KEGG   ENZYME: 3.1.1.79Help
Entry
EC 3.1.1.79                 Enzyme                                 

Name
hormone-sensitive lipase;
HSL
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
diacylglycerol acylhydrolase
Reaction(IUBMB)
(1) diacylglycerol + H2O = monoacylglycerol + a carboxylate [RN:R05209];
(2) triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369];
(3) monoacylglycerol + H2O = glycerol + a carboxylate [RN:R07293]
Reaction(KEGG)
Substrate
diacylglycerol [CPD:C00165];
H2O [CPD:C00001];
triacylglycerol [CPD:C00422];
monoacylglycerol [CPD:C01885]
Product
monoacylglycerol [CPD:C01885];
carboxylate [CPD:C00060];
diacylglycerol [CPD:C00165];
glycerol [CPD:C00116]
Comment
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
History
EC 3.1.1.79 created 2004
Orthology
K07188  hormone-sensitive lipase
Genes
HSA: 3991(LIPE)
PTR: 456076(LIPE)
PPS: 100975071(LIPE)
GGO: 101145804(LIPE)
PON: 100445800(LIPE)
NLE: 100603864(LIPE)
MCC: 707997(LIPE)
MCF: 102143368(LIPE)
CSAB: 103234777(LIPE)
RRO: 104658678(LIPE)
RBB: 108513895(LIPE)
CJC: 100387953(LIPE)
SBQ: 101052652(LIPE)
MMU: 16890(Lipe)
MCAL: 110298158(Lipe)
MPAH: 110336545(Lipe)
RNO: 25330(Lipe)
MUN: 110563910(Lipe)
CGE: 100755300(Lipe)
NGI: 103744591(Lipe)
HGL: 101709284(Lipe)
CCAN: 109691865(Lipe)
OCU: 100339941(LIPE)
TUP: 102477502(LIPE)
CFA: 403607(LIPE)
VVP: 112931218(LIPE)
AML: 100479605(LIPE)
UMR: 103680155(LIPE)
UAH: 113243521(LIPE)
ORO: 101384261(LIPE)
ELK: 111161566
FCA: 751818(LIPE)
PTG: 102952452(LIPE)
PPAD: 109257948(LIPE)
AJU: 106987707(LIPE)
BTA: 286879(LIPE)
BOM: 102266815(LIPE)
BIU: 109572731(LIPE)
BBUB: 102389675(LIPE)
CHX: 100860801(LIPE)
OAS: 100169699(LIPE)
SSC: 397583(LIPE)
CFR: 102520149(LIPE)
CDK: 105090211(LIPE)
BACU: 103006716(LIPE)
LVE: 103074607(LIPE)
OOR: 101277193(LIPE)
DLE: 111180817(LIPE)
PCAD: 102989235(LIPE)
ECB: 100069598(LIPE)
EPZ: 103558823(LIPE) 103563985
EAI: 106847929 106847941(LIPE)
MYB: 102247234(LIPE)
MYD: 102764534(LIPE)
MNA: 107534157(LIPE)
HAI: 109374451(LIPE)
DRO: 112320229(LIPE)
PALE: 102889858(LIPE)
RAY: 107502572(LIPE)
MJV: 108393430(LIPE)
LAV: 100670874(LIPE)
TMU: 101361564
MDO: 103104890(LIPE)
SHR: 100926393(LIPE)
PCW: 110219706(LIPE)
OAA: 103167455(LIPE)
NMEL: 110392043(LIPE)
TGU: 115492914
AAM: 106487870(LIPE)
ASN: 102386893(LIPE)
AMJ: 102571969(LIPE)
CPIC: 101953217(LIPE)
ACS: 107982284
PVT: 110086763(LIPE)
PBI: 103054092(LIPE)
PMUR: 107289716(LIPE)
TSR: 106550581(LIPE)
PMUA: 114603349(LIPE)
GJA: 107106853(LIPE) 107117837
XLA: 100174796(lipe.L) 108697769(lipe.S)
XTR: 733899(lipe)
NPR: 108799329(LIPE)
DRE: 557893(lipeb)
IPU: 108256376(lipe) 108272659
PHYP: 113532968(lipe) 113535092
AMEX: 103030794(lipe) 103036112
EEE: 113571934(lipe) 113578376
TRU: 101067661(lipe) 101070911
LCO: 104927333(lipe) 104928056
MZE: 101473301 101485272(lipe)
ONL: 100534456(lipe) 100708083
OLA: 101157970(lipe) 101160745
XMA: 102217205 102234893(lipe)
XCO: 114138258(lipe) 114156439
PRET: 103473021 103477914(lipe)
NFU: 107379673(lipe) 107394884
KMR: 108229521 108235517(lipe)
ALIM: 106523738(lipe) 106530086
AOCE: 111564221(lipe) 111580224
CSEM: 103388799(lipe) 103393953
POV: 109633466(lipe) 109640422
LCF: 108880754(lipe) 108899366
SDU: 111230513 111236037(lipe)
SLAL: 111657262(lipe) 111661080
HCQ: 109513537 109531659(lipe)
