KEGG   ENZYME: 3.1.1.7
Entry
EC 3.1.1.7                  Enzyme                                 

Name
acetylcholinesterase;
true cholinesterase;
choline esterase I;
cholinesterase;
acetylthiocholinesterase;
acetylcholine hydrolase;
acetyl.beta-methylcholinesterase;
AcCholE
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
acetylcholine acetylhydrolase
Reaction(IUBMB)
acetylcholine + H2O = choline + acetate [RN:R01026]
Reaction(KEGG)
R01026
Substrate
acetylcholine [CPD:C01996];
H2O [CPD:C00001]
Product
choline [CPD:C00114];
acetate [CPD:C00033]
Comment
Acts on a variety of acetic esters; also catalyses transacetylations.
History
EC 3.1.1.7 created 1961
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K01049  acetylcholinesterase
Genes
HSA: 43(ACHE)
PTR: 100609296(ACHE)
PPS: 100980268(ACHE)
GGO: 101143749(ACHE)
PON: 100939726(ACHE)
NLE: 100579679(ACHE)
MCC: 713370(ACHE)
MCF: 102143626(ACHE)
CSAB: 103246711(ACHE)
RRO: 104673636(ACHE)
RBB: 108538169(ACHE)
CJC: 100392257(ACHE)
SBQ: 101046755(ACHE)
MMU: 11423(Ache)
MCAL: 110294470(Ache)
MPAH: 110312838(Ache)
RNO: 83817(Ache)
MUN: 110540909(Ache) 110562057
CGE: 100770679(Ache)
NGI: 103733499(Ache)
HGL: 101705724(Ache)
CCAN: 109698103(Ache)
TUP: 102479743(ACHE)
CFA: 489828(ACHE)
VVP: 112935693(ACHE)
AML: 100482126(ACHE)
UMR: 103670049(ACHE)
UAH: 113267843(ACHE)
ORO: 101381258(ACHE)
ELK: 111145623
FCA: 493674(ACHE)
PTG: 102948945(ACHE)
PPAD: 109251308(ACHE)
AJU: 106974601(ACHE)
BTA: 540446(ACHE)
BOM: 102281882(ACHE)
BIU: 109578757(ACHE)
BBUB: 102394935(ACHE)
CHX: 102186824(ACHE)
OAS: 101123006(ACHE)
SSC: 100621099(ACHE)
CFR: 102504654(ACHE)
CDK: 105088569(ACHE)
BACU: 103020153(ACHE)
LVE: 103068775(ACHE)
OOR: 101274257(ACHE)
DLE: 111181988(ACHE)
PCAD: 102996571(ACHE)
ECB: 100069149(ACHE)
EPZ: 103555645(ACHE)
EAI: 106839303(ACHE)
MYB: 102261529(ACHE)
MYD: 102759473(ACHE)
MNA: 107540883(ACHE)
HAI: 109374921(ACHE)
DRO: 112315001(ACHE)
PALE: 102880690(ACHE)
RAY: 107500005(ACHE)
MJV: 108409369(ACHE)
LAV: 100674399(ACHE)
TMU: 101347790
MDO: 100017989(ACHE)
SHR: 100923959(ACHE)
PCW: 110202821(ACHE)
OAA: 100087817(ACHE)
GGA: 396388(ACHE)
MGP: 104916025
CJO: 107306985
NMEL: 110390758
TGU: 115492695
LSR: 110476289(ACHE)
PHI: 102108729(ACHE)
ETL: 114071966(ACHE)
FPG: 101910874
AAM: 106496644(ACHE)
AMJ: 102557852(ACHE) 102564998
PVT: 110071630 110082363(ACHE)
PBI: 103056206 103058113(ACHE)
PMUR: 107285030(ACHE)
TSR: 106556425(ACHE)
PMUA: 114581751(ACHE) 114588580
XLA: 100158421(ache.L) 108703508
XTR: 100490673(ache)
NPR: 108791493(ACHE)
DRE: 114549(ache)
IPU: 108264160 108267799(ache)
AMEX: 103030643 103043295(ache)
EEE: 113580505 113580815(ache)
TRU: 101066574(ache)
LCO: 104932387(ache)
NCC: 104945369(ache)
MZE: 101467455 101478115(ache)
ONL: 100697913(ache) 102080527
OLA: 101161586(ache)
XMA: 102223293 102225183(ache)
XCO: 114157331(ache) 114160632
PRET: 103459627 103480137(ache)
