KEGG   ENZYME: 3.1.1.84
Entry
EC 3.1.1.84                 Enzyme                                 

Name
cocaine esterase;
CocE;
hCE2;
hCE-2;
human carboxylesterase 2
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
cocaine benzoylhydrolase
Reaction(IUBMB)
cocaine + H2O = ecgonine methyl ester + benzoate [RN:R06728]
Reaction(KEGG)
R06728
Substrate
cocaine [CPD:C01416];
H2O [CPD:C00001]
Product
ecgonine methyl ester [CPD:C12448];
benzoate [CPD:C00180]
Comment
Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3].
History
EC 3.1.1.84 created 2010
Pathway
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03927  carboxylesterase 2
K21017  cocaine esterase
Genes
HSA: 8824(CES2)
PTR: 467996 740768(CES2)
PPS: 100975226 100994078(CES2)
GGO: 101128458 109023585 109023694 115931020
PON: 100431215 103892689
NLE: 100599562 100605306
MCC: 695543 697524(CES2)
MCF: 102119346 102120721
CSAB: 103233135 103233136
RRO: 104655660
RBB: 108515424(CES2)
CJC: 100400260(CES2)
SBQ: 101048566(CES2)
MMU: 102022(Ces2a) 234669(Ces2b) 234671(Ces2c) 234673(Ces2e) 436059(Ces2h) 71903(Ces2f) 72361(Ces2g)
RNO: 100365112(Ces2) 100910144(Ces2) 108348093 171118(Ces2c) 192257(Ces2e) 246252(Ces2a) 291952(Ces2g) 498940(Ces2h) 679149 679356 679368 685645(Ces2j) 688542
TUP: 102475270(CES2)
CFA: 489769(CES2)
VVP: 112929395(CES2)
AML: 109488335
UMR: 103673676(CES2)
UAH: 113252340(CES2)
ORO: 101369971(CES2)
ELK: 111153057
FCA: 101096775(CES2)
PTG: 102953134(CES2)
PPAD: 109270797(CES2)
AJU: 106971297(CES2)
BTA: 505928(CES2)
BOM: 102275039(CES2)
BIU: 109572559(CES2)
BBUB: 102392274(CES2)
CHX: 102175705(CES2)
OAS: 101109730(CES2)
CFR: 102510209(CES2)
CDK: 105088467(CES2)
BACU: 103021148(CES2)
LVE: 103072403(CES2)
OOR: 101273896(CES2)
DLE: 111179660(CES2)
PCAD: 102983047(CES2)
ECB: 100065668(CES2)
EPZ: 103542667(CES2)
EAI: 106839477(CES2)
MJV: 108390336
LAV: 100656329(CES2)
TMU: 101342563
MDO: 100144614(CES2.1) 100144616(CES2.3) 100144617(CES2.2)
GGA: 415787
CJO: 107319329
NMEL: 110404137
TGU: 100223441(CES2)
LSR: 110480652(CES2)
SCAN: 103821144(CES2)
GFR: 102044313
PHI: 102111003(CES2)
PMAJ: 107210014(CES2)
CCAE: 111934790
CCW: 104687401
ETL: 114072840
FPG: 101920626
CLV: 102097851
EGZ: 104123641
NNI: 104013261
ACUN: 113484325
AMJ: 102564228 102564454(CES2)
CMY: 102944601
CPIC: 101934951(CES4A)
PVT: 110087110
PMUA: 114601883
GJA: 107110321
XTR: 100144981(ces3.1) 100493652(ces3.5) 100493819 100493994 100494149(ces3.7) 116410405 394897(ces5a) 779633(ces3.4)
DRE: 561967(si:ch211-93f2.1)
SRX: 107751276
SANH: 107675266
SGH: 107589308
IPU: 108275184
PHYP: 113529749
EEE: 113588530
LCO: 104936423
NCC: 104942402
XMA: 102219135
XCO: 114152720
NFU: 107388968
KMR: 108239947
ALIM: 106515621
CSEM: 103380524
POV: 109624467
LCF: 108875311
SDU: 111228462
SLAL: 111655346
ELS: 105018420(ces1)
SFM: 108942053
SKO: 100375895
DME: Dmel_CG3841(CG3841)
DSE: 6611829
DSI: Dsimw501_GD23616(Dsim_GD23616)
DSR: 110177899
DPE: 6589534
DWI: 6643743
DAZ: 108611978
DNV: 108649581
SOC: 105197701
AEC: 105147603
VEM: 105563523
LHU: 105667709
OBO: 105284958
PCF: 106784260
NVI: 100123964
ATD: 109601549
BMOR: 101737611
PMAC: 106708995
HAW: 110380661
TNL: 113492805
PXY: 105385172
DNX: 107169188
AGS: 114125585
RMD: 113555912
CSCU: 111622434
CEL: CELE_F13H6.3(cest-33)
PCAN: 112555799
EPA: 110254598
ADF: 107339511
PDAM: 113664729
SPIS: 111333254
QSU: 111983793
ANI: AN7521.2
ANG: ANI_1_1504104(An12g02340) ANI_1_216174(An10g00780) ANI_1_2170074(An08g08030) ANI_1_3242024(An02g13340) ANI_1_370054(An06g00340) ANI_1_692114(An13g02160) ANI_1_712104(An12g05590) ANI_1_854114(An13g03800)
 » show all
Reference
1  [PMID:18987161]
  Authors
Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG
  Title
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
  Journal
Mol Pharmacol 75:318-23 (2009)
DOI:10.1124/mol.108.049486
Reference
2  [PMID:10698749]
  Authors
Bresler MM, Rosser SJ, Basran A, Bruce NC
  Title
Gene cloning and nucleotide sequencing and properties of a cocaine esterase from  Rhodococcus sp. strain MB1.
  Journal
Appl Environ Microbiol 66:904-8 (2000)
DOI:10.1128/AEM.66.3.904-908.2000
  Sequence
Reference
3  [PMID:1551831]
  Authors
Britt AJ, Bruce NC, Lowe CR
  Title
Identification of a cocaine esterase in a strain of Pseudomonas maltophilia.
  Journal
J Bacteriol 174:2087-94 (1992)
DOI:10.1128/JB.174.7.2087-2094.1992
Reference
4  [PMID:11742345]
  Authors
Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA
  Title
Crystal structure of a bacterial cocaine esterase.
  Journal
Nat Struct Biol 9:17-21 (2002)
DOI:10.1038/nsb742
  Sequence
Reference
5  [PMID:9169443]
  Authors
Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF
  Title
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
  Journal
J Biol Chem 272:14769-75 (1997)
DOI:10.1074/jbc.272.23.14769
  Sequence
[hsa:8824]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.84
IUBMB Enzyme Nomenclature: 3.1.1.84
ExPASy - ENZYME nomenclature database: 3.1.1.84
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.84
BRENDA, the Enzyme Database: 3.1.1.84

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