KEGG   ENZYME: 2.8.5.1
Entry
EC 2.8.5.1                  Enzyme                                 
Name
S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent);
cysK2 (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Thiosulfotransferases
Sysname
thiosulfate:3-phospho-L-serine thiosulfotransferase
Reaction(IUBMB)
O-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate [RN:R12092]
Reaction(KEGG)
R12092
Substrate
O-phospho-L-serine [CPD:C01005];
thiosulfate [CPD:C00320]
Product
S-sulfo-L-cysteine [CPD:C05824];
phosphate [CPD:C00009]
Comment
The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC 2.5.1.144, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent).
History
EC 2.8.5.1 created 2018
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K22847  S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)
Genes
SMAFD781_0294
SERASer39006_009330
SERQCWC46_09325
DICDpoa569_001723
VGABSQ33_06610
THISHZT40_06145
BMAEDM78_1587
BPMBURPS1710b_2157
BPLBURPS1106A_2021
BPDBURPS668_2001
BPRGBP346_A2047
BPSEBDL_236
BPSMBBQ_1576
BPSUBBN_1701
BPSDBBX_2173
BPZBP1026B_I1669
BPQBPC006_I2069
BPKBBK_3200
BPSHDR55_2808
BPSABBU_411
BPSOX996_2431
BUTX994_878
BOKDM82_5241
BOCBG90_5368
BUUWS70_22945
BVEAK36_3728
BGDbgla_1g16450
BGOBM43_2871
BUKMYA_4746
AAAAcav_2531
SNIVSFSGTM_32230
SURSTAUR_4852
MBDMEBOL_007806 MEBOL_007807
CFUSCYFUS_006579
MLNA9174_34630
MOPMesop_2827
MESMEJ066_12365
MJREB229_34580
AAKAA2016_5082 AA2016_6364
ESJSJ05684_a37250
RIRBN877_p0206
RGARGR602_PB00321
ABAWD5400_09955
OANOant_0655
OAHDR92_2288
BVVBHK69_31135
BOIBLM15_29675
CHELAL346_15250
TAWEI545_21195
AZMDM194_14960
AOZHUE56_06355
SBFJCM31447_02650
BTFYBT020_25570 YBT020_25575
BTMMC28_E121
BTNBTF1_31996
BWDCT694_33820
BTROFJR70_30745
BLEBleG1_0497
BKOCKF48_11865
VIGBKP57_04910
RMFD5E69_05065
BBEBBR47_51900 BBR47_51910
TUMCBW65_03370 CBW65_03375
TABCIG75_03435 CIG75_03440
KPULGXN76_08325 GXN76_08330 GXN76_09110
KEBGXN75_06655 GXN75_06660
STDSPPN_10420
LBTAYR52_04430
MTURv0848(cysK2)
MTVRVBD_0848
MRAMRA_0856(cysK2)
MTFTBFG_10865
MTBTBMG_03142
MTKTBSG_03162
MTZTBXG_003121
MTGMRGA327_05335
MTIMRGA423_05325
MTECCDC5079_0783
MTURCFBS_0891(cysK2)
MTLCCDC5180_0776
MTOMTCTRI2_0871(cysK2)
MTDUDA_0848(cysK2)
MTNERDMAN_0940(cysK2)
MTJJ112_04555
MTUBMT7199_0867
MTUEJ114_04515
MTXM943_04445
MTULTBHG_00836
MTUTHKBT1_0891(cysK2)
MTUUHKBT2_0892(cysK2)
MTQHKBS1_0891(cysK2)
MBOBQ2027_MB0871(cysK2)
MBBBCG_0900(cysK2)
MBTJTY_0870(cysK2)
MBMBCGMEX_0871(cysK2)
MBKK60_009060
MBXBCGT_0654
MAFMAF_08570(cysK2)
MMICRN08_0944
MCEMCAN_08501(cysK2)
MCQBN44_10929(cysK)
MCVBN43_20299(cysK)
MCXBN42_20624(cysK)
MCZBN45_20137(cysK)
MIDMIP_04157 MIP_04205 MIP_04245 MIP_06534 MIP_06538
MYOOEM_27880 OEM_28170 OEM_32590 OEM_32620
MCHIAN480_12830 AN480_12925 AN480_17285 AN480_29515 AN480_29600
