KEGG   ENZYME: 3.1.1.89
Entry
EC 3.1.1.89                 Enzyme                                 
Name
protein phosphatase methylesterase-1;
PME-1;
PPME1
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
[phosphatase 2A protein]-leucine ester acylhydrolase
Reaction(IUBMB)
[phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol
Substrate
[phosphatase 2A protein]-leucine methyl ester;
H2O [CPD:C00001]
Product
[phosphatase 2A protein]-leucine;
methanol [CPD:C00132]
Comment
A key regulator of protein phosphatase 2A. The methyl ester is formed by EC 2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus.
History
EC 3.1.1.89 created 2011
Orthology
K13617  protein phosphatase methylesterase 1
Genes
HSA51400(PPME1)
PTR451419(PPME1)
PPS100976774(PPME1)
GGO101140575(PPME1)
PON100173996(PPME1)
NLE100592354(PPME1)
MCC718858(PPME1)
MCF101865123(PPME1)
CSAB103248028(PPME1)
CATY105578753(PPME1)
PANU101017680(PPME1)
TGE112607186(PPME1)
RRO104665123(PPME1)
RBB108537618(PPME1)
TFN117079781(PPME1)
PTEH111540856(PPME1)
CJC100398273(PPME1)
SBQ101040531(PPME1)
CSYR103274861(PPME1)
MMUR105860292(PPME1)
LCAT123641046(PPME1)
OGA100961355(PPME1)
MMU72590(Ppme1)
MCAL110297214(Ppme1)
MPAH110336561(Ppme1)
RNO361613(Ppme1)
MCOC116102644(Ppme1)
MUN110563565(Ppme1)
CGE100753403(Ppme1)
MAUA101834020(Ppme1)
PLEU114698719(Ppme1)
MORG121453287 121459119
AAMP119802692(Ppme1)
NGI103749826(Ppme1)
HGL101711871(Ppme1)
CPOC100726445(Ppme1)
CCAN109691557(Ppme1)
DORD105984093(Ppme1)
DSP122114241(Ppme1)
NCAR124960410
OCU100358403(PPME1)
OPI101535378(PPME1)
TUP102481322(PPME1)
CFA612812(PPME1)
CLUD112667433(PPME1)
VVP112928655(PPME1)
VLG121476426(PPME1)
AML100472410(PPME1)
UMR103678118(PPME1)
UAH113269305(PPME1)
UAR123804175(PPME1)
ELK111159433
LLV125078177
MPUF101672670(PPME1)
ORO101378001(PPME1)
EJU114218677(PPME1)
ZCA113913886(PPME1)
MLX118004245(PPME1)
FCA101094949(PPME1)
PYU121039269(PPME1)
PBG122483350(PPME1)
PTG102958634(PPME1)
PPAD109267182(PPME1)
AJU106977985(PPME1)
HHV120229639(PPME1)
BTA535390(PPME1)
BOM102280327(PPME1)
BIU109569024(PPME1)
BBUB102394851(PPME1)
CHX102185484(PPME1)
OAS101105849(PPME1)
ODA120876774(PPME1)
CCAD122450368(PPME1)
SSC100624455(PPME1)
CFR102522134(PPME1)
CBAI105083312(PPME1)
CDK105097011(PPME1)
VPC102526269(PPME1)
BACU103012189(PPME1)
LVE103071698(PPME1)
OOR101277369(PPME1)
DLE111184853(PPME1)
PCAD102979969(PPME1)
PSIU116758454(PPME1)
ECB100065317(PPME1)
EPZ103564584(PPME1)
EAI106831685(PPME1)
MYB102243633(PPME1)
MYD102759562(PPME1)
MMYO118664651(PPME1)
MLF102434956(PPME1)
MNA107533676(PPME1)
PKL118712740(PPME1)
HAI109386306(PPME1)
