KEGG   ENZYME: 3.1.1.1Help
Entry
EC 3.1.1.1                  Enzyme                                 

Name
carboxylesterase;
ali-esterase;
B-esterase;
monobutyrase;
cocaine esterase;
procaine esterase;
methylbutyrase;
vitamin A esterase;
butyryl esterase;
carboxyesterase;
carboxylate esterase;
carboxylic esterase;
methylbutyrate esterase;
triacetin esterase;
carboxyl ester hydrolase;
butyrate esterase;
methylbutyrase;
alpha-carboxylesterase;
propionyl esterase;
nonspecific carboxylesterase;
esterase D;
esterase B;
esterase A;
serine esterase;
carboxylic acid esterase;
cocaine esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
carboxylic-ester hydrolase
Reaction(IUBMB)
a carboxylic ester + H2O = an alcohol + a carboxylate [RN:R00630]
Reaction(KEGG)
Substrate
carboxylic ester [CPD:C02391];
H2O [CPD:C00001]
Product
alcohol [CPD:C00069];
carboxylate [CPD:C00060]
Comment
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
History
EC 3.1.1.1 created 1961
Pathway
ec00983  Drug metabolism - other enzymes
Orthology
K01044  carboxylesterase 1
K03927  carboxylesterase 2
K03928  carboxylesterase
K15743  carboxylesterase 3/5
Genes
HSA: 1066(CES1) 221223(CES5A) 23491(CES3) 8824(CES2)
PTR: 454098(CES5A) 454378(CES3) 467996 740768(CES2) 747009 750059 750120
PPS: 100975226 100980372 100986122 100990164 100990515 100993402(CES5A) 100993746(CES1) 100994078(CES2)
GGO: 101128088 101128458 101136153 101143341(CES3) 101149966(CES1) 101150328(CES5A) 101152974 101153337 109023585 109023694 109023710
PON: 100172153(CES3) 100174711(CES1) 100431215 100451021 100460832(CES5A) 103892689
NLE: 100590392 100599005(CES1) 100599348(CES5A) 100599562 100605306 100605971(CES3)
MCC: 695543 697524 699486(CES1) 699601(CES5A) 707292 707412(CES1)
MCF: 102119346 102120721 102126883 102127252 102127617 102128556 102129184(CES1) 102129802(CES5A)
CSAB: 103233017(CES5A) 103233018(CES1) 103233020 103233135 103233136 103233528 103233529
RRO: 104655660 104655662 104655691(CES3) 104660505 104660506 104665602 104665604 104671477 104671485 104676793
CJC: 100390116 100390472(CES1) 100390838(CES5A) 100400260(CES2) 103789505(CES3)
MMU: 102022(Ces2a) 104158(Ces1d) 13884(Ces1c) 13897(Ces1e) 13909(Ces3b) 234564(Ces1f) 234669(Ces2b) 234671(Ces2c) 234673(Ces2e) 382053(Ces3a) 436059(Ces2h) 67935(Ces5a) 72361(Ces2g)
RNO: 100125372(Ces1f) 100365112(Ces2) 100910144(Ces2) 113902(Ces1d) 171118(Ces2c) 24346(Ces1c) 246252(Ces2a) 291863 291952(Ces2g) 29225(Ces1e) 307660(Ces5a) 498940(Ces2h) 679149 679368 689754(Ces3a)
TUP: 102475270(CES2) 102481101(CES1) 102482069(CES5A)
CFA: 403643(CES1) 445456(CES5A) 489769(CES2)
AML: 100465627(CES1) 100465876(CES5A) 100482837(CES3) 109488335
UMR: 103673676(CES2) 103673785(CES5A) 103673786(CES1)
