KEGG   ENZYME: 3.1.1.84
Entry
EC 3.1.1.84                 Enzyme                                 
Name
cocaine esterase;
CocE;
hCE2;
hCE-2;
human carboxylesterase 2
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
cocaine benzoylhydrolase
Reaction(IUBMB)
cocaine + H2O = ecgonine methyl ester + benzoate [RN:R06728]
Reaction(KEGG)
R06728
Substrate
cocaine [CPD:C01416];
H2O [CPD:C00001]
Product
ecgonine methyl ester [CPD:C12448];
benzoate [CPD:C00180]
Comment
Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3].
History
EC 3.1.1.84 created 2010
Pathway
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03927  carboxylesterase 2
K21017  cocaine esterase
Genes
HSA8824(CES2)
PTR129135258 740768(CES2)
PPS100975226 100994078(CES2) 117976260
GGO101128088 101128458 109023694 115931020
PON100431215 103892689
PPYG129015596 129015600
NLE100599562 100605306
HMH116471363
MCC695543 697524(CES2)
MCF102119346 102120721
MTHB126945004 126945006
MNI105491450 105491451
CSAB103233135 103233136
CATY105587408
PANU101004448(CES2)
TGE112617781(CES2)
MLEU105545096 105545097 105545098
RRO104655660
RBB108515424(CES2)
TFN117087920(CES2)
PTEH111540340 113223003 113223004 113223015
CANG105504588 105504634
CJC100400260(CES2)
SBQ101048566(CES2)
CIMI108311718(CES2)
ANAN105728014(CES2) 110567479
CSYR103252046(CES2)
MMUR105858918(CES2)
LCAT123625093 123625242(CES2)
PCOQ105823384(CES2)
OGA100964610
MMU234669(Ces2b) 234671(Ces2c) 234673(Ces2e) 436059(Ces2h) 72361(Ces2g)
MCAL110299650 110299697 110299698 110299699 110299706 110299923 110299978 110300204
MPAH110337265 110337266 110337268 110337289 110337290(Ces2) 110337412 110337821
RNO100910144(Ces2) 171118(Ces2c) 192257(Ces2e) 291952(Ces2g) 498940(Ces2h) 679149(Ces2b) 688542(Ces2el1)
MCOC116067872 116068024 116070020 116070021 116070022 116070024 116070025 116070026
ANU117722901 117722902 117722903 117722904 117722905 117722906 117723501
MUN110540321 110540323 110540326 110540327 110545478 110545492 110546258 110559744 110559745 110559756 132656824
CGE100756666(Ces2) 100759838 100763140 100763617 100764100 100769250 100770025 100770313
MAUA101827999 101836296 101836543 101837070 101839668(Ces2) 101841093 101841813 101842264 101844888 121136303 121136304
PROB127213854 127213866 127213968 127234560 127234561 127234562 127234563 127234564 127234567
PLEU114681071 114681072 114681081 114681082 114681092 114681095 114681101 114689099 114703526 114703533 114703551
MORG121446759 121446817 121446819 121446820 121447005 121447115 121447116 121447118 121447341
MFOT126502454 126502544 126502545 126502547 126502548 126502549 126502550 126502552 126502565 126503061
AAMP119801724 119801725 119801812 119801814 119801816 119801817 119801819 119801820 119801821 119801822 119801825 119802117
NGI103738920 103738931 103744494
HGL101696584 101696949 101725754(Ces2)
CPOC100714126 100724941 100734360
CCAN109674541 109680192 109693959
DORD105982928 105983009 105983010 105983013 105983014
DSP122126068 122126069 122126094 122126095 122126097 122126103 122126105
PLOP125358318 125358319 125358320 125358328 125358329
NCAR124967589 124967590
MMMA107144789 107144792 107144794 107144795 107144796 107151010 107151077 125610346
OCU100343045 100343300 100351488 100352246 100357474 100358248 127486289 127491327
OPI101516012 101516256 101516986 101530689
TUP102475270(CES2)
GVR103591640(CES2)
CFA489769(CES2)
CLUD112646465(CES2)
VVP112929395(CES2)
VLG121500212(CES2)
NPO129497656
AML109488335
UMR103673676(CES2)
UAH113252340(CES2)
UAR123803472(CES2)