DRO112316107(PPME1)
AJM119051737(PPME1)
PDIC114499548(PPME1)
PHAS123805612(PPME1)
MMF118627993(PPME1)
RFQ117030576(PPME1)
PALE102893967(PPME1)
PGIG120590338(PPME1)
PVP105303634(PPME1)
RAY107519134(PPME1)
MJV108396678 108404775(PPME1)
TOD119255618(PPME1)
SARA101542176(PPME1)
LAV100668583(PPME1)
TMU101357572
DNM101443421(PPME1)
MDO100011602(PPME1)
GAS123240502(PPME1)
SHR100921513(PPME1)
PCW110210589(PPME1)
OAA100087028(PPME1)
GGA419058(PPME1)
PCOC116237159(PPME1)
MGP100550791(PPME1)
CJO107308632(PPME1)
NMEL110392153(PPME1)
APLA101798216(PPME1)
ACYG106042399(PPME1)
AFUL116489758(PPME1)
TGU100228154(PPME1)
LSR110477859(PPME1)
SCAN103818431(PPME1)
PMOA120496518(PPME1)
OTC121333608(PPME1)
PRUF121349693(PPME1)
GFR102038533(PPME1)
FAB101820109(PPME1)
PHI102108695(PPME1)
PMAJ107214792(PPME1)
CCAE111942589(PPME1)
CCW104698111(PPME1)
CBRC103625255(PPME1)
ETL114067492(PPME1)
ZAB102072554(PPME1)
ACHL103797857(PPME1)
FPG101913352(PPME1)
FCH102052338(PPME1)
CLV102092524(PPME1)
EGZ104133053(PPME1)
NNI104022708(PPME1)
PLET104622373(PPME1)
PCRI104036027(PPME1)
ACUN113481017(PPME1)
TALA104365380(PPME1)
PADL103921129(PPME1)
ACHC115353345(PPME1)
HALD104318932(PPME1)
CCRI104166569(PPME1)
EHS104508259(PPME1)
CMAC104479228(PPME1)
FGA104078088(PPME1)
GSTE104253789(PPME1)
MNB103777270(PPME1)
OHA104334947(PPME1)
AAM106495805(PPME1)
AROW112975285(PPME1)
NPD112949177(PPME1)
DNE112989996(PPME1)
ASN102370897(PPME1)
AMJ102569517(PPME1)
CPOO109306901(PPME1)
GGN109300817(PPME1)
PSS102444844(PPME1)
CMY102935651(PPME1)
CPIC101952993(PPME1)
TST117871328(PPME1)
CABI116825270(PPME1)
MRV120403952(PPME1)
ACS100552369 100556089 103282115
PVT110078116(PPME1)
SUND121924953(PPME1)
PBI103065992(PPME1)
PMUR107287044(PPME1)
PGUT117676417(PPME1)
VKO123033559(PPME1)
PMUA114595534(PPME1)
ZVI118085317(PPME1)
STOW125430557 125430778
XLA444718 446717(ppme1.S)
XTR100495664(ppme1)
NPR108803473(PPME1)
RTEM120928880(PPME1)
BBUF120996548(PPME1)
BGAR122935094(PPME1)
DRE335124(ppme1)
SRX107715282 107725720 107748094 107752422 107756124
SANH107653220 107669378 107694430 107700048
SGH107548200 107550164 107564410 107567180
CCAR109063994 109063995 109084580 109085971
CAUA113038573 113063974 113092301
PPRM120494731(ppme1)
MAMB125252899(ppme1) 125260310
IPU108275807 108279251(ppme1)
PHYP113530683 113541630(ppme1)
SMEO124398445(ppme1) 124398933
TFD113649679(ppme1) 113655466
AMEX103024383 103026835(ppme1)
EEE113573230(ppme1)
TRU101067569(ppme1) 115250484
TNGGSTEN00014935G001 GSTEN00022196G001
LCO104919713(ppme1) 104932261
NCC104945498(ppme1) 104948502
CGOB115018894(ppme1) 115023548