CVG: 107087074 107105217(ache)
NFU: 107384702(ache) 107395693
KMR: 108242293(ache) 108249375
ALIM: 106522559 106526978(ache)
AOCE: 111564172(ache) 111576904
POV: 109637562 109637703(ache)
LCF: 108895215(ache) 108897432
SDU: 111223642(ache) 111224923
SLAL: 111656836 111668006(ache)
HCQ: 109516489(ache) 109528831
BPEC: 110164437 110170808(ache)
MALB: 109957265(ache)
SALP: 111952210(ache)
ELS: 105020329 105027647(ache)
SFM: 108922841(ache)
PKI: 111846325(ache)
CMK: 103173352(ache) 103176317
RTP: 109921778
DME: Dmel_CG17907(Ace) Dmel_CG4757(CG4757)
DSI: Dsimw501_GD18733(Dsim_GD18733) Dsimw501_GD20515(Dsim_Ace) Dsimw501_GD25183(Dsim_GD25183)
TCA: 659368(AChE) 662258(AChE-1)
BMOR: 100126869(ae45) 101740604 692776(ace2) 692783(ace1)
CEL: CELE_W09B12.1(ace-1) CELE_Y44E3A.2(ace-2) CELE_Y48B6A.7(ace-4)
CBR: CBG02827(Cbr-ace-4) CBG14965(Cbr-ace-2) CBG16374(Cbr-ace-1)
BMY: Bm1_47660
TSP: Tsp_03785
OBI: 106883662
PDAM: 113670233
SPIS: 111327410
NTE: NEUTE1DRAFT91848(NEUTE1DRAFT_91848)
ANG: ANI_1_1074034(An03g01700) ANI_1_1078124(An14g00860) ANI_1_1182084(An09g02270) ANI_1_1718064(An07g04470) ANI_1_2006104(An12g06560) ANI_1_2022144(An16g08070) ANI_1_2588074(An08g11860) ANI_1_384054(An06g00460)
ABP: AGABI1DRAFT31604(AGABI1DRAFT_31604) AGABI1DRAFT42497(AGABI1DRAFT_42497)
ABV: AGABI2DRAFT115977(AGABI2DRAFT_115977) AGABI2DRAFT147288(AGABI2DRAFT_147288)
DFA: DFA_11035
LWA: SAMEA4504053_2929(pnbA)
 » show all
Reference
1
  Authors
Augustinsson, K.-B.
  Title
Cholinesterases. A study in comparative enzymology.
  Journal
Acta Physiol Scand 15, Suppl. 2 (1948)
Reference
2  [PMID:13522650]
  Authors
BERGMANN F, RIMON S, SEGAL R.
  Title
Effect of pH on the activity of eel esterase towards different substrates.
  Journal
Biochem J 68:493-9 (1958)
DOI:10.1042/bj0680493
Reference
3  [PMID:5073758]
  Authors
Ciliv G, Ozand PT.
  Title
Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior.
  Journal
Biochim Biophys Acta 284:136-56 (1972)
DOI:10.1016/0005-2744(72)90053-8
Reference
4  [PMID:5238989]
  Authors
Leuzinger W, Baker AL, Cauvin E.
  Title
Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point.
  Journal
Proc Natl Acad Sci U S A 59:620-3 (1968)
DOI:10.1073/pnas.59.2.620
Reference
5  [PMID:14885021]
  Authors
NACHMANSOHN D, WILSON IB.
  Title
The enzymic hydrolysis and synthesis of acetylcholine.
  Journal
Adv Enzymol Relat Subj Biochem 12:259-339 (1951)
DOI:10.1002/9780470122570.ch5
Reference
6  [PMID:14377597]
  Authors
ZITTLE CA, DELLAMONICA ES, CUSTER JH, KRIKORIAN R.
  Title
Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction.
  Journal
Arch Biochem 56:469-75 (1955)
DOI:10.1016/0003-9861(55)90267-8
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.7
IUBMB Enzyme Nomenclature: 3.1.1.7
ExPASy - ENZYME nomenclature database: 3.1.1.7
BRENDA, the Enzyme Database: 3.1.1.7
CAS: 9000-81-1

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