750
MMAT: MMAGJ_19530
MBOK: MBOE_14510
MSEI: MSEDJ_04440 MSEDJ_56640
MBRM: L2Z93_000522
MPAE: K0O64_29635
MRF: MJO55_28375
MDF: K0O62_16700
MAB: MAB_4864
MABL: MMASJCM_0455
MCHE: BB28_04970
CGL: Cgl0263(Cgl0263) Cgl1511(Cgl1511)
CGB: cg0319(arsX) cg1706
CGU: WA5_0259(ArsX) WA5_1454
CGT: cgR_0341 cgR_1571
CGS: C624_01660 C624_08360
CGG: C629_01660 C629_08370
CGM: cgp_0319(arsX) cgp_1706
CGJ: AR0_01610 AR0_08095
CGQ: CGLAR1_01615 CGLAR1_07960
CGX: SB89_01435 SB89_07795
CEF: CE0876 CE1501
CDE: CDHC02_0082(arsC1)
CDZ: CD31A_0079(arsC1)
CDB: CDBH8_0082(arsC1)
CJK: jk2004(arsC)
CUR: cu0032
CUA: CU7111_0033(arsC)
CAR: cauri_1082(arsX)
CRD: CRES_1295(arsC)
CVA: CVAR_2931(arsC)
CHN: A605_06245
CCN: H924_01135
CTER: A606_00525
CMD: B841_09220 B841_13026
CFN: CFAL_03365
CCG: CCASEI_09340
CVT: B843_01660
CGY: CGLY_11930(arsC)
CII: CIMIT_04805
CUV: CUREI_01230
COA: DR71_561 DR71_747
CDO: CDOO_12005
CHM: B842_00420 B842_10360
CSX: CSING_05920(arsX)
CMQ: B840_09910(arsC1)
CKU: UL82_02615
CEI: CEPID_00240 CEPID_01715
CTED: CTEST_03000 CTEST_03005(arsC1)
CUT: CUTER_10045
CLW: CLAC_10615
CDX: CDES_00615 CDES_00620(arsC1) CDES_01420(arsC2)
CSP: WM42_0272
CSTA: CSTAT_05620
CCJZ: ccrud_07335
CPHO: CPHO_07460
CFC: CFLV_02210
CGV: CGLAU_09665(arsC1)
CSPH: CSPHI_10100 CSPHI_10350
CAMG: CAMM_00370 CAMM_08775
CMIN: NCTC10288_01454(arsX)
CXE: FOB82_03660 FOB82_03850 FOB82_07390
CEE: CENDO_04840(arsC1)
CSAN: E3227_04240
CSUR: N24_0382 N24_1603
CKF: I6I12_07730
CLIA: C3E79_09835
CAMC: I6I65_05065
CUO: CUROG_00495(arsC1)
CLIZ: G7Y31_04800
CTUB: I6I74_10115
CLUJ: IAU68_01345
CQN: G7Y29_00895
CKW: CKALI_00715(arsC1)
CCOE: CETAM_10555(arsC4)
COK: COCCU_06340(arsC2)
CORY: FQV43_03475
CWK: IA203_02025
CFY: I6L56_06735
CPSL: KBP54_01555
CHIN: J5O04_00915
CJH: CJEDD_01590(arsC1)
BFV: C628_01495 C628_08295
NFA: PNF2_260
NFR: ERS450000_05859(arsC_5)
NSL: BOX37_21330
NWL: NWFMUON74_17380 NWFMUON74_39800
NGP: LTT66_31380
RER: RER_pREL1-01620(arsC)
REY: O5Y_29285
ROP: ROP_00190
RPY: Y013_26135
RBY: CEJ39_06560
RHB: NY08_3233
RAV: AAT18_23435
RFA: A3L23_01427(arsC1)
RHS: A3Q41_01930(arsC1_1)
RHW: BFN03_10935
RRZ: CS378_13250
RHU: A3Q40_02951(arsC1_1) A3Q40_03063(arsC1_3) A3Q40_03401(arsC1_5)
RHQ: IM25_09890 IM25_24205
RHOD: AOT96_30980
RRT: 4535765_02655(arsC_3)
RCR: NCTC10994_02721(arsC_1)
RTM: G4H71_05865 G4H71_14205
ROZ: CBI38_24520
RPSK: JWS13_03240 JWS13_04680
GBR: Gbro_0790 Gbro_2681
GPO: GPOL_174p01510
GOR: KTR9_0732 KTR9_4996
GOQ: ACH46_10955
GTA: BCM27_04020
GIT: C6V83_10885 C6V83_11130
GRU: GCWB2_00360(arsC1)
GOM: D7316_04665(arsC1)
GAV: C5O27_15845 C5O27_17450 C5O27_17970
GOD: GKZ92_00575 GKZ92_00650
GAM: GII34_11100
GPD: GII33_10605 GII33_22975
GJI: H1R19_03605
GOI: LK459_12170
GHN: MVF96_03820 MVF96_09930
GAMI: IHQ52_14250 IHQ52_20355
GMG: NWF22_22870
GSI: P5P27_09760
TPR: Tpau_2232
