KEGG   ENZYME: 3.1.1.103
Entry
EC 3.1.1.103                Enzyme                                 
Name
teichoic acid D-alanine hydrolase;
fmtA (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
teichoic acid D-alanylhydrolase
Reaction(IUBMB)
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine [RN:R11965]
Reaction(KEGG)
R11965
Substrate
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
H2O [CPD:C00001]
Product
[(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
D-alanine [CPD:C00133]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface. The activity greatly increases methicillin resistance in MRSA strains.
History
EC 3.1.1.103 created 2018
Orthology
K22580  teichoic acid D-alanine hydrolase
Genes
SDOSD1155_07555
BSRI33_1881
BSLA7A1_3392
BSHBSU6051_16950(pbpX)
BSYI653_08695
BSUTBSUB_01826(pbpX)
BSULBSUA_01826(pbpX)
BSUSQ433_09635
BSOBSNT_08209(pbpX)
BSNBSn5_20580
BSQB657_16950(pbpX)
BSXC663_1738(pbpX)
BSPU712_08885
BSSBSUW23_08715(pbpX)
BSTGYO_2049
BLIBL02713(pbpX)
BLDBLi00181(pbpX)
BLHBaLi_c02020(pbpX)
BAYRBAM_016790
BAQBACAU_1650(pbpX)
BYABANAU_1650(pbpX)
BAMPB938_08705
BQYMUS_1851(pbpX)
BAMLBAM5036_1616(pbpX)
BAMARBAU_1656(pbpX)
BAMNBASU_1635(pbpX)
BAMBBAPNAU_2072(pbpX)
BAMTAJ82_09540
BAMYV529_16380(ampC)
BMPNG74_01740(pbpX_2)
BAOBAMF_1767(pbpX)
BAZBAMTA208_08665(pbpX)
BQLLL3_01854(pbpX)
BXHBAXH7_01767(pbpX)
BAMIKSO_010955
BAMCU471_17200
BAMFU722_08880
BSIACWD84_12830
BAEBATR1942_06275
BVMB9C48_08565
BSONS101395_04881
BHTDIC78_00920
BMOJHC660_17580(pbpX)
BTEQG4P54_08825
BIQAN935_08825
BCABCE_3507 BCE_4110
BCRBCAH187_A3518 BCAH187_A4174
BCBBCB4264_A3498
BCQBCQ_3295(bla) BCQ_3833
BNCBCN_3307 BCN_3955
BCERBCK_14985 BCK_17770
BCEFBcrFT9_02665 BcrFT9_03155
BCYBcer98_2742
BTBBMB171_C3163 BMB171_C3707 BMB171_P0160
BTTHD73_3735 HD73_4342
BTHRYBT1520_18415 YBT1520_21525
BTHIBTK_18405 BTK_21375
BTCCT43_CH4049
BTFYBT020_17115 YBT020_19905
BTMMC28_2645
BTGBTB_c41780(pbpX3)
BTHTH175_ch4115
BTHUYBT1518_22395
BTHYAQ980_09635 AQ980_12640
BWEBcerKBAB4_3210 BcerKBAB4_3872
BWWbwei_0908 bwei_1441
BMYOBG05_1979 BG05_2505
BTYBtoyo_0712
BMYCDJ92_1138
BBYCY96_19305
BWDCT694_21755
BMOBMLA2C4_18155
BNTGSN03_19160
BPACLMD38_06870
BGYBGLY_0167
BSAFBSL056_08300
BITBIS30_19325
BCABEFK13_09295
BRYM0696_09150
BJSMY9_1841
BACWQR42_08215
BACPSB24_01310
BACBOY17_11475
BACYQF06_07515
BACLBS34A_18620(pbpX)
BALMBsLM_1791
BACSAUL54_02145
BGIBGM20_02865
LPAKGDS87_11575
VIGBKP57_06435
SAUSA0909(fmtA)
SAVSAV1057(fmt)
SAWSAHV_1049(fmt)
SAHSaurJH1_1139
SAJSaurJH9_1116
SAMMW0940(fmt)
SASSAS0992
SARSAR1030(fmt)
SACSACOL1066
SAXUSA300HOU_1001(fmt1)
SAASAUSA300_0959(fmt)
SAOSAOUHSC_00998
SAENWMN_0926
SADSAAV_1021
SUUM013TW_0988(fmtA)
SUVSAVC_04450
SUESAOV_1003
SUJSAA6159_00913(fmtA)
SUKSAA6008_01012
SUCECTR2_912
