KEGG ENZYME: 3.1.1.93

ENZYME: 3.1.1.93

Entry

EC 3.1.1.93 Enzyme

Name

mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

mycophenolic acid O-acyl-glucuronide-ester hydrolase

Reaction(IUBMB)

mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:R10134]

Reaction(KEGG)

R10134

Substrate

mycophenolic acid O-acyl-glucuronide [CPD:C20383];
H2O [CPD:C00001]

Product

mycophenolate [CPD:C20380];
D-glucuronate [CPD:C00191]

Comment

This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.

History

EC 3.1.1.93 created 2012

Orthology

K13702

abhydrolase domain-containing protein 10

Genes

HSA:	55347(ABHD10)

PTR:	743016(ABHD10)

PPS:	100969335(ABHD10)

GGO:	101142961(ABHD10)

PON:	100171612(ABHD10)

NLE:	100581462(ABHD10)

MCC:	707464(ABHD10)

MCF:	102118678(ABHD10)

CSAB:

103228334(ABHD10)

RRO:	104660639(ABHD10)

RBB:	108539224(ABHD10)

CJC:	100393480(ABHD10)

SBQ:	101051108(ABHD10)

MMU:	213012(Abhd10)

MCAL:

110311667(Abhd10)

MPAH:

110329711(Abhd10)

RNO:	103693563 303953(Abhd10)

MUN:	110566241(Abhd10)

CGE:	100770127(Abhd10)

NGI:	103745090(Abhd10)

HGL:	101701879(Abhd10)

CCAN:

109681464(Abhd10)

OCU:	100350766(ABHD10)

TUP:	102474419(ABHD10)

CFA:	478561(ABHD10)

VVP:	112913422(ABHD10)

AML:	100476551(ABHD10)

UMR:	103677324(ABHD10)

UAH:	113251195(ABHD10)

ORO:	101366526(ABHD10)

ELK:

111152069

FCA:	101086743(ABHD10)

PTG:	102971108(ABHD10)

PPAD:

109266375(ABHD10)

AJU:	106972278(ABHD10)

BTA:	515563(ABHD10)

BOM:	102265166(ABHD10)

BIU:	109572046(ABHD10)

BBUB:

102400696(ABHD10)

OAS:

101119354

SSC:	100623142(ABHD10)

CFR:	102510750(ABHD10)

CDK:	105093220(ABHD10)

BACU:

103017939(ABHD10)

LVE:	103082279(ABHD10)

OOR:	101275519(ABHD10)

DLE:	111187458(ABHD10)

PCAD:

102994110(ABHD10)

ECB:	100071551(ABHD10)

EPZ:	103557805(ABHD10)

EAI:	106844707(ABHD10)

MYB:	102262816(ABHD10)

MNA:	107527433(ABHD10)

DRO:	112320647(ABHD10)

PALE:

102894447(ABHD10)

RAY:	107513727(ABHD10)

MJV:	108394132(ABHD10)

LAV:	100668546(ABHD10)

TMU:

101352962

MDO:	100011506(ABHD10)

SHR:	100931213(ABHD10)

PCW:	110222243(ABHD10)

OAA:	100092679(ABHD10)

GGA:	418419(ABHD10)

MGP:	100549655(ABHD10)

CJO:	107321403(ABHD10)

NMEL:

110400848(ABHD10)

APLA:

101796199(ABHD10)

ACYG:

106039267(ABHD10)

TGU:	100222969(ABHD10)

LSR:	110473108(ABHD10)

SCAN:

103820735(ABHD10)

GFR:	102044285(ABHD10)

FAB:	101808891(ABHD10)

PHI:	102107053(ABHD10)

PMAJ:

107203157(ABHD10)

CCAE:

111943382(ABHD10)

CCW:	104686992(ABHD10)

ETL:	114066511(ABHD10)

FPG:	101915956(ABHD10)

FCH:	102056155(ABHD10)

CLV:	102096483(ABHD10)

EGZ:	104131646(ABHD10)

NNI:	104014174(ABHD10)

ACUN:

113485698(ABHD10)

PADL:

103916828(ABHD10)

AAM:	106490709(ABHD10)

ASN:	102385542(ABHD10)

AMJ:	106737278(ABHD10)

PSS:	102458815(ABHD10)

CMY:	102929983 102945397(ABHD10)

CPIC:

101934365(ABHD10) 103305912

ACS:	100568102(abhd10)

PVT:	110079017 110088006(ABHD10)

PMUR:

107292381(ABHD10)

TSR:	106554265(ABHD10)

PMUA:

114585574 114595916

GJA:	107105909(ABHD10)

XLA:	108708114(abhd10.L)

XTR:	100135182(abhd10)

NPR:	108787367(ABHD10)

DRE:	492622(abhd10b) 568517(abhd10a)

SRX:	107705222 107716420 107719764 107752263

SANH:

107654210 107662095 107701684 107702908

SGH:	107560335 107585007 107591218

CCAR:

109083194

IPU:	108256739 108260175

PHYP:

113531013 113541236

AMEX:

103023636 103029082

EEE:	113573885 113587534

TRU:	101064185(abhd10)

TNG:	GSTEN00023858G001

LCO:	104924970(abhd10)

NCC:	104963504(abhd10)

MZE:	101477718(abhd10)

ONL:	100695557(abhd10)

OLA:	101158731(abhd10)

XMA:	102231232(abhd10)

XCO:	114137112(abhd10)

PRET:

103456613(abhd10)

CVG:	107090797(abhd10)

NFU:	107382881(abhd10)

KMR:	108230485(abhd10)

ALIM:

106513444(abhd10)

AOCE:

111572464(abhd10)

CSEM:

103377136(abhd10)

POV:	109629676(abhd10)

LCF:	108881776(abhd10)

SDU:	111220964(abhd10)

SLAL:

111662834(abhd10)

HCQ:	109530957(abhd10)

BPEC:

110160917(abhd10)

MALB:

109960112(abhd10)

SASA:

106563603 106579539(abhd10) 106597800 106603051(ABHDA)

OTW:	112215392 112227697 112228918 112231211

SALP:

111950765 111964314 111972821 112068193

ELS:	105010867(abhd10) 105019597

SFM:	108939604(abhd10)

PKI:	111840272(abhd10)

LCM:	102363885 102365255(ABHD10)

CMK:	103178632 103187693

RTP:	109913921 109932921

BFO:

CIN:

SPU:

APLC:

SKO:

PVM:

LAK:	106155863 106155864

NVE:

5516562

EPA:

110250931

ADF:	107330292 107355576

AMIL:

114954652

PDAM:

113678819

SPIS:

111334387

CCP:	CHC_T00003770001

AFR:

AFE_0544

AFE:	Lferr_0700

ACU:

Atc_2203

AFJ:	AFERRID_17710

» show all

Reference

1 [PMID:22294686]

Authors

Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T

Title

Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.

Journal

J Biol Chem 287:9240-9 (2012)
DOI:10.1074/jbc.M111.271288

Sequence

[hsa:55347]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.93

IUBMB Enzyme Nomenclature:

3.1.1.93

ExPASy - ENZYME nomenclature database:

3.1.1.93

BRENDA, the Enzyme Database:

3.1.1.93

DBGET integrated database retrieval system