ELK111153057
LLV125088777
MPUF101686704(CES2)
NVS122911368(CES2)
ORO101369971(CES2)
EJU114201353
ZCA113936519(CES2)
MLX118023692(CES2)
NSU110592839
LWW102726219(CES2)
FCA101096775(CES2)
PYU121045422(CES2)
PCOO112857583(CES2)
PBG122494353(CES2)
PVIV125152766(CES2)
LRUF124511371
PTG102953134(CES2)
PPAD109270797(CES2)
PUC125916357
AJU106971297
HHV120224125(CES2)
BTA505928(CES2)
BOM102275039(CES2)
BIU109572559(CES2)
BBUB102392274(CES2)
BBIS104996724(CES2)
CHX102175705(CES2)
OAS101109730(CES2)
BTAX128063405(CES2)
ODA120872779(CES2)
CCAD122420541(CES2)
MBEZ129547033(CES2)
CFR102510209(CES2)
CBAI105074805(CES2)
CDK105088467(CES2)
VPC102525530(CES2)
BACU103021148(CES2)
BMUS118884746
LVE103072403(CES2)
OOR101273896(CES2)
DLE111179660(CES2)
PSIU116743945
NASI112391231(CES2)
ECB100065668(CES2)
EPZ103542667(CES2)
EAI106839477(CES2)
RFQ117034766(CES2)
MJV108390336(CES2)
TOD119248923
SARA101550805(CES2)
SETR126027378
LAV100656329(CES2)
TMU101342563
ETF101645089(CES2)
DNM101431108(CES2)
MDO100144614(CES2.1) 100144616(CES2.3)
GAS123234657
SHR100927223 100927475
AFZ127547933 127547934
PCW110210440 110210449 110210450
TVP118840807 118840809 118840810 118840811 118840812 118840813 118840818 118840820 118840821 118840822 118840823 118840826 118842639 118842644
OAA100088459(CES3)
APLA101790993
ACYG106033299
CATA118246396
AFUL116493927
TGU100223441(CES2)
LSR110480652(CES2)
SCAN103821144(CES2)
PMOA120497109
OTC121337233
PRUF121351021(CES2)
GFR102044313
FAB101818606
OMA130257830
PHI102111003(CES2)
PMAJ107210014(CES2)
CCAE111934790
CCW104687401(CES2)
CBRC103617223
ZAB102067159
ZLE135452737
ACHL103799953
SVG106863217
MMEA130587064
HRT120757963
FPG101920626
FCH102058178
CLV102097851
EGZ104123641
NNI104013261
PCRI104025171
EHS104503845
ACUN113484325
TALA104367373
ACHC115345980
HALD104316836
HLE104842639
AGEN126041306
GCL127021351
CCRI104163148
CSTI104561230
CMAC104483039
MUI104535541
BREG104643245
FGA104082589
GSTE104251778
LDI104341620
MNB103768631
OHA104339218
DPUB104300808
ACAR104518591
CPEA104396339
AVIT104271407
CVF104283222
RTD128908594
CUCA104065442
AAM106483256
AROW112962757
NPD112944947
SCAM104143980
ASN102383955 102384208
AMJ102564001(CES5A) 102564228 102564454(CES2)
CPOO109310611 109310612 109310613
GGN109289511(CES2) 109289512
PSS102456231 102456807
CMY102944378 102944601
CCAY125620668
DCC119841351
TST117886569(CES2) 117886753
CABI116838507
MRV120384504 120384835
ACS100551630 100558831 100559168 100562582 100565018
ASAO132766368 132766370 132775213
PVT110087110
SUND121914365(CES2)
PBI103067569
TSR106538661
PGUT117670461
APRI131183986
PTEX113445339
NSS113429225
PMUA114601888
PRAF128420304
ZVI118086955
HCG128327212
GJA107110321
EMC129344079
XLA100381172(ces3.4.L) 108713509 108714105 108714107
XTR100144981(ces3.1) 100493652(ces3.5) 100493819 100493994 100494149(ces3.7) 116410405 394897(ces5a) 779633(ces3.4)
NPR108792172 108801510
RTEM120916837 120916838 120917793 120917802 120917808
BBUF120980150 120981073 120981074 120981075 120981076 120981078
BGAR122920439 122920466 122920938 122921027 122921028 122921029 122922357
DRE561967(si:ch211-93f2.1)
SRX107751276
SANH107675266
SGH107589308 107595238
CAUA113043554 113043556
CGIB128014118 128014156
PTET122330893(ces2b)
LROH127160965
OMC131534960 131534961
PPRM120460416(ces2b)
RKG130086051(ces2b)
MAMB125247453(ces2b)
CIDE127506727
MASI127435562 127437090
TROS130551565(ces2b)
TDW130414410(ces2b)
MANU129433249(ces2b)
IPU108275184(ces2b)
IFU128617669(ces2b)
PHYP113529749
SMEO124392293(ces2b)
