KEGG   ENZYME: 3.1.1.108
Entry
EC 3.1.1.108                Enzyme                                 
Name
iron(III)-enterobactin esterase;
fes (gene name);
pfeE (gene name);
enterochelin hydrolase;
enterochelin esterase;
ferric enterobactin esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
iron(III)-enterobactin hydrolase
Reaction(IUBMB)
iron(III)-enterobactin + 3 H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex + 2 N-(2,3-dihydroxybenzoyl)-L-serine (overall reaction);
(1a) iron(III)-enterobactin + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex;
(1b) iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex + N-(2,3-dihydroxybenzoyl)-L-serine;
(1c) iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex + N-(2,3-dihydroxybenzoyl)-L-serine
Substrate
iron(III)-enterobactin;
H2O [CPD:C00001];
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex;
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex
Product
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex;
N-(2,3-dihydroxybenzoyl)-L-serine [CPD:C04204];
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex;
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex
Comment
The enzyme, isolated from the bacterium Escherichia coli, allows the bacterium to grow in limited iron conditions. It can also act on enterobactin (with no complexed iron) and the aluminium(III) analogue of iron(III)-enterobactin. The trimer formed is further hydrolysed to form the dimer and the monomer.
History
EC 3.1.1.108 created 2019
Orthology
K07214  iron(III)-enterobactin esterase
K23722  iron(III)-enterobactin esterase
Genes
ECOb0585(fes)
ECJJW0576(fes)
ECDECDH10B_0544(fes) ECDH10B_0652(fes)
EBWBWG_0457(fes)
ECOKECMDS42_0445(fes)
ECEZ0725(fes)
ECSECs_0624(fes)
ECFECH74115_0669(fes)
ETWECSP_0638(fes)
ELXCDCO157_0608
EOIECO111_0614(fes)
EOJECO26_0659(fes)
EOHECO103_0592(fes)
ECOOECRM13514_0606(fes)
ECOHECRM13516_0550(fes)
ESLO3K_18670
ESOO3O_06625
ESMO3M_18650
ECKEC55989_0576(fes)
ECGE2348C_0486(fes)
EOKG2583_0747(fes)
ELRECO55CA74_03660
ELHETEC_0614
ECWEcE24377A_0604(fes)
EUNUMNK88_616
ECPECP_0616
ENAECNA114_0527(fes)
ECOSEC958_0704
ECVAPECO1_1464(fes)
ECOAAPECO78_06500
ECXEcHS_A0634(fes)
ECMEcSMS35_0604(fes)
ECYECSE_0651
ECRECIAI1_0568(fes)
ECQECED1_0580(fes)
EUMECUMN_0678(fes)
ECTECIAI39_0561(fes)
EOCCE10_0584(fes)
EBRECB_00551(fes)
EBLECD_00551(fes)
EBEB21_00540(fes)
EBDECBD_3071
ECIUTI89_C0586(fes)
EIHECOK1_0596(fes)
ECZECS88_0623(fes)
ECCc0671(fes)
ELOEC042_0622(fes)
ELNNRG857_02645
ESEECSF_0525
ECLEcolC_3060
EKOEKO11_3281
EKFKO11_20745(fes)
EABECABU_c06340(fes)
EDHEcDH1_3042
EDJECDH1ME8569_0554(fes)
ELUUM146_14585
ELWECW_m0639(fes)
ELLWFL_03175(fes)
ELCi14_0646(fes)
ELDi02_0646(fes)
ELPP12B_c0570
ELFLF82_0646(fes)
ECOLLY180_03170
ECOIECOPMV1_00602(fes_1)
ECOJP423_02865
EFEEFER_2510(fes)
EALEAKF1_ch0877c(fes)
EMAC1192_09790
ESZFEM44_17355
STYSTY0629(fes)
STTt2282(fes)
SEXSTBHUCCB_24170
SENTTY21A_11580
STMSTM0586(fes)
SEOSTM14_0684(fes)
SEVSTMMW_06511
