KEGG   ENZYME: 3.1.1.93
Entry
EC 3.1.1.93                 Enzyme                                 
Name
mycophenolic acid acyl-glucuronide esterase;
mycophenolic acid acyl-glucuronide deglucuronidase;
AcMPAG deglucuronidase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
mycophenolic acid O-acyl-glucuronide-ester hydrolase
Reaction(IUBMB)
mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate [RN:R10134]
Reaction(KEGG)
R10134
Substrate
mycophenolic acid O-acyl-glucuronide [CPD:C20383];
H2O [CPD:C00001]
Product
mycophenolate [CPD:C20380];
D-glucuronate [CPD:C00191]
Comment
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
History
EC 3.1.1.93 created 2012
Orthology
K13702  abhydrolase domain-containing protein 10
Genes
HSA55347(ABHD10)
PTR743016(ABHD10)
PPS100969335(ABHD10)
GGO101142961(ABHD10)
PON100171612(ABHD10)
NLE100581462(ABHD10)
MCC707464(ABHD10)
MCF102118678(ABHD10)
MTHB126947809
CSAB103228334(ABHD10)
CATY105596256(ABHD10)
PANU101025562(ABHD10)
TGE112619556(ABHD10)
RRO104660639(ABHD10)
RBB108539224(ABHD10)
TFN117083542(ABHD10)
PTEH111543108(ABHD10)
CJC100393480(ABHD10)
SBQ101051108(ABHD10)
CSYR103269003(ABHD10)
MMUR105883899(ABHD10)
LCAT123630552(ABHD10)
OGA100963866(ABHD10)
MMU213012(Abhd10)
MCAL110311667(Abhd10)
MPAH110329711(Abhd10)
RNO303953(Abhd10)
MCOC116085959(Abhd10)
MUN110566241(Abhd10)
CGE100770127(Abhd10)
MAUA101842357(Abhd10)
PLEU114694953(Abhd10)
MORG121461853(Abhd10)
MFOT126505692
AAMP119825710(Abhd10)
NGI103745090(Abhd10)
HGL101701879(Abhd10)
CPOC100733320(Abhd10)
CCAN109681464(Abhd10)
DORD105994887(Abhd10)
DSP122105677(Abhd10)
NCAR124992877
OCU100350766
OPI101525217(ABHD10)
TUP102474419(ABHD10)
GVR103607634(ABHD10)
CFA478561(ABHD10)
CLUD112678547(ABHD10)
VVP112913422(ABHD10)
VLG121474210(ABHD10)
AML100476551(ABHD10)
UMR103677324(ABHD10)
UAH113251195(ABHD10)
ELK111152069
LLV125097091
MPUF101686491(ABHD10)
ORO101366526(ABHD10)
EJU114214838(ABHD10)
ZCA113918474(ABHD10)
MLX118007115(ABHD10)
NSU110582469(ABHD10)
LWW102740506(ABHD10)
FCA101086743(ABHD10)
PYU121036222(ABHD10)
PBG122491428(ABHD10)
LRUF124501565 124526923
PTG102971108(ABHD10)
PPAD109266375(ABHD10)
AJU106972278(ABHD10)
HHV120244057(ABHD10)
BTA515563(ABHD10)
BOM102265166(ABHD10)
BIU109572046(ABHD10)
BBUB102400696(ABHD10)
BBIS104997812(ABHD10)
OAS101119354(TAGLN3)
CCAD122428857(ABHD10)
SSC100623142(ABHD10)
CFR102510750(ABHD10)
CBAI105081551(ABHD10)
CDK105093220(ABHD10)
VPC102535218(ABHD10)
BACU103017939(ABHD10)
LVE103082279(ABHD10)
OOR101275519(ABHD10)
DLE111187458(ABHD10)
PCAD102994110(ABHD10)
PSIU116753570(ABHD10)
ECB100071551(ABHD10)
EPZ103557805(ABHD10)
EAI106844707(ABHD10)
MYB102262816(ABHD10)
MMYO118676233(ABHD10)
MLF106694329(ABHD10)
MNA107527433(ABHD10)
