KEGG   ENZYME: 3.1.1.83Help
Entry
EC 3.1.1.83                 Enzyme                                 

Name
monoterpene epsilon-lactone hydrolase;
MLH
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
isoprop(en)ylmethyloxepan-2-one lactonohydrolase
Reaction(IUBMB)
(1) isoprop(en)ylmethyloxepan-2-one + H2O = 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction);
(2) 4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate [RN:R06390 R06392];
(3) 7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate [RN:R08979]
Reaction(KEGG)
Substrate
isoprop(en)ylmethyloxepan-2-one;
H2O [CPD:C00001];
4-isopropenyl-7-methyloxepan-2-one [CPD:C11414];
7-isopropyl-4-methyloxepan-2-one [CPD:C18066]
Product
6-hydroxyisoprop(en)ylmethylhexanoate;
6-hydroxy-3-isopropenylheptanoate [CPD:C11417];
6-hydroxy-3,7-dimethyloctanoate [CPD:C18067]
Comment
The enzyme catalyses the ring opening of epsilon-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective.
History
EC 3.1.1.83 created 2008
Pathway
ec00903  Limonene and pinene degradation
ec00930  Caprolactam degradation
Orthology
K14731  epsilon-lactone hydrolase
Genes
QSU: 112008051
PFY: PFICI_02360
BZE: COCCADRAFT_39010
PFJ: MYCFIDRAFT_210278
BCOM: BAUCODRAFT_239045
GTT: GUITHDRAFT_118216
ESA: ESA_02202
CSK: ES15_2347
CSJ: CSK29544_03486
CSI: P262_03397
CMJ: AFK66_011470
CUI: AFK65_08070
KMI: VW41_09205
CAMA: F384_09330
CAF: AL524_12985
CFAR: CI104_15685
CIR: C2U53_24995
CNT: JT31_03385
CEM: LH23_14865
CEN: LH86_14025
KRD: A3780_19065
KCO: BWI95_14550
KOT: EH164_13480
SRR: SerAS9_1101
SRL: SOD_c22360(bah)
SRY: M621_12290
SPLY: Q5A_012510(mlhB)
SRS: SerAS12_1101
SRZ: AXX16_3111
SERA: Ser39006_011640 Ser39006_016450
SERQ: CWC46_11635 CWC46_16450
SERM: CLM71_10275
RAQ: Rahaq2_2003
SOD: Sant_2259
DDC: Dd586_1427
DDQ: DDI_1172
DAQ: DAQ1742_03296
EBI: EbC_28410
PAO: Pat9b_5702
HAV: AT03_09025
HPAR: AL518_16800
OPO: DSM2777_09130
PSHI: SAMEA2665130_1587(mlhB)
FAU: Fraau_0093 Fraau_1899
XBA: C7S18_02135
VGA: BSQ33_01620
PGB: H744_2c2075
PDS: CAY62_06330
PNC: NCGM2_3078
PAEU: BN889_02296
PAEG: AI22_18580
PPW: PputW619_1687
PPJ: RK21_02866
PST: PSPTO_4277
PFZ: AV641_14495
PSEC: CCOS191_3029 CCOS191_3234
PKR: AYO71_15305
PSET: THL1_4241
PYM: AK972_1926
ANO: RR32_12550
ALC: OTEC02_13310
ACAL: BUM88_05475 BUM88_18905
ACW: A0J50_11920
AHL: AHTJS_00635
AWU: BEN71_13550
MBAH: HYN46_02885
MAQ: Maqu_2165
MHC: MARHY1062
MAD: HP15_877
MBS: MRBBS_1574(bah) MRBBS_2608(est)
MSX: AU14_05420 AU14_10040
MPQ: ABA45_12300
MARI: ACP86_15495
MLQ: ASQ50_17060
MSQ: BKP64_09745
MARA: D0851_07340 D0851_18060
GNI: GNIT_3308
