KEGG   ENZYME: 3.1.1.93
Entry
EC 3.1.1.93                 Enzyme                                 
Name
mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
mycophenolic acid O-acyl-glucuronide-ester hydrolase
Reaction(IUBMB)
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:R10134]
Reaction(KEGG)
R10134
Substrate
mycophenolic acid O-acyl-glucuronide [CPD:C20383];
H2O [CPD:C00001]
Product
mycophenolate [CPD:C20380];
D-glucuronate [CPD:C00191]
Comment
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
History
EC 3.1.1.93 created 2012
Orthology
K13702  abhydrolase domain-containing protein 10
Genes
HSA55347(ABHD10)
PTR743016(ABHD10)
PPS100969335(ABHD10)
GGO101142961(ABHD10)
PON100171612(ABHD10)
PPYG129032816(ABHD10)
NLE100581462(ABHD10)
HMH116466960(ABHD10)
MCC707464(ABHD10)
MCF102118678(ABHD10)
MTHB126947809
MNI105470414(ABHD10)
CSAB103228334(ABHD10)
CATY105596256(ABHD10)
PANU101025562(ABHD10)
TGE112619556(ABHD10)
MLEU105531743(ABHD10)
RRO104660639(ABHD10)
RBB108539224(ABHD10)
TFN117083542(ABHD10)
PTEH111543108(ABHD10)
CANG105505077(ABHD10)
CJC100393480(ABHD10)
SBQ101051108(ABHD10)
CIMI108317393(ABHD10)
ANAN105723080(ABHD10)
CSYR103269003(ABHD10)
MMUR105883899(ABHD10)
LCAT123630552(ABHD10)
PCOQ105816743(ABHD10)
OGA100963866(ABHD10)
MMU213012(Abhd10)
MCAL110311667(Abhd10)
MPAH110329711(Abhd10)
RNO303953(Abhd10)
MCOC116085959(Abhd10)
ANU117718123(Abhd10)
MUN110566241(Abhd10)
CGE100770127(Abhd10)
MAUA101842357(Abhd10)
PROB127227218(Abhd10)
PLEU114694953(Abhd10)
MORG121461853(Abhd10)
MFOT126505692
AAMP119825710(Abhd10)
NGI103745090(Abhd10)
HGL101701879(Abhd10)
CPOC100733320(Abhd10)
CCAN109681464(Abhd10)
DORD105994887(Abhd10)
DSP122105677(Abhd10) 122124238
PLOP125351672(Abhd10)
NCAR124992877
MMMA107136327(Abhd10)
OCU100350766
OPI101525217(ABHD10)
TUP102474419(ABHD10)
GVR103607634(ABHD10)
CFA478561(ABHD10)
CLUD112678547(ABHD10)
VVP112913422(ABHD10)
VLG121474210(ABHD10)
NPO129503887(ABHD10)
AML100476551(ABHD10)
UMR103677324(ABHD10)
UAH113251195(ABHD10)
UAR123784077(ABHD10)
ELK111152069
LLV125097091
MPUF101686491(ABHD10)
MNP132010202(ABHD10)
MLK131825147(ABHD10)
NVS122908497(ABHD10)
ORO101366526(ABHD10)
EJU114214838(ABHD10)
ZCA113918474(ABHD10)
MLX118007115(ABHD10)
NSU110582469(ABHD10)
LWW102740506(ABHD10)
FCA101086743(ABHD10) 101091343
PYU121015670 121036222(ABHD10)
PCOO112850375(ABHD10)
PBG122491428(ABHD10)
PVIV125175570(ABHD10)
LRUF124501565 124526923
PTG102971108(ABHD10)
PPAD109266375(ABHD10)
PUC125920946 125935644
AJU106972278 106975249
HHV120244057(ABHD10)
BTA515563(ABHD10)
BOM102265166(ABHD10)
BIU109572046(ABHD10)
BBUB102400696(ABHD10)
BBIS104997812(ABHD10)
OAS121815999(ABHD10)
