KEGG   ENZYME: 3.1.1.8
Entry
EC 3.1.1.8                  Enzyme                                 
Name
cholinesterase;
pseudocholinesterase;
butyrylcholine esterase;
non-specific cholinesterase;
choline esterase II (unspecific);
benzoylcholinesterase;
choline esterase;
butyrylcholinesterase;
propionylcholinesterase;
BtChoEase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
acylcholine acylhydrolase
Reaction(IUBMB)
an acylcholine + H2O = choline + a carboxylate [RN:R01029]
Reaction(KEGG)
R01029 > R01026
Substrate
acylcholine [CPD:C01777];
H2O [CPD:C00001]
Product
choline [CPD:C00114];
carboxylate [CPD:C00060]
Comment
Acts on a variety of choline esters and a few other compounds.
History
EC 3.1.1.8 created 1961
Orthology
K01050  cholinesterase
Genes
HSA590(BCHE)
PTR460830(BCHE)
PPS100972372(BCHE)
GGO101135975(BCHE)
PON100174585(BCHE)
NLE100586324(BCHE)
MCC700484(BCHE)
MCF102130167(BCHE)
CSAB103221309(BCHE)
CATY105586031(BCHE)
PANU101009710(BCHE)
TGE112619166(BCHE)
RRO104655785(BCHE)
RBB108541031(BCHE)
TFN117083680(BCHE)
PTEH111543509(BCHE)
CJC100409326(BCHE)
SBQ101029649(BCHE)
CSYR103275007(BCHE)
MMUR105881536(BCHE)
LCAT123630232(BCHE)
OGA100949904(BCHE)
MMU12038(Bche)
MCAL110291327(Bche)
MPAH110320510(Bche)
RNO65036(Bche)
MCOC116093000(Bche)
MUN110542708(Bche)
CGE100767789(Bche)
MAUA101824800(Bche)
PLEU114691700(Bche)
MORG121452949(Bche)
AAMP119826758(Bche)
NGI103728609(Bche)
HGL101712877(Bche)
CPOC100729351(Bche)
CCAN109679490(Bche)
DORD105985636(Bche)
DSP122107300(Bche)
NCAR124993443
OCU100338759(BCHE)
OPI101519650(BCHE)
TUP102496968(BCHE)
CFA488143(BCHE)
VVP112926647(BCHE)
VLG121477622(BCHE)
AML100464904(BCHE)
UMR103664429(BCHE)
UAH113254164(BCHE)
UAR123801250(BCHE)
ELK111150537
LLV125099941
MPUF101677748(BCHE)
ORO101382195(BCHE)
EJU114209134(BCHE)
ZCA113918739(BCHE)
MLX118005971(BCHE)
FCA493960(BCHE)
PYU121033948(BCHE)
PBG122491767(BCHE)
PTG102952605(BCHE)
PPAD109262087(BCHE)
AJU106987452(BCHE)
HHV120247210(BCHE)
BTA534616(BCHE)
BOM102267863(BCHE)
BIU109558593(BCHE)
BBUB102415170(BCHE)
CHX102187168(BCHE)
OAS101102112(BCHE)
ODA120869124(BCHE)
CCAD122444966(BCHE)
SSC100624138(BCHE)
CFR102523324(BCHE)
CBAI105066668(BCHE)
CDK105085977(BCHE)
VPC102526765(BCHE)
BACU103011235(BCHE)
LVE103076485(BCHE)
OOR101285649(BCHE)
DLE111175690(BCHE)
PCAD102980766(BCHE)
PSIU116752571(BCHE)
ECB100033901(BCHE)
EPZ103552042(BCHE)
EAI106842409(BCHE)
MYB102257140(BCHE)
MYD102753302(BCHE)
MMYO118677212(BCHE)
MLF102429389(BCHE)
MNA107539297(BCHE)
PKL118723668(BCHE)
HAI109373265(BCHE)
DRO112304765(BCHE)
SHON118987435(BCHE)
AJM119046161(BCHE)
PDIC114491095(BCHE)
PHAS123827483(BCHE)
MMF118617324(BCHE)
RFQ117031022(BCHE)
PALE102883546(BCHE)
PGIG120598617(BCHE)
PVP105305364(BCHE)
RAY107509906(BCHE)
MJV108403818(BCHE)
TOD119257654(BCHE)
SARA101555142(BCHE)
LAV100666102(BCHE)
TMU101353513
DNM101426579(BCHE)
MDO100618084(BCHE)
GAS123240285(BCHE)
