KEGG   ENZYME: 2.8.4.6
Entry
EC 2.8.4.6                  Enzyme                                 
Name
S-methyl-1-thioxylulose 5-phosphate methylthiotransferase;
1-methylthioxylulose 5-phosphate sulfurylase (incorrect)
Class
Transferases;
Transferring sulfur-containing groups;
Transferring alkylthio groups
Sysname
S-methyl-1-thio-D-xylulose 5-phosphate:glutathione methylthiotransferase
Reaction(IUBMB)
S-methyl-1-thio-D-xylulose 5-phosphate + glutathione = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione [RN:R12946]
Reaction(KEGG)
R12946
Substrate
S-methyl-1-thio-D-xylulose 5-phosphate [CPD:C22359];
glutathione [CPD:C00051]
Product
1-deoxy-D-xylulose 5-phosphate [CPD:C11437];
S-(methylsulfanyl)glutathione [CPD:C22462]
Comment
The enzyme, characterized from the bacterium Rhodospirillum rubrum, belongs to the cupin superfamily and contains a manganese ion. It participates in an anaerobic salvage pathway that restores methionine from S-methyl-5'-thioadenosine. The enzyme was assayed in vitro using L-dithiothreitol instead of glutathione.
History
EC 2.8.4.6 created 2021
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K01767  S-methyl-1-thioxylulose 5-phosphate methylthiotransferase
Genes
TSYTHSYN_29580
AEHMlg_1167
HHAHhal_0468
HHKHH1059_21130
NAXHC341_12520
GBIPG2T_15065
URUDSM104443_00898(cupin)
UPLDSM104440_00832(cupin)
RBHB4966_02740
AZQG3580_15320
ZPAC3497_02355
BEBABWI17_00105
DESDSOUD_0056
DVEDESUT3_33930
RPARPA2170
RPBRPB_3226
RPCRPC_2183
RPDRPD_2234
RPERPE_3677
RPTRpal_2463
RPXRpdx1_3351
BOIBLM15_28095
MSLMsil_1243
MTUNMTUNDRAET4_0552
RVARvan_0193
MBRYB1812_01620
PSINCAK95_04590
RAPRHOA_5229(cupin)
RRURru_A2000
RRFF11_10280
RPMRSPPHO_02787
DMTDESME_06725
TMRTmar_0399
THEFE1B22_05655
THEPDYI95_001765
VPRVpar_1444
VATB7L28_07300
VRM44547418_01521
VDNNCTC11831_01551
VNKVEIT17_14130
VRGOKW85_07495
DPNBCB69_05105
DHODia5BBH33_00830
PUFUFO1_2835
PLANA1s21148_02520
CAPCLDAP_27020
THUGKNN16_02745 KNN16_02770
MRBMrub_0901
MREK649_04145
MSVMesil_0323
MTAIMtai_v1c06540
FGIOP10G_0984
CTMCabther_A1595
CVLJ8C06_04320
CHLOJ8C02_07855
RMRRmar_1883
RMGRhom172_0982
CPRVCYPRO_1178
DTPJZK55_15660
 » show all
Reference
1  [PMID:23042035]
  Authors
Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA.
  Title
A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.
  Journal
Nat Chem Biol 8:926-32 (2012)
DOI:10.1038/nchembio.1087
  Sequence
[rru:Rru_A2000]
Reference
2  [PMID:23035785]
  Authors
Warlick BP, Evans BS, Erb TJ, Ramagopal UA, Sriram J, Imker HJ, Sauder JM, Bonanno JB, Burley SK, Tabita FR, Almo SC, Sweedler JS, Gerlt JA.
  Title
1-methylthio-D-xylulose 5-phosphate methylsulfurylase: a novel route to 1-deoxy-D-xylulose 5-phosphate in Rhodospirillum rubrum.
  Journal
Biochemistry 51:8324-6 (2012)
DOI:10.1021/bi301215g
Reference
3  [PMID:25705145]
  Authors
Cho K, Evans BS, Wood BM, Kumar R, Erb TJ, Warlick BP, Gerlt JA, Sweedler JV.
  Title
Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.
  Journal
Metabolomics 11:503-17 (2015)
DOI:10.1007/s11306-014-0713-3
  Sequence
[rru:Rru_A2000]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.4.6
IUBMB Enzyme Nomenclature: 2.8.4.6
ExPASy - ENZYME nomenclature database: 2.8.4.6
BRENDA, the Enzyme Database: 2.8.4.6

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