ELY117245917 117262305(ppme1)
EFO125884426 125898701(ppme1)
PLEP121952427(ppme1) 121962483
SLUC116060780 116064821(ppme1)
ECRA117955803(ppme1)
ESP116700725(ppme1)
PFLV114566661(ppme1)
GAT120821725 120821917(ppme1)
PPUG119215566(ppme1) 119222974
MSAM119895834(ppme1) 119913002
CUD121504913 121518831(ppme1)
ALAT119026866 119031971(ppme1)
MZE101480187(ppme1)
ONL100702941(ppme1)
OAU116330290(ppme1)
OLA101161182(ppme1)
OML112142838(ppme1)
XMA102227617(ppme1)
XCO114153550(ppme1)
XHE116728774(ppme1)
PRET103475729(ppme1)
PFOR103133977(ppme1)
PLAI106964196(ppme1)
PMEI106919077(ppme1)
GAF122844640(ppme1)
CVG107087867(ppme1)
CTUL119791061(ppme1)
GMU124875862(ppme1)
NFU107386549(ppme1)
KMR108247414(ppme1)
ALIM106516402(ppme1)
NWH119420656(ppme1)
AOCE111579860(ppme1) 111588621
MCEP124997626 125021658(ppme1)
CSEM103395319(ppme1)
POV109628404(ppme1) 109645225
SSEN122767205 122780116(ppme1)
HHIP117752140 117774309(ppme1)
HSP118102461 118122433(ppme1)
LCF108886844 108894034(ppme1)
SDU111234482(ppme1)
SLAL111653916(ppme1) 111673201
XGL120797275 120802177(ppme1)
HCQ109512517(ppme1) 109516492
BPEC110168160(ppme1) 110174692
MALB109959579(ppme1)
BSPL114869559(ppme1)
SASA100195184(ppme1) 106567820(ppme1) 106578192(PPME1)
OTW112239720 112250212 112257714
OMY110531331 110533794 110537327
OGO123998845 124017345 124017783
ONE115105687 115123458 115135778
SALP111950709 111981645(ppme1) 112074029
SNH120040279 120044285 120057157
CCLU121554403 121573696 121579965
ELS105006233(ppme1)
SFM108921181(ppme1) 108938266
PKI111842942(ppme1) 111856810
AANG118210294(ppme1) 118231550
LOC102682357(ppme1) 102686668
PSPA121302910(ppme1)
ARUT117405489 117420664 117972938
LCM102360160(PPME1) 102362562
CMK103177144(ppme1)
RTP109910661(ppme1)
BFO118420347
BBEL109470615
CIN100176026
SCLV120341100
SPU578324
APLC110977215
SKO102804327
DMEDmel_CG5068(CG5068)
DER6544978
DSE6604969
DSIDsimw501_GD14146(Dsim_GD14146)
DYADyak_GE20797
DAN6507004
DSR110190797
DPO4814002
DPE6602985
DMN108153174
DWI6646318
DGR6558817
DMODmoj_GI13827
DAZ108612419
DNV108651954
DHE111599780
DVI6624138
CCAT101451395
BOD106619802
MDE101894178
SCAC106093099
LCQ111685709
LSQ119609121
HIS119649899
AGAAgaP_AGAP008336
ACOZ120957203
AARA120902489
ASTE118509134
AAG5568805
AALB109409264
CQUCpipJ_CPIJ010405
CPII120425914
CNS116342886
BCOO119074975
AME550901
ACER107995258
ALAB122715794
BIM100746942
BBIF117209671
BVK117238950
BVAN117164235
BTER100643963
BPYO122568797
CCAL108625662
OBB114872605
MGEN117224047
NMEA116424712
CGIG122402438
SOC105194297
MPHA105839146
AEC105150051
ACEP105620642
PBAR105426948
VEM105558819
HST105182758
