Entry
Name
protein phosphatase methylesterase-1;
PME-1;
PPME1
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
[phosphatase 2A protein]-leucine ester acylhydrolase
Reaction(IUBMB)
[phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol
Substrate
[phosphatase 2A protein]-leucine methyl ester;
H2O [CPD:
C00001 ]
Product
[phosphatase 2A protein]-leucine;
methanol [CPD:
C00132 ]
Comment
A key regulator of protein phosphatase 2A. The methyl ester is formed by EC
2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus.
History
EC 3.1.1.89 created 2011
Orthology
K13617 protein phosphatase methylesterase 1
Genes
MORG : 121453287 121459119
PCAD : 102979969(PPME1) 102996595
TVP : 118832701 118838713(PPME1)
ACS : 100552369 100556089 103282115
STOW : 125430557 125430778
XLA : 444718 446717(ppme1.S)
SRX : 107715282 107725720 107748094 107752422 107756124
SANH : 107653220 107669378 107694430 107700048
SGH : 107548200 107550164 107564410 107567180
CCAR : 109063994 109063995 109084580 109085971
CAUA : 113038573 113063974 113092301
CGIB : 127942227 127986505
PTET : 122326039(ppme1) 122332718 122349104
LROH : 127153001(ppme1) 127154538
OMC : 131528790(ppme1) 131532247
MAMB : 125252899(ppme1) 125260310
CIDE : 127503453 127504666
CERY : 137009013 137012624(ppme1)
MASI : 127418800 127428473 127431323
IFU : 128619320 128622501(ppme1)
PHYP : 113530683 113541630(ppme1)
SMEO : 124398445(ppme1) 124398933
TFD : 113649679(ppme1) 113655466
TRN : 134330159(ppme1) 134333697
AMEX : 103024383 103026835(ppme1)
CMAO : 118820308(ppme1) 118823061
CHAR : 105890528(ppme1) 105904845
TRU : 101067569(ppme1) 115250484
TFS : 130532437 130537188(ppme1)
TNG : GSTEN00014935G001 GSTEN00022196G001
LCO : 104919713(ppme1) 104932261
NCC : 104945498(ppme1) 104948502
TBEN : 117469821 117469993(ppme1)
CGOB : 115018894(ppme1) 115023548
GACU : 117538455(ppme1) 117549319
EMAC : 134872802(ppme1) 134876194
ELY : 117245917 117262305(ppme1)
EFO : 125884426 125898701(ppme1)
PLEP : 121952427(ppme1) 121962483
SLUC : 116060780 116064821(ppme1)
GAT : 120821725 120821917(ppme1)
PPUG : 119215566(ppme1) 119222974
AFB : 129093825 129113655(ppme1)
CLUM : 117743193(ppme1) 117748095
CANA : 137792678 137803142(ppme1)
CVE : 137874868 137876611(ppme1)
MSAM : 119895834(ppme1) 119913002
SCHU : 122870184 122888678(ppme1)
CUD : 121504913 121518831(ppme1)
ALAT : 119026866 119031971(ppme1)
AOCE : 111579860(ppme1) 111588621
MCEP : 124997626 125021658(ppme1)
POV : 109628404(ppme1) 109645225
SSEN : 122767205 122780116(ppme1)
HHIP : 117752140 117774309(ppme1)
HSP : 118102461 118122433(ppme1)
PPLT : 128430549 128457457(ppme1)
SMAU : 118284696 118301399(ppme1)
SLAL : 111653916(ppme1) 111673201
XGL : 120797275 120802177(ppme1)
HCQ : 109512517(ppme1) 109516492
SSCV : 125981716(ppme1) 125992528
SBIA : 133492084(ppme1) 133494583
PEE : 133398084 133416326(ppme1)
PTAO : 133467587(ppme1) 133472965
BPEC : 110168160(ppme1) 110174692
