KEGG   ENZYME: 3.1.1.103
Entry
EC 3.1.1.103                Enzyme                                 
Name
teichoic acid D-alanine hydrolase;
fmtA (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
teichoic acid D-alanylhydrolase
Reaction(IUBMB)
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine [RN:R11965]
Reaction(KEGG)
R11965
Substrate
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
H2O [CPD:C00001]
Product
[(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
D-alanine [CPD:C00133]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface. The activity greatly increases methicillin resistance in MRSA strains.
History
EC 3.1.1.103 created 2018
Orthology
K22580  teichoic acid D-alanine hydrolase
Genes
SDO: SD1155_07555
BSR: I33_1881
BSL: A7A1_3392
BSH: BSU6051_16950(pbpX)
BSY: I653_08695
BSUT: BSUB_01826(pbpX)
BSUL: BSUA_01826(pbpX)
BSUS: Q433_09635
BSO: BSNT_08209(pbpX)
BSN: BSn5_20580
BSQ: B657_16950(pbpX)
BSX: C663_1738(pbpX)
BSP: U712_08885
BSS: BSUW23_08715(pbpX)
BST: GYO_2049
BLI: BL02713(pbpX)
BLD: BLi00181(pbpX)
BLH: BaLi_c02020(pbpX)
BAY: RBAM_016790
BAQ: BACAU_1650(pbpX)
BYA: BANAU_1650(pbpX)
BAMP: B938_08705
BQY: MUS_1851(pbpX)
BAML: BAM5036_1616(pbpX)
BAMA: RBAU_1656(pbpX)
BAMN: BASU_1635(pbpX)
BAMB: BAPNAU_2072(pbpX)
BAMT: AJ82_09540
BAMY: V529_16380(ampC)
BMP: NG74_01740(pbpX_2)
BAO: BAMF_1767(pbpX)
BAZ: BAMTA208_08665(pbpX)
BQL: LL3_01854(pbpX)
BXH: BAXH7_01767(pbpX)
BAMI: KSO_010955
BAMC: U471_17200
BAMF: U722_08880
BSIA: CWD84_12830
BAE: BATR1942_06275
BVM: B9C48_08565
BSON: S101395_04881
BHT: DIC78_00920
BMOJ: HC660_17580(pbpX)
BTEQ: G4P54_08825
BIQ: AN935_08825
BCA: BCE_3507 BCE_4110
BCR: BCAH187_A3518 BCAH187_A4174
BCB: BCB4264_A3498
BCQ: BCQ_3295(bla) BCQ_3833
BNC: BCN_3307 BCN_3955
BCER: BCK_14985 BCK_17770
BCEF: BcrFT9_02665 BcrFT9_03155
BCY: Bcer98_2742
BTB: BMB171_C3163 BMB171_C3707 BMB171_P0160
BTT: HD73_3735 HD73_4342
BTHR: YBT1520_18415 YBT1520_21525
BTHI: BTK_18405 BTK_21375
BTC: CT43_CH4049
BTF: YBT020_17115 YBT020_19905
BTM: MC28_2645
BTG: BTB_c41780(pbpX3)
BTHT: H175_ch4115
BTHU: YBT1518_22395
BTHY: AQ980_09635 AQ980_12640
BWE: BcerKBAB4_3210 BcerKBAB4_3872
BWW: bwei_0908 bwei_1441
BMYO: BG05_1979 BG05_2505
BTY: Btoyo_0712
BMYC: DJ92_1138
BBY: CY96_19305
BWD: CT694_21755
BMOB: MLA2C4_18155
BNT: GSN03_19160