DQU106750147
CFO105251621
FEX115238755
LHU105678140
PGC109852690
OBO105278142
PCF106789039
PFUC122524382
VPS122634310
NVI116415689
CSOL105360424
TPRE106658679
MDL103574367
CGLO123269907
FAS105266303
DAM107036285
AGIF122858135
LHT122508370
CCIN107267338
TCA661489
DPA109537187
SOY115876669
ATD109594701
CSET123313055
AGB108910962
LDC111507997
NVL108558927
APLN108733812
PPYR116165598
OTU111414181
BMOR101735326
BMAN114248299
MSEX115440492
DPLKGM_207686
BANY112053069
PMAC106707416 106721777
PPOT106110126
PXU106122242
PRAP111000426
ZCE119829195
HAW110371390
HZE124640834
TNL113499450
SLIU111348782
OFU114357059
PXY105382621 105394951
API100161823
DNX107168183 107172524
AGS114119451
RMD113550664
BTAB109034209
DCI103510336
CLEC106668518
HHAL106688160
NLU111056833
PHUPhum_PHUM491370
FOC113210715
TPAL117652255
ZNE110832548
CSEC111871170
FCD110858216
DPXDAPPUDRAFT_306900
DMK116920577
PVM113807309 113807310
PJA122263242
HAME121865776
PCLA123772098
PTRU123498763
HAZT108672600
EAF111703748
LSM121118838
PPOI119091171 119093040 119108314
ISCIscW_ISCW017323
DSV119449418
RSAN119382456
RMP119177913
VDE111251858
VJA111272218
TUT107363315
DPTE113797420
DFR124498231
CSCU111630623
PTEP107453469
SDM118188729
CELCELE_B0464.9(B0464.9)
CBRCBG_10085
BMYBM_BM1819(Bm1819)
LOALOAG_06335
NAINECAME_14253
TSPTsp_01169
HROHELRODRAFT_75640
LGILOTGIDRAFT_234330
PCAN112558792
BGT106074324
GAE121375755
HRF124124995
CRG105318323
MYI110449521
PMAX117328966
MMER123557063
OBI106874864
OSN115217447 115228652
LAK106150520
SMMSmp_211030
OVIT265_13620
EGLEGR_06738
NVE5513605
EPA110245071
ATEN116292593
ADF107349478
AMIL114968718
PDAM113675117
SPIS111338691
DGT114528169
XEN124446073
HMG100205631
TADTRIADDRAFT_24785
AQU100640410
ATHAT4G10050
ALY9308557
CRB17881128
CSAT104707293 104721375 104737000
EUSEUTSA_v10028776mg
BRP103858551
BNA106423448 106436446
BOE106331585
RSZ108846001 108847807
THJ104815846
CPAP110818748
CIT102618805
CICCICLE_v10020855mg
PVY116106548 116106560
MINC123202983 123207148 123228960
TCC18592887
GRA105769978
GHI107914023 107957633
GAB108453108
DZI111287206
EGR104449824
GMX100797966 100800704
GSJ114373423 114405933
PVUPHAVU_002G036200g
VRA106778089
VAR108320903
VUN114173666 114173680 114173702 114174549
CCAJ109810865
APRC113868592
MTRMTR_5g008450
CAM101492485
LJALj2g3v2124220.1(Lj2g3v2124220.1)
ADU107488370
AIP107643156
AHF112749765 112801376
LANG109331752
FVE101309637
RCN112176497
PPER18792262
PMUM103319362
PAVI110755985
PDUL117629351
MDM103441794 114821520
PXB103928189
ZJU107421438
MNT21408200
CSV101204951
CMO103498681
BHJ120080244
MCHA111012093
CMAX111472065