ORO: 101369673(CES3) 101369971(CES2) 101376982(CES5A) 101377267(CES1)
FCA: 101087285(CES4A) 101096775(CES2) 101097032(CES3) 445455(CES5A) 493774(CES1)
PTG: 102953134(CES2) 102954300(CES4A) 102954575(CES3) 102957516(CES1) 102957999(CES5A)
AJU: 106971297(CES2) 106971322(CES4A) 106971342(CES3) 106973293(CES1) 106973294(CES5A)
BTA: 505928(CES2) 508916 512098(CES1) 513112(CES3) 513992(CES5A)
BIU: 109572157(CES5A) 109572559(CES2) 109572562(CES3) 109572563(CES4A) 109572788 109572944
PHD: 102327438(CES4A) 102327808(CES3) 102328178(CES2) 102338123 102341926(CES5A) 102342275
OAS: 101105682(CES3) 101109730(CES2) 101109991(CES4A) 101116336 101116756 780451(CES5A)
SSC: 100302694(CES5A) 100626873(CES3) 397478(CES1)
CFR: 102509275(CES1) 102509741(CES4A) 102509977(CES3) 102510209(CES2) 102516349 102524466
CDK: 105088466(CES3) 105088467(CES2) 105096169(CES5A) 105096170(CES1)
BACU: 103011388(CES5A) 103013635(CES3) 103015234 103021148(CES2)
HAI: 109388783(CES2) 109395626(CES1) 109395627(CES5A)
RSS: 109457112(CES5A) 109457113(CES1) 109459204(CES2)
PALE: 102881795(CES4A) 102884308(CES5A) 102884390(CES1)
MDO: 100019607(CES3) 100144614(CES2.1) 100144615(CES1) 100144616(CES2.3) 100144617(CES2.2)
OAA: 100079382(CES1) 100682155
GGA: 415786(CES1L1) 415787 769339(CES1L2) 769704
MGP: 104912916
GFR: 102044313
PHI: 102108247 102111003(CES2)
PMAJ: 107210014(CES2)
AMJ: 102563772(CES1) 102564001(CES5A) 102564228 102564454(CES2)
CMY: 102944601
PBI: 103049679 103067569(CES2)
GJA: 107110321 107110324(CES1)
DRE: 561967(si:ch211-93f2.1) 566132(ces2)
CSEM: 103380524
ELS: 105018420(ces1) 105018583
LCM: 102345732
DME: Dmel_CG17148(Est-P) Dmel_CG2505(alpha-Est2) Dmel_CG34139(Nlg4) Dmel_CG3841 Dmel_CG6917(Est-6)
DSI: Dsimw501_GD23616(Dsim_GD23616)
MDE: 101890018
CEL: CELE_C52A10.2(C52A10.2) CELE_F13H6.3(F13H6.3) CELE_R12A1.4(ges-1)
CBR: CBG18921
TSP: Tsp_00383
ADF: 107339511
ANI: AN7521.2
ANG: ANI_1_216174(An10g00780) ANI_1_712104(An12g05590)
ABE: ARB_01072
TVE: TRV_02843
PTE: PTT_11550
XAL: XALC_1776
SML: Smlt1420
SMT: Smal_1188
SMZ: SMD_1258
LEM: LEN_0204
PFL: PFL_4885
PPRO: PPC_4894(est)
PFS: PFLU_1129
PFB: VO64_4246
PMAN: OU5_4732(est)
PSEM: TO66_24995
PSOS: POS17_4861
PANR: A7J50_1127
LPN: lpg2845
LPH: LPV_3200
LPO: LPO_3147
LPM: LP6_2874
LPF: lpl2757
LPP: lpp2904
LPC: LPC_3129
LPA: lpa_04134
LPE: lp12_2835
LLO: LLO_0203
LHA: LHA_3097
LOK: Loa_02786
TMC: LMI_0170
PSAL: PSLF89_664
LHK: LHK_01719
RPI: Rpic_0843
RME: Rmet_0604
CGD: CR3_3773(yvaK)
BMAE: DM78_3476
BMAI: DM57_09795
BPS: BPSS0716
BPSE: BDL_3950
BPSM: BBQ_5476
BPSU: BBN_4118
BPSD: BBX_5788
BPK: BBK_3772
BPSH: DR55_4632
BPSA: BBU_5326
BPSO: X996_3900
BUT: X994_3899
BOK: DM82_12
BOC: BG90_1009
BCN: Bcen_5069
BCJ: BCAM0092
