KEGG   ENZYME: 3.1.11.3Help
Entry
EC 3.1.11.3                 Enzyme                                 

Name
exodeoxyribonuclease (lambda-induced);
lambda exonuclease;
phage lambda-induced exonuclease;
Escherichia coli exonuclease IV;
E. coli exonuclease IV;
exodeoxyribonuclease IV;
exonuclease IV
Class
Hydrolases;
Acting on ester bonds;
Exodeoxyribonucleases producing 5'-phosphomonoesters
BRITE hierarchy
Reaction(IUBMB)
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates
Comment
Preference for double-stranded DNA. Does not attack single-strand breaks.
History
EC 3.1.11.3 created 1972 as EC 3.1.4.28, transferred 1978 to EC 3.1.11.3
Orthology
K01143  exodeoxyribonuclease (lambda-induced)
K21526  exonuclease
Genes
ECI: UTI89_C1275
ECV: APECO1_221
STY: STY1016(exo)
STT: t1924(exo)
ENT: Ent638_1002
HAR: HEAR2308
BTR: BT_0376(exo) BT_0425(exo) BT_0563(exo) BT_0980(exo) BT_0984(exo) BT_2304(exo)
Taxonomy
Reference
1  [PMID:5256235]
  Authors
Lindahl T, Gally JA, Edelman GM.
  Title
Deoxyribonuclease IV: a new exonuclease from mammalian tissues.
  Journal
Proc Natl Acad Sci U S A 62:597-603 (1969)
DOI:10.1073/pnas.62.2.597
Reference
2  [PMID:6017737]
  Authors
Little JW.
  Title
An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction.
  Journal
J Biol Chem 242:679-86 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.11.3
IUBMB Enzyme Nomenclature: 3.1.11.3
ExPASy - ENZYME nomenclature database: 3.1.11.3
BRENDA, the Enzyme Database: 3.1.11.3
CAS: 37367-70-7

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