KEGG   ENZYME: 3.1.1.104
Entry
EC 3.1.1.104                Enzyme                                 
Name
5-phospho-D-xylono-1,4-lactonase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
5-phospho-D-xylono-1,4-lactone hydrolase
Reaction(IUBMB)
(1) D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate [RN:R12248];
(2) L-arabino-1,4-lactone 5-phosphate + H2O = 5-phospho-L-arabinate [RN:R12249]
Reaction(KEGG)
R12248 R12249
Substrate
D-xylono-1,4-lactone 5-phosphate [CPD:C22034];
H2O [CPD:C00001];
L-arabino-1,4-lactone 5-phosphate [CPD:C22036]
Product
5-phospho-D-xylonate [CPD:C22035];
5-phospho-L-arabinate [CPD:C22037]
Comment
The enzyme, characterized from Mycoplasma spp., contains a binuclear metal center with two zinc cations. The enzyme is specific for the phosphorylated forms, and is unable to hydrolyse non-phosphorylated 1,4-lactones.
History
EC 3.1.1.104 created 2018
Orthology
K23149  5-phospho-D-xylono-1,4-lactonase
Genes
ENFAKI40_3139
KOXKOX_20855
KOEA225_3033
KOMHR38_19150
KOKKONIH1_14895
KOCAB185_21050
KLLBJF97_15080
KLWDA718_14585
KGRJJJ10_13880
RTGNCTC13098_03643(php)
AHNNCTC12129_02540(php)
ASUBNLZ15_10940
SFWWN53_15210
SFOZ042_08460
SODSant_2195
PTROG5S35_35665
DEAFPZ08_19085
MAADAZF01_19095
MLUTJET14_19970
BCIRC2I06_15540
BMHBMWSH_3190
BHABH0225
GTKGT3570_09910
GWCGWCH70_1411
GYCGYMC61_2929
GYAGYMC52_2058
PCALBV455_00343
ANMGFC28_1630
ANLGFC29_3804
ANDGRQ40_04765
LAGRFJQ98_07330 FJQ98_10055
LMACI6G82_12020
VIGBKP57_10630 BKP57_16535
VPNA21D_02505
VPTKBP50_00160 KBP50_13415
LAOAOX59_03770
SALEEPH95_03720
MSEMGMB29_22465
SEDDERJ70_15945
BOUI5818_03850
LMOlmo1970 lmo2648
LMNLM5578_0212 LM5578_2171
LMYLM5923_0212 LM5923_2122
LMTLMRG_01117 LMRG_02193
LMOCLMOSLCC5850_2032 LMOSLCC5850_2660
LMOEBN418_2361 BN418_3129
LMOBBN419_2363 BN419_3141
LMODLMON_2041 LMON_2671
LMOWAX10_04090 AX10_07385
LMOQLM6179_0059 LM6179_2740
LMRLMR479A_2080 LMR479A_2783
LMOMIJ09_11500 IJ09_15365
LMFLMOf2365_2620
LMCLm4b_02614
LMOGBN389_26070
LMPMUO_13220
LMOLLMOL312_2607
LMOJLM220_16622
LMOZLM1816_02247
LMOXAX24_11255
LMHLMHCC_2886
LMQLMM7_2760
LMLlmo4a_2712
LMGLMKG_00359 LMKG_03009
LMSLMLG_0461 LMLG_1268
LMJLMOG_01266 LMOG_01862
LMWLMOSLCC2755_2661
LMXLMOSLCC2372_2036 LMOSLCC2372_2714
LMZLMOSLCC2482_2660
LMONLMOSLCC2376_2545
LMOSLMOSLCC7179_1942 LMOSLCC7179_2618
LMOOLMOSLCC2378_2650
LMOYLMOSLCC2479_2033 LMOSLCC2479_2714
LMOTLMOSLCC2540_2688
LMOALMOATCC19117_2657
LMOKCQ02_13470
LMVY193_02370
LINlin2797
LWElwe2597
LSGlse_2552
LIVLIV_2559
LIIJL52_13500
LIWAX25_13705
LIAJL58_13730
LIOJL53_14170
LMARLAX80_012910
GYMGYMC10_4834
POWIJ21_01040 IJ21_48420
PIBBBD41_01880
PVOPVOR_18344
PLWD5F53_05945
PLUTEI981_16445
PCHIPC41400_08250
NTRB0W44_08145 B0W44_16725
KEBGXN75_05840
LKLDKL58_04825
LCLLOCK919_0418
LZEKG087_01740
EAVEH197_05570
ACGAWM71_03805
HHJNQ487_04785 NQ487_21590
FPLAA4U99_17820
CFEMHCR03_00145
ROBCK5_19980
ARFAR1Y2_2852
ACACEYQ97_04045
WHJH9Q79_11500
STHSTH554
CMIUB1H56_03045
TEPTepRe1_2016
TAETepiRe1_2173
HHLHalha_0786
SPOAEQM13_05590
MPNMPN_497
MPMMPNA4970
MPBC985_01205
MTAUJS510_02840
MHYmhp389
MHJMHJ_0373
MHPMHP7448_0377
MHNMHP168_419
MHYLMHP168L_419
MHYOMHL_1423
MCOMCJ_003290
MHRMHR_0460
MHHMYM_0485
MHMSRH_03585
MHSMOS_520
MHVQ453_0522
MFQMYF_01500
MDSMDIS_01885
MNUNCTC10166_00011
MOENCTC10151_00584
MGBVO56_00565
MGLYNCTC10194_00462
MPUMYPU_5930(MYPU_5930)
MSYMS53_0025
MSOVY93_00150
MAAMAG6390
MALMAGa7350
MFRMFE_00350
MFMMfeM64YM_0028
MFPMBIO_0658