BTAX128051281(ABHD10)
CCAD122428857(ABHD10)
MBEZ129553003(ABHD10)
SSC100623142(ABHD10)
CFR102510750(ABHD10)
CBAI105081551(ABHD10)
CDK105093220(ABHD10)
VPC102535218(ABHD10)
BACU103017939(ABHD10)
BMUS118894859(ABHD10)
LVE103082279(ABHD10)
OOR101275519(ABHD10) 101289740
DLE111187458(ABHD10)
PCAD102983066 102994110(ABHD10)
PSIU116753570(ABHD10)
NASI112393239(ABHD10)
ECB100071551(ABHD10)
EPZ103557805(ABHD10)
EAI106844707(ABHD10)
MYB102262816(ABHD10)
MMYO118676233(ABHD10)
MLF106694329(ABHD10)
PKL118723377(ABHD10)
EFUS103290780(ABHD10)
MNA107527433(ABHD10)
DRO112320647(ABHD10)
SHON118993151(ABHD10)
AJM119048640(ABHD10)
PDIC114490537(ABHD10)
PHAS123826724(ABHD10)
MMF118617218(ABHD10)
PPAM129073680(ABHD10)
RFQ117014274(ABHD10)
PALE102894447(ABHD10)
PGIG120598186(ABHD10)
PVP105305948(ABHD10)
RAY107513727(ABHD10)
MJV108394132(ABHD10)
TOD119257533(ABHD10)
SARA101548117(ABHD10)
LAV100668546(ABHD10)
TMU101352962
ETF101654506(ABHD10)
DNM101421889(ABHD10)
MDO100011506(ABHD10)
GAS123239506(ABHD10)
SHR100931213(ABHD10)
AFZ127554048
PCW110222243(ABHD10)
TVP118839683(ABHD10)
OAA100092679(ABHD10)
GGA418419(ABHD10)
PCOC116226921(ABHD10)
MGP100549655(ABHD10)
CJO107321403(ABHD10)
TPAI128092201(ABHD10)
LMUT125696238(ABHD10)
NMEL110400848(ABHD10)
APLA101796199(ABHD10)
ACYG106039267(ABHD10) 125180116
CATA118245021(ABHD10)
AFUL116493047(ABHD10)
TGU100222969(ABHD10)
LSR110473108(ABHD10)
SCAN103820735(ABHD10)
PMOA120506452(ABHD10)
OTC121339228(ABHD10)
PRUF121351627(ABHD10)
GFR102044285(ABHD10)
FAB101808891(ABHD10)
OMA130259606(ABHD10)
PHI102107053(ABHD10)
PMAJ107203157(ABHD10)
CCAE111943382(ABHD10)
CCW104686992(ABHD10)
CBRC103613984(ABHD10)
ETL114066511(ABHD10)
ZAB102073375(ABHD10)
ZLE135453524(ABHD10)
ACHL103803291(ABHD10)
SVG106856614(ABHD10)
MMEA130576872(ABHD10)
HRT120749285(ABHD10)
FPG101915956(ABHD10)
FCH102056155(ABHD10)
CLV102096483(ABHD10)
EGZ104131646(ABHD10)
NNI104014174(ABHD10)
PCRI104028777(ABHD10)
PLET104625471(ABHD10)
EHS104508509(ABHD10)
PCAO104053839(ABHD10)
ACUN113485698(ABHD10)
TALA104357912(ABHD10)
PADL103916828(ABHD10)
AFOR103895093(ABHD10)
ACHC115343878(ABHD10)
HALD104314899(ABHD10)
HLE104831837(ABHD10)
AGEN126048838
GCL127029392
CCRI104157917(ABHD10)
CSTI104549405(ABHD10)
CMAC104473366(ABHD10)
MUI104545084(ABHD10)
BREG104629749(ABHD10)
FGA104077615(ABHD10)
GSTE104263766(ABHD10)
LDI104340155(ABHD10)
MNB103781193(ABHD10)
OHA104335506(ABHD10)
NNT104402050(ABHD10)
SHAB115601552(ABHD10)
PGUU104457952(ABHD10)
ACAR104517907(ABHD10)
CPEA104385013(ABHD10)
AVIT104267505(ABHD10)
CVF104289537(ABHD10)
RTD128915270(ABHD10)
CUCA104056004(ABHD10)
TEO104384718(ABHD10)
BRHI104488078(ABHD10)
AAM106490709(ABHD10)
AROW112962305(ABHD10)