SHR100930262(BCHE)
PCW110210063(BCHE)
OAA100074368(BCHE)
GGA395358(BCHE)
PCOC116235503(BCHE)
MGP100538485(BCHE)
CJO107318341(BCHE)
NMEL110398546(BCHE)
APLA101790679(BCHE)
ACYG106031959(BCHE)
AFUL116492790(BCHE)
TGU100229708(BCHE)
LSR110480346(BCHE)
SCAN103815273(BCHE)
PMOA120504387(BCHE)
OTC121336685(BCHE)
PRUF121353853(BCHE)
GFR102044616(BCHE)
FAB101808546(BCHE)
PHI102106247(BCHE)
PMAJ107209012(BCHE)
CCAE111933811(BCHE)
CCW104688062(BCHE)
ETL114063686(BCHE)
ZAB102072439(BCHE)
FPG101918906(BCHE)
FCH102056322(BCHE)
CLV102095857(BCHE)
EGZ104133796(BCHE)
NNI104021968(BCHE)
PLET104622118(BCHE)
ACUN113483541(BCHE)
TALA104358596(BCHE)
PADL103924946(BCHE)
ACHC115347349(BCHE)
AAM106499612(BCHE)
AROW112964128(BCHE)
NPD112952463(BCHE)
DNE112986476(BCHE)
ASN102386904(BCHE)
AMJ102575868(BCHE)
CPOO109308403(BCHE)
GGN109287949(BCHE)
PSS102451430(BCHE)
CMY102946073(BCHE)
CPIC101939015(BCHE)
TST117883016(BCHE) 117887147
CABI116821456(BCHE) 116824944
MRV120371313(BCHE)
ACS100555848(bche) 100557088 100557286 100557484 100557679 100557878 100561946 100562140 100563136 100563524
PVT110085517(BCHE) 110089316 110089325 110089326 110089332
SUND121920291 121923972 121923975 121926224(BCHE)
PBI103050649(BCHE) 103053034 103053272
PMUR107292518(BCHE) 107295938 107295939 107295940 107296158 107296160 107297515 107298145 107298147 107298148 107298149 107298150 107298151 107298706 107298708 107298709
TSR106553925 106555442(BCHE)
PGUT117656570 117660120 117667965 117667967 117667993 117667994 117667996 117667997 117678218(BCHE)
VKO123019533 123025577(BCHE) 123027199 123027200 123034512
PMUA114588401 114588544 114588578 114588623 114588625 114588637 114588661 114588677 114597946(BCHE)
ZVI118078788 118078789 118081089 118081093 118081094 118081096 118081097 118081098 118081099 118093668(BCHE)
GJA107106357 107112558(BCHE) 107113101 107118952 107120837 107120838 107125131
STOW125425530 125427692 125427696 125427705 125428959 125428963 125428965 125428966 125428967 125428968 125428974 125438594(BCHE)
XLA108698834 108699002 108700455 108717029(bche.L) 108717579(bche.S)
XTR100135377(bchel) 100494295 100495889(bche)
NPR108798271 108802121(BCHE)
RTEM120920639 120920832 120936724(BCHE)
BBUF120997859(BCHE)
BGAR122935694(BCHE)
SRX107735268
SANH107660675
SGH107600247
CAUA113118135
MAMB125254062
AMEX103037776
EEE113576961
TRU101063701 101063924 101068568 115246693 115251497 115251528 115251574
TNGGSTEN00011760G001 GSTEN00013093G001
LCO104936069(bche)
NCC104958666
CGOB115017910(bche)
ELY117260330
PLEP121943269
SLUC116045598
ECRA117942376
PFLV114553157
GAT120826877
PPUG119222381
MSAM119883329
CUD121526566
ALAT119012960
MZE101487581
ONL100692786
OAU116330372
OLA100529181(bche) 101169010
OML112139820 112149957
XMA102217182 102221435 102224809 102234152
XCO114133308 114133367
XHE116707979 116708132 116737261 116737315
PRET103474418(bche)
PFOR103151276 103153789
PLAI106942224 106952917