TSM: ASU32_00530 ASU32_12160
TPUL: TPB0596_23590
DTM: BJL86_2701
DIZ: CT688_15040
DPC: A6048_15740
CMI: CMM_1218
CMS: CMS1869
CMC: CMN_01192
CMH: VO01_05040
CCAP: AES38_05660
CZH: H9X71_05730
CPHA: FGI33_07215
CCAF: FGD68_08200
MIO: AOA12_13845
CRY: B7495_16445
LARI: KI794_04110
HEA: HL652_11650
FRN: F1C15_00910
PSEV: USB125703_00671(arsC1)
GSD: M3M28_07865 M3M28_11005
GMN: GMOLON4_2517(arsC) GMOLON4_456(arsC)
ART: Arth_0216
ARR: ARUE_c37620(arsC1)
ARM: ART_1218
ARL: AFL94_14170
ARW: MB46_01225
ARH: AHiyo8_47360
ARY: ATC04_03770
ARU: ASPU41_11760
ARN: CGK93_07195
ARX: ARZXY2_1396
ACRY: AC20117_05500 AC20117_20545
ARTP: E5206_02920
AAGI: NCTC2676_1_02650(arsC_2)
ASUF: MNQ99_01815 MNQ99_09650
ARTY: AHiyo4_37440
ARI: UM93_12980
AAU: AAur_pTC20062(arsC)
APN: Asphe3_30920
PSUL: AU252_16550
PSNI: NIBR502771_04635
PSEY: GU243_09875
AAI: AARI_27780
GAR: AOZ07_14235
GCR: GcLGCM259_2402
GLU: F0M17_13635
GPR: JQN66_14130
GMI: NMP99_14215
GMY: XH9_11780
KPL: KPaMU14_08670 KPaMU14_12045
KII: KocCE7_11735
MLU: Mlut_20630
MICK: B1A86_00010310
MYU: M8233_09955
RTER: IDM49_02415
RAMA: IDM48_10305
NAE: BHE16_07095
CMUA: P8192_05380
PAEY: KUF55_05415 KUF55_06905
BFA: Bfae_31160
BRX: BH708_02980 BH708_11115
BGG: CFK41_01995
BRZ: CFK38_04240
BRR: C1N80_06605
BKI: M4486_09340
BRHA: NLU66_05165
BHH: Bra3105_06125
BHQ: BRM3_06760
DVA: DAD186_00200
DJJ: COP05_00265
JDE: Jden_2256
DNI: HX89_07210
DAY: FV141_13120
DERM: H7F30_04315
ALX: LVQ62_01725
SKE: Sked_11640
OEK: FFI11_002730
PSEI: GCE65_13845
JME: EEW87_012795
JAY: H7A72_04460
ORZ: FNH13_07180 FNH13_09095
OCP: NF557_01595
BLIN: BLSMQ_3134
BRI: FDF13_04100
BSPO: L1F31_00755
HALT: IM660_15450
RSUA: LQF12_13350
TFA: BW733_00815
TEZ: BKM78_11200
TLA: TLA_TLA_02256(arsC1_2)
PRV: G7070_02075
BRT: J4N02_02090
NRO: K8W59_11835
NBT: KLP28_11380
GOB: Gobs_4719
BSD: BLASA_1853
MMAR: MODMU_1928
KRA: Krad_0500
PAUT: Pdca_70720
PPEL: H6H00_08315
FSL: EJO69_07130
FLH: EJ997_12550
EKE: EK0264_08520
 » show all
Reference
1  [PMID:19286650]
  Authors
Ordonez E, Van Belle K, Roos G, De Galan S, Letek M, Gil JA, Wyns L, Mateos LM, Messens J
  Title
Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
  Journal
J Biol Chem 284:15107-16 (2009)
DOI:10.1074/jbc.M900877200
  Sequence
[cgl:Cgl1511 Cgl0263]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.4.2
IUBMB Enzyme Nomenclature: 2.8.4.2
ExPASy - ENZYME nomenclature database: 2.8.4.2
BRENDA, the Enzyme Database: 2.8.4.2

  All links  
Gene (313)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (307)   
   KEGG MGENES (4)   
   RefGene (1)   
Protein sequence (427)   
   UniProt (423)   
   SWISS-PROT (4)   
DNA sequence (367)   
   GenBank (187)   
   EMBL (180)   
Protein domain (2)   
   InterPro (2)   
All databases (1109)   

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