KEGG ENZYME: 3.1.2.1

ENZYME: 3.1.2.1

Entry

EC 3.1.2.1                  Enzyme

Name

acetyl-CoA hydrolase;
acetyl-CoA deacylase;
acetyl-CoA acylase;
acetyl coenzyme A hydrolase;
acetyl coenzyme A deacylase;
acetyl coenzyme A acylase;
acetyl-CoA thiol esterase

Class

Hydrolases;
Acting on ester bonds;
Thioester hydrolases

Sysname

acetyl-CoA hydrolase

Reaction(IUBMB)

acetyl-CoA + H2O = CoA + acetate [RN:R00227]

Reaction(KEGG)

R00227

Substrate

acetyl-CoA [CPD:C00024];
H2O [CPD:C00001]

Product

CoA [CPD:C00010];
acetate [CPD:C00033]

History

EC 3.1.2.1 created 1961

Pathway

ec00620

Pyruvate metabolism

ec01100

Metabolic pathways

Orthology

K01067

acetyl-CoA hydrolase

Genes

HSA:	134526(ACOT12)

PTR:	461769(ACOT12)

PPS:	100970341(ACOT12)

GGO:	101152146(ACOT12)

PON:	100438971(ACOT12)

PPYG:

129037558(ACOT12)

NLE:	100598208(ACOT12)

HMH:	116471044(ACOT12)

SSYN:

129493063(ACOT12)

MCC:	711665(ACOT12)

MCF:	102142119(ACOT12)

MTHB:

126957582

MNI:	105475057(ACOT12)

CSAB:

103223934(ACOT12)

CATY:

105599135(ACOT12)

PANU:

101004670(ACOT12)

TGE:	112626400(ACOT12)

MLEU:

105550615(ACOT12)

RRO:	104680192(ACOT12)

RBB:	108528919(ACOT12)

TFN:	117064963(ACOT12)

PTEH:

111544509(ACOT12)

CANG:

105506269(ACOT12)

CJC:	100391176(ACOT12)

SBQ:	101041377(ACOT12)

CIMI:

108288692(ACOT12)

ANAN:

105734670(ACOT12)

CSYR:

103256160(ACOT12)

MMUR:

105882202(ACOT12)

LCAT:

123648070(ACOT12)

PCOQ:

105826489(ACOT12)

OGA:	100952911(ACOT12)

MMU:	74156(Acot12)

MCAL:

110307632(Acot12)

MPAH:

110328781(Acot12)

RNO:	170570(Acot12)

MCOC:

116083947(Acot12)

ANU:	117700534(Acot12)

ASYL:

127666998(Acot12)

MUN:	110566047(Acot12)

CGE:	100752768(Acot12)

MAUA:

101834949(Acot12)

PROB:

127221057(Acot12)

PLEU:

114708044(Acot12)

MORG:

121455808(Acot12)

MFOT:

126508494

AAMP:

119808983(Acot12)

NGI:	103750264(Acot12)

HGL:	101703913(Acot12)

CPOC:

100729776(Acot12)

CCAN:

109682295(Acot12)

DORD:

105985401(Acot12)

DSP:	122117156(Acot12)

DMER:

138807215 138832916(Acot12)

PLOP:

125340113(Acot12)

NCAR:

124987086

MMMA:

107152369(Acot12)

ITI:	101955717(Acot12)

OCU:	100338318 127482676

OPI:	101522047(ACOT12)

TUP:	102476138(ACOT12)

GVR:	103585603(ACOT12)

CFA:	488925(ACOT12)

CLUD:

112653855(ACOT12)

VVP:	112915585(ACOT12)

VLG:	121489896(ACOT12)

NPO:	129521004(ACOT12)

AML:	100476121(ACOT12)

UMR:	103681503(ACOT12)

UAH:	113254979(ACOT12)

UAR:	123791521(ACOT12)

ELK:

111148302

LLV:

125101077

MPUF:

101681932(ACOT12)

MNP:	132028775(ACOT12)

MLK:	131832414(ACOT12)

NVS:	122918030(ACOT12)

ORO:	101382166(ACOT12)

EJU:	114217625(ACOT12)