PMEI106909853 106917369 106927785
GAF122832366 122832367 122832368
CVG107094201
CTUL119775260
GMU124882933 124883561
NFU107396314
KMR108240502
ALIM106520635(bche)
NWH119411545 119428442
AOCE111579784
POV109634558
SSEN122773025
HHIP117773028
HSP118101342 118106032
LCF108886340
SDU111238463
SLAL111652649
XGL120791543
HCQ109525520
BPEC110174478
MALB109960365(bche)
BSPL114863255 114868622
SASA106594026 106613213
OTW112267306
OMY110503211
OGO124006271
ONE115123259
SALP112072018
SNH120041944
SFM108924671(bche) 108936474
PKI111833787(bche) 111856645
AANG118210328
LOC102683466(bche) 102695990
PSPA121320047 121326369
ARUT117416907
CMK103176352 103179126
RTP109922351
BFO118404325 118404973 118406999 118409065 118413153 118415181 118415802 118425929 118428123
BBEL109461617 109462284 109462794 109462866 109472136 109475926 109476514 109476946 109477843 109483355 109487316
CIN100176294 101242882 104265460 104265954
SCLV120327956 120329611 120329646 120330057 120330384 120331351 120335313 120336223 120336445 120338407 120341329 120346109
SPU100890850 100893063 115918236 115924648 115929625 574831 574908 575073 577109 583460 586904 591182
APLC110973520 110976526 110981745 110984437 110985158 110987283 110987287 110987295 110987296 110987297 110987307 110987309 110991019
SKO100303578(bche) 100366282 100367244 100368838 100371735 100371898 100372049 100372193 100375195 102808295
DER6553283 6553329
DSIDsimw501_GD19480(Dsim_GD19480)
DYADyak_GE25790
DSR110188692
DPODpse_GA10886
DPE6594346 6594354
DMN108155687 108156708
DWI6648024 6652178
DHE111602801
AGAAgaP_AGAP006228
AAG23687491
AALB109399466 109403033
CQUCpipJ_CPIJ000049 CpipJ_CPIJ000051 CpipJ_CPIJ007824 CpipJ_CPIJ013917 CpipJ_CPIJ016337
CPII120421924
CNS116350822
BCOO119075169 119084155 119084157
AME413047
MPHA105831643
AEC105143853
ACEP105620070
VEM105567353
LHU105672628 105678413
OBO105275605 105278764
NVI107981954
AGIF122850555
CCIN107274027
DPA109533868
SOY115883324
ATD109598007
CSET123311223
AGB108912487
LDC111502203
NVL108559572 108562061
APLN108733024 112905645
PPYR116163792 116164043 116171566
BMOR100329150(cce-1) 101735768 101744318 101744461 101745376
BMAN114239459 114242459
DPLKGM_206052
PMAC106707404 106709739 106720047
ZCE119831942 119838155
HAW110374429 110378334
TNL113493996 113502190 113502193 113505876 113508563 113508564
DCI103512641
CLEC106670868 106670903
FOC113211542 113212246 113215099
CSEC111866864
PVM113810840
PJA122249260 122251258
PCHN125040628 125040681
HAME121861266
PCLA123768664
PTRU123519471
HAZT108680884
EAF111698983
LSM121128991 121129347
PPOI119089805 119103143
ISCIscW_ISCW001079 IscW_ISCW001748 IscW_ISCW001875 IscW_ISCW004315 IscW_ISCW006205 IscW_ISCW006206 IscW_ISCW006617 IscW_ISCW006896 IscW_ISCW010310 IscW_ISCW010323 IscW_ISCW011399 IscW_ISCW014411 IscW_ISCW014780 IscW_ISCW017638 IscW_ISCW020818 IscW_ISCW020819 IscW_ISCW020821 IscW_ISCW021542 IscW_ISCW022246 IscW_ISCW024669