CMOS111432673
CPEP111796923
RCU8277186
JCU105638066
HBR110673390
MESC110607137
POP18104347 7455254
PEU105112257 105133825
PALZ118059387 118061573
JRE109001417
QSU111994848 112013347
QLO115958951
TWL119990422 120011063
VVI100248151
VRI117906672
SLY101265196
SPEN107003053
SOT102584754
SSTN125866208
CANN107847559
NTA107774961 107789083 107820919 107825366
NSY104210163 104212138
NTO104111701
NAU109221913 109244101
INI109148528
ITR116015372
SIND105175018
OEU111402022
EGT105974462
SSPL121806568
HAN110904512
ECAD122596157
LSV111886257
CCAV112523064
DCR108223539
CSIN114266892
BVG104898059
SOE110780072 110802751
CQI110682781 110696511
NNU104589189
MING122069238
TSS122667604
PSOM113283324 113356518
NCOL116244931 116262134
OSA4335946
DOSAOs04t0443500-01(Os04g0443500)
OBR102706468
BDI100829971
ATS109737664 109756603
TDC119355240 119364371
TAES123045552 123053392 123189302
TUA125538391
SBI110436356
SITA101754005
SVS117864022
PVIR120641090 120681944
PHAI112901264
PDA103704776 103711084
EGU105051665
MUS103979411
PEQ110027568
AOF109824366
ATR18427713
SMOSELMODRAFT_270426 SELMODRAFT_415578
PPP112283126
CRECHLRE_12g521250v5
VCNVOLCADRAFT_77814
MNGMNEG_7024
CSLCOCSUDRAFT_19971
CVRCHLNCDRAFT_9699
APROF751_1201
OLUOSTLU_4675
OTAOT_ostta02g05470
BPGBathy15g00030
MISMICPUN_108996
MPPMICPUCDRAFT_21810
CMECYME_CMP230C
GSLGasu_38280
CCPCHC_T00003680001
SCEYHR075C(PPE1)
SEUBDI49_2480
SPAOSPAR_H01170
AGOAGOS_AGR359C
ERCEcym_8174
KLAKLLA0_D13046g
KMXKLMA_50348(PPE1)
LTHKLTH0H15026g
VPOKpol_1030p46
ZROZYRO0D10692g
CGRCAGL0J10736g
NDINDAI_0C01940(NDAI0C01940)
TPFTPHA_0E01080(TPHA0E01080)
TBLTBLA_0A03160(TBLA0A03160)
TDLTDEL_0E02690(TDEL0E02690)
TGBHG536_0E02820
KAFKAFR_0D04700(KAFR0D04700)
KNGKNAG_0B04550(KNAG0B04550)
ZMKHG535_0C03380
PPAPAS_chr4_0232
DHADEHA2A01562g
PICPICST_42666
PGUPGUG_04937
SPAASPAPADRAFT_135961
LELLELG_01130
CALCAALFM_C201520WA(PPE1)
CTPCTRG_01243
COTCORT_0A13450
CDUCD36_16370(PPE1)
CTENCANTEDRAFT_133257
YLIYALI0A20086g
CLUCLUG_03272
CLUSA9F13_01g09196
CAURCJI97_003937
SLBAWJ20_2892(PPE1)
PKZC5L36_0E03750
BNNFOA43_000710
BBRXBRETT_001127
OPAHPODL_04041
SLUDSCDLUD_004566
NCRNCU00954
NTENEUTE1DRAFT90214(NEUTE1DRAFT_90214)
SMPSMAC_00231
PANPODANSg10009
TTTTHITE_72992
MTMMYCTH_2294923
CTHRCTHT_0053880
MGRMGG_15748
PPEIPpBr36_01163
TMNUCRPA7_7650
SSCKSPSK_03334
FGRFGSG_00587
FPUFPSE_04617
FVRFVEG_01051
FOXFOXG_00463
NHENECHADRAFT_74817
TRETRIREDRAFT_104400
TRRM419DRAFT_33332
MAWMAC_03049
MAJMAA_11223
CMTCCM_09540
PLJVFPFJ_04951
VALVDBG_04449
VDAVDAG_08768
CFJCFIO01_13469
CHIGCH63R_01043
SAPOSAPIO_CDS8957
ELAUCREL1_2286
PFYPFICI_01206
