KEGG ENZYME: 3.1.1.25

ENZYME: 3.1.1.25

Entry

EC 3.1.1.25                 Enzyme

Name

1,4-lactonase;
gamma-lactonase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

1,4-lactone hydroxyacylhydrolase

Reaction(IUBMB)

a 1,4-lactone + H2O = a 4-hydroxyacid [RN:R03708]

Reaction(KEGG)

R03708 > R02933 R03034

Substrate

1,4-lactone [CPD:C01770];
H2O [CPD:C00001]

Product

4-hydroxyacid [CPD:C01991]

Comment

The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.

History

EC 3.1.1.25 created 1972, modified 1981

Pathway

ec00052

Galactose metabolism

ec00053

Ascorbate and aldarate metabolism

ec01100

Metabolic pathways

Reference

1 [PMID:4958984]

Authors

Fishbein WN, Bessman SP.

Title

Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase.

Journal

J Biol Chem 241:4835-41 (1966)

Reference

2 [PMID:4958985]

Authors

Fishbein WN, Bessman SP.

Title

Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibra.

Journal

J Biol Chem 241:4842-7 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.25

IUBMB Enzyme Nomenclature:

3.1.1.25

ExPASy - ENZYME nomenclature database:

3.1.1.25

BRENDA, the Enzyme Database:

3.1.1.25

CAS:	37278-38-9

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