MVS: MVIS_1336
MYA: MORIYA_1698
SPOI: IMCC21906_01685
ZAL: AZF00_12560
OSG: BST96_07835 BST96_20200
HJA: BST95_03040 BST95_13270
CYY: CPC19_07720
WOC: BA177_14650
HCH: HCH_00518
HAHE: ENC22_02080 ENC22_02160 ENC22_02165
HAF: C8233_16630
HAA: A5892_04760
CMAI: BFX80_05265
ADI: B5T_02070
APAC: S7S_05675 S7S_08505 S7S_11230
ALN: AS19_02010
AXE: P40_09905
KAK: Kalk_00635 Kalk_02370
TOL: TOL_3423
TOR: R615_16050
GSN: YC6258_00636
OME: OLMES_0598 OLMES_2019 OLMES_2033
OCM: CBP12_03720
OPF: CBP31_00855
SOK: D0B54_04590 D0B54_07365 D0B54_07385 D0B54_08365 D0B54_19470 D0B54_21635 D0B54_22665
PSPI: PS2015_2259
CRZ: D1345_16310
RSO: RSc0439
RSC: RCFBP_21045
RSL: RPSI07_2931
RSN: RSPO_c02959
RSM: CMR15_30466
RSE: F504_463
RPI: Rpic_0315
RPF: Rpic12D_0330
RMN: TK49_05270
RIN: ACS15_0433
RPU: CDC45_02255
REU: Reut_C6042
CBW: RR42_s2281
BMA: BMA0171
BMV: BMASAVP1_A2776
BML: BMA10229_A2303
BMN: BMA10247_2383
BMAL: DM55_1576
BMAE: DM78_417
BMAQ: DM76_1555
BMAI: DM57_2208
BMAF: DM51_3147
BMAZ: BM44_905
BMAB: BM45_498
BPS: BPSL0623
BPM: BURPS1710b_0827
BPL: BURPS1106A_0668
BPD: BURPS668_0652
BPR: GBP346_A0580
BPSE: BDL_1380
BPSM: BBQ_2803
BPSU: BBN_2926
BPSD: BBX_3327
BPZ: BP1026B_I2902
BPQ: BPC006_I0653
BPK: BBK_861
BPSH: DR55_469
BPSA: BBU_1527
BPSO: X996_76
BUT: X994_2091
BTE: BTH_I0539 BTH_I2358
BTQ: BTQ_1562 BTQ_562
BTJ: BTJ_1923 BTJ_795
BTZ: BTL_2034 BTL_3159
BTD: BTI_3164
BTV: BTHA_2237 BTHA_3442
BTHE: BTN_1553 BTN_2729
BTHM: BTRA_2317 BTRA_37
BTHA: DR62_1740
BTHL: BG87_2 BG87_2259
BOK: DM82_52
BOC: BG90_969
BUU: WS70_14625
BUR: Bcep18194_A6075
BCN: Bcen_2135
BCH: Bcen2424_2747
BCM: Bcenmc03_2773
BCJ: BCAL0859
BCEN: DM39_2836
BCEW: DM40_362
BCEO: I35_2810
BAM: Bamb_2797
BAC: BamMC406_2664
BMU: Bmul_0552
BMJ: BMULJ_02709
BMK: DM80_2170(estE5)
BMUL: NP80_2879 NP80_4819
BCT: GEM_0695
BCED: DM42_2327
BCEP: APZ15_01595
BDL: AK34_343
BPYR: ABD05_03765
BCON: NL30_26820
BDF: WI26_13245
BLAT: WK25_13310
BTEI: WS51_24105
BSEM: WJ12_13740
BPSL: WS57_32480
BMEC: WJ16_14085
BSTG: WT74_14545
BSTL: BBJ41_15040
BGL: bglu_1g30970
BGU: KS03_550
BUG: BC1001_0344
BGF: BC1003_0355
BGD: bgla_1g34550
BGO: BM43_949
BYI: BYI23_A002810 BYI23_C010570
BUO: BRPE64_ACDS02780 BRPE64_CCDS06130
BUE: BRPE67_ACDS02710 BRPE67_CCDS00350
BUL: BW21_3313 BW21_6301
BUQ: AC233_01955
BGP: BGL_1c32620
BPLA: bpln_1g31630
BUD: AQ610_15855 AQ610_19290
BUZ: AYM40_01900 AYM40_26740 AYM40_26745
BUM: AXG89_07800
BUI: AX768_00900
BXE: Bxe_A4064 Bxe_C1047
BXB: DR64_1740 DR64_8754
BPH: Bphy_0360
BGE: BC1002_0355
BPX: BUPH_08107
BPY: Bphyt_0635
BFN: OI25_1075
BCAI: K788_0003961 K788_0005715