NPD112949291(ABHD10)
TGT104572620(ABHD10)
DNE112996796(ABHD10)
SCAM104144210(ABHD10)
ASN102385542(ABHD10)
AMJ106737278(ABHD10)
CPOO109305601(ABHD10)
GGN109303542(ABHD10)
PSS102458815(ABHD10)
CMY102945397(ABHD10)
CCAY125625379 125645242(ABHD10)
DCC119845909(ABHD10) 119846694
CPIC101934365(ABHD10)
TST117876338(ABHD10)
CABI116825372(ABHD10)
MRV120374287(ABHD10)
ACS100568102(abhd10)
ASAO132771991(ABHD10)
PVT110088006(ABHD10)
SUND121917195 121917241
PMUR107292381(ABHD10)
CTIG120317430(ABHD10)
TSR106554265(ABHD10)
APRI131200068(ABHD10)
PTEX113436374
NSS113409792
VKO123029448(ABHD10)
PMUA114595916
PRAF128402322 128412851(ABHD10)
ZVI118085555(TAGLN3)
HCG128351285(ABHD10)
GJA107105909(ABHD10)
STOW125431668(ABHD10)
EMC129325863(ABHD10)
XLA108708114(abhd10.L)
XTR100135182(abhd10)
NPR108787367(ABHD10)
RTEM120927295(ABHD10)
BBUF120995192(ABHD10)
BGAR122932823(ABHD10)
MUO115470721(ABHD10)
GSH117360149(ABHD10)
DRE492622(abhd10b) 568517(abhd10a)
SRX107705222 107716420 107719764 107752263
SANH107654210 107662095 107701684 107702908
SGH107560335 107591218
CCAR109083194
CAUA113066252 113094237(abhd10)
CGIB127946364 127958882 128013102
PTET122325199(abhd10a) 122329649(abhd10b)
LROH127155852(abhd10b) 127165953(abhd10a)
OMC131532927(abhd10b) 131541554(abhd10a)
PPRM120472369(abhd10a) 120476088(abhd10b)
RKG130082529(abhd10a) 130083892(abhd10b)
MAMB125258509(abhd10b) 125267789(abhd10a)
CIDE127505858 127512985
MASI127426322 127432087 127437266
TROS130547197(abhd10b) 130570531(abhd10a)
TDW130413696(abhd10b) 130420184(abhd10a)
MANU129426437(abhd10b) 129441085(abhd10a)
IPU108256739(abhd10b) 108260175(abhd10a)
IFU128599979(abhd10b) 128603478(abhd10a)
PHYP113531013 113541236
SMEO124379080(abhd10a) 124403690(abhd10b)
TFD113650886(abhd10a) 113658054(abhd10b)
TVC132840115(abhd10b) 132840796(abhd10a)
TRN134301101(abhd10b)
AMEX103023636(abhd10a) 103029082(abhd10b)
CMAO118799016(abhd10b) 118814824(abhd10a)
EEE113573885 113587534
CHAR105890224(abhd10b) 105904395(abhd10a)
TRU101064185(abhd10)
TFS130513738(abhd10b)
TNGGSTEN00023858G001
LCO104924970(abhd10)
NCC104963504(abhd10)
TBEN117497398(abhd10b)
CGOB115025601(abhd10)
PGEO117465827(abhd10b)
GACU117554992(abhd10b)
EMAC134883739(abhd10b)
ELY117264784(abhd10b)
EFO125881844(abhd10b)
PLEP121960688(abhd10b)
SLUC116037886(abhd10b)
ECRA117938181(abhd10b)
ESP116672574(abhd10)
PFLV114549385(abhd10)
GAT120811539(abhd10b)
PPUG119198369(abhd10b)
AFB129110637(abhd10b)
CLUM117749343(abhd10b)
PSWI130206070(abhd10b)
MSAM119909648(abhd10b)
SCHU122866267(abhd10b)
CUD121527098(abhd10b)
ALAT119009020(abhd10b)
MZE101477718(abhd10)
ONL100695557(abhd10)
OAU116319768(abhd10b)
OLA101158731(abhd10)