SUTSAT0131_01092
SUQHMPREF0772_12177
SUZMS7_1014(fmtA)
SUDST398NM01_1054
SUXSAEMRSA15_08880(fmt)
SUWSATW20_10530(fmt)
SUGSAPIG1054
SUFSARLGA251_09710(fmt)
SAUASAAG_02168
SAUERSAU_000944(fmtA)
SAUNSAKOR_00978
SAUSSA40_0927(fmt)
SAUUSA957_0942(fmt)
SAUGSA268_0945(fmt)
SAUZSAZ172_0997(fmtA)
SAUTSAI1T1_2007480
SAUJSAI2T2_1007500
SAUKSAI3T3_1007490
SAUQSAI4T8_1007480
SAUVSAI7S6_1007490(fmtA)
SAUWSAI5S5_1007450(fmtA)
SAUXSAI6T6_1007460(fmtA)
SAUYSAI8T7_1007490(fmtA)
SAUFX998_1056
SABSAB0923(fmt)
SUYSA2981_1011(fmtA)
SAUBC248_1082(fmt)
SAUMBN843_9630
SAUCCA347_973(fmtA)
SAURSABB_01023(fmtA)
SAUIAZ30_05045
SAUDCH52_00600
SAMSNI36_05060
SUHSAMSHR1132_09050
SERSERP0641
SEPSE_0754
SEPPSEB_00730
SEPSDP17_2087(fmtA)
SHASH1907(fmt)
SHHShL2_01771
SSPSSP1736
SCASCA_0665
SLGSLGD_01819
SLNSLUG_18150(fmt)
SSDSPSINT_0518
SDTSPSE_1942(fmtA)
SDPNCTC12225_02173(fmtA)
SWAA284_08550
SPASSTP1_2114
SXYBE24_02600
SXLSXYLSMQ121_1737
SXOSXYL_01880(fmtA)
SHUSHYC_01895
SCAPAYP1020_0379(pbpX)
SSCHLH95_09295
SSCZRN70_10070
SAGQEP23_08225
SEQOSE1039_08140
SSIFAL483_06610 AL483_06615
SCVA4G25_04610
SLZB5P37_08435
SCOHBZ166_00595
SNLBJD96_09640
SKLC7J89_10440
SHOMEGX58_01415
SCARDWB96_09410
SCHRDWB92_01740
SARLSAP2_17690
SPICSAMEA4384060_1899(fmtA_2)
SSHNCTC13712_01002(fmtA_1)
SSIMSAMEA4384339_0968(fmtA_1)
SLLOISP08_08725
SAULI6G39_08025
SSACI6I31_07495
SPSDJMB28_09405
STASHYI43_08930
SSCUCEP64_08355
SFFFOB90_10230
SSTESAMEA4384403_1803(fmtA)
MLENH3V22_13610
MVTI6J10_02355
MCLMCCL_0555 MCCL_0556
MCAKMCCS_07670(pbpX_1) MCCS_07680(pbpX_2)
MARYLAU42_03235 LAU42_03240
LMNLM5578_0568
LMYLM5923_0567
LMTLMRG_00222
LMOCLMOSLCC5850_0533(pbpX)
LMOEBN418_0618
LMOBBN419_0627
LMODLMON_0540
LMOWAX10_11220
LMOQLM6179_0845(pbpX)
LMRLMR479A_0552(pbpX)
LMOMIJ09_07650
LMFLMOf2365_0569
LMCLm4b_00566
LMOGBN389_05770(pbpX)
LMPMUO_02950
LMOLLMOL312_0548(pbpX)
LMOJLM220_07172
LMOZLM1816_10972
LMOXAX24_15625
LMHLMHCC_2091
LMQLMM7_0570(yfeW)
LMLlmo4a_0555(pbpX)
LMGLMKG_01356
LMSLMLG_2787
LMJLMOG_02216
LMWLMOSLCC2755_0545(pbpX)
LMXLMOSLCC2372_0549(pbpX)
LMZLMOSLCC2482_0542(pbpX)
LMONLMOSLCC2376_0519(pbpX)
LMOSLMOSLCC7179_0515(pbpX)
LMOOLMOSLCC2378_0564(pbpX)
LMOYLMOSLCC2479_0547(pbpX)
LMOTLMOSLCC2540_0545(pbpX)
LMOALMOATCC19117_0570(pbpX)
LMOKCQ02_02930
LMVY193_13035
LINlin0544
LWElwe0501
LGZNCTC10812_00946(fmtA_1) NCTC10812_01209(fmtA_2)
LMARLAX80_002425
SAGSAG0658
SANgbs0640
SAKSAK_0786
SGCA964_0654
SAGSSaSA20_0551
SAGLGBS222_0540
SAGMBSA_7450
SAGPV193_03115
SAGCDN94_03115
SAGTGBSCOH1_0580
SAGEEN72_04025
SAGGEN73_03725
SAGNW903_0749
LJFFI9785_1472(pbpX) FI9785_1730
LJHLJP_1717c
LJNT285_07215 T285_08775
LACLBA0059(pbpX) LBA0858 LBA1006 LBA1605(pbpX)
LADLA14_0059 LA14_0882 LA14_1021 LA14_1596
LAFSD55_0058(pbpX1) SD55_0880 SD55_1021 SD55_1605(pbpX2)
LDBLdb1644 Ldb1645