BCEO: I35_4101
BCED: DM42_5062
BUB: BW23_4210
BSEM: WJ12_21060
BMEC: WJ16_20265
BUL: BW21_5216
BPH: Bphy_5564
PNU: Pnuc_0952
PPNO: DA70_08585
PPNM: LV28_22055
PSPU: NA29_20715
PAPI: SG18_15295
BHZ: ACR54_00338(est)
AXX: ERS451415_00849(est_1) ERS451415_05100(est_2)
AAV: Aave_4327
AAA: Acav_4230
DAC: Daci_0130
CTES: O987_00715
CFU: CFU_2349(est)
CARE: LT85_2294
RGE: RGE_17280
MEH: M301_1784
MEP: MPQ_1272
SLT: Slit_0449
GCA: Galf_1158
DSU: Dsui_2923
DAR: Daro_1174
PCA: Pcar_0758
DEU: DBW_0938
DVU: DVU1824
DVL: Dvul_1336
DVM: DvMF_0547
DDE: Dde_1813
DRT: Dret_1708
ADE: Adeh_3458
MXA: MXAN_6764
HOH: Hoch_0218
ARA: Arad_4493
AVI: Avi_5529
RPA: RPA4646
RPB: RPB_3278
RPT: Rpal_5127
XAU: Xaut_1037
HDN: Hden_1966
BSU: BSU33620(yvaK)
BSR: I33_3484
BSL: A7A1_2581
BSH: BSU6051_33620(yvaK)
BSUT: BSUB_03590(yvaK)
BSUL: BSUA_03590(yvaK)
BSUS: Q433_18445
BSS: BSUW23_16480(yvaK)
BST: GYO_3679
BSO: BSNT_09943(yvaK)
BSQ: B657_33620(yvaK)
BSX: C663_3233(est)
BLI: BL03481(yvaK)
BLD: BLi03642(est)
BLH: BaLi_c36500(yvaK)
BAY: RBAM_030910(yvaK)
BAQ: BACAU_3117(yvaK)
BYA: BANAU_3278(yvaK)
BAMP: B938_15835
BAML: BAM5036_3005(yvaK)
BAMA: RBAU_3226(yvaK)
BAMN: BASU_3007(yvaK)
BAMB: BAPNAU_3285(yvaK)
BAMT: AJ82_17470
BAMY: V529_33520(yvaK)
BMP: NG74_03259(est)
BAO: BAMF_3217(yvaK)
BAZ: BAMTA208_17085(yvaK)
BQL: LL3_03500(yvaK)
BXH: BAXH7_03488(yvaK)
BQY: MUS_3689(yvaK)
BAMI: KSO_003680
BAMC: U471_32060
BAMF: U722_16605
BATR: TD68_13790
BHA: BH3554
BAN: BA_5335(estA)
BAR: GBAA_5335(estA)
BAT: BAS4957
BAH: BAMEG_5389(estA)
BAI: BAA_5366(estA)
BANT: A16_53490
BANR: A16R_54120
BANS: BAPAT_5116
BANV: DJ46_4002(est)
BCE: BC5130
BCA: BCE_5233(estA)
BCZ: BCE33L4819(est)
BCR: BCAH187_A5279(estA)
BCB: BCB4264_A5244(estA)
BCU: BCAH820_5215(estA)
BCG: BCG9842_B5708(estA)
BCQ: BCQ_4935(estA)
BCX: BCA_5241(estA)
BAL: BACI_c51120(est)
BNC: BCN_5028
BCF: bcf_25580
BCER: BCK_09750
BTK: BT9727_4809(est)
BTL: BALH_4623(est)
BTB: BMB171_C4702(estA)
BTT: HD73_5462
BTC: CT43_CH5158(estA)
BTG: BTB_c53210(est)
BTI: BTG_23085
BTW: BF38_858(est)
BWW: bwei_4668(estA1)
BMYC: DJ92_2176(est)
BMYO: BG05_928(est)
BCL: ABC3005
BPU: BPUM_3032
BPUM: BW16_16305
BPUS: UP12_15810
BMEG: BG04_2037(est) BG04_5418
BCOA: BF29_1359(est) BF29_3097
BJS: MY9_3410
BMET: BMMGA3_14630(est)
BACW: QR42_15285
BACP: SB24_13295
BACB: OY17_18765
BACO: OXB_0145
BACY: QF06_15165
BACL: BS34A_36690(yvaK)
BALM: BsLM_3372
BGY: BGLY_4027(est)
BKW: BkAM31D_20390(est)
BBEV: BBEV_0595(est)
AFL: Aflv_2499
ANM: GFC28_3096(est)
AAMY: GFC30_586(est)
ANL: GFC29_2339(est)
AXL: AXY_18260
VPN: A21D_00095(est)
BSE: Bsel_1126
SAR: SAR0457 SAR0835(est)
SAC: SACOL0499 SACOL0845(est)
SAD: SAAV_0400 SAAV_0745(est)
SUZ: MS7_0430 MS7_0830(est)