BPAC: LMD38_06870
BGY: BGLY_0167
BSAF: BSL056_08300
BIT: BIS30_19325
BCAB: EFK13_09295
BRY: M0696_09150
BJS: MY9_1841
BACW: QR42_08215
BACP: SB24_01310
BACB: OY17_11475
BACY: QF06_07515
BACL: BS34A_18620(pbpX)
BALM: BsLM_1791
BACS: AUL54_02145
BGI: BGM20_02865
LPAK: GDS87_11575
VIG: BKP57_06435
SAU: SA0909(fmtA)
SAV: SAV1057(fmt)
SAW: SAHV_1049(fmt)
SAH: SaurJH1_1139
SAJ: SaurJH9_1116
SAM: MW0940(fmt)
SAS: SAS0992
SAR: SAR1030(fmt)
SAC: SACOL1066
SAX: USA300HOU_1001(fmt1)
SAA: SAUSA300_0959(fmt)
SAO: SAOUHSC_00998
SAE: NWMN_0926
SAD: SAAV_1021
SUU: M013TW_0988(fmtA)
SUV: SAVC_04450
SUE: SAOV_1003
SUJ: SAA6159_00913(fmtA)
SUK: SAA6008_01012
SUC: ECTR2_912
SUT: SAT0131_01092
SUQ: HMPREF0772_12177
SUZ: MS7_1014(fmtA)
SUD: ST398NM01_1054
SUX: SAEMRSA15_08880(fmt)
SUW: SATW20_10530(fmt)
SUG: SAPIG1054
SUF: SARLGA251_09710(fmt)
SAUA: SAAG_02168
SAUE: RSAU_000944(fmtA)
SAUN: SAKOR_00978
SAUS: SA40_0927(fmt)
SAUU: SA957_0942(fmt)
SAUG: SA268_0945(fmt)
SAUZ: SAZ172_0997(fmtA)
SAUT: SAI1T1_2007480
SAUJ: SAI2T2_1007500
SAUK: SAI3T3_1007490
SAUQ: SAI4T8_1007480
SAUV: SAI7S6_1007490(fmtA)
SAUW: SAI5S5_1007450(fmtA)
SAUX: SAI6T6_1007460(fmtA)
SAUY: SAI8T7_1007490(fmtA)
SAUF: X998_1056
SAB: SAB0923(fmt)
SUY: SA2981_1011(fmtA)
SAUB: C248_1082(fmt)
SAUM: BN843_9630
SAUC: CA347_973(fmtA)
SAUR: SABB_01023(fmtA)
SAUI: AZ30_05045
SAUD: CH52_00600
SAMS: NI36_05060
SUH: SAMSHR1132_09050
SER: SERP0641
SEP: SE_0754
SEPP: SEB_00730
SEPS: DP17_2087(fmtA)
SHA: SH1907(fmt)
SHH: ShL2_01771
SSP: SSP1736
SCA: SCA_0665
SLG: SLGD_01819
SLN: SLUG_18150(fmt)
SSD: SPSINT_0518
SDT: SPSE_1942(fmtA)
SDP: NCTC12225_02173(fmtA)
SWA: A284_08550
SPAS: STP1_2114
SXY: BE24_02600
SXL: SXYLSMQ121_1737
SXO: SXYL_01880(fmtA)
SHU: SHYC_01895
SCAP: AYP1020_0379(pbpX)
SSCH: LH95_09295
SSCZ: RN70_10070
SAGQ: EP23_08225
SEQO: SE1039_08140
SSIF: AL483_06610 AL483_06615
SCV: A4G25_04610
SLZ: B5P37_08435
SCOH: BZ166_00595
SNL: BJD96_09640
SKL: C7J89_10440
SHOM: EGX58_01415
SCAR: DWB96_09410
SCHR: DWB92_01740
SARL: SAP2_17690
SPIC: SAMEA4384060_1899(fmtA_2)
SSH: NCTC13712_01002(fmtA_1)
SSIM: SAMEA4384339_0968(fmtA_1)
SLLO: ISP08_08725
SAUL: I6G39_08025
SSAC: I6I31_07495
SPSD: JMB28_09405
STAS: HYI43_08930
SSCU: CEP64_08355
SFF: FOB90_10230
SSTE: SAMEA4384403_1803(fmtA)
MLEN: H3V22_13610
MVT: I6J10_02355