BPEC: 110168856 110174235(lipe)
MALB: 109954692(lipe) 109958776
SFM: 108922191(lipe)
PKI: 111854848(tmem145)
LCM: 102346636(LIPE)
RTP: 109926478(lipe)
CIN: 100181083
SPU: 585712
APLC: 110988815
SKO: 100376662
DME: Dmel_CG11055(Hsl)
DER: 6547758
DSI: Dsimw501_GD11499(Dsim_GD11499)
DSR: 110179545
DPE: 6593171
DWI: 6640914
DAZ: 108616685
DNV: 108654876
DHE: 111593545
MDE: 101899540
LCQ: 111687523
AAG: 5566934
AME: 413702
BIM: 100748813
BTER: 100646474
CCAL: 108623011
OBB: 114874463
SOC: 105198580
MPHA: 105835099
AEC: 105143573
ACEP: 105620501
PBAR: 105428403
VEM: 105562337
HST: 105188918
DQU: 106743086
LHU: 105676433
PGC: 109856830
OBO: 105286291
PCF: 106788649
NVI: 100120573
CSOL: 105364358
MDL: 103568258
TCA: 664547
DPA: 109543096
ATD: 109602787
NVL: 108569775
BMOR: 101737209
BMAN: 114239644
PRAP: 110998313
HAW: 110384566
TNL: 113495550
PXY: 105392962
API: 100159927
DNX: 107171212
AGS: 114124269
RMD: 113549469
BTAB: 109032262
CLEC: 106668997
ZNE: 110826823
FCD: 110844206
DPTE: 113797455
CSCU: 111613708
PTEP: 107442104
CEL: CELE_C46C11.1(hosl-1)
CBR: CBG14512
TSP: Tsp_02264
PCAN: 112567841
CRG: 105345018
MYI: 110445915
OBI: 106878881
SHX: MS3_01741
EGL: EGR_02179
EPA: 110241065
AMIL: 114951856
PDAM: 113675352
SPIS: 111332161
DGT: 114524710
HMG: 100210426
AQU: 105314138
SPAR: SPRG_01501
 » show all
Taxonomy
Reference
1  [PMID:10940339]
  Authors
Holm C, Osterlund T, Laurell H, Contreras JA.
  Title
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
  Journal
Annu Rev Nutr 20:365-93 (2000)
DOI:10.1146/annurev.nutr.20.1.365
Reference
2  [PMID:7240206]
  Authors
Fredrikson G, Stralfors P, Nilsson NO, Belfrage P.
  Title
Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.
  Journal
J Biol Chem 256:6311-20 (1981)
Reference
3  [PMID:14169138]
  Authors
VAUGHAN M, BERGER JE, STEINBERG D.
  Title
HORMONE-SENSITIVE LIPASE AND MONOGLYCERIDE LIPASE  ACTIVITIES IN ADIPOSE TISSUE.
  Journal
J Biol Chem 239:401-9 (1964)
Reference
4  [PMID:8912675]
  Authors
Osterlund T, Danielsson B, Degerman E, Contreras JA, Edgren G, Davis RC, Schotz MC, Holm C.
  Title
Domain-structure analysis of recombinant rat hormone-sensitive lipase.
  Journal
Biochem J 319 ( Pt 2):411-20 (1996)
Reference
5  [PMID:3196730]
  Authors
Lee FT, Adams JB, Garton AJ, Yeaman SJ.
  Title
Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones.
  Journal
Biochim Biophys Acta 963:258-64 (1988)
DOI:10.1016/0005-2760(88)90289-5
Reference
6  [PMID:9162045]
  Authors
Wei S, Lai K, Patel S, Piantedosi R, Shen H, Colantuoni V, Kraemer FB, Blaner WS.
  Title
Retinyl ester hydrolysis and retinol efflux from BFC-1beta adipocytes.
  Journal
J Biol Chem 272:14159-65 (1997)
DOI:10.1074/jbc.272.22.14159
Reference
7  [PMID:2794798]
  Authors
Tsujita T, Ninomiya H, Okuda H.
  Title
p-nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue.
  Journal
J Lipid Res 30:997-1004 (1989)
Reference
8  [PMID:14725507]
  Authors
Yeaman SJ.
  Title
Hormone-sensitive lipase--new roles for an old enzyme.
  Journal
Biochem J 379:11-22 (2004)
DOI:10.1042/BJ20031811
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.79
IUBMB Enzyme Nomenclature: 3.1.1.79
ExPASy - ENZYME nomenclature database: 3.1.1.79
BRENDA, the Enzyme Database: 3.1.1.79

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