PSPW: BJG93_10875
PARA: BTO02_02910 BTO02_22630 BTO02_29695
PARB: CJU94_03090
PHS: C2L64_02020 C2L64_23595 C2L64_26355
PTER: C2L65_01805 C2L65_22025 C2L65_26970
PGP: CUJ91_02100
PCJ: CUJ87_01815
PTS: CUJ90_02030
BRH: RBRH_02118
BPC: BPTD_0142
BPER: BN118_0536
BPET: B1917_0149
BPEU: Q425_2600
BPAR: BN117_4085
BBM: BN115_2009 BN115_4160
BBH: BN112_3938
BBX: BBS798_2974 BBS798_4261
AFA: UZ73_02730
AFQ: AFA_12560
AAQU: D3M96_13140
POL: Bpro_5566
HYR: BSY239_2151
HYB: Q5W_20125
MELA: C6568_17105
AON: DEH84_13270
DSU: Dsui_1821
GEB: GM18_3868
PPD: Ppro_3541
DTO: TOL2_C11080
CCX: COCOR_04675(bah)
AGE: AA314_00828
CFUS: CYFUS_004828 CYFUS_004913
SCL: sce9229
SCU: SCE1572_52130
SAMY: DB32_005108
LLU: AKJ09_02666 AKJ09_07042
MRM: A7982_00310 A7982_12321
PACA: ID47_12025
MLO: mll1869 mlr0240
MLN: A9174_17235
MOP: Mesop_2463 Mesop_3308
MAM: Mesau_03191
MESP: C1M53_07290
MES: Meso_2945
PHT: BLM14_24410
PLA: Plav_0870 Plav_1797
RBS: RHODOSMS8_00446(mlhB) RHODOSMS8_01177(mlhB) RHODOSMS8_02277(mlhB) RHODOSMS8_02360(mlhB) RHODOSMS8_02362(mlhB) RHODOSMS8_02364(mlhB)
ARA: Arad_8697
RET: RHE_CH01714
REC: RHECIAT_CH0001790
REL: REMIM1_CH01751
REP: IE4803_CH01730
REI: IE4771_CH01782
RLE: RL1817
RLT: Rleg2_1370
RLG: Rleg_1475
RLB: RLEG3_17755
RLU: RLEG12_17975
RTR: RTCIAT899_PC03150
RHL: LPU83_pLPU83d0095
RGA: RGR602_PC02341
RHN: AMJ98_CH01754
RPHA: AMC79_CH01762
RHX: AMK02_CH01764
RHK: Kim5_CH01851
REZ: AMJ99_CH01833
RJG: CCGE525_02335 CCGE525_28340
NGL: RG1141_PA10900
BRC: BCCGELA001_11680 BCCGELA001_30945
BIC: LMTR13_16160 LMTR13_36185
BRK: CWS35_14895
VGO: GJW-30_1_03245(mlhB)
XAU: Xaut_4571
SNO: Snov_0624
MEX: Mext_0126 Mext_1328 Mext_4178
MEA: Mex_1p1125 Mex_1p4568
MDI: METDI1973 METDI5177
MCH: Mchl_1529 Mchl_4547
MPO: Mpop_3187 Mpop_4691
MZA: B2G69_02805 B2G69_14110
MRD: Mrad2831_5450
MET: M446_3685
MNO: Mnod_2885 Mnod_8210
MOR: MOC_6028
META: Y590_20855
MAQU: Maq22A_1p30955(aes)
MPHY: MCBMB27_04751
MEE: DA075_06345 DA075_25730
METD: C0214_05695 C0214_22910
METX: A3862_03420
METS: DK389_03765 DK389_13610
METI: DK427_09555
MOC: BB934_24820
MSL: Msil_0233 Msil_0649
MTUN: MTUNDRAET4_1429(bah)
DEQ: XM25_11830
RHZ: RHPLAN_03320 RHPLAN_68090
MSC: BN69_0666 BN69_2292
MBRY: B1812_18180
MROS: EHO51_09335 EHO51_14010
MTW: CQW49_09095
RBM: TEF_13045 TEF_19115
CAK: Caul_5125
CMB: CSW64_20015
SIT: TM1040_0451
RMB: K529_002030
RCP: RCAP_rcc00461(est)
RHP: LPB142_03855
RBL: B6K69_06675 B6K69_17725
OAT: OAN307_c38980
OAR: OA238_c04710
OTM: OSB_05210(mlhB)
LMD: METH_01625
LEJ: ETW24_01925
CID: P73_3829
CEH: CEW89_09910
CMAG: CBW24_00310
MALG: MALG_03045