MCL: MCCL_0555 MCCL_0556
MCAK: MCCS_07670(pbpX_1) MCCS_07680(pbpX_2)
MARY: LAU42_03235 LAU42_03240
LMN: LM5578_0568
LMY: LM5923_0567
LMT: LMRG_00222
LMOC: LMOSLCC5850_0533(pbpX)
LMOE: BN418_0618
LMOB: BN419_0627
LMOD: LMON_0540
LMOW: AX10_11220
LMOQ: LM6179_0845(pbpX)
LMR: LMR479A_0552(pbpX)
LMOM: IJ09_07650
LMF: LMOf2365_0569
LMC: Lm4b_00566
LMOG: BN389_05770(pbpX)
LMP: MUO_02950
LMOL: LMOL312_0548(pbpX)
LMOJ: LM220_07172
LMOZ: LM1816_10972
LMOX: AX24_15625
LMH: LMHCC_2091
LMQ: LMM7_0570(yfeW)
LML: lmo4a_0555(pbpX)
LMG: LMKG_01356
LMS: LMLG_2787
LMJ: LMOG_02216
LMW: LMOSLCC2755_0545(pbpX)
LMX: LMOSLCC2372_0549(pbpX)
LMZ: LMOSLCC2482_0542(pbpX)
LMON: LMOSLCC2376_0519(pbpX)
LMOS: LMOSLCC7179_0515(pbpX)
LMOO: LMOSLCC2378_0564(pbpX)
LMOY: LMOSLCC2479_0547(pbpX)
LMOT: LMOSLCC2540_0545(pbpX)
LMOA: LMOATCC19117_0570(pbpX)
LMOK: CQ02_02930
LMV: Y193_13035
LIN: lin0544
LWE: lwe0501
LGZ: NCTC10812_00946(fmtA_1) NCTC10812_01209(fmtA_2)
LMAR: LAX80_002425
SAG: SAG0658
SAN: gbs0640
SAK: SAK_0786
SGC: A964_0654
SAGS: SaSA20_0551
SAGL: GBS222_0540
SAGM: BSA_7450
SAGP: V193_03115
SAGC: DN94_03115
SAGT: GBSCOH1_0580
SAGE: EN72_04025
SAGG: EN73_03725
SAGN: W903_0749
LJF: FI9785_1472(pbpX) FI9785_1730
LJH: LJP_1717c
LJN: T285_07215 T285_08775
LAC: LBA0059(pbpX) LBA0858 LBA1006 LBA1605(pbpX)
LAD: LA14_0059 LA14_0882 LA14_1021 LA14_1596
LAF: SD55_0058(pbpX1) SD55_0880 SD55_1021 SD55_1605(pbpX2)
LDB: Ldb1644 Ldb1645
LBU: LBUL_1523 LBUL_1524
LDE: LDBND_1553 LDBND_1554
LDL: LBU_1404 LBU_1405
LGA: LGAS_1459
LHE: lhv_0070 lhv_0912 lhv_1103 lhv_1192
LHL: LBHH_0081 LBHH_0974 LBHH_1106 LBHH_1247
LHR: R0052_00420 R0052_05750 R0052_06505 R0052_07365
LHV: lhe_0078 lhe_0876 lhe_1002 lhe_1083
LHH: LBH_0054 LBH_0761 LBH_0901
LHD: HUO_01315 HUO_06210 HUO_06715 HUO_07495
LCR: LCRIS_00057 LCRIS_00552(pbp1) LCRIS_00881 LCRIS_01083(pbpX)
LAM: LA2_04505 LA2_05270
LAI: LAC30SC_00255 LAC30SC_04310 LAC30SC_05065
LAY: LAB52_04290 LAB52_05025
LKE: WANG_0789 WANG_1631(pbpX)
LAW: LACWKB8_0097
LAE: LBAT_0074 LBAT_0258
LGL: AO203_02730 AO203_07280 AO203_08025 AO203_08705
LAMY: B1745_00330
LKL: DKL58_00405
LAPI: DKL56_00340
LHS: DLD54_00485
LTA: H1A07_07225 H1A07_08850
LUU: H4B44_00405 H4B44_06810
LPAI: GYM71_00530
LCL: LOCK919_2316
LPI: LBPG_02057
LCX: LCA12A_0680
LRH: LGG_02141
LRG: LRHM_2058
LRL: LC705_02148
