KEGG   ENZYME: 2.8.5.1
Entry
EC 2.8.5.1                  Enzyme                                 
Name
S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent);
cysK2 (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Thiosulfotransferases
Sysname
thiosulfate:3-phospho-L-serine thiosulfotransferase
Reaction(IUBMB)
O-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate [RN:R12092]
Reaction(KEGG)
R12092
Substrate
O-phospho-L-serine [CPD:C01005];
thiosulfate [CPD:C00320]
Product
S-sulfo-L-cysteine [CPD:C05824];
phosphate [CPD:C00009]
Comment
The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC 2.5.1.144, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent).
History
EC 2.8.5.1 created 2018
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K22847  S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)
Genes
SMAF: D781_0294
SERA: Ser39006_009330
SERQ: CWC46_09325
DIC: Dpoa569_001723
VGA: BSQ33_06610
THIS: HZT40_06145
BMAE: DM78_1587
BPM: BURPS1710b_2157
BPL: BURPS1106A_2021
BPD: BURPS668_2001
BPR: GBP346_A2047
BPSE: BDL_236
BPSM: BBQ_1576
BPSU: BBN_1701
BPSD: BBX_2173
BPZ: BP1026B_I1669
BPQ: BPC006_I2069
BPK: BBK_3200
BPSH: DR55_2808
BPSA: BBU_411
BPSO: X996_2431
BUT: X994_878
BOK: DM82_5241
BOC: BG90_5368
BUU: WS70_22945
BVE: AK36_3728
BGD: bgla_1g16450
BGO: BM43_2871
BUK: MYA_4746
AAA: Acav_2531
SNIV: SFSGTM_32230
MLN: A9174_34630
MOP: Mesop_2827
MESM: EJ066_12365
MJR: EB229_34580
AAK: AA2016_5082 AA2016_6364
ESJ: SJ05684_a37250
RIR: BN877_p0206
RGA: RGR602_PB00321
ABAW: D5400_09955
OAN: Oant_0655
OAH: DR92_2288
BVV: BHK69_31135
BOI: BLM15_29675
CHEL: AL346_15250
TAW: EI545_21195
AZM: DM194_14960
AOZ: HUE56_06355
SUR: STAUR_4852
MBD: MEBOL_007806 MEBOL_007807
CFUS: CYFUS_006579
SBF: JCM31447_02650
BTF: YBT020_25570 YBT020_25575
BTM: MC28_E121
BTN: BTF1_31996
BWD: CT694_33820
BTRO: FJR70_30745
BLE: BleG1_0497
BKO: CKF48_11865
VIG: BKP57_04910
RMF: D5E69_05065
BBE: BBR47_51900 BBR47_51910
BHUI: LOK74_02695
TUM: CBW65_03370 CBW65_03375
TAB: CIG75_03435 CIG75_03440
KPUL: GXN76_08325 GXN76_08330 GXN76_09110
KEB: GXN75_06655 GXN75_06660
STD: SPPN_10420
LBT: AYR52_04430
MTU: Rv0848(cysK2)
MTV: RVBD_0848
MRA: MRA_0856(cysK2)
MTF: TBFG_10865
MTB: TBMG_03142
MTK: TBSG_03162
MTZ: TBXG_003121
MTG: MRGA327_05335
MTI: MRGA423_05325
MTE: CCDC5079_0783
MTUR: CFBS_0891(cysK2)
MTL: CCDC5180_0776
MTO: MTCTRI2_0871(cysK2)
MTD: UDA_0848(cysK2)
MTN: ERDMAN_0940(cysK2)
MTJ: J112_04555
MTUB: MT7199_0867