OML112151528(abhd10b)
CSAI133423548(abhd10b)
XMA102231232(abhd10)
XCO114137112(abhd10)
XHE116711700(abhd10)
PRET103456613(abhd10)
PFOR103139725(abhd10)
PLAI106963487(abhd10)
PMEI106903340(abhd10)
GAF122824625(abhd10b)
PPRL129364941(abhd10b)
CVG107090797(abhd10)
CTUL119788906(abhd10b)
GMU124858114(abhd10b)
NFU107382881(abhd10)
KMR108230485(abhd10b)
ALIM106513444(abhd10)
NWH119426245(abhd10b)
AOCE111572464(abhd10)
MCEP125024374(abhd10b)
CSEM103377136(abhd10)
POV109629676(abhd10)
SSEN122783657(abhd10b)
HHIP117753990(abhd10b)
HSP118098422(abhd10b)
PPLT128425667(abhd10b)
SMAU118291292(abhd10b)
LCF108881776(abhd10b)
SDU111220964(abhd10)
SLAL111662834(abhd10)
XGL120790099(abhd10b)
HCQ109530957(abhd10)
SSCV125986281
SBIA133492940(abhd10b)
PEE133396690(abhd10b)
PTAO133470054(abhd10b)
BPEC110160917(abhd10)
MALB109960112(abhd10)
BSPL114853587(abhd10b)
SJO128382402(abhd10b)
SASA106563603 106579539(abhd10) 106603051(ABHDA)
STRU115151017 115154800 115195498 115204406
OTW112215392 112227697 112228918 112231211
OMY110489656 110510083(abhd10a) 110534098 110535334(abhd10b)
OGO123991321(abhd10b) 124006516 124007108 124039131
ONE115104939 115116492 115119170 115135531
OKI109873043 109874266 109899243 109909870
OKE118370120 118374202(abhd10b) 118385028 118390468
SALP111950765 111964314 111972821 112068193
SNH120021392 120027852(abhd10b) 120050339 120056629(abhd10a)
CCLU121541249 121549848(abhd10b) 121569247 121579573
ELS105010867(abhd10)
SFM108939604(abhd10)
PKI111840272(abhd10)
AANG118225150 118235068(abhd10a)
LOC102686052(abhd10)
PSPA121302785(abhd10b)
ARUT117406831 117968348
PSEX120523853(abhd10b)
LCM102363885 102365255(ABHD10)
CMK103178632 103187693
RTP109932921
CPLA122540637 122550451
HOC132816637 132829600
LERI129698329 129712298
PMRN116955905(ABHD10)
LRJ133358526(ABHD10)
BFO118431657
BBEL109477506
LPIC129266396
IEL124161989 124162330
PCHN125046926
CQD128691703 128697180
ESN127010382 127010383
MNZ135214432 135222008
LSM121114146 121114736
TCF131892958
PPOI119103717
PMEO129583308
LJP135472658
LAK106155863
NVE5516562
EPA110250931
ATEN116303550
ADF107330292 107355576
AMIL114954652
PDAM113678819
SPIS111334387
HSY130644795
RES135685104
 » show all
Reference
1  [PMID:22294686]
  Authors
Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
  Title
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
  Journal
J Biol Chem 287:9240-9 (2012)
DOI:10.1074/jbc.M111.271288
  Sequence
[hsa:55347]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.93
IUBMB Enzyme Nomenclature: 3.1.1.93
ExPASy - ENZYME nomenclature database: 3.1.1.93
BRENDA, the Enzyme Database: 3.1.1.93

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