LRA: LRHK_2149
LRO: LOCK900_2102
LRC: LOCK908_2211
LRE: Lreu_1924
LRF: LAR_1801
LRU: HMPREF0538_21124
LRT: LRI_1866
LRR: N134_10195
LVA: LV515_05195
LFN: LF145_07135
LNG: BSQ50_00975
LBH: Lbuc_0085 Lbuc_0092
LBN: LBUCD034_0131(pbpX1)
LPAR: FAM21731_00881 FAM21731_00888
LKF: DNL43_05595
LHIL: G8J22_00383
LZY: LZ3411_1809
LSUA: H3M12_00105
LPD: AYR62_06155
PPE: PEPE_0564
PPEN: T256_03075
PACI: A4V11_09625
LSA: LCA_0648
LCV: FBA2_03350
LHB: D1010_12850
LCI: LCK_00771
WCE: WS08_0647
WCT: WS74_0649
WCI: WS105_0709
WVR: IE337_04570 IE337_04585
EFC: EFAU004_01360
EFAU: EFAU085_00973
EFU: HMPREF0351_10933
EHR: EHR_00080
EMU: EMQU_0916
EDU: LIU_05530
ETH: CK496_08425
MPS: MPTP_1050
MPX: MPD5_0898
VPI: BW732_08825
VCP: H9L18_02050
VHY: G7082_04090
ACIT: HPK19_15190
SRD: SD10_11505
MYR: MYRA21_2893
MPW: MPR_1758
MOD: AS202_14180
EAO: BD94_0966
EGO: BBD34_13620
CHH: A0O34_16270
CNK: EG343_06155
 » show all
Reference
1  [PMID:9371333]
  Authors
Komatsuzawa H, Sugai M, Ohta K, Fujiwara T, Nakashima S, Suzuki J, Lee CY, Suginaka H
  Title
Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of triton X-100 in methicillin-resistant Staphylococcus aureus.
  Journal
Antimicrob Agents Chemother 41:2355-61 (1997)
DOI:10.1128/AAC.41.11.2355
  Sequence
[sau:SA0909]
Reference
2  [PMID:22564846]
  Authors
Qamar A, Golemi-Kotra D
  Title
Dual roles of FmtA in Staphylococcus aureus cell wall biosynthesis and autolysis.
  Journal
Antimicrob Agents Chemother 56:3797-805 (2012)
DOI:10.1128/AAC.00187-12
Reference
3  [PMID:26861022]
  Authors
Rahman MM, Hunter HN, Prova S, Verma V, Qamar A, Golemi-Kotra D
  Title
The Staphylococcus aureus Methicillin Resistance Factor FmtA Is a d-Amino Esterase That Acts on Teichoic Acids.
  Journal
MBio 7:e02070-15 (2016)
DOI:10.1128/mBio.02070-15
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.103
IUBMB Enzyme Nomenclature: 3.1.1.103
ExPASy - ENZYME nomenclature database: 3.1.1.103
BRENDA, the Enzyme Database: 3.1.1.103

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (408)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (406)   
   KEGG MGENES (1)   
Protein sequence (16)   
   UniProt (8)   
   SWISS-PROT (8)   
Protein domain (2)   
   InterPro (2)   
All databases (431)   

Download RDF
DBGET integrated database retrieval system