LBULBUL_1523 LBUL_1524
LDELDBND_1553 LDBND_1554
LDLLBU_1404 LBU_1405
LGALGAS_1459
LHElhv_0070 lhv_0912 lhv_1103 lhv_1192
LHLLBHH_0081 LBHH_0974 LBHH_1106 LBHH_1247
LHRR0052_00420 R0052_05750 R0052_06505 R0052_07365
LHVlhe_0078 lhe_0876 lhe_1002 lhe_1083
LHHLBH_0054 LBH_0761 LBH_0901
LHDHUO_01315 HUO_06210 HUO_06715 HUO_07495
LCRLCRIS_00057 LCRIS_00552(pbp1) LCRIS_00881 LCRIS_01083(pbpX)
LAMLA2_04505 LA2_05270
LAILAC30SC_00255 LAC30SC_04310 LAC30SC_05065
LAYLAB52_04290 LAB52_05025
LKEWANG_0789 WANG_1631(pbpX)
LAWLACWKB8_0097
LAELBAT_0074 LBAT_0258
LGLAO203_02730 AO203_07280 AO203_08025 AO203_08705
LAMYB1745_00330
LKLDKL58_00405
LAPIDKL56_00340
LHSDLD54_00485
LTAH1A07_07225 H1A07_08850
LUUH4B44_00405 H4B44_06810
LPAIGYM71_00530
LCLLOCK919_2316
LPILBPG_02057
LCXLCA12A_0680
LRHLGG_02141
LRGLRHM_2058
LRLLC705_02148
LRALRHK_2149
LROLOCK900_2102
LRCLOCK908_2211
LRELreu_1924
LRFLAR_1801
LRUHMPREF0538_21124
LRTLRI_1866
LRRN134_10195
LVALV515_05195
LFNLF145_07135
LNGBSQ50_00975
LBHLbuc_0085 Lbuc_0092
LBNLBUCD034_0131(pbpX1)
LPARFAM21731_00881 FAM21731_00888
LKFDNL43_05595
LHILG8J22_00383
LZYLZ3411_1809
LSUAH3M12_00105
LPDAYR62_06155
PPEPEPE_0564
PPENT256_03075
PACIA4V11_09625
LSALCA_0648
LCVFBA2_03350
LHBD1010_12850
LCILCK_00771
WCEWS08_0647
WCTWS74_0649
WCIWS105_0709
WVRIE337_04570 IE337_04585
EFCEFAU004_01360
EFAUEFAU085_00973
EFUHMPREF0351_10933
EHREHR_00080
EMUEMQU_0916
EDULIU_05530
ETHCK496_08425
MPSMPTP_1050
MPXMPD5_0898
VPIBW732_08825
VCPH9L18_02050
VHYG7082_04090
ACITHPK19_15190
SRDSD10_11505
MYRMYRA21_2893
MPWMPR_1758
MODAS202_14180
EAOBD94_0966
EGOBBD34_13620
CHHA0O34_16270
CNKEG343_06155
 » show all
Reference
1  [PMID:9371333]
  Authors
Komatsuzawa H, Sugai M, Ohta K, Fujiwara T, Nakashima S, Suzuki J, Lee CY, Suginaka H
  Title
Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of triton X-100 in methicillin-resistant Staphylococcus aureus.
  Journal
Antimicrob Agents Chemother 41:2355-61 (1997)
DOI:10.1128/AAC.41.11.2355
  Sequence
[sau:SA0909]
Reference
2  [PMID:22564846]
  Authors
Qamar A, Golemi-Kotra D
  Title
Dual roles of FmtA in Staphylococcus aureus cell wall biosynthesis and autolysis.
  Journal
Antimicrob Agents Chemother 56:3797-805 (2012)
DOI:10.1128/AAC.00187-12
Reference
3  [PMID:26861022]
  Authors
Rahman MM, Hunter HN, Prova S, Verma V, Qamar A, Golemi-Kotra D
  Title
The Staphylococcus aureus Methicillin Resistance Factor FmtA Is a d-Amino Esterase That Acts on Teichoic Acids.
  Journal
MBio 7:e02070-15 (2016)
DOI:10.1128/mBio.02070-15
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.103
IUBMB Enzyme Nomenclature: 3.1.1.103
ExPASy - ENZYME nomenclature database: 3.1.1.103
BRENDA, the Enzyme Database: 3.1.1.103

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