MTUE: J114_04515
MTX: M943_04445
MTUL: TBHG_00836
MTUT: HKBT1_0891(cysK2)
MTUU: HKBT2_0892(cysK2)
MTQ: HKBS1_0891(cysK2)
MBO: BQ2027_MB0871(cysK2)
MBB: BCG_0900(cysK2)
MBT: JTY_0870(cysK2)
MBM: BCGMEX_0871(cysK2)
MBK: K60_009060
MBX: BCGT_0654
MAF: MAF_08570(cysK2)
MMIC: RN08_0944
MCE: MCAN_08501(cysK2)
MCQ: BN44_10929(cysK)
MCV: BN43_20299(cysK)
MCX: BN42_20624(cysK)
MCZ: BN45_20137(cysK)
MID: MIP_04157 MIP_04205 MIP_04245 MIP_06534 MIP_06538
MYO: OEM_27880 OEM_28170 OEM_32590 OEM_32620
MCHI: AN480_12830 AN480_12925 AN480_17285 AN480_29515 AN480_29600
MMI: MMAR_4768(cysK2)
MMAE: MMARE11_45970(cysK2)
MLI: MULP_04996(cysK2)
MPSE: MPSD_49410(cysK2)
MSHO: MSHO_57790(cysK2)
MMC: Mmcs_1444 Mmcs_4197
MKM: Mkms_1462 Mkms_4263
MJL: Mjls_4424 Mjls_4560
MMM: W7S_14240 W7S_14385 W7S_21760 W7S_21775
MKN: MKAN_10175
MYV: G155_21715
MHAD: B586_05670
MDX: BTO20_20670 BTO20_20760
MKU: I2456_00990 I2456_17810
MGRO: FZ046_14055
MXE: MYXE_22280
MPAG: C0J29_31405 C0J29_31440
MBAI: MB901379_04178(sbnA_1)
MGAU: MGALJ_18520(cysK2)
MLJ: MLAC_02480(cysK2)
MSPG: F6B93_06430 F6B93_19150
MOT: LTS72_16170 LTS72_26020 LTS72_26040
MVA: Mvan_5856
MGI: Mflv_0899
MSP: Mspyr1_52450 Mspyr1_54570
MCB: Mycch_5733
MFT: XA26_44300
MRH: MycrhN_2793
MDU: MDUV_43860(cysK2)
MCHT: MCHIJ_52420(cysK2)
MFX: MFAL_33300(cysK2)
MIJ: MINS_20690(cysK2)
MALV: MALV_20470(cysK2_1) MALV_50380(cysK2_2)
MGAD: MGAD_03450(cysK2_1) MGAD_06270(cysK2_2)
MAUB: MAUB_63090(cysK2)
MPOF: MPOR_48650(cysK2)
MPHU: MPHO_09990(cysK2)
MMUC: C1S78_013240
MMAT: MMAGJ_03010(cysK2)
MBOK: MBOE_29480(cysK2)
MFG: K6L26_10040 K6L26_16565
MSEI: MSEDJ_56520(cysK2)
MFLV: NCTC10271_02348(cysK_2)
MCEE: MCEL_42540(cysK2)
MBRM: L2Z93_001217
MMON: EWR22_22650
MSEN: K3U95_08190
MPAE: K0O64_20125
MAB: MAB_1273
MMV: MYCMA_0230 MYCMA_0678
MABB: MASS_1270
MABL: MMASJCM_1298
MCHE: BB28_06270
MIZ: BAB75_02755 BAB75_06875
MSTE: MSTE_01244
MSAO: MYCSP_05585
MSAL: DSM43276_01140(sbnA_2)
NFA: PNF1_240 PNF1_800
NCY: NOCYR_1301 NOCYR_4030
NBR: O3I_021850
NSL: BOX37_11300
NSR: NS506_03058
NTP: CRH09_21180
NOZ: DMB37_03710
NOD: FOH10_16975
NAH: F5544_18010
NAD: NCTC11293_02051(cysK_2) NCTC11293_02191(cysK_3) NCTC11293_04496(cysK_4) NCTC11293_04790(cysK_5)
NWL: NWFMUON74_57370
NIE: KV110_14465 KV110_15955
NHU: H0264_22000 H0264_27310
NYA: LTV02_07100
NGP: LTT66_12425 LTT66_12465 LTT66_12585 LTT66_12675 LTT66_12700 LTT66_30510 LTT66_32490
NSPU: IFM12276_49830(cysK2)
ROP: ROP_04290 ROP_pROB01-02110