CON: TQ29_02625 TQ29_18790 TQ29_18930
LABR: CHH27_17765
DAA: AKL17_0614
YAN: AYJ57_05790
YPAC: CEW88_11820
SUAM: BOO69_15965 BOO69_22540
SPSE: SULPSESMR1_00054(mlhB) SULPSESMR1_04141(mlhB)
SULZ: C1J03_20375
SULI: C1J05_11545
SULD: B5M07_02855 B5M07_18400
DON: BSK21_11280
TPRO: Ga0080559_TMP2462 Ga0080559_TMP388
TOM: BWR18_18875
PABY: Ga0080574_TMP1603
THW: BMG03_16410
RMM: ROSMUCSMR3_01282(mlhB)
ROK: RAK1035_0234
LVS: LOKVESSMR4R_03943(mlhB)
AHT: ANTHELSMS3_01617(mlhB)
RBG: BG454_11665
SAGU: CDO87_08480
THAA: CFI11_19185 CFI11_20600
SALO: EF888_03140
PSEB: EOK75_12120
RBZ: B9057_02335
GAK: X907_0626
HBC: AEM38_14050
NTD: EGO55_18125
SPHP: LH20_19455
SMAZ: LH19_13525
SPHQ: BWQ93_19965
SPHD: HY78_29685
SPAN: AWL63_23800
SPMI: K663_18136
SPHB: EP837_03270
SPHT: K426_25054
SFLA: SPHFLASMR4Y_03196(mlhB)
ELQ: Ga0102493_112842
GBE: GbCGDNIH1_2223
GBH: GbCGDNIH2_2223
GBC: GbCGDNIH3_2223
GBS: GbCGDNIH4_2223
ACR: Acry_0629 Acry_1086
AMV: ACMV_08050 ACMV_12400 ACMV_19570
ASZ: ASN_2469 ASN_2476
ATO: CIW82_10145
ABS: AZOBR_60003
ABQ: ABAZ39_18570
PBR: PB2503_06407
PGM: PGRAT_14970
POD: PODO_10710
PAEN: P40081_17585
PAEF: R50345_11090
PAEQ: R50912_16365
PAEJ: H70737_10530
PRI: PRIO_3266
PDH: B9T62_11755
COHN: KCTCHS21_34820
AAC: Aaci_1055
AAD: TC41_1091
LCR: LCRIS_01604
LKO: ABN16_06975
LZY: LZ3411_2128
LALW: BTM29_02005
LALI: LA20249_02405
CACE: CACET_c16930
FPLA: A4U99_07575
BFI: CIY_00430
CCT: CC1_05780
BYL: A4V09_01095
BPRO: PMF13cell1_05279(mlhB)
AWO: Awo_c27960
IBU: IB211_02089
CBAR: PATL70BA_2983 PATL70BA_3190 PATL70BA_3191
SRI: SELR_pSRC100510
SELO: AXE86_08720
MCHI: AN480_04385
MSA: Mycsm_06641
MMC: Mmcs_1513 Mmcs_1535
MKM: Mkms_1536 Mkms_1558
MMM: W7S_11295
MSM: MSMEG_3010
MSG: MSMEI_2935(lipR)
MSB: LJ00_14980
MSN: LI99_14985
MSH: LI98_14990
MGO: AFA91_24835
MVQ: MYVA_1608 MYVA_4965 MYVA_4988
MLL: B1R94_12645
MCHE: BB28_23770
MSTE: MSTE_01521(bah_1) MSTE_03925(bah_2)
NFR: ERS450000_00738(mlhB_1)
NNO: NONO_c26760(bah)
NSL: BOX37_12970
NSR: NS506_05568
NTP: CRH09_04340 CRH09_33145
RHA: RHA1_ro06680
RPY: Y013_12975
RRZ: CS378_11575 CS378_11785
GOR: KTR9_2433 KTR9_3182 KTR9_3184
GTA: BCM27_16255 BCM27_16265
GIT: C6V83_09960 C6V83_09970
DTM: BJL86_0673
DIT: C3V38_01035 C3V38_09175
DIZ: CT688_03090
DPC: A6048_03035
DLU: A6035_03335 A6035_10850
SCO: SCO3415(SCE9.22)
SCB: SCAB_77011
SVL: Strvi_6435 Strvi_8470
SCT: SCAT_p1569
SCY: SCATT_p01550
SBH: SBI_01199
SALU: DC74_221
SALL: SAZ_01570
SLV: SLIV_20695
SVT: SVTN_00775
STRE: GZL_01131 GZL_01558
SCX: AS200_02030
SGS: AVL59_18550 AVL59_21665
SLS: SLINC_0027
SNR: SNOUR_04770 SNOUR_38915