SEYSL1344_0574(fes)
SEMSTMDT12_C06480
SEJSTMUK_0591(fes)
SEBSTM474_0606(fes)
SEFUMN798_0635(fes)
SETUSTU288_11445
SETCCFSAN001921_14105
SENRSTMDT2_05771(fes)
SENDDT104_06141(fes)
SENICY43_03215
SEENSE451236_08950
SPTSPA2148(fes)
SEKSSPA1998
SPQSPAB_02977
SEISPC_0598(fes)
SECSCH_0617(fes)
SEHSeHA_C0698
SHBSU5_01276
SENHCFSAN002069_05915
SEEHSEEH1578_12360
SEESNSL254_A0639
SENNSN31241_15900
SEWSeSA_A0744
SEASeAg_B0625
SENSQ786_02860
SEDSeD_A0682
SEGSG0590(fes)
SELSPUL_2380(fes)
SEGASPUCDC_2366(fes)
SETSEN0555(fes)
SENAAU38_02840
SENOAU37_02835
SENVAU39_02840
SENQAU40_03125
SENLIY59_02895
SENJCFSAN001992_08405
SEECCFSAN002050_09540
SEEBSEEB0189_016350
SEEPI137_10850
SENBBN855_5780(fes)
SENEIA1_03075
SENCSEET0819_09895
SESSARI_02350
SBGSBG_0494(fes)
SBZA464_559
SBVN643_02455
SALZEOS98_16195
SFLSF0497(fes)
SFXS0503(fes)
SFVSFV_0530(fes)
SFESFxv_0550(fes)
SFNSFy_0644
SFSSFyv_0681
SFTNCTC1_00517(fes)
SSNSSON_0535(fes)
SBOSBO_0445(fes)
SBCSbBS512_E0486(fes)
SDYSDY_0513(fes)
SDZAsd1617_00666
SHQA0259_06600
ENCECL_03116
ENLA3UG_05980
ECLGEC036_11450
ECLEECNIH2_06640
ECLNECNIH4_16650
ECLIECNIH5_05760
ECLXLI66_05630
ECLYLI62_06540
ECLZLI64_06135
EHMAB284_19250
EXFBFV63_05760
ECLAECNIH3_05770
ECLCECR091_05750
EAUDI57_12890
EKBBFV64_05690
ENOECENHK_06050
EECEcWSU1_01159(fes)
ECANCWI88_16485
ERNBFV67_05460
ECLSLI67_006730
ECHGFY206_07045(fes)
ESHC1N69_05805
ENTEnt638_1117
EASEntas_1083
ENRH650_21555
ENXNI40_005475
ENFAKI40_3704
LNICWR52_06495
EBGFAI37_00760
ENDA4308_09780
ENZG0034_05800(fes)
ENSHWQ15_14240(fes)
ENKLOC22_16495(fes)
ESAESA_02729
CSKES15_2799
CSZCSSP291_12870
CSJCSK29544_04016
CCONAFK62_05625
CDMAFK67_05830
CSIP262_04084
CMJAFK66_014080
CUIAFK65_05605
CMWAFK63_13055
CTUCTU_12330(fes)
KPNKPN_00603(fes)
KPUKP1_1548(fes)
KPMKPHS_14380
KPPA79E_3637
KPHKPNIH24_21615
KPZKPNIH27_06660
KPVKPNIH29_07350
KPWKPNIH30_07390
KPYKPNIH31_07265
KPGKPNIH32_07495
KPCKPNIH10_07175
KPQKPR0928_07085
KPTVK055_1933(fes)
KPOKPN2242_05875
KPJN559_3723
KPID364_03165
KPAKPNJ1_03981
KPSKPNJ2_04025
KPXPMK1_02934(fes)
KPBFH42_24045
KPNEKU54_019265
KPNULI86_19090
KPNKBN49_1659(fes)
KVAKvar_3765
KPEKPK_3975(fes)
KPKA593_17470
KVDKR75_14930
KVQSP68_21560
KOXKOX_13895
KOEA225_1598
KOYJ415_23640
KOMHR38_12640
KOKKONIH1_07845
KOCAB185_28275
KQUAVR78_11680
EAEEAE_13605
EARCCG31250
KQVB8P98_20670
KLLBJF97_08230
KLWDA718_20505
KARLGL98_18295(fes)
KGRJJJ10_20325(fes)
RORRORB6_12070
RPLNB1209_19765
RAODSD31_18615
RTGNCTC13098_05443(fes_2)
REEelectrica_03715(fes)
CROROD_05951(fes)
CKOCKO_02577
CFDCFNIH1_13020
CBRAA6J81_10170
CWECO701_15845
CYOCD187_17315
CPOTFOB25_04805(fes)
CFQC2U38_06870
CSEDJY391_15430(fes)
CAMAF384_02575
CAFAL524_19715
CIFAL515_07580
CFARCI104_07285
CIRC2U53_16480
CIEAN232_23405
CPARCUC49_02710
CTELGBC03_23010(fes)
CITZE4Z61_10670
CARSE1B03_08085
EBTEBL_c13820(fes)
PGELG71_22030
ESCEntcl_3210
KLEAO703_06195
KSAC813_08910
KORAWR26_18335(fes)
KRDA3780_05945
KCOBWI95_11705
KOTEH164_16385
KPSEIP581_05980(fes)
KIENCTC12125_02382(fes)
KASKATP_32760