RBY: CEJ39_01350
RAV: AAT18_22155
RRZ: CS378_11920 CS378_13030
ROZ: CBI38_04050 CBI38_35580
RPSK: JWS13_03465 JWS13_26880
GBR: Gbro_2603
GTA: BCM27_13560
GRU: GCWB2_23375(sbnA)
GHN: MVF96_12890
GAMI: IHQ52_14205 IHQ52_19325
TPR: Tpau_3720
SGB: WQO_01640 WQO_04430
SFI: SFUL_851
SANL: KZO11_01405
SGRF: SGFS_004950 SGFS_063680
SCB: SCAB_81941 SCAB_89801(cysK2)
SVL: Strvi_2260 Strvi_4637
SHY: SHJG_0605 SHJG_8381
SHO: SHJGH_0438 SHJGH_8142
SRC: M271_00285
SMAL: SMALA_0850 SMALA_4055 SMALA_6628 SMALA_7561 SMALA_7563 SMALA_7774
SSOI: I1A49_07750 I1A49_36915 I1A49_42710
SFA: Sfla_0474
SBH: SBI_00132 SBI_00304
SDV: BN159_2321(cysK2)
SALS: SLNWT_1273 SLNWT_3845
STRP: F750_6520
SCI: B446_01550 B446_33740
SVT: SVTN_20190
STRE: GZL_08241 GZL_08796
SLD: T261_1932 T261_4035 T261_7505
SLC: SL103_18575
SXI: SXIM_05300 SXIM_52660
STRM: M444_23765 M444_32695
STRC: AA958_14630
SCZ: ABE83_10045
SCX: AS200_14540 AS200_15240 AS200_16900 AS200_44535
SRW: TUE45_01194(sbnA_1)
STRF: ASR50_33795
SLE: sle_13800(sle_13800)
SCLF: BB341_05285 BB341_14930
SGS: AVL59_16865 AVL59_23090 AVL59_26925
SGM: GCM10017557_07060(cysK2)
SPHW: NFX46_26080
SLS: SLINC_7467
SNR: SNOUR_37030 SNOUR_39960
SALU: DC74_1087 DC74_7059
SALL: SAZ_05930 SAZ_36615
SPLU: LK06_030140
STRD: NI25_07115 NI25_07360
SNW: BBN63_00355 BBN63_06130 BBN63_15905
SAUO: BV401_08065
SVU: B1H20_34215
SGV: B1H19_31615
SLAU: SLA_3947
SALF: SMD44_04024(cysK)
SALJ: SMD11_0828(cysK) SMD11_3205(cysK) SMD11_3206(cysK)
SLX: SLAV_04965(sbnA1)
SFK: KY5_3864c
SNZ: DC008_00750
SRJ: SRO_0812 SRO_1336 SRO_1552 SRO_1553
SLK: SLUN_04225 SLUN_22160 SLUN_34600
SQZ: FQU76_32795
SCYA: EJ357_01025 EJ357_01035 EJ357_03935 EJ357_35980
SKA: CP970_06505 CP970_22905
SGZ: C0216_19470 C0216_31660 C0216_32070
SNK: CP967_00905 CP967_12430
SRK: FGW37_29235
SGAL: CP966_04205
SSPO: DDQ41_25875
SVR: CP971_29440
SPAD: DVK44_32435
SAQU: EJC51_04875 EJC51_43285
SGF: HEP81_00791 HEP81_01303 HEP81_01738 HEP81_01739
SCAV: CVT27_24660
SSEO: D0Z67_27225 D0Z67_27230
SBY: H7H31_32515
SRIM: CP984_09290
SSUB: CP968_04435 CP968_16780 CP968_31390
SPHV: F9278_03965
SFUG: CNQ36_29700
SPAC: B1H29_04705
STSU: B7R87_01045
SCHA: CP983_03760 CP983_10120
SGX: H4W23_12745 H4W23_21435
SCOE: CP976_38290
SBAT: G4Z16_01825
SSPB: CP982_39520
SNF: JYK04_01698(cysK2_1) JYK04_07072(cysK2_3)
SBRO: GQF42_08375
SATA: C5746_34085
SFEU: IM697_20050
SDW: K7C20_01110
SAUH: SU9_000815
SPRA: CP972_26945
SPEU: CGZ69_35680 CGZ69_35790
