KEGG ENZYME: 3.1.1.57

ENZYME: 3.1.1.57

Entry

EC 3.1.1.57                 Enzyme

Name

2-pyrone-4,6-dicarboxylate lactonase;
2-pyrone-4,6-dicarboxylate hydrolase;
2-pyrone-4,6-dicarboxylate lactonohydrolase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase

Reaction(IUBMB)

2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [RN:R04277]

Reaction(KEGG)

R04277

Substrate

2-oxo-2H-pyran-4,6-dicarboxylate;
H2O [CPD:C00001]

Product

(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate [CPD:C04434]

Comment

The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3].

History

EC 3.1.1.57 created 1986, modified 2010

Pathway

ec00362

Benzoate degradation

ec00627

Aminobenzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K10221

2-pyrone-4,6-dicarboxylate lactonase

Genes

CAMA:

F384_17445

CFAR:

CI104_02855

CTEL:

GBC03_28060

SFG:	AV650_17165

SOD:	Sant_P0178

ETO:	RIN69_02900

GSS:	NYR30_00505

XBN:	AB3X10_22480

SRH:	BAY15_1814

SLM:	BIZ42_18450

SCYC:

AB1723_05150

DYG:	DYGSA30_06780

LRZ:	BJI69_03965

LPY:	FIV34_03355

VNA:	PN96_18540

VEJ:	VEJY3_18106

VFL:	AL536_10305

VZI:	G5S32_20200

VOS:	KNV97_07825

VIB:	VspSTUT11_39050

VCK:	PG915_07505

GKD:	K6Q96_09565

PPF:

Pput_1365

PPW:	PputW619_1458

POR:	APT59_12355

PAST:

N015_12615

PFE:	PSF113_3475

PCG:	AXG94_02720

PMED:

E3Z27_14230

PMUD:

NCTC8068_03362

PLUL:

FOB45_15885

PSIL:

PMA3_19000

PEZ:	HWQ56_16715

PSIV:

LZ023_19020

EMO:	DM558_04795

ENTO:

MTZ49_15295

MARA:

D0851_19030

ASEI:

I8T81_09360

PCAR:

PC2016_2102

AAW:	AVL56_08870

ALR:	DS731_01470

ALTO:

AltI4_17260

PAT:

Patl_3887

ALII:

QR722_00520

HARO:

R50071_20750

MPAF:

R5R33_07695

NAX:	HC341_04190

ALCA:

ASALC70_03590

ADI:

B5T_01356

MMW:	Mmwyl1_3940

MME:	Marme_0834

MPC:	Mar181_0382

MPRI:

MP3633_0450

MARD:

IBG28_02955

MFOI:

JSY38_12240

MPRF:

J8N69_06135

MRHI:

KDW99_17850

MPON:

MACH16_05310

MATH:

THO17_19110

MGEO:

CFI10_14880

MARL:

HH196_02865

AJP:	AMJAP_1185(ligI)

GSN:	YC6258_04097

RFO:	REIFOR_00531

SALN:

SALB1_0063

NAQ:	D0T90_09315

NBL:	GJV52_09135

VFF:	VITFI_CDS3222

VIT:	ADP71_27530

VST:	LVJ81_00720

VMS:	LVJ82_10335

AMAH:

DLM_2157

AQS:	DKK66_18675

RIN:	ACS15_1397

REU:	Reut_C5930

COX:	E0W60_28375

CUPP:

CTP10_R60700

BCEN:

DM39_4038 DM39_4100 DM39_6517

BGF:	BC1003_5360

BGD:	bgla_2g19270

BGO:

BM43_5655

BUQ:	AC233_29335

BGP:	BGL_1c25240

BPLA:

bpln_1g24790

BXB:

DR64_7785

BPH:

Bphy_3206

BPX:	BUPH_06640

BFN:

OI25_113

BCAI:

K788_0006188

PARA:

BTO02_05925 BTO02_23040

PHS:	C2L64_34390 C2L64_37600

PTER:

C2L65_33605

PGP:	CUJ91_26860

PCJ:	CUJ87_23740

PMEG:

FNZ07_25800

PACS:

FAZ98_30405 FAZ98_33245 FAZ98_33260

PEW:	KZJ38_18180

PSAA:

QEN71_19515

PKF:	RW095_18475

PLAD:

PPGU16_60570 PPGU16_70870

PAZZ:

PBP221_63020 PBP221_73300

PDQ:	CL55_00003560

POLY:

PSHI2_03820 PSHI2_17640

POLN:

PSHI8_03820 PSHI8_17650

PTX:	ABW99_00705 ABW99_15630

PNR:	AT302_25990

PFIB:

PI93_003455

PANX:

OYT13_06195

HYF:	DTO96_100891(ligI)

TCAR:

U0034_19920

BPAR:

BN117_2264

BPA:

BPP1284

BBH:	BN112_0173

BBR:

BB2349

BBX:	BBS798_2187

BPT:	Bpet0728 Bpet3422

BHO:	D560_0873 D560_3710

BHM:	D558_0859 D558_3685

BHZ:	ACR54_02168 ACR54_03619(ligI_2)

BBRO:

BAU06_03665 BAU06_04480 BAU06_06650 BAU06_13430

BFZ:	BAU07_03750 BAU07_04035 BAU07_04450 BAU07_16320 BAU07_19595

BPDZ:

BBN53_10960

BOH:	AKI39_03430 AKI39_06460 AKI39_09600 AKI39_11980 AKI39_12615 AKI39_20815 AKI39_22565

BGM:	CAL15_05970 CAL15_12605

BOJ:	CBF45_13160

BGV:	CAL12_03880 CAL12_06980 CAL12_10265 CAL12_13730 CAL12_14570

AXY:	AXYL_01969

AXO:	NH44784_001151 NH44784_058711

AXN:	AX27061_1863

AXX:	ERS451415_01862

ADT:	APT56_08855

AIS:	BUW96_00550

ASW:	CVS48_21110 CVS48_26370

ACHR:

C2U31_15515

ACHB:

DVB37_07935 DVB37_11190

ADY:	HLG70_13200

ACHO:

H4P35_08075 H4P35_15065

AMUI:

PE062_04850 PE062_11790

APES:

FOC84_02725

AAEG:

RA224_22990

ASEL:

RAS12_04015 RAS12_13025

ACHM:

V6V88_08175 V6V88_15560

ACHA:

KYT87_08450 KYT87_11980

AVH:	WHX56_14445

ACHH:

ABFG95_23420

PUT:

PT7_3226

PUS:	CKA81_10530

POLL:

OEG81_01970

AKA:	TKWG_14735 TKWG_21325

AMIM:

MIM_c16210 MIM_c34700

CDN:	BN940_08546

CGIN:

ABRZ00_13670

AFQ:

AFA_05525

AAQU:

D3M96_07065

ALCN:

MID00_01260

PHN:	PAEH1_07120

OUE:	I6G29_08380

PIG:	EGT29_12205 EGT29_16255 EGT29_16550 EGT29_24545 EGT29_25320

KGY:	EHF36_13180

PARK:

LSG25_04100 LSG25_05075 LSG25_17350

RFR:

Rfer_0332

RSB:	RS694_12685

RHY:	RD110_16990 RD110_21830 RD110_24765

RHF:	EUB48_12935

RHOA:

HZ993_17895

RHOB:

HTY51_09970 HTY51_11310

RMK:	RAN89_04800

RLH:	MIZ03_2381

RHOF:

AB3G31_09650

POL:	Bpro_2147 Bpro_4322

PNA:

Pnap_2029

PVAC:

HC248_00682(ligI_1) HC248_01466(ligI_2)

ACK:	C380_22710

ACRA:

BSY15_1205

ACID:

CBP33_05240

ACIP:

CBP36_05690 CBP36_20280

ACIN:

CBP34_05075

ACIS:

CBP35_13250 CBP35_20355

ACIO:

EAG14_01250

ARAD:

KI609_21450

ATEM:

PQV96_01115

ACIQ:

ACDW_40070

ACIV:

EXV95_14935

ASAH:

AVXHC19_43160

AAV:

Aave_4267

AAA:

Acav_4169

AMON:

H9L24_06090

VEI:	Veis_0169 Veis_2408 Veis_3066

DAC:

Daci_4447

DEL:	DelCs14_1671 DelCs14_2357

DTS:	BI380_01385 BI380_07820

DHK:	BO996_20110

DLA:	I6G47_02125 I6G47_02305 I6G47_32015 I6G47_32140 I6G47_33670

VAP:	Vapar_6113

VPD:	VAPA_2c10340 VAPA_2c11270

VAZ:	H7F35_17440

VAE:	RZE79_31385

CTT:	CtCNB1_2743

CTES:

O987_16270

CKE:	B5M06_09340

COF:	FOZ74_08480

CODO:

LAD35_20160

AANT:

HUK68_10985

CRJ:	QMY55_10895

CENP:

M9799_00860 M9799_14165

COMB:

MJ205_10695 MJ205_22085

CSQU:

N4T19_01935 N4T19_14275

ADN:	Alide_4174

ADK:	Alide2_0520 Alide2_4515

RTA:

Rta_24780

OTK:	C6570_16460

LIM:	L103DPR2_01496(ligI)

LIH:	L63ED372_01143(ligI_1)

LIMI:

LINBF2_10130 LINBF2_19250

HYR:	BSY239_2224

HYB:

Q5W_10750

HYL:	LPB072_16075

HYC:	E5678_08765

HPSE:

HPF_08075(ligI1)

HYN:	F9K07_00745 F9K07_05175 F9K07_12195 F9K07_24190

HTN:	KI616_18180

HCZ:	G9Q37_10000

HYY:	JNX00_11375

HYDR:

SOM08_11675

HYDA:

ABSY19_00685 ABSY19_24590

DIH:	G7047_27830

DRG:	H9K76_20700

DIM:	K2L43_12780 K2L43_18885

CBAA:

SRAA_1352

CBAB:

SMCB_0793

HGR:	DW355_02315 DW355_09705

PAIS:

PFX98_15230

MIU:	ABE85_07990

SNN:	EWH46_19135

SMIO:

CATMQ487_08060

ATER:

MW290_00320 MW290_13880

LCH:

Lcho_3635

RGU:	A4W93_03355

XYK:	GT347_11365 GT347_11560 GT347_26755

SHD:	SUTH_01240

URU:	DSM104443_02499(pmdD_2)

ABRE:

pbN1_38950

AZO:	azo2539(ligI)

AOA:

dqs_2696

AZR:	CJ010_16070

THU:	AC731_016800

THAU:

C4PIVTH_0882(pmdD)

TCL:

Tchl_1060

TAK:	Tharo_1101

DDZ:	DSYM_13540

MAMO:

A6B35_15240

NIY:	FQ775_19495

NTU:	NTH_03186(ligI)

MESO:

BSQ44_12990

MES:

Meso_3726

CHEA:

PVE73_08355

ORM:	HTY61_00100

SIX:	BSY16_5482

AVV:	RvVAT039_pl06810

RLE:	pRL120277(ligI)

RII:	FFM53_025315

RLS:	HB780_11945

RAW:	NE851_22960

ARA:

Arad_8733

NGL:	RG1141_CH43630

NGG:	RG540_CH44040

NEO:	CYG48_21440

NPM:	QEO92_26905

RHT:	NT26_0603 NT26_1310

RFV:	RFYW14_01477

BJA:	blr1242(blr1242) blr3839(blr3839)

BJU:	BJ6T_13040 BJ6T_60170

BJP:	RN69_06380 RN69_29150

BRA:	BRADO2340(ligI) BRADO2391

BBT:	BBta_2700(ligI) BBta_2744

BRS:	S23_44030 S23_65540

AOL:	S58_48340 S58_52120 S58_52590

BRC:	BCCGELA001_04240 BCCGELA001_15980

BRAD:

BF49_1201 BF49_3410

BIC:	LMTR13_15080 LMTR13_21630

BRO:	BRAD285_4997(ligI)

BRK:	CWS35_38395

BOT:	CIT37_07880 CIT37_34690

BRQ:	CIT40_12005 CIT40_29075

BGQ:	X265_04980 X265_24095 X265_24100

BGZ:	XH91_21300 XH91_21305

BSYM:

CIT39_11245 CIT39_28095

BBET:

F8237_03010 F8237_03015 F8237_12095 F8237_35230

BARH:

WN72_04320 WN72_20635 WN72_20640

BVZ:	BRAD3257_5191 BRAD3257_8444

BDG:	LPJ38_08565 LPJ38_21385

BSEI:

KMZ68_25440

BBAN:

J4G43_004760 J4G43_021195

BCAN:

BcanWSM471_16670 BcanWSM471_34820

BCOU:

IC761_21855 IC761_21860

BXN:	I3J27_15270 I3J27_15275 I3J27_36535

BROS:

QUH67_03995 QUH67_19330 QUH67_21775

BRAZ:

LRP30_02780 LRP30_16645 LRP30_16650

BOY:	LQG66_12390 LQG66_12620 LQG66_36580

BRAY:

ML401_12510 ML401_12515 ML401_31580

RPA:	TX73_024420

RPB:

RPB_0874

RPD:

RPD_0984

RPE:

RPE_0749

RPT:

Rpal_5181

RPX:	Rpdx1_4875

RBK:	E0H22_10750

RHOR:

ONR75_21045 ONR75_21880

RHOL:

RBJ75_17730

TRB:	HB776_04630 HB776_05165 HB776_11045 HB776_27395

TARD:

RSO67_04875 RSO67_21185 RSO67_28490 RSO67_29010

BVV:	BHK69_03810

BOSE:

RMR04_08395

AZC:	AZC_1318 AZC_3354 AZC_3355

STAR:

G3545_13620 G3545_16175

AQI:	J5J86_07020 J5J86_07025

PTAW:

DW352_05710 DW352_13180 DW352_13205

MOC:	BB934_00255

MTEZ:

HPT29_013245

RHZ:	RHPLAN_09550 RHPLAN_19760 RHPLAN_24990 RHPLAN_69890

PHL:	KKY_2368 KKY_3753

PEM:	OF122_18540

MHAR:

L1P08_01585

MMED:

Mame_04561

PSIN:

CAK95_20335 CAK95_22265

BRN:	D1F64_00900 D1F64_06545

PHR:	C6569_13335

PSTG:

E8M01_01060 E8M01_07400 E8M01_14330 E8M01_20450 E8M01_22940

PAQT:

E8L99_01690

BSB:	Bresu_2121

BGOE:

IFJ75_11210

MALG:

MALG_02281

YAN:	AYJ57_14085

AHT:	ANTHELSMS3_03529(ligI)

OCD:	FHY55_07535

RMH:	LVO79_00060

MALU:

KU6B_25090

TGL:	HFZ77_17800

SEDI:

EBB79_03590

PPSO:

QPJ95_03910

PGV:	SL003B_2852

CMAG:

CBW24_02315 CBW24_05765

MANH:

LA6_001696

FRB:	AB6B37_07300

NAR:

Saro_2819

NPP:	PP1Y_Mpl10379

NPN:	JI59_20860

NOV:	TQ38_025055 TQ38_028380

NOR:	FA702_07585

NDR:	HT578_09000 HT578_09575

NHUM:

PQ457_10925

NOL:	NSDW_09500

NCP:	U0041_18330

NOVO:

IM701_02425

SMAZ:

LH19_17725

SINA:

KNJ79_13885

SPFD:

SPYCA_3663

RDI:	CMV14_06855

SPHI:

TS85_18485

SSAN:

NX02_17535

SPAN:

AWL63_08175

SKR:	BRX40_12220

SPHC:

CVN68_17275

SPII:

G7077_01545

SSUA:

FPZ54_06180

SBIN:

SBA_ch2_7350

SGLC:

M1K48_07870

SHAN:

PPZ50_15755

SNOS:

K8P63_14350

SDON:

M9980_11045

SAAP:

E2E30_05140

SCH:	Sphch_3897

SSY:	SLG_12570(ligI) SLG_31300

SPHB:

EP837_03485(ligI)

SPHR:

BSY17_3453(ligI)

SHYD:

CJD35_16790 CJD35_19540

SYA:	A6768_17510

SPYG:

YGS_C2P1466

SAMI:

SAMIE_1030480

SPAG:

sphantq_03937(ligI_1) sphantq_04495(ligI_2)

SPCA:

GL174_18700 GL174_21740

SPWT:

N6H05_08785

SPHG:

AZE99_04470

SFLA:

SPHFLASMR4Y_02981(ligI)

SPHY:

CHN51_00930

BLAS:

BSY18_3517(ligI)

BFW:	B5J99_08380

ACOB:

P0Y56_12145

SPHS:

ETR14_07960

POQ:	KZX46_07365

PMEA:

KTC28_03795

ALB:

AEB_P0191

AAY:	WYH_01902(ligI)

ADO:	A6F68_01086(ligI)

CMAN:

A9D14_17210

POT:	E2E27_18085

RGI:	RGI145_21145

ROS:	CTJ15_00865

RMUC:

FOB66_01820

SHUM:

STHU_14070

SVC:	STVA_09650

ABS:	AZOBR_p310190(ligI)

