KEGG   ENZYME: 2.8.4.2
Entry
EC 2.8.4.2                  Enzyme                                 
Name
arsenate-mycothiol transferase;
ArsC1;
ArsC2;
mycothiol:arsenate transferase
Class
Transferases;
Transferring sulfur-containing groups;
Transferring alkylthio groups
Sysname
mycothiol:arsenate S-arsenotransferase
Reaction(IUBMB)
arsenate + mycothiol = arseno-mycothiol + H2O
Substrate
arsenate [CPD:C11215];
mycothiol [CPD:C06717]
Product
arseno-mycothiol;
H2O [CPD:C00001]
Comment
Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione.
History
EC 2.8.4.2 created 2010
Orthology
K18701  arsenate-mycothiol transferase
Genes
SKSFCN78_07980
NOHG5V57_14365
MAVMAV_1497
MJLMjls_1444
MDXBTO20_20570
MKUI2456_17785
MPAGC0J29_32075
MBRDMBRA_47590
MDFK0O62_16700
MPAEK0O64_29635
MSPGF6B93_09465
MVAMvan_3220
MGIMflv_1656
MSPMspyr1_53720
MCBMycch_4038 Mycch_5680
MFTXA26_02280
MRHMycrhN_2862 MycrhN_4470
MAUUNCTC10437_04855(arsC_4)
MMAGMMAD_27920
MFXMFAL_17510 MFAL_31790
MALVMALV_01950
MTYMTOK_20570
MPSCMPSYJ_13340 MPSYJ_17680
MARZMARA_04190 MARA_39360 MARA_62170
MHEVMHEL_32750
MMATMMAGJ_19530
MBOKMBOE_14510
MSEIMSEDJ_04440 MSEDJ_56640
MABMAB_4864
MABLMMASJCM_0455
MCHEBB28_04970
CGLCgl0263(Cgl0263) Cgl1511(Cgl1511)
CGBcg0319(arsX) cg1706
CGUWA5_0259(ArsX) WA5_1454
CGTcgR_0341 cgR_1571
CGSC624_01660 C624_08360
CGGC629_01660 C629_08370
CGMcgp_0319(arsX) cgp_1706
CGJAR0_01610 AR0_08095
CGQCGLAR1_01615 CGLAR1_07960
CGXSB89_01435 SB89_07795
CEFCE0876 CE1501
CDECDHC02_0082(arsC1)
CDZCD31A_0079(arsC1)
CDBCDBH8_0082(arsC1)
CJKjk2004(arsC)
CURcu0032
CUACU7111_0033(arsC)
CARcauri_1082(arsX)
CRDCRES_1295(arsC)
CVACVAR_2931(arsC)
CHNA605_06245
CCNH924_01135
CTERA606_00525
CMDB841_09220 B841_13026
CFNCFAL_03365
CCGCCASEI_09340
CVTB843_01660
CGYCGLY_11930(arsC)
CIICIMIT_04805
CUVCUREI_01230
COADR71_561 DR71_747
CDOCDOO_12005
CHMB842_00420 B842_10360
CSXCSING_05920(arsX)
CMQB840_09910(arsC1)
CKUUL82_02615
CEICEPID_00240 CEPID_01715
CTEDCTEST_03000 CTEST_03005(arsC1)
CUTCUTER_10045
CLWCLAC_10615
CDXCDES_00615 CDES_00620(arsC1) CDES_01420(arsC2)
CSPWM42_0272
CSTACSTAT_05620
CCJZccrud_07335
CPHOCPHO_07460
CFCCFLV_02210
CGVCGLAU_09665(arsC1)
CSPHCSPHI_10100 CSPHI_10350
CAMGCAMM_00370 CAMM_08775
CMINNCTC10288_01454(arsX)
CXEFOB82_03660 FOB82_03850 FOB82_07390
CEECENDO_04840(arsC1)
CSANE3227_04240
CSURN24_0382 N24_1603
CKFI6I12_07730
CLIAC3E79_09835
CAMCI6I65_05065
CUOCUROG_00495(arsC1)
CLIZG7Y31_04800
CTUBI6I74_10115
CLUJIAU68_01345
CQNG7Y29_00895
CKWCKALI_00715(arsC1)
CCOECETAM_10555(arsC4)
COKCOCCU_06340(arsC2)
CORYFQV43_03475
CWKIA203_02025
BFVC628_01495 C628_08295
NFAPNF2_260