SSLSS1G_04430
BFUBCIN_01g05340(Bcppe1)
MBEMBM_01393
PSCOLY89DRAFT_604283
GLZGLAREA_00375
ANIAN0293.2
AFMAFUA_1G03080
ACTACLA_031580
NFINFIA_021530
AORAO090005000808 AO090005000809
ANGANI_1_2536014(An01g05310)
APUUAPUU_11822S(PPE1)
PCSPc22g25290
PDPPDIP_83480
TMFPMAA_051390
CIMCIMG_04766
CPWCPC735_070690
UREUREG_06751
PBLPAAG_05641
PBNPADG_07752
ABEARB_04505
TVETRV_03650
AJEHCAG_04749
BGHBDBG_04488
PNOSNOG_04640
PTEPTT_07281
BZECOCCADRAFT_2277
BSCCOCSADRAFT_82308
BORCOCMIDRAFT_33793
AALTCC77DRAFT_1019541
ZTRMYCGRDRAFT_109512
PFJMYCFIDRAFT_190198
BCOMBAUCODRAFT_110514
NPAUCRNP2_4221
TMLGSTUM_00008745001
SPOSPBP4H10.17c
CNECNI02890
CNBCNBH2760
CNGCNAG_04152
CGICGB_H5360C
TMSTREMEDRAFT_28267
TASAA1Q1_06744
PPLPOSPLDRAFT_90069
TVSTRAVEDRAFT_126181
DSQDICSQDRAFT_89681
PCOPHACADRAFT_251781
SHSSTEHIDRAFT_127806
HIRHETIRDRAFT_127293
PSQPUNSTDRAFT_128531
ADLAURDEDRAFT_84998
FMEFOMMEDRAFT_75727
GTRGLOTRDRAFT_43878
LBCLACBIDRAFT_252813
CCICC1G_06233
ABPAGABI1DRAFT42433(AGABI1DRAFT_42433)
ABVAGABI2DRAFT115941(AGABI2DRAFT_115941)
PCUBJR316_0006366
MRRMoror_2413
MOREE1B28_013629
CPUTCONPUDRAFT_139918
SLASERLADRAFT_370151
WSEWALSEDRAFT_48598
WICJ056_000997
UMAUMAG_10944
PFPPFL1_00347
MGLMGL_3324
MRTMRET_2368
MSYMMSY001_3132
PGRPGTG_16653
MLRMELLADRAFT_40609
MBRMONBRDRAFT_35614
SREPTSG_03017
DDIDDB_G0281651(ppme1)
DPPDICPUDRAFT_90599
DFADFA_02740(ppme1)
ACANACA1_270620
BEQBEWA_019680
BMICBmR1_04g09770
TGOTGME49_262140
TETTTHERM_000444539 TTHERM_00444540
PTMGSPATT00010737001 GSPATT00019491001 GSPATT00023421001 GSPATT00026281001
SMINv1.2.031501.t1(symbB.v1.2.031501.t1)
NGDNGA_2114820
PIFPITG_21316
SPARSPRG_10013
GTTGUITHDRAFT_115212
TBRTb11.01.5750
TBGTbgDal_XI15820
TCR511727.100
LMALMJF_32_0910
LIFLINJ_32_0960
LDOLDBPK_320960
LMILMXM_31_0910
LBZLBRM_32_1000
LPANLPMP_320970
NGRNAEGRDRAFT_71456
TVATVAG_466760
 » show all
Reference
1  [PMID:10318862]
  Authors
Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC
  Title
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.
  Journal
J Biol Chem 274:14382-91 (1999)
DOI:10.1074/jbc.274.20.14382
  Sequence
[hsa:51400] [mmu:72590]
Reference
2  [PMID:18394995]
  Authors
Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y
  Title
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
  Journal
Cell 133:154-63 (2008)
DOI:10.1016/j.cell.2008.02.041
  Sequence
[hsa:51400]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.89
IUBMB Enzyme Nomenclature: 3.1.1.89
ExPASy - ENZYME nomenclature database: 3.1.1.89
BRENDA, the Enzyme Database: 3.1.1.89

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