SJO : 128371250(ppme1) 128383595
SASA : 100195184(ppme1) 106567820(ppme1) 106578192(PPME1)
STRU : 115149036 115154498 115194728
OTW : 112239720 112250212 112257714
OMY : 110531331 110533794 110537327
OGO : 123998845 124017345 124017783
ONE : 115105687 115123458 115135778
OKI : 109872914 109881161 109892621
OKE : 118369214 118390224 118391289
SALP : 111950709 111981645(ppme1) 112074029
SNH : 120040279 120044285 120057157
CCLU : 121554403 121573696 121579965
SFM : 108921181(ppme1) 108938266
PKI : 111842942(ppme1) 111856810
AANG : 118210294(ppme1) 118231550
LOC : 102682357(ppme1) 102686668
ARUT : 117405489 117420664 117972938
PSEX : 120523210(ppme1) 120528541
LCM : 102360160(PPME1) 102362562
DSI : Dsimw501_GD14146(Dsim_GD14146)
PMAC : 106707416 106721777
CFEL : 113363460 113383360
PPOI : 119091171 119093040 119108314
CEL : CELE_B0464.9(B0464.9)
DPOL : 127876767 127876893
CSAT : 104707293 104721375 104737000
MINC : 123202983 123207148 123228960
HSYR : 120118533 120154435 120157565 120180489
VUN : 114173666 114173680 114173702 114174549
MSYL : 126601813 126632321
PALZ : 118059387 118061573
CILL : 122302359 122302361
NTA : 107774961 107789083 107820919 107825366
PSOM : 113283324 113356518
TAES : 123045552 123053392 123189302
MFLO : 136493055 136497088
PVIR : 120641090 120681944
NCOL : 116244931 116262134
SMO : SELMODRAFT_270426 SELMODRAFT_415578
CGR : 2889616(GVI51_J10549)
NDI : NDAI_0C01940(NDAI0C01940)
TPF : TPHA_0E01080(TPHA0E01080)
TBL : TBLA_0A03160(TBLA0A03160)
TDL : TDEL_0E02690(TDEL0E02690)
KAF : KAFR_0D04700(KAFR0D04700)
KNG : KNAG_0B04550(KNAG0B04550)
LBG : 92209652(LODBEIA_P44560)
CAL : CAALFM_C201520WA(PPE1)
YLI : 2906043(YALI2_A00312g)
NTE : NEUTE1DRAFT90214(NEUTE1DRAFT_90214)
SMP : 10809277(SMAC4_00231)
FPOA : FPOAC1_000610(PPE1)
TATV : 25776401(TrAtP1_007748)
PLJ : 28887080(PLICBS_002376)
CDET : 87939780(CDEST_03277)
BFU : BCIN_01g05340(Bcppe1)
AOR : AO090005000808 AO090005000809
PTRR : 6346041(PtrM4_138960)
SPO : 2541371(SPOM_SPBP4H10.17C)
CDEP : 91084305(L203_100089)
KMG : 30164125(I203_103590)
KNE : 92181062(IAR55_003804)
CCAC : CcaHIS019_0100740(PPE1)
ABP : AGABI1DRAFT42433(AGABI1DRAFT_42433)
ABV : AGABI2DRAFT115941(AGABI2DRAFT_115941)
PSTR : Pst134EA_004623 Pst134EA_032539 Pst134EA_032769
TET : TTHERM_000444539 TTHERM_00444540
PTM : GSPATT00010737001 GSPATT00019491001 GSPATT00023421001 GSPATT00026281001
LMAT : 92511845(LSCM1_01733)
LOI : 92358715(LSCM4_02761)
LEIS : 94178544(GH5_03052)
LENR : 94169480(CUR178_02209)
LEIN : 94185966(JIQ42_02246)
PHET : 94288554(JKF63_02452)
SSAO : 94294178(SS50377_20155)
» show all
Taxonomy
Reference
Authors
Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC
Title
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.
Journal
Sequence
Reference
Authors
Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y
Title
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.89
ExPASy - ENZYME nomenclature database: 3.1.1.89