Entry
Name
monoterpene epsilon-lactone hydrolase;
MLH
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
isoprop(en)ylmethyloxepan-2-one lactonohydrolase
Reaction(IUBMB)
(1) isoprop(en)ylmethyloxepan-2-one + H2O = 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction);
(2) 4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate [RN:
R06390 R06392 ];
(3) 7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate [RN:
R08979 ]
Reaction(KEGG)
Substrate
isoprop(en)ylmethyloxepan-2-one;
H2O [CPD:
C00001 ];
4-isopropenyl-7-methyloxepan-2-one [CPD:
C11414 ];
7-isopropyl-4-methyloxepan-2-one [CPD:
C18066 ]
Product
6-hydroxyisoprop(en)ylmethylhexanoate;
6-hydroxy-3-isopropenylheptanoate [CPD:
C11417 ];
6-hydroxy-3,7-dimethyloctanoate [CPD:
C18067 ]
Comment
The enzyme catalyses the ring opening of epsilon-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective.
History
EC 3.1.1.83 created 2008
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K14731 epsilon-lactone hydrolase
Genes
CON : TQ29_18790 TQ29_18930
SPSE : SULPSESMR1_04141(mlhB)
LVS : LOKVESSMR4R_03943(mlhB)
SPAG : sphantq_03288(mlhB_1) sphantq_04480(mlhB_2)
NFR : ERS450000_00738(mlhB_1)
RRZ : CS378_11575 CS378_11785
RKO : JWS14_15895 JWS14_20950 JWS14_43755
RPSK : JWS13_28455 JWS13_31000 JWS13_42110 JWS13_42175 JWS13_43350
RHJS : OYT95_22945 OYT95_35445
GOD : GKZ92_20420 GKZ92_20525
SDEC : L3078_00625 L3078_03500
SAKB : K1J60_39635 K1J60_42320
SCOA : QU709_03220 QU709_42465
BSPO : L1F31_01650 L1F31_01865 L1F31_11510
AMQ : AMETH_2426 AMETH_3877
PPEL : H6H00_18840 H6H00_19435 H6H00_19590
PMAD : BAY61_09880 BAY61_19415
ACTY : OG774_12490 OG774_29150
SBAE : DSM104329_02046(mlhB_1)
» show all
Taxonomy
Reference
Authors
van der Vlugt-Bergmans CJ, van der Werf MJ
Title
Genetic and biochemical characterization of a novel monoterpene epsilon-lactone hydrolase from Rhodococcus erythropolis DCL14.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.83
ExPASy - ENZYME nomenclature database: 3.1.1.83