DSV119430965 119432471 119432783 119432784 119433150 119437501 119440368 119440394 119440604 119440640 119440722 119444723 119445039 119445203 119445205 119445206 119448588 119448596 119448619 119448622 119449690 119449693 119455199 119455678 119455700 119455716 119456011 119456080 119456156 119456157 119456160 119456316 119456379 119456382 119456383 119456386 119456445 119456744 119456775 119456931 119456955 119456998 119457012 119457024 119457037 119457039 119457040 119457042 119457043 119457044 119457046 119457049 119461075 119463652 119463656 119465172 119465173 119465174 119465307
RSAN119377312 119377318 119381069 119381527 119381597 119385637 119385643 119385651 119385736 119385893 119385989 119386269 119386400 119391729 119392027 119392769 119393106 119393107 119393271 119393272 119393273 119393275 119393281 119393347 119393373 119393457 119393458 119393459 119393461 119393601 119393665 119393698 119393727 119393856 119393857 119393926 119394586 119394587 119394589 119394590 119394685 119394959 119395846 119396137 119402061 119403308 119403488 119403489 119403623 119404299 119405641 119405642
RMP119164105 119164425 119164522 119164628 119165266 119165376 119165487 119166381 119166885 119169292 119169965 119171573 119171575 119171691 119171692 119171693 119171695 119171770 119171771 119171772 119171775 119171776 119172045 119172087 119172101 119172186 119172231 119172574 119172599 119172600 119172690 119172787 119172792 119172897 119173989 119174344 119177871 119177872 119179280 119185021 119185747 119186352
VDE111246636 111247592 111247950 111250776 111251954 111254234 111254737
VJA111258890 111262097 111264812 111266802 111268059 111268179 111268971 111270226
TUT107359147 107359187 107359968 107363836 107364072 107364849 107366027 107367804 107367921 107367965 107368128 107368264 107368977 107369291 107369761 107369773 107370097 107370236 107370243 107370672 107370732 107371514
DPTE113788534 113790040 113790044 113790506 113790733 113790961 113792507 113792557 113792601 113792742 113795000 113795025 113795027 113795600 113795994 113796239 113799862
DFR124490365 124490671 124491867 124492097 124494083 124494462 124495653 124496328 124496483 124497053 124497055 124497056 124497206 124498741 124499084 124499151 124499271
CSCU111613582 111613585 111620294 111622420 111622421 111622422 111634639 111634642 111634645 111634659 111634660 111635558 111635565 111635567 111635569 111635571 111635572 111635579 111639911 111639919 111640542
PTEP107451311 107454551 107455030 107457137
SDM118180047 118182971 118182972 118189430
CELCELE_Y48B6A.8(ace-3)
CBRCBG_02828(Cbr-ace-3)
LOALOAG_09411 LOAG_18563
NAINECAME_08193 NECAME_08254 NECAME_08462
TSPTsp_03473 Tsp_09554
HROHELRODRAFT_114110 HELRODRAFT_120724
LGILOTGIDRAFT_113227
PCAN112553181 112576848
BGT106053816 106063087 106065810 106072498
