KEGG   ENZYME: 3.1.1.107
Entry
EC 3.1.1.107                Enzyme                                 
Name
apo-salmochelin esterase;
iroE (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
apo-salmochelin esterase
Reaction(IUBMB)
(1) enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer [RN:R12473];
(2) triglucosyl-enterobactin + H2O = triglucosyl-(2,3-dihydroxybenzoylserine)3 [RN:R12474];
(3) diglucosyl-enterobactin + H2O = diglucosyl-(2,3-dihydroxybenzoylserine)3 [RN:R12475];
(4) monoglucosyl-enterobactin + H2O = monoglucosyl-(2,3-dihydroxybenzoylserine)3 [RN:R12476]
Reaction(KEGG)
Substrate
enterobactin [CPD:C05821];
H2O [CPD:C00001];
triglucosyl-enterobactin [CPD:C22182];
diglucosyl-enterobactin [CPD:C22181];
monoglucosyl-enterobactin [CPD:C22180]
Product
N-(2,3-dihydroxybenzoyl)-L-serine trimer [CPD:C22185];
triglucosyl-(2,3-dihydroxybenzoylserine)3 [CPD:C22186];
diglucosyl-(2,3-dihydroxybenzoylserine)3 [CPD:C22187];
monoglucosyl-(2,3-dihydroxybenzoylserine)3 [CPD:C22188]
Comment
This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. Unlike EC 3.1.1.108, ferric enterobactin esterase, which acts only on enterobactin, this enzyme can also act on the C-glucosylated forms known as salmochelins. Unlike EC 3.1.1.109, ferric salmochelin esterase (IroD), IroE prefers apo siderophores as substrates, and is assumed to act before the siderophores are exported out of the cell. It hydrolyses the trilactone only once, producing linearized trimers.
History
EC 3.1.1.107 created 2019
Orthology
K23721  apo-salmochelin esterase
Genes
ECPECP_0303
ECVAPECO1_O1CoBM138
ECIUTI89_C1119(iroE)
EIHECOK1_1108
ECZECS88_p0125(iroE)
ECCc1251(iroE)
ELNNRG857_30013(iroE)
EABECABU_c12080(iroE)
ELUUM146_12310
ELCi14_1145(iroE)
ELDi02_1145(iroE)
ECOIECOPMV1_01079(besA)
STYSTY2893
STTt2671(iroE)
SEXSTBHUCCB_28110
SENTTY21A_13525
STMSTM2776(iroE)
SEOSTM14_3347(iroE)
SEVSTMMW_27431
SEYSL1344_2761(iroE)
SEMSTMDT12_C28300
SEJSTMUK_2764(iroE)
SEBSTM474_2911(iroE)
SEFUMN798_3012(iroE)
SETUSTU288_14055
SETCCFSAN001921_03200
SENRSTMDT2_26821(iroE)
SENDDT104_27781(iroE)
SENICY43_14515
SEENSE451236_19975
SPTSPA2632(iroE)
SEKSSPA2454
SPQSPAB_03447
SEISPC_2816(iroE)
SECSCH_2707(IroE)
SEHSeHA_C2952
SHBSU5_03263
SENHCFSAN002069_18385
SEEHSEEH1578_22695
SEESNSL254_A2971
SENNSN31241_38640
SEWSeSA_A2918
SEASeAg_B2888
SENSQ786_13325
SEDSeD_A3074
SEGSG2682(iroE)
SELSPUL_2768
SEGASPUCDC_2754
SETSEN2622(iroE)
SENAAU38_13300
SENOAU37_13310
SENVAU39_13310
SENQAU40_14975
SENLIY59_13885
SENJCFSAN001992_19655
SEECCFSAN002050_20165
SEEBSEEB0189_006300
SEEPI137_13200
SENBBN855_28090
SENEIA1_13250
SENCSEET0819_20690
SESSARI_00201
SALZEOS98_05670
SDYSDY_1023(iroE)
SDZAsd1617_01304
ECLEECNIH2_07800
ECLYLI62_07655
ECLOENC_19100
EHMAB284_18105
ECANCWI88_15325
ENRH650_22950
ENFAKI40_2302
ENKLOC22_17635
KPMKPHS_26150
KPPA79E_2547
KPHKPNIH24_15215
KPZKPNIH27_12690
KPWKPNIH30_13495
KPYKPNIH31_12570
KPGKPNIH32_13345
KPCKPNIH10_13020
KPQKPR0928_13040
KPTVK055_0807
KPOKPN2242_11295
KPRKPR_2579(iroE)
KPJN559_2629
KPID364_08595
KPAKPNJ1_02810
KPSKPNJ2_02780
KPXPMK1_04010(besA)
KPBFH42_04395
KPNEKU54_013165
KPNULI86_13100
KPNKBN49_2787(iroE)
KPKA593_23135
KVDKR75_20945
KVQSP68_01910
KOEA225_3752
KOYJ415_13370
KOMHR38_22595
KOKKONIH1_18910
KOCAB185_17340
KQUAVR78_17510
EAEEAE_03285
EARCCG33323
KQVB8P98_14035
KLLBJF97_18680
KARLGL98_12790
KGRJJJ10_10230
RORRORB6_02445
RAODSD31_08805
RTGNCTC13098_04507(besA)
CKOCKO_01683
EBTEBL_c27810(iroE)
PGELG71_24415
KSAC813_07505
KRDA3780_07345
KPSEIP581_07325
YREHEC60_09580
EBUCUC76_02585
GQUAWC35_23175
RBADH2866_00485
PAOPat9b_4972
TCIA7K98_03300
AJORZ95_06965
ARJDOM24_05950
AWUBEN71_01045
AGUAS4_00690
ABERBSR55_20840
ACHICDG60_07165
ABOUACBO_17120(iroE)
 » show all
Reference
1  [PMID:16076215]
  Authors
Lin H, Fischbach MA, Liu DR, Walsh CT
  Title
In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes.
  Journal
J Am Chem Soc 127:11075-84 (2005)
DOI:10.1021/ja0522027
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.107
IUBMB Enzyme Nomenclature: 3.1.1.107
ExPASy - ENZYME nomenclature database: 3.1.1.107
BRENDA, the Enzyme Database: 3.1.1.107

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