KEGG   ENZYME: 3.1.1.102
Entry
EC 3.1.1.102                Enzyme                                 

Name
mono(ethylene terephthalate) hydrolase;
MHET hydrolase;
MHETase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
4-[(2-hydroxyethoxy)carbonyl]benzoate acylhydrolase
Reaction(IUBMB)
4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = terephthalate + ethylene glycol [RN:R11541]
Reaction(KEGG)
R11541
Substrate
4-[(2-hydroxyethoxy)carbonyl]benzoate [CPD:C21450];
H2O [CPD:C00001]
Product
terephthalate [CPD:C06337];
ethylene glycol [CPD:C01380]
Comment
The enzyme, isolated from the bacterium Ideonella sakaiensis, has no activity with poly(ethylene terephthalate) PET (cf. EC 3.1.1.101, poly(ethylene terephthalate) hydrolase).
History
EC 3.1.1.102 created 2016
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21105  mono(ethylene terephthalate) hydrolase
Reference
1  [PMID:26965627]
  Authors
Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, Toyohara K, Miyamoto K, Kimura Y, Oda K
  Title
A bacterium that degrades and assimilates poly(ethylene terephthalate).
  Journal
Science 351:1196-9 (2016)
DOI:10.1126/science.aad6359
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.102
IUBMB Enzyme Nomenclature: 3.1.1.102
ExPASy - ENZYME nomenclature database: 3.1.1.102
BRENDA, the Enzyme Database: 3.1.1.102

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