LAXAPT61_16670
LEIC2U54_10790
LEHC3F35_05680
LEEDVA44_17810
LERGNG29_06005(fes)
LEAGNG26_05685(fes)
LAZA8A57_05875
LEFLJPFL01_1158
LEWDAI21_20930
BUFD8682_09825
BAGEBADSM9389_30990
METYMRY16398_41570
AHNNCTC12129_03611(fes)
YREHEC60_00215(fes)
SGOEA8O29_016645(fes)
KINAB182_18230
PDZHHA33_20775(fes)
IZHFEM41_12855
PSGCG163CM_22540(fes)
EBFD782_3254
EBCC2U52_29510
YENYE3622(fes)
YEPYE105_C3311
YELLC20_00746
YEWCH47_4177
YETCH48_2301
YEFFORC2_0630
YEEYE5303_03351(fes)
YALAT01_1917
YFRAW19_2626(fes)
YINCH53_2395
YKRCH54_3162
YROCH64_2002
YRUBD65_1350
YRBUGYR_07475
YAKACZ76_06030
YMADA391_03015 DA391_07265
YHID5F51_19225
YCAF0T03_18540(fes)
YMOHRD69_01705(fes)
SMARSM39_1907 SM39_3042 SM39_4668
SMACSMDB11_1731 SMDB11_4409
SMWSMWW4_v1c03110(fes) SMWW4_v1c24640
SPESpro_3429
SRRSerAS9_3622
SRLSOD_c33500(fes)
SRYM621_18215
SPLYQ5A_018150(fes)
SRSSerAS12_3623
SRASerAS13_3624
SMAFD781_2010 D781_3215
SLQM495_17670
SERFL085_02500 L085_16415
SERSSERRSCBI_01415 SERRSCBI_11590
SFWWN53_26525
SFGAV650_22610
SRZAXX16_1856 AXX16_3119
SERASer39006_010845
SERQCWC46_10840
SERMCLM71_10240 CLM71_16995
SQUE4343_23555
SFJSAMEA4384070_0301(fes_1) SAMEA4384070_1827(fes_2)
SOFNCTC11214_03236(fes)
SSURATE40_009005 ATE40_022300
SURIJ0X03_11620(fes) J0X03_22430(fes)
SRHZFO014_17240 FO014_23405
RAHRahaq_0549
RACEJHW33_19395(fes)
RAAQ7S_02735
RVCJ9880_10530(fes)
RBADH2866_06290(fes)
PWAPecwa_3735
PPARA8F97_22815
PECW5S_3876
PWSA7983_03720
DDDDda3937_03040(cbsH)
DZEDd1591_1320
DDCDd586_2815
DZCW909_13780
DSOA4U42_02240
CEDLH89_19420
DFNCVE23_15105
DDQDDI_2789
DAQDAQ1742_01261(cbsH)
DICDpoa569_001069
DDADd703_1492
BNGEH206_19930
BIZHC231_21070(fes)
LBQCKQ53_17090
LPOPI6N93_11275(fes)
EBIEbC_40180
EGEEM595_0492(fes)
EPECI789_04440
ERWIGN242_07970(fes)
PVAPvag_3665(fes)
PAGGAL522_06455
PAOPat9b_0494 Pat9b_5347
KLNLH22_19790
PAGCBEE12_09235
PANSFCN45_02445 FCN45_21755
PDISD8B20_02120
PGZC2E15_02675
MINTC7M51_02067(fes_1) C7M51_04039(fes_2)
MTHIC7M52_00774(fes_1)
TCIA7K98_01205
TPTYNCTC11468_00311(fes)
XBOXBJ1_1439(fes)
XBVXBW1_1502(fes)
XDOXDD1_0637(fes)
XHOA9255_12800
VAGN646_0836
VANVAA_02078
LAGN175_10495
VAUVANGNB10_cI0889(vabH)
VGABSQ33_15330
VQICCZ37_04320
VSRVspart_01405(fes)
VZIG5S32_12520(fes)
PAEPA2689
PAEVN297_2771
PAEIN296_2771
PAUPA14_29340
PAPPSPA7_3965
PAGPLES_24151
PAFPAM18_2283
PNCNCGM2_3716
PAEBNCGM1900_3809
PDKPADK2_11200
PSGG655_11535
PRPM062_14275
PAEPPA1S_12140
PAERPA1R_gp0497
PAEMU769_11705
PAELT223_12295
PAESSCV20265_2559
PAEGAI22_21760
PAECM802_2768
PAEOM801_2637
PCQPcP3B5_13800(besA)
PMUIG4G71_15355
PPUPP_0532
PPFPput_0566
PPGPputGB1_0577
PPWPputW619_0583
PPBPPUBIRD1_0572
PPIYSA_06075
PPXT1E_5747
PPUTL483_02790
PPUNPP4_05680
PORAPT59_14305
PMOLCLJ08_15730
PFLPFL_2662
PPRCPFLCHA0_c27290(besA)
PPROPPC_2711
PENPSEEN0617
PLULFOB45_05265
PDRH681_11815
PLQAA042_21025
PPVNJ69_15890
PSOSPOS17_2656
PPSLBJP27_05285 BJP27_15020
PEZHWQ56_12500(fes)
PSEPC4K39_2669
PXAKSS93_06175
PFAKKSS94_03040
PMAMKSS90_02905
PTWTUM18999_28180
ANORR32_09170