ABQ:	ABAZ39_27970

AZT:	TSH58p_32560

AARE:

D3093_31925

ADJ:	ACIU1J_25840

NCB:	C0V82_22465

MAGX:

XM1_1090(ligI)

MAGN:

WV31_13610

MAG:

amb0254

THGO:

M9H61_06140 M9H61_18830

MAGQ:

MGMAQ_2663(ligI)

NACI:

NUH88_04090

SNEA:

NBZ79_04470

GSO:	PH603_12810

AVP:	AVENP_2168(ligI)

MICA:

P0L94_13930

PARH:

I5S86_08100

ROA:	Pd630_LPD00182 Pd630_LPD04715

RHJS:

OYT95_18005

SALB:

XNR_3393

SSX:	SACTE_0140

SVL:	Strvi_8545

SRC:	M271_28945

SMAL:

SMALA_3249

SSOI:

I1A49_20040

SFA:

Sfla_0533

STRP:

F750_6349

STRF:

ASR50_30550

SKY:	D0C37_14365

SGM:	GCM10017557_04190 GCM10017557_43730

SGRS:

V9K83_01930

STRD:

NI25_00230

SAUO:

BV401_19740

SLAU:

SLA_7097

SGD:	ELQ87_11405

SAST:

CD934_19155

SFUG:

CNQ36_19910

SBAT:

G4Z16_15895

SHUN:

DWB77_01944(ligI)

SVD:	CP969_30940

SPRA:

CP972_00310

SROI:

IAG44_39510

SLF:	JEQ17_24545

SRUG:

F0345_01640

SVIO:

HWN34_17295

STUB:

MMF93_31845

SSPN:

LXH13_37095

STEE:

F3L20_15125

SLUO:

PS467_17945

SGLY:

P8A20_36590

STRV:

EZV63_01705

KSK:	KSE_75150(pcmC)

KIT:	CFP65_0441

KIS:	HUT16_35045

PPHP:

VTA80_03105

MAUR:

BOH66_06365

MHOS:

CXR34_05665

MOO:	BWL13_00075(ligI)

MRG:	SM116_16200

AMIN:

AUMI_19400

AUM:	AURMO_01270

AUW:	AURUGA1_00418(ligI)

AUT:	AINA4_04030

ART:

Arth_4374

ARTP:

E5206_14130

ARTZ:

FCN77_22495

ACH:

Achl_3359

APN:	Asphe3_42370

SATK:

SA2016_0445

CCYC:

SCMU_02400(pcmC)

SPUE:

AB5L97_18185

PEI:	H9L10_00560

BSPO:

L1F31_00790

DCP:	RN607_01880

AMAZ:

LUW76_45705

SEN:	SACE_5048(ligI)

AMQ:	AMETH_1375(ligI) AMETH_3608(ligI)

AACD:

LWP59_06715 LWP59_16015

APRT:

MUY14_18935

ARHD:

VSH64_11550

AMOG:

QRX60_22205 QRX60_32600

ACAB:

QRX50_34160

ANW:	QP939_25445 QP939_44715

AMYD:

K1T34_01675 K1T34_43540

ABAR:

AMYBAR_001329 AMYBAR_003142 AMYBAR_003806

PSEE:

FRP1_17600

PSEQ:

AD006_02315 AD006_25055

PECQ:

AD017_04645 AD017_10140

PHH:	AFB00_07640

PMAD:

BAY61_18825

JTL:	M6D93_14085

VAB:

WPS_31650

» show all

Reference

1 [PMID:7142106]

Authors

Kersten PJ, Dagley S, Whittaker JW, Arciero DM, Lipscomb JD.

Title

2-pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species.

Journal

J Bacteriol 152:1154-62 (1982)

Reference

2 [PMID:6841353]

Authors

Maruyama K.

Title

Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.

Journal

J Biochem (Tokyo) 93:557-65 (1983)
DOI:10.1093/oxfordjournals.jbchem.a134210

Reference

3 [PMID:21219457]

Authors

Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E

Title

Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.

Journal

Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.57

IUBMB Enzyme Nomenclature:

3.1.1.57

ExPASy - ENZYME nomenclature database:

3.1.1.57

UM-BBD (Biocatalysis/Biodegradation Database):

3.1.1.57

BRENDA, the Enzyme Database:

3.1.1.57

CAS:	84177-55-9

DBGET integrated database retrieval system