PKL118723377(ABHD10)
DRO112320647(ABHD10)
SHON118993151(ABHD10)
AJM119048640(ABHD10)
PDIC114490537(ABHD10)
PHAS123826724(ABHD10)
MMF118617218(ABHD10)
RFQ117014274(ABHD10)
PALE102894447(ABHD10)
PGIG120598186(ABHD10)
PVP105305948(ABHD10)
RAY107513727(ABHD10)
MJV108394132(ABHD10)
TOD119257533(ABHD10)
SARA101548117(ABHD10)
LAV100668546(ABHD10)
TMU101352962
ETF101654506(ABHD10)
DNM101421889(ABHD10)
MDO100011506(ABHD10)
GAS123239506(ABHD10)
SHR100931213(ABHD10)
PCW110222243(ABHD10)
OAA100092679(ABHD10)
GGA418419(ABHD10)
PCOC116226921(ABHD10)
MGP100549655(ABHD10)
CJO107321403(ABHD10)
NMEL110400848(ABHD10)
APLA101796199(ABHD10)
ACYG106039267(ABHD10) 125180116
AFUL116493047(ABHD10)
TGU100222969(ABHD10)
LSR110473108(ABHD10)
SCAN103820735(ABHD10)
PMOA120506452(ABHD10)
OTC121339228(ABHD10)
PRUF121351627(ABHD10)
GFR102044285(ABHD10)
FAB101808891(ABHD10)
PHI102107053(ABHD10)
PMAJ107203157(ABHD10)
CCAE111943382(ABHD10)
CCW104686992(ABHD10)
CBRC103613984(ABHD10)
ETL114066511(ABHD10)
ZAB102073375(ABHD10)
ACHL103803291(ABHD10)
FPG101915956(ABHD10)
FCH102056155(ABHD10)
CLV102096483(ABHD10)
EGZ104131646(ABHD10)
NNI104014174(ABHD10)
PLET104625471(ABHD10)
PCRI104028777(ABHD10)
PCAO104053839(ABHD10)
ACUN113485698(ABHD10)
TALA104357912(ABHD10)
PADL103916828(ABHD10)
AFOR103895093(ABHD10)
ACHC115343878(ABHD10)
HALD104314899(ABHD10)
HLE104831837(ABHD10)
AGEN126048838
GCL127029392
CCRI104157917(ABHD10)
CSTI104549405(ABHD10)
EHS104508509(ABHD10)
CMAC104473366(ABHD10)
MUI104545084(ABHD10)
FGA104077615(ABHD10)
GSTE104263766(ABHD10)
LDI104340155(ABHD10)
MNB103781193(ABHD10)
OHA104335506(ABHD10)
NNT104402050(ABHD10)
PGUU104457952(ABHD10)
ACAR104517907(ABHD10)
CPEA104385013(ABHD10)
AVIT104267505(ABHD10)
CVF104289537(ABHD10)
CUCA104056004(ABHD10)
TEO104384718(ABHD10)
BRHI104488078(ABHD10)
AAM106490709(ABHD10)
AROW112962305(ABHD10)
NPD112949291(ABHD10)
TGT104572620(ABHD10)
DNE112996796(ABHD10)
SCAM104144210(ABHD10)
ASN102385542(ABHD10)
AMJ106737278(ABHD10)
CPOO109305601(ABHD10)
GGN109303542(ABHD10)
PSS102458815(ABHD10)
CMY102945397(ABHD10)
CPIC101934365(ABHD10)
TST117876338(ABHD10)
CABI116825372(ABHD10)
MRV120374287(ABHD10)
ACS100568102(abhd10)
PVT110088006(ABHD10)
SUND121917195
PMUR107292381(ABHD10)
CTIG120317430(ABHD10)
TSR106554265(ABHD10)
PGUT117663284(ABHD10)
VKO123029448(ABHD10)
PMUA114595916
ZVI118085555(TAGLN3)
GJA107105909(ABHD10)
STOW125431668(ABHD10)
XLA108708114(abhd10.L)
XTR100135182(abhd10)
NPR108787367(ABHD10)
BGAR122932823(ABHD10)
DRE492622(abhd10b) 568517(abhd10a)
SRX107705222 107716420 107719764 107752263
SANH107654210 107662095 107701684 107702908
SGH107560335 107591218
CCAR109083194
CAUA113066252 113094237(abhd10)
PPRM120472369(abhd10a) 120476088(abhd10b)
MAMB125258509(abhd10b) 125267789(abhd10a)