TFD113660170(ces2b)
TVC132856800(ces2b)
AMEX103039298(ces2b)
CMAO118811571(ces2b)
EEE113588530
TRU101072925
ELY117262726(ces2b)
EFO125887381(ces2b)
CUD121514881(ces2b)
ALAT119024860(ces2b)
XMA102219135
XCO114152720
XHE116733800
PRET103466351
PFOR103133668
PLAI106940756
PMEI106927557
GAF122835717(ces2b)
PPRL129365043(ces2b)
CVG107103788
CTUL119793101(ces2b)
NFU107388968
KMR108239947(ces2b)
ALIM106515621
NWH119416198(ces2b)
AOCE111562986
PPLT128443864(ces2b)
BPEC110165928
BSPL114856899(ces2b)
SASA106561275
STRU115197354
OTW112218711(ces2b)
OMY110497598(ces2b)
OGO124035236(ces2b)
ONE115134122
OKI109867413
OKE118395789(ces2b)
SALP111962483
SNH120066400(ces2b)
ELS105018420(ces1)
HOC132823858(ces2b)
BFO118428684
BBEL109462698 109483411 109483412
SCLV120335093 120335133 120335134
LPIC129255792
AJC117108038
AFUN125771618 125772418
VCAN122409658
CCRN123292535
ACOO126847405
CQD128689925 128697980
ABRU129976143
CELCELE_F13H6.3(cest-33)
PVUL126824031 126832712
PCAN112573738
BGT106065808
CRG105320590
CVN111108533 111108571 111109028 111109043 111112310 111115698 111120469
CANU128163769 128164761 128165361 128172882 128175757 128184222
OED125666537
MYI110447492
PMAX117341889
MMER123550608
RPHI132718159 132731976 132734300 132743566
MAEA128213277 128213278 128218268 128234160 128234865 128235258 128235753 128236053 128243081 128245353
LJP135462828 135467347 135470902 135471279 135478107
LAK106152594 106152708 106179257 106179598
LLON135482503 135484501 135484856 135490017
RES135695348
TMNUCRPA7_3922
NHENECHADRAFT_14316 NECHADRAFT_34817
FFCNCS54_00004800
FKRNCS57_00001800
PCHMVFPPC_07654
AMUSLMH87_008478
CFJCFIO01_04311
CHIGCH63R_08414
PFYPFICI_06258 PFICI_10972 PFICI_14061
SSLSS1G_10875
BFUBCIN_02g02430 BCIN_04g06190 BCIN_04g06920
ANIANIA_07521
AFMAFUA_3G09230
NFINFIA_067910
AORAO090023000559
ANGAn10g00780 An12g05590
AFVAFLA_006904
ALUCAKAW2_60934A AKAW2_71008A
ACHEACHE_60497S
APUUAPUU_80486S
PCSN7525_005705
POUPOX_c04319
TRGTRUGW13939_02569 TRUGW13939_11744
AALTCC77DRAFT_980293
NPAUCRNP2_4636
PTRCPtA15_7A623
 » show all
Reference
1  [PMID:18987161]
  Authors
Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG
  Title
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
  Journal
Mol Pharmacol 75:318-23 (2009)
DOI:10.1124/mol.108.049486
Reference
2  [PMID:10698749]
  Authors
Bresler MM, Rosser SJ, Basran A, Bruce NC
  Title
Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1.
  Journal
Appl Environ Microbiol 66:904-8 (2000)
DOI:10.1128/AEM.66.3.904-908.2000
  Sequence
Reference
3  [PMID:1551831]
  Authors
Britt AJ, Bruce NC, Lowe CR
  Title
Identification of a cocaine esterase in a strain of Pseudomonas maltophilia.
  Journal
J Bacteriol 174:2087-94 (1992)
DOI:10.1128/JB.174.7.2087-2094.1992
Reference
4  [PMID:11742345]
  Authors
Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA
  Title
Crystal structure of a bacterial cocaine esterase.
  Journal
Nat Struct Biol 9:17-21 (2002)
DOI:10.1038/nsb742
  Sequence
Reference
5  [PMID:9169443]
  Authors
Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF
  Title
Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
  Journal
J Biol Chem 272:14769-75 (1997)
DOI:10.1074/jbc.272.23.14769
  Sequence
[hsa:8824]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.84
IUBMB Enzyme Nomenclature: 3.1.1.84
ExPASy - ENZYME nomenclature database: 3.1.1.84
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.84
BRENDA, the Enzyme Database: 3.1.1.84

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