Entry
Name
mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
mycophenolic acid O-acyl-glucuronide-ester hydrolase
Reaction(IUBMB)
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:
R10134 ]
Reaction(KEGG)
Substrate
mycophenolic acid O-acyl-glucuronide [CPD:
C20383 ];
H2O [CPD:
C00001 ]
Product
Comment
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
History
EC 3.1.1.93 created 2012
Orthology
K13702 abhydrolase domain-containing protein 10
Genes
LRUF : 124501565 124526923
ACYG : 106039267(ABHD10) 125180116
DRE : 492622(abhd10b) 568517(abhd10a)
SRX : 107705222 107716420 107719764 107752263
SANH : 107654210 107662095 107701684 107702908
CAUA : 113066252 113094237(abhd10)
PPRM : 120472369(abhd10a) 120476088(abhd10b)
MAMB : 125258509(abhd10b) 125267789(abhd10a)
IPU : 108256739(abhd10b) 108260175(abhd10a)
PHYP : 113531013 113541236
SMEO : 124379080(abhd10a) 124403690(abhd10b)
TFD : 113650886(abhd10a) 113658054(abhd10b)
AMEX : 103023636 103029082
SASA : 106563603 106579539(abhd10) 106603051(ABHDA)
STRU : 115151017 115154800 115195498 115204406
OTW : 112227697 112228918 112231211
OMY : 110489656 110510083(abhd10a) 110534098 110535334(abhd10b)
OGO : 123991321(abhd10b) 124006516 124007108 124039131
SALP : 111950765 111964314 111972821 112068193
SNH : 120021392 120027852(abhd10b) 120050339 120056629(abhd10a)
CCLU : 121541249 121549848(abhd10b) 121569247 121579573
AANG : 118225150 118235068(abhd10a)
ARUT : 117406831 117968348
LCM : 102363885 102365255(ABHD10)
PCHN : 125038097 125046926
LSM : 121114146 121114736 121117467
» show all
Taxonomy
Reference
Authors
Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
Title
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.93
ExPASy - ENZYME nomenclature database: 3.1.1.93