MMCMmcs_1444 Mmcs_4197
MKMMkms_1462 Mkms_4263
MJLMjls_4424 Mjls_4560
MMIMMAR_4768(cysK2)
MMAEMMARE11_45970(cysK2)
MMMW7S_14240 W7S_14385 W7S_21760 W7S_21775
MLIMULP_04996(cysK2)
MKNMKAN_10175
MYVG155_21715
MHADB586_05670
MDXBTO20_20670 BTO20_20760
MKUI2456_00990 I2456_17810
MGROFZ046_14055
MXEMYXE_22280
MPAGC0J29_31405 C0J29_31440
MBAIMB901379_04178(sbnA_1)
MPSEMPSD_49410(cysK2)
MSHOMSHO_57790(cysK2)
MGAUMGALJ_18520(cysK2)
MLJMLAC_02480(cysK2)
MSENK3U95_08190
MPAEK0O64_20125
MSPGF6B93_06430 F6B93_19150
MOTLTS72_16170 LTS72_26020 LTS72_26040
MVAMvan_5856
MGIMflv_0899
MSPMspyr1_52450 Mspyr1_54570
MCBMycch_5733
MFTXA26_44300
MRHMycrhN_2793
MDUMDUV_43860(cysK2)
MCHTMCHIJ_52420(cysK2)
MFXMFAL_33300(cysK2)
MIJMINS_20690(cysK2)
MALVMALV_20470(cysK2_1) MALV_50380(cysK2_2)
MGADMGAD_03450(cysK2_1) MGAD_06270(cysK2_2)
MAUBMAUB_63090(cysK2)
MPOFMPOR_48650(cysK2)
MPHUMPHO_09990(cysK2)
MMUCC1S78_013240
MMATMMAGJ_03010(cysK2)
MBOKMBOE_29480(cysK2)
MFGK6L26_10040 K6L26_16565
MSEIMSEDJ_56520(cysK2)
MFLVNCTC10271_02348(cysK_2)
MCEEMCEL_42540(cysK2)
MABMAB_1273
MMVMYCMA_0230 MYCMA_0678
MABBMASS_1270
MABLMMASJCM_1298
MCHEBB28_06270
MIZBAB75_02755 BAB75_06875
MSTEMSTE_01244
MSAOMYCSP_05585
MSALDSM43276_01140(sbnA_2)
NFAPNF1_800
NCYNOCYR_1301 NOCYR_4030
NBRO3I_021850
NSLBOX37_11300
NSRNS506_03058
NTPCRH09_21180
NOZDMB37_03710
NODFOH10_16975
NAHF5544_18010
NADNCTC11293_02051(cysK_2) NCTC11293_02191(cysK_3) NCTC11293_04496(cysK_4) NCTC11293_04790(cysK_5)
NWLNWFMUON74_57370
NIEKV110_14465 KV110_15955
NHUH0264_22000 H0264_27310
NYALTV02_07100
NGPLTT66_12425 LTT66_12465 LTT66_12585 LTT66_12675 LTT66_12700 LTT66_30510 LTT66_32490
ROPROP_04290 ROP_pROB01-02110
RBYCEJ39_01350
RAVAAT18_22155
RRZCS378_11920 CS378_13030
ROZCBI38_04050 CBI38_35580
GBRGbro_2603
GTABCM27_13560
GRUGCWB2_23375(sbnA)
GHNMVF96_12890
GAMIIHQ52_14205 IHQ52_19325
TPRTpau_3720
SGBWQO_01640 WQO_04430
SCBSCAB_81941 SCAB_89801(cysK2)
SVLStrvi_2260 Strvi_4637
SHYSHJG_0605 SHJG_8381
SHOSHJGH_0438 SHJGH_8142
SRCM271_00285
SMALSMALA_0850 SMALA_4055 SMALA_6628 SMALA_7561 SMALA_7563 SMALA_7774
SSOII1A49_07750 I1A49_36915 I1A49_42710
SFASfla_0474
SBHSBI_00132 SBI_00304
SDVBN159_2321(cysK2)
SALSSLNWT_1273 SLNWT_3845
STRPF750_6520
SFISFUL_851
SCIB446_01550 B446_33740
SALUDC74_1087 DC74_7059
SALLSAZ_05930 SAZ_36615
SVTSVTN_20190
STREGZL_08241 GZL_08796
SLDT261_1932 T261_4035 T261_7505
SLCSL103_18575
SXISXIM_05300 SXIM_52660
STRMM444_23765 M444_32695
STRCAA958_14630
SCZABE83_10045
SCXAS200_14540 AS200_15240 AS200_16900 AS200_44535
SRWTUE45_01194(sbnA_1)
STRFASR50_33795
SLEsle_13800(sle_13800)
SCLFBB341_05285 BB341_14930
SGSAVL59_16865 AVL59_23090 AVL59_26925
SGMGCM10017557_07060(cysK2)
SLSSLINC_7467
SNRSNOUR_37030 SNOUR_39960
SPLULK06_030140