MBVMBOVPG45_0738
MBHMMB_0685
MBIMbov_0724
MBQK668_03420
MCYMCYN_0239(MCYN0239)
MGALNCTC10186_00569
MCITNCTC10181_00028
SCLASCLARK_001372
SCHISCHIN_v1c08130
MPEMYPE7240(MYPE7240)
CGSC624_06205 C624_06210
CGGC629_06205 C629_06210
CHNA605_05210
CPHOCPHO_02670
NODFOH10_13705
RHBNY08_873
RCRNCTC10994_00393(opd_2)
RKOJWS14_29035
RGOKYT97_18940
GTABCM27_14830
SCOSCO1036(SCG20A.16)
SMASAVERM_1441
SHYSHJG_2502
SHOSHJGH_2266
SCTSCAT_1545
SCYSCATT_15470
SFASfla_5771
SBHSBI_09288
STRPF750_0814
SALUDC74_1809
SALLSAZ_09625
SLVSLIV_32610
STREGZL_07336
SCWTU94_03900
SLDT261_6934
SLCSL103_12815
STRCAA958_27395
SCZABE83_32575
SCXAS200_39165
SRWTUE45_01400
SLEsle_60670(sle_60670)
STRTA8713_03415
SGSAVL59_29800
STSIA4E84_04590
SALWCP975_04035
SLSSLINC_0963
SNRSNOUR_33465
STRDNI25_33995
SSIAA7J05_30975
SPUNBFF78_37065
SGVB1H19_08565
SALFSMD44_00848
SALJSMD11_6417
STROSTRMOE7_07285
SFKKY5_0854
SGEDWG14_07652(php)
SRJSRO_6508
SDXC4B68_36230
SCYAEJ357_41890
SKACP970_38705
SNKCP967_31760
SHAWCEB94_05080
SVRCP971_05975
SPADDVK44_01260
SAQUEJC51_07280
SGFHEP81_06852
SCAVCVT27_02030
SRIMCP984_34780
SCHACP983_38905
SCOECP976_04540
SBATG4Z16_07610
SSPBCP982_38000
SPLACP981_05870
SBROGQF42_06880
STUIGCM10017668_63790
SHUNDWB77_06582(php)
SCYGS1361_05430
SDWK7C20_05505
SAUHSU9_004505
SMOBJ7W19_02660
SROIIAG44_05130
SXNIAG42_31875
SHKJ2N69_03980
SDDD9753_31680
SACTDMT42_04055
SMAOCAG99_16140
SINEKI385_08660 KI385_38830
SLFJEQ17_42675
SAOVG3H79_34095
KAUB6264_01175
KITCFP65_6282
TWHTWT_650(php)
TWSTW672
LXYO159_25590
LEIFHF024_16730
CMICMM_0542
MTSMTES_1124
MIMAKG07_10840
MIXAB663_000457
MIPAXH82_04460
MPALBO218_11585
MICRBMW26_15580
MFOLDXT68_15000
MWAE4K62_09260
MSEDE3O41_04335
MOYCVS54_03323(php)
MCHNHCR76_16380
MICSC1N74_15445
FRPAX769_09265
AGFET445_10680
AARCG127AT_06040
SALCC2138_02820
HUWFPZ11_01125
PLAPEAO79_06605
HEAHL652_20370
AGXAGREI_2031
ARNCGK93_22120
BRZCFK38_11635
SERWFY030_14425
PACPPA0879
PAKHMPREF0675_3936
PAVTIA2EST22_04380
PAXTIA2EST36_04350
PAZTIA2EST2_04300
PAWPAZ_c09150
PADTIIST44_10255
PCNTIB1ST10_04545
PACCPAC1_04655
PACHPAGK_1270
PACNTIA1EST1_04320
CACNRN83_04765
PRAPALO_06665
PRLBCB70_00860
PACDEGX94_01620
PAUSNCTC13651_00913
PPCHMPREF9154_1159
PRVG7070_13955
KQIF1D05_19635
ACTWF7P10_05300
SROSros_2491
ACEAcel_0570
NMLNamu_1523
AMDAMED_4921
AMNRAM_25050
AMMAMES_4862
AMZB737_4862
APRTMUY14_13020
KALKALB_2148
MCRAID554_30675
AIHAiant_54560
PLABC6361_30510
PLATC6W10_35590
PFLAPflav_028930
ASERAsera_50630
CAICaci_2395
ASGFB03_07190
ACTTDDD63_05295
ACTPB6G06_01785
ACTCCHIBA101_0539
AVCNCTC10951_02841
AMAMHPC72_08120
WIKH8R18_00285
BCORBCOR_1325
BIIBINDI_1256
BSCABBSC_0796
BACTAB656_05160
BSUEBS3272_02725
CWOCwoe_2978
OLSOlsu_0016
ERZER308_14515
CAPCLDAP_29710
THUGKNN16_07550
SDYNMal52_43850(opd)
PCORKS4_19500
STRSterm_0217 Sterm_2488 Sterm_3191
HHYHalhy_6821
SPIRCWM47_02725
RHOZGXP67_35405
RSIRunsl_4738
FAEFAES_2377(php)
MARTBTR34_13640
MLTVC82_1986
AALGAREALGSMS7_00436
 » show all
Reference
1  [PMID:24955762]
  Authors
Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM
  Title
Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.
  Journal
Biochemistry 53:4727-38 (2014)
DOI:10.1021/bi500595c
  Sequence
[msy:MS53_0025] [maa:MAG6390]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.104
IUBMB Enzyme Nomenclature: 3.1.1.104
ExPASy - ENZYME nomenclature database: 3.1.1.104
BRENDA, the Enzyme Database: 3.1.1.104

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