GAE121373317 121376368 121376513 121376523 121376906 121377087 121377748 121377976 121378110 121385205 121390448 121390752 121391215
HRF124111087 124111124 124115046 124123036 124124691 124124692 124124693 124124694 124124695 124124696 124127951 124128425 124129759 124131279 124131283 124132272 124132300 124140743 124140744 124140809 124143338 124143359 124143362 124151622 124151624
HRJ124253179 124254823 124254828 124255637 124255646 124255652 124259217 124259219 124259227 124259230 124259239 124259241 124259530 124259536 124259537 124259538 124261051 124261052 124265952 124271722 124271723 124271726 124271727 124271737 124271739 124271740 124271741 124273335 124273356 124273358 124273359 124273360 124274962 124276635 124277576 124277577 124277578 124284358 124285488 124286233 124287311 124288396 124288402 124288403 124288404
CRG105324736 105334045 105339908 105346662 117684640
MYI110452978 110454068 110456246 110456825 110464483 110464502
PMAX117314721 117314936 117324885 117325032 117327722 117336936 117343016
MMER123524367 123531877 123531976 123531977 123532861 123536466 123536793 123540321 123542223 123542497 123542725 123545527 123545529 123545634 123550112 123550979 123550996 123551634 123553011 123557642 123557643 123558503 123558994 123559135 123559396 123562070 123563596 123563598 123563600
OBI106874952 106876840 106876841 106878554 106878556 106882574
OSN115214869 115216415 115216429 115216430 115216431 115216478 115216730 115216734 115229743
LAK106152684 106152694 106154198 106156812 106175595 106181447 112041607
SMMSmp_125350 Smp_136690
OVIT265_05062
NVE5507804
EPA110238498 110238499 110240194 110243256 110250977 110253442
ATEN116287340 116287580 116296631 116296650 116296669 116296796 116302557
ADF107337265
AMIL114966144 114970972
PDAM113671067 113671068 113679597
SPIS111332804 111334584
DGT114519481 114521661 114521680 114521690 114528552 114531287 114531337 114538529 114540278
XEN124433341 124433444 124433445 124435553 124440053 124456797 124456798 124458412 124458413
TADTRIADDRAFT_31933 TRIADDRAFT_32031 TRIADDRAFT_32071 TRIADDRAFT_61104 TRIADDRAFT_61106 TRIADDRAFT_61120
AQU100634023
QSU111996406 112019612 112030257
DHADEHA2E05940g
NTENEUTE1DRAFT89843(NEUTE1DRAFT_89843)
SMPSMAC_01444
TTTTHITE_2037188
CTHRCTHT_0021930
TMNUCRPA7_2355 UCRPA7_4768
SSCKSPSK_01554 SPSK_06046
FGRFGSG_03095 FGSG_03601 FGSG_13655
FPUFPSE_00817 FPSE_02130 FPSE_05487
FVRFVEG_06442 FVEG_08870 FVEG_12524 FVEG_13359
FOXFOXG_09590
NHENECHADRAFT_46438 NECHADRAFT_54124 NECHADRAFT_79670 NECHADRAFT_85213 NECHADRAFT_92078 NECHADRAFT_95089
MAJMAA_00630
CMTCCM_02901
PLJVFPFJ_05580
CFJCFIO01_03292 CFIO01_04303
SAPOSAPIO_CDS6941 SAPIO_CDS8797 SAPIO_CDS9480
ELAUCREL1_2737
PFYPFICI_00574 PFICI_01478 PFICI_02129 PFICI_03404 PFICI_07962 PFICI_08572 PFICI_09380 PFICI_10482 PFICI_10994 PFICI_12188 PFICI_12270 PFICI_12443 PFICI_12579
SSLSS1G_00376 SS1G_11853
