KEGG   ENZYME: 3.1.1.107
Entry
EC 3.1.1.107                Enzyme                                 

Name
apo-salmochelin esterase;
iroE (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
apo-salmochelin esterase
Reaction(IUBMB)
(1) enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer [RN:R12473];
(2) triglucosyl-enterobactin + H2O = triglucosyl-(2,3-dihydroxybenzoylserine)3 [RN:R12474];
(3) diglucosyl-enterobactin + H2O = diglucosyl-(2,3-dihydroxybenzoylserine)3 [RN:R12475];
(4) monoglucosyl-enterobactin + H2O = monoglucosyl-(2,3-dihydroxybenzoylserine)3 [RN:R12476]
Reaction(KEGG)
Substrate
enterobactin [CPD:C05821];
H2O [CPD:C00001];
triglucosyl-enterobactin [CPD:C22182];
diglucosyl-enterobactin [CPD:C22181];
monoglucosyl-enterobactin [CPD:C22180]
Product
N-(2,3-dihydroxybenzoyl)-L-serine trimer [CPD:C22185];
triglucosyl-(2,3-dihydroxybenzoylserine)3 [CPD:C22186];
diglucosyl-(2,3-dihydroxybenzoylserine)3 [CPD:C22187];
monoglucosyl-(2,3-dihydroxybenzoylserine)3 [CPD:C22188]
Comment
This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. Unlike EC 3.1.1.108, ferric enterobactin esterase, which acts only on enterobactin, this enzyme can also act on the C-glucosylated forms known as salmochelins. Unlike EC 3.1.1.109, ferric salmochelin esterase (IroD), IroE prefers apo siderophores as substrates, and is assumed to act before the siderophores are exported out of the cell. It hydrolyses the trilactone only once, producing linearized trimers.
History
EC 3.1.1.107 created 2019
Orthology
K23721  apo-salmochelin esterase
Genes
ECP: ECP_0303
ECV: APECO1_O1CoBM138
ECI: UTI89_C1119(iroE)
EIH: ECOK1_1108
ECZ: ECS88_p0125(iroE)
ECC: c1251(iroE)
ELN: NRG857_30013(iroE)
EAB: ECABU_c12080(iroE)
ELU: UM146_12310
ELC: i14_1145(iroE)
ELD: i02_1145(iroE)
ECOI: ECOPMV1_01079(besA)
STY: STY2893
STT: t2671(iroE)
STM: STM2776(iroE)
SEO: STM14_3347(iroE)
SEY: SL1344_2761(iroE)
SEJ: STMUK_2764(iroE)
SEB: STM474_2911(iroE)
SEF: UMN798_3012(iroE)
SENR: STMDT2_26821(iroE)
SEND: DT104_27781(iroE)
SENI: CY43_14515
SPT: SPA2632(iroE)
SEK: SSPA2454
SEI: SPC_2816(iroE)
SEC: SCH_2707(IroE)
SHB: SU5_03263
SENS: Q786_13325
SED: SeD_A3074
SEG: SG2682(iroE)
SEL: SPUL_2768
SET: SEN2622(iroE)
SENA: AU38_13300
SENO: AU37_13310
SENV: AU39_13310
SENQ: AU40_14975
SENL: IY59_13885
SEEP: I137_13200
SENE: IA1_13250
SDY: SDY_1023(iroE)
ECLO: ENC_19100
ECLY: LI62_07655
KPP: A79E_2547
KPR: KPR_2579(iroE)
KPJ: N559_2629
KPX: PMK1_04010(besA)
KPNU: LI86_13100
KPNK: BN49_2787(iroE)
KOE: A225_3752
EAE: EAE_03285
EAR: CCG33323
CKO: CKO_01683
EBT: EBL_c27810(iroE)
RTG: NCTC13098_04507(besA)
AGU: AS4_00690
 » show all
Reference
1  [PMID:16076215]
  Authors
Lin H, Fischbach MA, Liu DR, Walsh CT
  Title
In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes.
  Journal
J Am Chem Soc 127:11075-84 (2005)
DOI:10.1021/ja0522027
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.107
IUBMB Enzyme Nomenclature: 3.1.1.107
ExPASy - ENZYME nomenclature database: 3.1.1.107
BRENDA, the Enzyme Database: 3.1.1.107

DBGET integrated database retrieval system