KEGG ENZYME: 3.1.1.59

ENZYME: 3.1.1.59

Entry

EC 3.1.1.59                 Enzyme

Name

juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase

Reaction(IUBMB)

(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN:R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN:R08149]

Reaction(KEGG)

R08149 R10983;
(other) R04608 R08150

Substrate

juvenile hormone I [CPD:C19613];
H2O [CPD:C00001];
juvenile hormone III [CPD:C09694]

Product

juvenile hormone I acid [CPD:C20992];
methanol [CPD:C00132];
juvenile hormone III acid [CPD:C16504]

Comment

Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.

History

EC 3.1.1.59 created 1989, modified 2015

Pathway

ec00981

Insect hormone biosynthesis

Orthology

K01063

juvenile-hormone esterase

Genes

DME:	Dmel_CG8425(Jhe)

DER:	113564355 6548853

DSE:

6609376

DSI:	Dsimw501_GD11160(Dsim_GD11160) Dsimw501_GD11161(Dsim_GD11161)

DYA:	Dyak_GE11753

DAN:

6494157

DSR:

110188938

DPO:

6899082

DPE:	6601344 6601345

DMN:	108158080 108160294 108160295

DWI:	124460021 26529390 26529636 26529934 6640104 6640209 6640210 6640211 6640534 6640538 6642291 6642292 6652305

DGR:

6560824

DMO:	Dmoj_GI19153 Dmoj_GI19154

DAZ:

108614905

DNV:

108652754

DHE:	111594015 111594041

DVI:

116650991

CCAT:

101455422 101455709 101459506(Jhedup2)

BDR:

125775307

RZE:

108366603

AOQ:	129243757 129243759

TDA:	119679320 119681516 119685708

MDE:

101898361

SCAC:

106095748 106095759 106096357 106096366

LCQ:	111684795 111684803 111689842 111689844 111689880

LSQ:	119614830 119614831 119614832 119614893 119615303

GFS:

119636606

ECOE:

129951017

CLON:

129607568

HIS:

119659715

AGA:	1276501 4576394 4576396 4576397

ACOZ:

120947906 120947907 120952446 120953460 120961449

AARA:

120895609 120895877 120895878 120895976 120895977

AMER:

121591702 121592357 121592358 121593649 121594183 121594184 121594372

ASTE:

118511476 118511478

AFUN:

125769211 125770360 125770361

AMOU:

128303069 128303071

AALI:

118467970 118467972

AAG:	5564561 5566107 5566114 5566115 5566144

AALB:

109409689 109409690 109409691 109409692

ASUA:

134217467 134217469

CQU:	CpipJ_CPIJ002073 CpipJ_CPIJ002074 CpipJ_CPIJ002075 CpipJ_CPIJ007135 CpipJ_CPIJ007140 CpipJ_CPIJ013026 CpipJ_CPIJ013027 CpipJ_CPIJ013028 CpipJ_CPIJ013029 CpipJ_CPIJ013175 CpipJ_CPIJ014154 CpipJ_CPIJ020045

CPII:

120415174 120421623 120424078 120424082 120424083 120428123 120428686 120430980 120430983 128093046 128093053

CNS:	116339894 116343186 116345269 116346537

BCOO:

119067276 119073846 119081748 119083194

ACER:

107994233 107998239

ALAB:

122712419

ADR:

102672496

AFLR:

100865786 100872445 116413875

BBIF:

117207348 117215610

BVK:	117239627 117239629

BVAN:

117160201 117165772 117165823

BAFF:

126916694 126916695 126916696

BPYO:

122565904 122565905

BPAS:

132905321 132905322 132914427

FVI:

122538242

OLG:

117605442

MGEN:

117223177

NMEA:

116430565 116430566

CGIG:

122398420 122398537

SOC:

105204452

ACEP:

105624427

CFO:

105253145

FEX:	115244260 115244603

PFUC:

122521421 122526321

VPS:

122626934

VCRB:

124428671

TPRE:

106648476 106648477 106648642 106649960 106651086 106654859

CGLO:

123264594 123265768

FAS:	105268394 105268604 105271909 105272368

DAM:	107036668 107037809 107037811 107037825 107041165 107044435

AGIF:

122849067 122852485 122857263

VCAN:

122409331 122418994

CCIN:

107268776 107270792

DSM:	124407039 124407637 124409783 124410412 124410413 124410414 124410415 124410416 124410419 124410422 124410522 124410523 124410524 124410525 124416654 124416721

NPT:	124210651 124212731 124214444 124214796 124218439 124218440 124218444 124219904 124219921 124220017

NFB:	124175828 124176639 124178099 124178327 124182254 124182256 124182257 124182258 124182260 124183288 124183541 124188061

NLO:	107219295 107221013 107221179 107222874 107224671 107224675 107224680 107225623 124292844 124293469 124294379 124296566

NVG:	124297689 124299274 124299661 124299662 124300638 124304606 124304608 124304609 124304612 124304615 124305757 124306490 124310056

AROA:

105690567 105691706

TCA:	658208(Tcjhe)

DPA:

109544202

SOY:	115874432 115880324

AGRG:

126735652 126742870

ATD:	109604357 109604377

CSET:

123320239

AGB:	108914511 108914512 108917334 108917359 108917459 108917768 111692882

LDC:	111503335 111503338 111509916

NVL:	108559512 108567338

APLN:

108736917 108739450 108739452 108739470 108739568 108739585

PPYR:

116162493 116166887 116167223 116170992 116174771 116174863 116174864 116175126 116177944 116179631

OTU:	111413493 111427441

MJU:

123875984

LSIN:

126977948

CFEL:

113368432

API:

100167473

DNX:

107163695

AGS:

114125584

RMD:	113560686 113560695 113560932

ACOO:

126838497

DVT:	126900232 126900235 126904457 126910303

BTAB:

109044387

HHAL:

106678779 106678781 106684895 106684907 106691387

NLU:

111060276

HVI:	124366927 124367584

MQU:	128982378 128982379 128995358 128995863 129002324 129002481

FOC:	113204778 113216791

TPAL:

117651814 117652006

ZNE:

110830303

CSEC:

111861666 111862711 111868484 111871333 111871335

SGRE:

126282181

BROR:

134531903

IEL:

124163490

DMK:

116931876

PCHN:

125027534 125033407

PCLA:

123755654

CQD:	128687322 128693473 128698083

PTRU:

123500966 123503046

ESN:

126980321

MNZ:

135196907

HAZT:

108676749

LSM:	121123268 121125935

TCF:

131880174

PPOI:

119100042 119100043 119100047 119100048 119100049 119100050 119100051 119100052 119101124 119101794 119101795

DSV:

119441975

RSAN:

119387580

VDE:

111247698

VJA:

111273776

DFR:

124498270

UDV:

129219351

HRJ:

124285713

MAEA:

128203514

» show all

Reference

Authors

de Kort CAD, Granger NA.

Title

Regulation of the juvenile hormone titer.

Journal

Annu Rev Entomol 26:1-28 (1981)

Reference

Authors

Mitsui T, Riddiford LM, Bellamy G.

Title

Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta).

Journal

Insect Biochem 9:637-643 (1979)

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.59

IUBMB Enzyme Nomenclature:

3.1.1.59

ExPASy - ENZYME nomenclature database:

3.1.1.59

BRENDA, the Enzyme Database:

3.1.1.59

CAS:	50812-15-2

DBGET integrated database retrieval system