SAUS: SA40_0395 SA40_0719(est)
SAUB: C248_0507 C248_0870(est)
SAUC: CA347_451 CA347_799(est)
SER: SERP0090 SERP0449(est)
SEPS: DP17_1510 DP17_1861(est)
SCA: SCA_0083 SCA_0431(est)
SDT: SPSE_1954(est)
SHU: SHYC_09790(est)
SCAP: AYP1020_0148(est_1) AYP1020_2177(est_2)
SSCH: LH95_09340
SSCZ: RN70_10110
SAGQ: EP23_00190
MCAK: MCCS_01780(est_1) MCCS_05120 MCCS_07350(est_2)
LMO: lmo2450
LMF: LMOf2365_2423(est-1)
LMOG: BN389_24130(est)
LMQ: LMM7_2492
LMS: LMLG_2121
LML: lmo4a_2453(est-1)
LMP: MUO_12230
LMW: LMOSLCC2755_2454(est-1)
LMX: LMOSLCC2372_2512(est-1)
LMZ: LMOSLCC2482_2453(est-1)
LMON: LMOSLCC2376_2342(est-1)
LMOC: LMOSLCC5850_2452(est-1)
LMOS: LMOSLCC7179_2362(est-1)
LMOO: LMOSLCC2378_2453(est-1)
LMOY: LMOSLCC2479_2512(est-1)
LMOT: LMOSLCC2540_2483(est-1)
LMOA: LMOATCC19117_2459(est-1)
LMOL: LMOL312_2410(est-1)
LMOE: BN418_2901
LMOB: BN419_2911
LMOD: LMON_2461
LMOW: AX10_06315
LMOX: AX24_10170
LMOQ: LM6179_1823(yvaK)
LMR: LMR479A_2575(yvaK)
LMOK: CQ02_12435
LMOM: IJ09_12560
LIN: lin2544
LWE: lwe2398(est-1)
LSG: lse_2349(est-1)
LIV: LIV_2355
PPOL: X809_03400
PMW: B2K_01040
PSWU: SY83_11900
ASOC: CB4_00780(est)
BTS: Btus_2137
LPL: lp_0796
LPJ: JDM1_0660
LPZ: Lp16_0631
LSA: LCA_1412
LBR: LVIS_0668
LCA: LSEI_0975
LPAP: LBPC_0914
LCB: LCABL_11380(estA)
LCS: LCBD_1118
LCE: LC2W_1125
LRE: Lreu_0393
LRF: LAR_0388
LRT: LRI_1539
LRH: LGG_00941(yvaK)
LRG: LRHM_0898
LRA: LRHK_980
LBH: Lbuc_1312
EFA: EF2618
EFL: EF62_2784
EFI: OG1RF_11995(est)
EFS: EFS1_2092
EFN: DENG_02555(yvaK)
EFQ: DR75_1323
EFM: M7W_944
EHR: EHR_08455
ECAS: ECBG_02781
EMU: EMQU_1996
EDU: LIU_11095
MPS: MPTP_1575
MPX: MPD5_0474
THL: TEH_17700
AUR: HMPREF9243_1286(est)
CRN: CAR_c04110(yvaK)
CML: BN424_874
CARC: NY10_2177
JDA: BW727_101081(est)
HSC: HVS_14630(est)
SWO: Swol_0278
SLP: Slip_1844
SGY: Sgly_3207
CTHM: CFE_0552
TACI: TDSAC_0148
PUF: UFO1_4007
PFT: JBW_00884
AIN: Acin_1211
MBJ: KQ51_01327(est)
SCO: SCO2123(SC6E10.17)
SGR: SGR_5380
SGB: WQO_08415
SCT: SCAT_1251
SFA: Sfla_4695
SBH: SBI_07839
SHY: SHJG_3606
SVE: SVEN_1783
SALB: XNR_4757
STRP: F750_1987
SFI: SFUL_1697
SALU: DC74_2608
SALL: SAZ_14360
STRE: GZL_06393
SLD: T261_6044
STRM: M444_10875
SPRI: SPRI_5376
SLE: sle_50160(sle_50160)
STRD: NI25_28560
SMAL: SMALA_2057
SLAU: SLA_1717
SALF: SMD44_02330(yvaK)
SALJ: SMD11_4932(yvaK)
SFK: KY5_2106
KSK: KSE_21630
ARM: ART_0096
ARX: ARZXY2_2294(yvaK) ARZXY2_2295(yvaK)
AAU: AAur_1691
KRH: KRH_15000
LMOI: VV02_16875
BLIN: BLSMQ_1988
MPH: MLP_41640
NCA: Noca_3105
NDK: I601_2684
KFL: Kfla_2828
PSIM: KR76_11120
NDA: Ndas_3127
NAL: B005_0087
SRO: Sros_2705
FAL: FRAAL5088
NML: Namu_3228
KRA: Krad_0730
AMD: AMED_2456(yvaK)
AMN: RAM_12490
AMM: AMES_2429(yvaK)
AMZ: B737_2430(yvaK)
AOI: AORI_2419(yvaK)
