KEGG   ENZYME: 3.1.1.7Help
Entry
EC 3.1.1.7                  Enzyme                                 

Name
acetylcholinesterase;
true cholinesterase;
choline esterase I;
cholinesterase;
acetylthiocholinesterase;
acetylcholine hydrolase;
acetyl.beta-methylcholinesterase;
AcCholE
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
acetylcholine acetylhydrolase
Reaction(IUBMB)
acetylcholine + H2O = choline + acetate [RN:R01026]
Reaction(KEGG)
Substrate
acetylcholine [CPD:C01996];
H2O [CPD:C00001]
Product
choline [CPD:C00114];
acetate [CPD:C00033]
Comment
Acts on a variety of acetic esters; also catalyses transacetylations.
History
EC 3.1.1.7 created 1961
Pathway
ec00564  Glycerophospholipid metabolism
Orthology
K01049  acetylcholinesterase
Genes
HSA: 43(ACHE)
PTR: 100609296(ACHE)
PPS: 100980268(ACHE)
GGO: 101143749(ACHE)
PON: 100939726(ACHE)
NLE: 100579679(ACHE)
MCC: 713370(ACHE)
MCF: 102143626(ACHE)
CSAB: 103246711(ACHE)
RRO: 104673636(ACHE)
RBB: 108538169(ACHE)
CJC: 100392257(ACHE)
SBQ: 101046755(ACHE)
MMU: 11423(Ache)
RNO: 83817(Ache)
CGE: 100770679(Ache)
NGI: 103733499(Ache)
HGL: 101705724(Ache)
CCAN: 109698103(Ache)
TUP: 102479743(ACHE)
CFA: 489828(ACHE)
AML: 100482126(ACHE)
UMR: 103670049(ACHE)
ORO: 101381258(ACHE)
FCA: 493674(ACHE)
PTG: 102948945(ACHE)
AJU: 106974601(ACHE)
BTA: 540446(ACHE)
BOM: 102281882(ACHE)
BIU: 109578757(ACHE)
PHD: 102322343(ACHE)
CHX: 102186824(ACHE)
OAS: 101123006(ACHE)
SSC: 100621099(ACHE)
CFR: 102504654(ACHE)
CDK: 105088569(ACHE)
BACU: 103020153(ACHE)
LVE: 103068775(ACHE)
OOR: 101274257(ACHE)
ECB: 100069149(ACHE)
EPZ: 103555645(ACHE)
EAI: 106839303(ACHE)
MYB: 102261529(ACHE)
MYD: 102759473(ACHE)
HAI: 109374921(ACHE)
RSS: 109458797(ACHE)
PALE: 102880690(ACHE)
LAV: 100674399(ACHE)
TMU: 101347790
MDO: 100017989(ACHE)
SHR: 100923959(ACHE)
OAA: 100087817(ACHE)
GGA: 396388(ACHE)
MGP: 104916025
APLA: 106020594
ACYG: 106029456
PHI: 102108729(ACHE)
FPG: 101910874
FCH: 102054139
AAM: 106496644(ACHE)
ASN: 102379700(ACHE)
AMJ: 102557852(ACHE) 102564998
PBI: 103056206 103058113(ACHE)
XLA: 100158421(ache.L) 108703508
XTR: 100490673(ache)
NPR: 108791493(ACHE)
DRE: 114549(ache)
IPU: 108264160 108267799(ache)
AMEX: 103030643 103043295(ache)
TRU: 101066574(ache)
LCO: 104932387(ache)
NCC: 104944652 104945369(ache)
MZE: 101467455 101478115(ache)
OLA: 101161586(ache)
XMA: 102223293 102225183(ache)
PRET: 103459627 103480137(ache)
NFU: 107384702(ache) 107395693
LCF: 108895215(ache) 108897432
HCQ: 109516489(ache) 109528831
BPEC: 110164437 110170808(ache)
ELS: 105020329 105027647(ache)
SFM: 108922841(ache)
CMK: 103173352(ache)
CIN: 100169895(ache)
DSI: Dsimw501_GD18733(Dsim_GD18733) Dsimw501_GD20515(Dsim_Ace)
DWI: Dwil_GK13999 Dwil_GK22772(Dwil_Ace)
AAG: 5575867
AME: 406104(AChE-2) 410270(ACE1)
NVI: 100115855(AChE-1) 100121967(AChE-2)
TCA: 655790 659368(AChE) 662258(AChE-1)
BMOR: 101740604 101743505 692776(ace2) 692783(ace1)
PXY: 105383901(Ace) 105385144 105385661(CCE016b) 105386751(ace-1(R)) 105389468
CEL: CELE_W09B12.1(ace-1) CELE_Y44E3A.2(ace-2) CELE_Y48B6A.7(ace-4)
CBR: CBG02827(Cbr-ace-4) CBG14965(Cbr-ace-2) CBG16374(Cbr-ace-1)
BMY: Bm1_47660
OBI: 106883662
ADF: 107358518
SMIN: v1.2.000997.t1(symbB.v1.2.000997.t1)
 » show all
Taxonomy
Reference
1
  Authors
Augustinsson, K.-B.
  Title
Cholinesterases. A study in comparative enzymology.
  Journal
Acta Physiol Scand 15, Suppl. 2 (1948)
Reference
2  [PMID:13522650]
  Authors
BERGMANN F, RIMON S, SEGAL R.
  Title
Effect of pH on the activity of eel esterase towards different substrates.
  Journal
Biochem J 68:493-9 (1958)
Reference
3  [PMID:5073758]
  Authors
Ciliv G, Ozand PT.
  Title
Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior.
  Journal
Biochim Biophys Acta 284:136-56 (1972)
DOI:10.1016/0005-2744(72)90053-8
Reference
4  [PMID:5238989]
  Authors
Leuzinger W, Baker AL, Cauvin E.
  Title
Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point.
  Journal
Proc Natl Acad Sci U S A 59:620-3 (1968)
DOI:10.1073/pnas.59.2.620
Reference
5  [PMID:14885021]
  Authors
NACHMANSOHN D, WILSON IB.
  Title
The enzymic hydrolysis and synthesis of acetylcholine.
  Journal
Adv Enzymol Relat Subj Biochem 12:259-339 (1951)
Reference
6  [PMID:14377597]
  Authors
ZITTLE CA, DELLAMONICA ES, CUSTER JH, KRIKORIAN R.
  Title
Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction.
  Journal
Arch Biochem 56:469-75 (1955)
DOI:10.1016/0003-9861(55)90267-8
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.7
IUBMB Enzyme Nomenclature: 3.1.1.7
ExPASy - ENZYME nomenclature database: 3.1.1.7
BRENDA, the Enzyme Database: 3.1.1.7
CAS: 9000-81-1

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