SROI: IAG44_03450 IAG44_37590
SXN: IAG42_02365 IAG42_34700
SANU: K7396_35040
SINE: KI385_01465 KI385_34740
SLF: JEQ17_05930 JEQ17_48745
SDEC: L3078_02335 L3078_05485
SAOV: G3H79_19475
SDUR: M4V62_42570
SYAN: NRK68_29180
SAKB: K1J60_40540 K1J60_43050
STAA: LDH80_19120
SNIG: HEK616_32350 HEK616_49510
SCAE: IHE65_40785
STUB: MMF93_00115
SCIR: STRCI_000178 STRCI_006265
SXT: KPP03845_100605(cysK2)
STUD: STRTU_001428 STRTU_007026
SENG: OJ254_29500
SGK: PET44_31135
SANT: QR300_40610
SYUN: MOV08_38245 MOV08_40815
KSK: KSE_05300
KAB: B7C62_18890
KIS: HUT16_01770
PACD: EGX94_11085
KFL: Kfla_5741
NGV: CDO52_26280
SRO: Sros_4971
NOW: GBF35_28730
NCX: Nocox_20005(sbnA1) Nocox_22035(sbnA2)
SEN: SACE_1726 SACE_6328
SACG: FDZ84_32280 FDZ84_35350(aroF)
AOI: AORI_3636(cysK) AORI_5322(cysK)
AJA: AJAP_20955 AJAP_38285
AMYB: BKN51_10615
AMYY: YIM_22540(sbnA1) YIM_35370(sbnA5)
AORI: SD37_07395
AROO: NQK81_04365 NQK81_21270 NQK81_21665 NQK81_28385 NQK81_35085
PSEQ: AD006_31200
PECQ: AD017_30035
PHH: AFB00_19415
PAUT: Pdca_05570 Pdca_71290
PBRO: HOP40_19980 HOP40_20520
PPEL: H6H00_28340 H6H00_28940
APRE: CNX65_22405 CNX65_23745
AMI: Amir_4500 Amir_4781
SESP: BN6_51430
SSYI: EKG83_17025 EKG83_20585
KAL: KALB_4827
KUT: JJ691_65140
KBU: Q4V64_35645
KPHY: AOZ06_34875
LED: BBK82_35780
AHG: AHOG_13695(cysK)
ACTA: C1701_17215
ALO: CRK55305
ACTU: Actkin_04206(sbnA_1)
CROS: N8J89_05750
STP: Strop_2310
SAQ: Sare_4585
MICH: FJK98_22250
MCAB: HXZ27_18850
MSAG: GCM10017556_36640 GCM10017556_36660 GCM10017556_51490
VMA: VAB18032_22180
VER: HUT12_14625
ASE: ACPL_336(cbs)
AFS: AFR_18475
ACTS: ACWT_0221
PRY: Prubr_63250
NHY: JQS43_24645
CCAZ: COUCH_15010
SNA: Snas_2436 Snas_4716
AEY: CDG81_05040
KBS: EPA93_15145 EPA93_15150 EPA93_15485
KAN: IMCC3317_07860(sbnA)
 » show all
Reference
1  [PMID:25022854]
  Authors
Steiner EM, Both D, Lossl P, Vilaplana F, Schnell R, Schneider G
  Title
CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.
  Journal
J Bacteriol 196:3410-20 (2014)
DOI:10.1128/JB.01851-14
  Sequence
[mtu:Rv0848]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.5.1
IUBMB Enzyme Nomenclature: 2.8.5.1
ExPASy - ENZYME nomenclature database: 2.8.5.1
BRENDA, the Enzyme Database: 2.8.5.1

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (527)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (498)   
   KEGG MGENES (28)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (541)   

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