KEGG   ENZYME: 3.1.1.100
Entry
EC 3.1.1.100                Enzyme                                 

Name
chlorophyllide a hydrolase;
bciC (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
chlorophyllide-a hydrolase
Reaction(IUBMB)
chlorophyllide a + H2O = 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d + methanol + CO2 [RN:R09061]
Reaction(KEGG)
R09061
Substrate
chlorophyllide a [CPD:C02139];
H2O [CPD:C00001]
Product
8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d;
methanol [CPD:C00132];
CO2 [CPD:C00011]
Comment
This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green filamentous bacteria (Chloroflexaceae), catalyses the first committed step in the biosynthesis of bacteriochlorophylls c, d, and e, the removal of the C-132-methylcarboxyl group from chlorophyllide a. The reaction is very similar to the conversion of pheophorbide a to pyropheophorbide a during chlorophyll a degradation, which is catalysed by EC 3.1.1.82, pheophorbidase.
History
EC 3.1.1.100 created 2016
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K21058  chlorophyllide a hydrolase
Genes
CAU: Caur_0916
CHL: Chy400_1001
CAG: Cagg_2236
CTM: Cabther_B0081
CVL: J8C06_12195
CHLO: J8C02_13080
CTE: CT1077
CPC: Cpar_1043
CLZ: BIU88_05675
CCH: Cag_1069
CLI: Clim_1212
PVI: Cvib_0856
PLT: Plut_1085
PPH: Ppha_1315
PAA: Paes_1150
CTS: Ctha_2200
 » show all
Reference
1  [PMID:21550979]
  Authors
Liu Z, Bryant DA
  Title
Identification of a gene essential for the first committed step in the biosynthesis of bacteriochlorophyll c.
  Journal
J Biol Chem 286:22393-402 (2011)
DOI:10.1074/jbc.M111.249433
  Sequence
[cte:CT1077] [ctm:Cabther_B0081]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.100
IUBMB Enzyme Nomenclature: 3.1.1.100
ExPASy - ENZYME nomenclature database: 3.1.1.100
BRENDA, the Enzyme Database: 3.1.1.100

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