Entry
Name
poly(ethylene terephthalate) hydrolase;
PETase;
PET hydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
poly(ethylene terephthalate) hydrolase
Reaction(IUBMB)
(ethylene terephthalate)n + H2O = (ethylene terephthalate)n-1 + 4-[(2-hydroxyethoxy)carbonyl]benzoate [RN:
R11540 ]
Reaction(KEGG)
Substrate
Product
(ethylene terephthalate)n-1;
4-[(2-hydroxyethoxy)carbonyl]benzoate [CPD:
C21450 ]
Comment
The enzyme, isolated from the bacterium Ideonella sakaiensis, also produces small amounts of terephthalate (cf. EC
3.1.1.102 , mono(ethylene terephthalate) hydrolase). The reaction takes place on PET-film placed in solution.
History
EC 3.1.1.101 created 2016
Pathway
ec00624 Polycyclic aromatic hydrocarbon degradation
ec01120 Microbial metabolism in diverse environments
Orthology
K21104 poly(ethylene terephthalate) hydrolase
Reference
Authors
Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, Toyohara K, Miyamoto K, Kimura Y, Oda K
Title
A bacterium that degrades and assimilates poly(ethylene terephthalate).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.1.1.101