KEGG   ENZYME: 3.1.1.100
Entry
EC 3.1.1.100                Enzyme                                 
Name
chlorophyllide a hydrolase;
bciC (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
chlorophyllide-a hydrolase
Reaction(IUBMB)
chlorophyllide a + H2O = 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d + methanol + CO2 [RN:R09061]
Reaction(KEGG)
R09061
Substrate
chlorophyllide a [CPD:C02139];
H2O [CPD:C00001]
Product
8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide d;
methanol [CPD:C00132];
CO2 [CPD:C00011]
Comment
This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green filamentous bacteria (Chloroflexaceae), catalyses the first committed step in the biosynthesis of bacteriochlorophylls c, d, and e, the removal of the C-132-methylcarboxyl group from chlorophyllide a. The reaction is very similar to the conversion of pheophorbide a to pyropheophorbide a during chlorophyll a degradation, which is catalysed by EC 3.1.1.82, pheophorbidase.
History
EC 3.1.1.100 created 2016
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K21058  chlorophyllide a hydrolase
Genes
CAUCaur_0916
CHLChy400_1001
CAGCagg_2236
CTMCabther_B0081
CVLJ8C06_12195
CHLOJ8C02_13080
CTECT1077
CPCCpar_1043
CLZBIU88_05675
CCHCag_1069
CPHCpha266_1276
CPBCphamn1_1371
CLIClim_1212
PVICvib_0856
PLTPlut_1085
PPHPpha_1315
PAAPaes_1150
PROCPtc2401_01155
PRSB9H02_05810
PROSCHL67_05920
CTSCtha_2200
 » show all
Reference
1  [PMID:21550979]
  Authors
Liu Z, Bryant DA
  Title
Identification of a gene essential for the first committed step in the biosynthesis of bacteriochlorophyll c.
  Journal
J Biol Chem 286:22393-402 (2011)
DOI:10.1074/jbc.M111.249433
  Sequence
[cte:CT1077] [ctm:Cabther_B0081]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.100
IUBMB Enzyme Nomenclature: 3.1.1.100
ExPASy - ENZYME nomenclature database: 3.1.1.100
BRENDA, the Enzyme Database: 3.1.1.100

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