STRDNI25_07115 NI25_07360
SNWBBN63_00355 BBN63_06130 BBN63_15905
SAUOBV401_08065
SVUB1H20_34215
SGVB1H19_31615
SLAUSLA_3947
SALFSMD44_04024(cysK)
SALJSMD11_0828(cysK) SMD11_3205(cysK) SMD11_3206(cysK)
SLXSLAV_04965(sbnA1)
SFKKY5_3864c
SNZDC008_00750
SRJSRO_0812 SRO_1336 SRO_1552 SRO_1553
SLKSLUN_04225 SLUN_22160 SLUN_34600
SQZFQU76_32795
SCYAEJ357_01025 EJ357_01035 EJ357_03935 EJ357_35980
SKACP970_06505 CP970_22905
SGZC0216_19470 C0216_31660 C0216_32070
SNKCP967_00905 CP967_12430
SRKFGW37_29235
SGALCP966_04205
SSPODDQ41_25875
SVRCP971_29440
SPADDVK44_32435
SAQUEJC51_04875 EJC51_43285
SGFHEP81_00791 HEP81_01303 HEP81_01738 HEP81_01739
SCAVCVT27_24660
SSEOD0Z67_27225 D0Z67_27230
SBYH7H31_32515
SRIMCP984_09290
SSUBCP968_04435 CP968_16780 CP968_31390
SPHVF9278_03965
SFUGCNQ36_29700
SPACB1H29_04705
STSUB7R87_01045
SCHACP983_03760 CP983_10120
SGXH4W23_12745 H4W23_21435
SCOECP976_38290
SBATG4Z16_01825
SSPBCP982_39520
SNFJYK04_01698(cysK2_1) JYK04_07072(cysK2_3)
SBROGQF42_08375
SATAC5746_34085
SFEUIM697_20050
SDWK7C20_01110
SAUHSU9_000815
SPRACP972_26945
SPEUCGZ69_35680 CGZ69_35790
SROIIAG44_03450 IAG44_37590
SXNIAG42_02365 IAG42_34700
SANUK7396_35040
SINEKI385_01465 KI385_34740
SLFJEQ17_05930 JEQ17_48745
SDECL3078_02335 L3078_05485
SAOVG3H79_19475
KSKKSE_05300
KABB7C62_18890
PACDEGX94_11085
KFLKfla_5741
NALB005_4174
NGVCDO52_26280
SROSros_4971
NOWGBF35_28730
NCXNocox_20005(sbnA1) Nocox_22035(sbnA2)
SENSACE_1726 SACE_6328
SACGFDZ84_32280 FDZ84_35350(aroF)
AOIAORI_3636(cysK) AORI_5322(cysK)
AJAAJAP_20955 AJAP_38285
AMYBBKN51_10615
AMYYYIM_22540(sbnA1) YIM_35370(sbnA5)
AORISD37_07395
PSEQAD006_31200
PECQAD017_30035
PHHAFB00_19415
PAUTPdca_05570 Pdca_71290
PBROHOP40_19980 HOP40_20520
APRECNX65_22405 CNX65_23745
AMIAmir_4500 Amir_4781
SESPBN6_51430
SSYIEKG83_17025 EKG83_20585
KALKALB_4827
KPHYAOZ06_34875
LEDBBK82_35780
AHGAHOG_13695(cysK)
ACTAC1701_17215
ALOCRK55305
ACTUActkin_04206(sbnA_1)
STPStrop_2310
SAQSare_4585
MICHFJK98_22250
MCABHXZ27_18850
MSAGGCM10017556_36640 GCM10017556_36660 GCM10017556_51490
VMAVAB18032_22180
ASEACPL_336(cbs)
AFSAFR_18475
ACTSACWT_0221
VERHUT12_14625
PRYPrubr_63250
NHYJQS43_24645
CCAZCOUCH_15010
SNASnas_2436 Snas_4716
AEYCDG81_05040
KBSEPA93_15145 EPA93_15150 EPA93_15485
KANIMCC3317_07860(sbnA)
 » show all
Reference
1  [PMID:25022854]
  Authors
Steiner EM, Both D, Lossl P, Vilaplana F, Schnell R, Schneider G
  Title
CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.
  Journal
J Bacteriol 196:3410-20 (2014)
DOI:10.1128/JB.01851-14
  Sequence
[mtu:Rv0848]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.5.1
IUBMB Enzyme Nomenclature: 2.8.5.1
ExPASy - ENZYME nomenclature database: 2.8.5.1
BRENDA, the Enzyme Database: 2.8.5.1

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