AMQ: AMETH_4901(yvaK)
ACTI: UA75_25410
ACAD: UA74_24830
ALL: CRK55713
CAI: Caci_6060
SNA: Snas_4937
TBI: Tbis_1312
SYG: sync_0827(est)
CYA: CYA_1871(est)
CYB: CYB_1563(est)
TEL: tll0989
AMR: AM1_E0093
GVI: gll2009
RCA: Rcas_3124
CAU: Caur_1058
CAG: Cagg_2553
HAU: Haur_1197
TRO: trd_1160
STI: Sthe_2075
ATM: ANT_27940
TRA: Trad_1307
TTH: TT_C1341
TTJ: TTHA1705
TAQ: TO73_2266
MRB: Mrub_2760
PBOR: BSF38_01000(est)
TPA: TP_0902
TPP: TPASS_0902(est)
TPB: TPFB_0902
TDE: TDE0187
TPED: TPE_0784
GAU: GAU_0165
GBA: J421_0517
SLI: Slin_6427
CTE: CT2271
CPC: Cpar_2030
CCH: Cag_1939
CLI: Clim_2449
PVI: Cvib_1726
PLT: Plut_2086
PPH: Ppha_2855
PAA: Paes_2227
TMA: TM1022
TMW: THMA_1043
TMQ: THMB_1043
TMX: THMC_1043
TPT: Tpet_1725
TRQ: TRQ2_1784
TNA: CTN_1557
TNP: Tnap_1739
TLE: Tlet_1810
TME: Tmel_0869
TAF: THA_1126
THER: Y592_05185
FNO: Fnod_0857
PMO: Pmob_0119
MARN: LN42_09590
DTN: DTL3_0052
KOL: Kole_1618
MOX: DAMO_0465
 » show all
Taxonomy
Reference
1  [PMID:4884138]
  Authors
Augusteyn RC, de Jersey J, Webb EC, Zerner B.
  Title
On the homology of the active-site peptides of liver carboxylesterases.
  Journal
Biochim Biophys Acta 171:128-37 (1969)
DOI:10.1016/0005-2744(69)90112-0
Reference
2  [PMID:4981346]
  Authors
Barker DL, Jencks WP.
  Title
Pig liver esterase. Physical properties.
  Journal
Biochemistry 8:3879-89 (1969)
Reference
3  [PMID:5353595]
  Authors
Bertram J, Krisch K.
  Title
Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney.
  Journal
Eur J Biochem 11:122-6 (1969)
DOI:10.1111/j.1432-1033.1969.tb00748.x
Reference
4  [PMID:13208632]
  Authors
BURCH J.
  Title
The purification and properties of horse liver esterase.
  Journal
Biochem J 58:415-26 (1954)
Reference
5  [PMID:5785220]
  Authors
Horgan DJ, Stoops JK, Webb EC, Zerner B.
  Title
Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase.
  Journal
Biochemistry 8:2000-6 (1969)
Reference
6
  Authors
Malhotra, O.P. and Philip, G.
  Title
Specificity of goat intestinal esterase.
  Journal
Biochem Z 346:386-402 (1966)
Reference
7  [PMID:6208846]
  Authors
Mentlein R, Schumann M, Heymann E.
  Title
Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes.
  Journal
Arch Biochem Biophys 234:612-21 (1984)
DOI:10.1016/0003-9861(84)90311-4
Reference
8  [PMID:5785222]
  Authors
Runnegar MT, Scott K, Webb EC, Zerner B.
  Title
Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase.
  Journal
Biochemistry 8:2013-8 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.1
IUBMB Enzyme Nomenclature: 3.1.1.1
ExPASy - ENZYME nomenclature database: 3.1.1.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.1
BRENDA, the Enzyme Database: 3.1.1.1
CAS: 9016-18-6

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