KEGG   ENZYME: 3.1.1.59
Entry
EC 3.1.1.59                 Enzyme                                 

Name
juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Reaction(IUBMB)
(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN:R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN:R08149]
Reaction(KEGG)
R08149 R10983;
(other) R04608 R08150
Substrate
juvenile hormone I [CPD:C19613];
H2O [CPD:C00001];
juvenile hormone III [CPD:C09694]
Product
juvenile hormone I acid [CPD:C20992];
methanol [CPD:C00132];
juvenile hormone III acid [CPD:C16504]
Comment
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
History
EC 3.1.1.59 created 1989, modified 2015
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K01063  juvenile-hormone esterase
Genes
DME: Dmel_CG8425(Jhe)
DER: 113564355 6548853
DSE: 6609376
DSI: Dsimw501_GD11160(Dsim_GD11160) Dsimw501_GD11161(Dsim_GD11161)
DYA: Dyak_GE11753
DAN: 6494157
DSR: 110188938
DPO: Dpse_GA25124
DPE: 6601344 6601345
DMN: 108158080 108160294 108160295
DGR: 6560824
DAZ: 108614905
DNV: 108652754
DVI: 116650991
CCAT: 101455422 101455709 101459506(Jhedup2)
MDE: 101898361
BIM: 100747687
BTER: 100644683
MGEN: 117223177
SOC: 105204452
ACEP: 105624427
CFO: 105253145
NVI: 100116956
TCA: 658208(Tcjhe)
DPA: 109544202
MSEX: 115449770
PXU: 106120154
ZCE: 119831887
TNL: 113499569
API: 100167473
DNX: 107163695
AGS: 114125584
BTAB: 109044387
DCI: 103521191
NLU: 111060276
ZNE: 110830303
DSV: 119441975
RSAN: 119387580
VDE: 111247698
VJA: 111273776
SDM: 118198391
 » show all
Reference
1
  Authors
de Kort, C.A.D. and Granger, N.A.
  Title
Regulation of the juvenile hormone titer.
  Journal
Annu Rev Entomol 26:1-28 (1981)
Reference
2
  Authors
Mitsui, T., Riddiford, L.M. and Bellamy, G.
  Title
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta).
  Journal
Insect Biochem 9:637-643 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.59
IUBMB Enzyme Nomenclature: 3.1.1.59
ExPASy - ENZYME nomenclature database: 3.1.1.59
BRENDA, the Enzyme Database: 3.1.1.59
CAS: 50812-15-2

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