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Entry
EC 2.8.5.1                  Enzyme                                 

Name
S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent);
cysK2 (gene name);
thiosulfate:3-phospho-L-serine thiosulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Thiosulfotransferases
BRITE hierarchy
Sysname
thiosulfate:3-phospho-L-serine thiosulfonotransferase
Reaction(IUBMB)
3-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate [RN:R12092]
Reaction(KEGG)
Substrate
3-phospho-L-serine [CPD:C01005];
thiosulfate [CPD:C00320]
Product
S-sulfo-L-cysteine [CPD:C05824];
phosphate [CPD:C00009]
Comment
The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC 2.5.1.144, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent).
History
EC 2.8.5.1 created 2018
Pathway
ec00270  Cysteine and methionine metabolism
Orthology
K22847  S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)
Genes
SUR: STAUR_4852
MBD: MEBOL_007806
CFUS: CYFUS_006579
BTF: YBT020_25570 YBT020_25575
BTM: MC28_E121
BTN: BTF1_31996
BLE: BleG1_0497
BKO: CKF48_11865
VIG: BKP57_04910
BBE: BBR47_51910
MTU: Rv0848(cysK2)
MTV: RVBD_0848
MRA: MRA_0856(cysK2)
MTUR: CFBS_0891(cysK2)
MTO: MTCTRI2_0871(cysK2)
MTD: UDA_0848(cysK2)
MTN: ERDMAN_0940(cysK2)
MTUE: J114_04515
MTUL: TBHG_00836
MTUT: HKBT1_0891(cysK2)
MTUU: HKBT2_0892(cysK2)
MTQ: HKBS1_0891(cysK2)
MBO: BQ2027_MB0871(cysK2)
MBB: BCG_0900(cysK2)
MBT: JTY_0870(cysK2)
MBM: BCGMEX_0871(cysK2)
MBX: BCGT_0654
MAF: MAF_08570(cysK2)
MMIC: RN08_0944
MCE: MCAN_08501(cysK2)
MCQ: BN44_10929(cysK)
MCV: BN43_20299(cysK)
MCX: BN42_20624(cysK)
MCZ: BN45_20137(cysK)
MMC: Mmcs_4197
MKM: Mkms_4263
MJL: Mjls_4560
MMI: MMAR_4768(cysK2)
MMAE: MMARE11_45970(cysK2)
MLI: MULP_04996(cysK2)
MHAD: B586_05670
MVA: Mvan_5856
MGI: Mflv_0899
MAB: MAB_1273
MABB: MASS_1270
MCHE: BB28_06270
MSTE: MSTE_01244
NFA: PNF1_800
GBR: Gbro_2603
GRU: GCWB2_23375(sbnA)
SGB: WQO_01640
SCB: SCAB_81941 SCAB_89801(cysK2)
SFA: Sfla_0474
SHY: SHJG_8381
SDV: BN159_2321(cysK2)
STRP: F750_6520
STRM: M444_32695
SPRI: SPRI_3639
SRW: TUE45_01194(sbnA_1)
SLE: sle_13800(sle_13800)
SLAU: SLA_3947
SALF: SMD44_04024(cysK)
SALJ: SMD11_0828(cysK) SMD11_3205(cysK) SMD11_3206(cysK)
SLX: SLAV_04965(sbnA1)
SFK: KY5_3864c
KSK: KSE_05300
SRO: Sros_4971
AOI: AORI_3636(cysK) AORI_5322(cysK)
AMI: Amir_4500
KAL: KALB_4827
ALO: CRK55305
SAQ: Sare_4585
ASE: ACPL_336(cbs)
ACTS: ACWT_0221
SNA: Snas_4716
 » show all
Taxonomy
Reference
1  [PMID:25022854]
  Authors
Steiner EM, Both D, Lossl P, Vilaplana F, Schnell R, Schneider G
  Title
CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.
  Journal
J Bacteriol 196:3410-20 (2014)
DOI:10.1128/JB.01851-14
  Sequence
[mtu:Rv0848]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.5.1
IUBMB Enzyme Nomenclature: 2.8.5.1
ExPASy - ENZYME nomenclature database: 2.8.5.1
BRENDA, the Enzyme Database: 2.8.5.1

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