NFRERS450000_05859(arsC_5)
NSLBOX37_21330
NWLNWFMUON74_17380 NWFMUON74_39800
NGPLTT66_31380
RERRER_pREL1-01620(arsC)
REYO5Y_29285
ROPROP_00190
RPYY013_26135
RBYCEJ39_06560
RHBNY08_3233
RAVAAT18_23435
RFAA3L23_01427(arsC1)
RHSA3Q41_01930(arsC1_1)
RHWBFN03_10935
RRZCS378_13250
RHUA3Q40_02951(arsC1_1) A3Q40_03063(arsC1_3) A3Q40_03401(arsC1_5)
RHQIM25_09890 IM25_24205
RHODAOT96_30980
RRT4535765_02655(arsC_3)
RCRNCTC10994_02721(arsC_1)
RTMG4H71_05865 G4H71_14205
GBRGbro_0790 Gbro_2681
GPOGPOL_174p01510
GORKTR9_0732 KTR9_4996
GOQACH46_10955
GTABCM27_04020
GITC6V83_10885 C6V83_11130
GRUGCWB2_00360(arsC1)
GOMD7316_04665(arsC1)
GAVC5O27_15845 C5O27_17450 C5O27_17970
GODGKZ92_00575 GKZ92_00650
GAMGII34_11100
GPDGII33_10605 GII33_22975
GJIH1R19_03605
GOILK459_12170
TPRTpau_2232
TSMASU32_00530 ASU32_12160
DTMBJL86_2701
DIZCT688_15040
DPCA6048_15740
CMICMM_1218
CMSCMS1869
CMCCMN_01192
CMHVO01_05040
CCAPAES38_05660
CZHH9X71_05730
MIOAOA12_13845
CRYB7495_16445
HEAHL652_11650
FRNF1C15_00910
PSEVUSB125703_00671(arsC1)
ARTArth_0216
ARRARUE_c37620(arsC1)
ARMART_1218
ARLAFL94_14170
ARWMB46_01225
ARHAHiyo8_47360
ARYATC04_03770
ARUASPU41_11760
ARNCGK93_07195
ARXARZXY2_1396
ACRYAC20117_05500 AC20117_20545
ARTPE5206_02920
AAGINCTC2676_1_02650(arsC_2)
ARIUM93_12980
AAUAAur_pTC20062(arsC)
APNAsphe3_30920
PSULAU252_16550
PSNINIBR502771_04635
PSEYGU243_09875
AAIAARI_27780
GARAOZ07_14235
GCRGcLGCM259_2402
GLUF0M17_13635
GPRJQN66_14130
KPLKPaMU14_08670 KPaMU14_12045
KIIKocCE7_11735
MLUMlut_20630
MICKB1A86_00010310
RTERIDM49_02415
RAMAIDM48_10305
NAEBHE16_07095
PAEYKUF55_05415 KUF55_06905
BFABfae_31160
BRXBH708_02980 BH708_11115
BGGCFK41_01995
BRZCFK38_04240
BRRC1N80_06605
DVADAD186_00200
DJJCOP05_00265
JDEJden_2256
DNIHX89_07210
DAYFV141_13120
ALXLVQ62_01725
SKESked_11640
OEKFFI11_002730
PSEIGCE65_13845
JMEEEW87_012795
ORZFNH13_07180 FNH13_09095
BLINBLSMQ_3134
BRIFDF13_04100
HALTIM660_15450
TFABW733_00815
TEZBKM78_11200
TLATLA_TLA_02256(arsC1_2)
PRVG7070_02075
BRTJ4N02_02090
NROK8W59_11835
GOBGobs_4719
BSDBLASA_1853
MMARMODMU_1928
KRAKrad_0500
PAUTPdca_70720
FSLEJO69_07130
FLHEJ997_12550
EKEEK0264_08520
 » show all
Reference
1  [PMID:19286650]
  Authors
Ordonez E, Van Belle K, Roos G, De Galan S, Letek M, Gil JA, Wyns L, Mateos LM, Messens J
  Title
Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
  Journal
J Biol Chem 284:15107-16 (2009)
DOI:10.1074/jbc.M900877200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.4.2
IUBMB Enzyme Nomenclature: 2.8.4.2
ExPASy - ENZYME nomenclature database: 2.8.4.2
BRENDA, the Enzyme Database: 2.8.4.2

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