KEGG   ENZYME: 3.1.1.95
Entry
EC 3.1.1.95                 Enzyme                                 

Name
aclacinomycin methylesterase;
RdmC;
aclacinomycin methyl esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
aclacinomycin T acylhydrolase
Reaction(IUBMB)
aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol [RN:R10545]
Reaction(KEGG)
R10545;
(other) R09337
Substrate
aclacinomycin T [CPD:C18634];
H2O [CPD:C00001]
Product
15-demethylaclacinomycin T [CPD:C20689];
methanol [CPD:C00132]
Comment
The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.
History
EC 3.1.1.95 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01110  Biosynthesis of secondary metabolites
Orthology
K15957  aclacinomycin methylesterase
Reference
1  [PMID:11004563]
  Authors
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
  Title
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
  Journal
Biochim Biophys Acta 1480:191-200 (2000)
DOI:10.1016/S0167-4838(00)00089-3
  Sequence
Reference
2  [PMID:12878604]
  Authors
Jansson A, Niemi J, Mantsala P, Schneider G
  Title
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
  Journal
J Biol Chem 278:39006-13 (2003)
DOI:10.1074/jbc.M304008200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.95
IUBMB Enzyme Nomenclature: 3.1.1.95
ExPASy - ENZYME nomenclature database: 3.1.1.95
BRENDA, the Enzyme Database: 3.1.1.95

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