ACALBUM88_09535
ASEII8T81_09865(fes)
ACDAOLE_09910
ASHAG8E00_09285
TTUTERTU_4065
MTHDA3224_14720
HCHHCH_03821
HAHEENC22_13300
ZPLZBT109_1263
MMEMarme_1354
MPRIMP3633_2429
MFOIJSY38_03020(fes)
GSNYC6258_02699
CVICV_2231(fes)
CVCBKX93_01140
CHROCXB49_11690
CHRIDK842_18515
CHRBDK843_01175
CARIFNU76_12980
JABVN23_17100
MASZC9I28_13410
MASYDPH57_08235
MPLIE1742_00975
MXAMXAN_0884
MYMA176_006097
MFBMFUL124B02_05025
MFULILAB_04295
MMASMYMAC_000908
CCROCMC5_070030
MSCBN69_2715
MROSEHO51_17295
PALWPSAL_031130
SECHB18_25900
PARHI5S86_03800
CCHOCCHOA_08195(fes)
RTMG4H71_08580(fes)
ROOG5S37_05685
LUOHHL09_06825
LPAVPLANPX_2482
PNDPla175_40900
GPNPan110_09520(fes)
MRIMal4_49540
LRSPX52LOC_04793
HBSIPV69_15170 IPV69_15565
ACAACP_2246
ACMAciX9_4467
TALBFTW19_03020
SUSAcid_3215
PFERIRI77_09335
GBAJ421_0760
FLASY85_22775
FGGFSB75_06515
ARACE0W69_019010
FLSGLV81_06940
MUCMuYL_4183
MGOTMgSA37_04449(fes)
MUHHYN43_001210
MRUBDEO27_001720 DEO27_013405
MGOSDIU38_018875
 » show all
Reference
1  [PMID:4330269]
  Authors
O'Brien IG, Cox GB, Gibson F
  Title
Enterochelin hydrolysis and iron metabolism in Escherichia coli.
  Journal
Biochim Biophys Acta 237:537-49 (1971)
DOI:10.1016/0304-4165(71)90274-1
  Sequence
[eco:b0585]
Reference
2  [PMID:150859]
  Authors
Greenwood KT, Luke RK
  Title
Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia Coli K-12. Properties of enterochelin esterase.
  Journal
Biochim Biophys Acta 525:209-18 (1978)
DOI:10.1016/0005-2744(78)90216-4
  Sequence
[eco:b0585]
Reference
3  [PMID:3040679]
  Authors
Pettis GS, McIntosh MA
  Title
Molecular characterization of the Escherichia coli enterobactin cistron entF and  coupled expression of entF and the fes gene.
  Journal
J Bacteriol 169:4154-62 (1987)
DOI:10.1128/jb.169.9.4154-4162.1987
Reference
4  [PMID:1534808]
  Authors
Brickman TJ, McIntosh MA
  Title
Overexpression and purification of ferric enterobactin esterase from Escherichia coli. Demonstration of enzymatic hydrolysis of enterobactin and its iron complex.
  Journal
J Biol Chem 267:12350-5 (1992)
  Sequence
[eco:b0585]
Reference
5  [PMID:8148617]
  Authors
Winkelmann G, Cansier A, Beck W, Jung G
  Title
HPLC separation of enterobactin and linear 2,3-dihydroxybenzoylserine derivatives: a study on mutants of Escherichia coli defective in regulation (fur), esterase (fes) and transport (fepA).
  Journal
Biometals 7:149-54 (1994)
DOI:10.1007/bf00140485
  Sequence
[eco:b0585]
Reference
6  [PMID:30086222]
  Authors
Perraud Q, Moynie L, Gasser V, Munier M, Godet J, Hoegy F, Mely Y, Mislin GLA, Naismith JH, Schalk IJ
  Title
A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa.
  Journal
ACS Chem Biol 13:2603-2614 (2018)
DOI:10.1021/acschembio.8b00543
  Sequence
[pae:PA2689]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.108
IUBMB Enzyme Nomenclature: 3.1.1.108
ExPASy - ENZYME nomenclature database: 3.1.1.108
BRENDA, the Enzyme Database: 3.1.1.108

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