BFUBCIN_02g08230 BCIN_03g04730 BCIN_09g04430 BCIN_12g02190 BCIN_12g05460 BCIN_15g05680
MBEMBM_00198 MBM_01345
PSCOLY89DRAFT_238953 LY89DRAFT_609908 LY89DRAFT_691377 LY89DRAFT_706064 LY89DRAFT_707445 LY89DRAFT_729132 LY89DRAFT_740843 LY89DRAFT_780882
GLZGLAREA_05683 GLAREA_07927 GLAREA_09925
AORAO090038000122
ANGANI_1_1452084(An09g05120)
AFVAFLA_012394
TMFPMAA_039600 PMAA_090830 PMAA_099010
TRGTRUGW13939_01714 TRUGW13939_08351
CIMCIMG_07360
CPWCPC735_001470
PBLPAAG_06011
PBNPADG_05989
AJEHCAG_04135
PNOSNOG_10699
PTEPTT_16577
BSCCOCSADRAFT_348589
BORCOCMIDRAFT_31251
AALTCC77DRAFT_1036003 CC77DRAFT_239201 CC77DRAFT_995142
ZTRMYCGRDRAFT_109625
PFJMYCFIDRAFT_108978 MYCFIDRAFT_167763 MYCFIDRAFT_43987
BCOMBAUCODRAFT_81033
NPAUCRNP2_3973 UCRNP2_8891
CGICGB_J0480C
TMSTREMEDRAFT_27125 TREMEDRAFT_60040
TASAA1Q1_07389
TVSTRAVEDRAFT_47993
DSQDICSQDRAFT_172133
SHSSTEHIDRAFT_144891 STEHIDRAFT_91928 STEHIDRAFT_91931
LBCLACBIDRAFT_317144 LACBIDRAFT_317167
ABPAGABI1DRAFT107560(AGABI1DRAFT_107560) AGABI1DRAFT129472(AGABI1DRAFT_129472)
ABVAGABI2DRAFT121127(AGABI2DRAFT_121127) AGABI2DRAFT145418(AGABI2DRAFT_145418) AGABI2DRAFT217766(AGABI2DRAFT_217766)
SLASERLADRAFT_374500 SERLADRAFT_374512 SERLADRAFT_443232
UMAUMAG_02864 UMAG_04247
MSYMMSY001_2168
MBRMONBRDRAFT_30292 MONBRDRAFT_31457
SREPTSG_12925
DPPDICPUDRAFT_146986 DICPUDRAFT_150002
DFADFA_06184
SMINv1.2.027506.t1(symbB.v1.2.027506.t1)
PIFPITG_20786
PSOJPHYSODRAFT_259933 PHYSODRAFT_507234
EHXEMIHUDRAFT_210675
NGRNAEGRDRAFT_30355 NAEGRDRAFT_64604 NAEGRDRAFT_71821
 » show all
Reference
1
  Authors
Augustinsson, K.-B.
  Title
Cholinesterases. A study in comparative enzymology.
  Journal
Acta Physiol Scand 15, Suppl. 2 (1948)
Reference
2  [PMID:13638253]
  Authors
AUGUSTINSSON KB, OLSSON B.
  Title
Esterases in the milk and blood plasma of swine. I. Substrate specificity and electrophoresis studies.
  Journal
Biochem J 71:477-84 (1959)
DOI:10.1042/bj0710477
Reference
3  [PMID:13032058]
  Authors
KOELLE GB.
  Title
Cholinesterases of the tissues and sera of rabbits.
  Journal
Biochem J 53:217-26 (1953)
DOI:10.1042/bj0530217
Reference
4  [PMID:14885021]
  Authors
NACHMANSOHN D, WILSON IB.
  Title
The enzymic hydrolysis and synthesis of acetylcholine.
  Journal
Adv Enzymol Relat Subj Biochem 12:259-339 (1951)
DOI:10.1002/9780470122570.ch5
Reference
5  [PMID:17780326]
  Authors
Sawyer CH
  Title
HYDROLYSIS OF CHOLINE ESTERS BY LIVER.
  Journal
Science 101:385-6 (1945)
DOI:10.1126/science.101.2624.385
Reference
6  [PMID:16747753]
  Authors
Strelitz F.
  Title
Studies on cholinesterase: 4. Purification of pseudo-cholinesterase from horse serum.
  Journal
Biochem J 38:86-8 (1944)
DOI:10.1042/bj0380086
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.8
IUBMB Enzyme Nomenclature: 3.1.1.8
ExPASy - ENZYME nomenclature database: 3.1.1.8
BRENDA, the Enzyme Database: 3.1.1.8
CAS: 9001-08-5

DBGET integrated database retrieval system