SPUN: BFF78_37270
KAB: B7C62_13340
KAU: B6264_28115
KIT: CFP65_1346
MIO: AOA12_04705
MHOS: CXR34_00665
FRP: AX769_00475 AX769_17090
AGM: DCE93_00225
PSAI: C3B54_111350
ARH: AHiyo8_02530 AHiyo8_02540
ARTP: E5206_14690
RSA: RSal33209_3415
BRX: BH708_14880 BH708_17145
BRV: CFK39_09695 CFK39_11325
BGG: CFK41_15660
BRZ: CFK38_01125
BSAU: DWV08_00605 DWV08_15640
BRR: C1N80_00110 C1N80_01585
DVA: DAD186_19960
LMOI: VV02_08280 VV02_16325
NDK: I601_1612(mlhB_1)
NGV: CDO52_20005
STRR: EKD16_11705(mlhB)
NOA: BKM31_12670 BKM31_25815
AOI: AORI_5780
AMQ: AMETH_2426 AMETH_3877 AMETH_4582
AMYC: CU254_10605
AAB: A4R43_05200 A4R43_22535
PDX: Psed_0489
PSEQ: AD006_28260 AD006_32125
PECQ: AD017_28655
KAL: KALB_5640 KALB_825
KPHY: AOZ06_24390 AOZ06_52000 AOZ06_52010
AHM: TL08_02820
ALO: CRK56647
PMAD: BAY61_09880 BAY61_19415
ACTN: L083_1282
AFS: AFR_22850
CAI: Caci_0700 Caci_2071
SNA: Snas_2426
AVU: BK816_00715
AYM: YM304_23300
RIV: Riv7116_6010
ATM: ANT_01270
CAP: CLDAP_11740
KBS: EPA93_02640
PBOR: BSF38_01313(mlhB)
LAJ: A0128_15180
LKM: EFP84_06965
TPX: Turpa_1186
ABAS: ACPOL_2645 ACPOL_3124
CTM: Cabther_B0566
GAU: GAU_2134
GPH: GEMMAAP_11135
GBA: J421_0799 J421_2156
NKO: Niako_0270 Niako_5847
SGN: SGRA_1209
HSW: Hsw_2878
HYM: N008_15000
HYG: AUC43_12170
HYH: D3Y59_01910
HYJ: FHG12_15260
PACT: CA264_17165
FLM: MY04_0387
FLL: EI427_11170
FPF: DCC35_08145
CHK: D4L85_05155 D4L85_30975 D4L85_31690
MFC: BRM9_1847
MFI: DSM1535_0030
MSUB: BK009_00100
METN: BK008_07895
METT: CIT01_07955
METO: CIT02_04740
MBG: BN140_0379
MEMA: MMAB1_0486(bah)
MBN: Mboo_0641
MFO: Metfor_0574
NFN: NFRAN_0681
 » show all
Taxonomy
Reference
1  [PMID:11157238]
  Authors
van der Vlugt-Bergmans  CJ, van der Werf  MJ.
  Title
Genetic and biochemical characterization of a novel monoterpene epsilon-lactone hydrolase from Rhodococcus erythropolis DCL14.
  Journal
Appl Environ Microbiol 67:733-41 (2001)
DOI:10.1128/AEM.67.2.733-741.2001
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.83
IUBMB Enzyme Nomenclature: 3.1.1.83
ExPASy - ENZYME nomenclature database: 3.1.1.83
BRENDA, the Enzyme Database: 3.1.1.83

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (9)   
   KEGG REACTION (6)   
   KEGG RCLASS (3)   
Gene (11233)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (663)   
   KEGG MGENES (8292)   
   RefGene (2277)   
Protein sequence (906)   
   UniProt (903)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (555)   
   RefSeq(nuc) (3)   
   GenBank (277)   
   EMBL (275)   
All databases (12720)   

Download RDF
DBGET integrated database retrieval system