IPU108256739(abhd10b) 108260175(abhd10a)
PHYP113531013 113541236
SMEO124379080(abhd10a) 124403690(abhd10b)
TFD113650886(abhd10a) 113658054(abhd10b)
AMEX103023636 103029082
EEE113573885 113587534
TRU101064185(abhd10)
TNGGSTEN00023858G001
LCO104924970(abhd10)
NCC104963504(abhd10)
CGOB115025601(abhd10)
ELY117264784(abhd10b)
EFO125881844(abhd10b)
PLEP121960688(abhd10b)
SLUC116037886(abhd10b)
ECRA117938181(abhd10b)
ESP116672574(abhd10)
PFLV114549385(abhd10)
GAT120811539(abhd10b)
PPUG119198369(abhd10b)
MSAM119909648(abhd10b)
CUD121527098(abhd10b)
ALAT119009020(abhd10b)
MZE101477718(abhd10)
ONL100695557(abhd10)
OAU116319768(abhd10b)
OLA101158731(abhd10)
OML112151528(abhd10b)
XMA102231232(abhd10)
XCO114137112(abhd10)
XHE116711700(abhd10)
PRET103456613(abhd10)
PFOR103139725(abhd10)
PLAI106963487(abhd10)
PMEI106903340(abhd10)
GAF122824625(abhd10b)
CVG107090797(abhd10)
CTUL119788906(abhd10b)
GMU124858114(abhd10b)
NFU107382881(abhd10)
KMR108230485(abhd10b)
ALIM106513444(abhd10)
NWH119426245(abhd10b)
AOCE111572464(abhd10)
MCEP125024374(abhd10b)
CSEM103377136(abhd10)
POV109629676(abhd10)
SSEN122783657(abhd10b)
HHIP117753990(abhd10b)
HSP118098422(abhd10b)
LCF108881776(abhd10b)
SDU111220964(abhd10)
SLAL111662834(abhd10)
XGL120790099(abhd10b)
HCQ109530957(abhd10)
BPEC110160917(abhd10)
MALB109960112(abhd10)
BSPL114853587(abhd10b)
SASA106563603 106579539(abhd10) 106603051(ABHDA)
STRU115151017 115154800 115195498 115204406
OTW112227697 112228918 112231211
OMY110489656 110510083(abhd10a) 110534098 110535334(abhd10b)
OGO123991321(abhd10b) 124006516 124007108 124039131
SALP111950765 111964314 111972821 112068193
SNH120021392 120027852(abhd10b) 120050339 120056629(abhd10a)
CCLU121541249 121549848(abhd10b) 121569247 121579573
ELS105010867(abhd10)
SFM108939604(abhd10)
PKI111840272(abhd10)
AANG118225150 118235068(abhd10a)
LOC102686052(abhd10)
PSPA121302785(abhd10b)
ARUT117406831 117968348
PSEX120523853(abhd10b)
LCM102363885 102365255(ABHD10)
CMK103178632 103187693
RTP109932921
BFO118431657
BBEL109477506
PCHN125038097 125046926
LSM121114146 121114736 121117467
PPOI119103717
LAK106155863
NVE5516562
EPA110250931
ATEN116303550
ADF107355576
AMIL114954652
PDAM113678819
SPIS111334387
 » show all
Reference
1  [PMID:22294686]
  Authors
Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T
  Title
Human alpha/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
  Journal
J Biol Chem 287:9240-9 (2012)
DOI:10.1074/jbc.M111.271288
  Sequence
[hsa:55347]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.93
IUBMB Enzyme Nomenclature: 3.1.1.93
ExPASy - ENZYME nomenclature database: 3.1.1.93
BRENDA, the Enzyme Database: 3.1.1.93

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