ZCA:	113928716(ACOT12)

MLX:	118016954(ACOT12)

NSU:	110589198(ACOT12)

LWW:	102735840(ACOT12)

FCA:	101091423(ACOT12)

PYU:	121013736(ACOT12)

PCOO:

112861363(ACOT12)

PBG:	122490434(ACOT12)

PVIV:

125166297(ACOT12)

LRUF:

124518597

LGF:	123607622(ACOT12)

AJU:

106967948

PTG:	102960516(ACOT12)

PPAD:

109274913(ACOT12)

PUC:

125935788

PLEZ:

122222212(ACOT12)

HHV:	120222314(ACOT12)

BTA:	525155(ACOT12)

BOM:	102273943(ACOT12)

BIU:	109562293(ACOT12)

BBUB:

102390801(ACOT12)

BBIS:

105005393(ACOT12)

CHX:	102172148(ACOT12)

OAS:	101118188(ACOT12)

BTAX:

128051582(ACOT12)

CSUM:

138086518(ACOT12)

ODA:	120863324(ACOT12)

CCAD:

122439571(ACOT12)

MREE:

136156367(ACOT12)

OVR:	110133843(ACOT12)

MBEZ:

129558968(ACOT12)

SSC:	100738062(ACOT12)

CFR:	102509429(ACOT12)

CBAI:

105064330(ACOT12)

CDK:	105084844(ACOT12)

VPC:	102529794(ACOT12)

BACU:

102999602(ACOT12)

BMUS:

118893401(ACOT12)

LVE:	103069255(ACOT12)

OOR:	101285482(ACOT12)

LALB:

132516928(ACOT12)

GMF:	115848452(ACOT12)

DDP:	132423453(ACOT12)

DLE:	111184738(ACOT12)

PCAD:

102986121(ACOT12)

PSIU:

116750862(ACOT12)

PPHC:

136121148(ACOT12)

NASI:

112406737(ACOT12)

ECB:	100073251(ACOT12)

EPZ:	103549612(ACOT12)

EAI:	106841156(ACOT12)

MYB:	102255432(ACOT12)

MYD:	102756728(ACOT12)

MMYO:

118656711(ACOT12)

MLF:	102419129(ACOT12)

MDT:	132233461(ACOT12)

MYUM:

139008723(ACOT12)

PKL:	118702935(ACOT12)

EFUS:

103305239(ACOT12)

MNA:	107535082(ACOT12)

DRO:	112307478(ACOT12)

SHON:

118977307(ACOT12)

AJM:	119059586(ACOT12)

PDIC:

114510948(ACOT12)

PHAS:

123824528(ACOT12)

MMF:	118642443(ACOT12)

PPAM:

129074655(ACOT12)

HAI:	109388132(ACOT12)

RFQ:	117024718(ACOT12)

PALE:

102888499(ACOT12)

PGIG:

120612585(ACOT12)

PVP:	105304674(ACOT12)

MJV:	108407043(ACOT12)

TOD:	119260987(ACOT12)

SARA:

101543838(ACOT12)

SFUM:

130021804(ACOT12)

SETR:

126001886(ACOT12)

TMU:

101357788

ETF:	101644675(ACOT12)

DNM:	101437381(ACOT12)

MDO:	100015770(ACOT12)

GAS:	123236514(ACOT12)

SHR:	100919572(ACOT12)

AFZ:

127559237

PCW:	110222640(ACOT12)

TVP:	118854354(ACOT12)

PBRV:

138158800(ACOT12)

MLAO:

141502794(ACOT12)

OAA:	100081254(ACOT12)

TACU:

119944568(ACOT12)

GGA:	431627(ACOT12)

PCOC:

116235329(ACOT12)

MGP:	104915280(ACOT12)

CJO:	107306526(ACOT12)

TPAI:

128089274(ACOT12)

LMUT:

125686791(ACOT12)

NMEL:

110389622(ACOT12)

APLA:

101791825(ACOT12)

ACYG:

106042718(ACOT12)

CATA:

118258651(ACOT12)

AFUL:

116501225(ACOT12)

TGU:	100219385(ACOT12)

LSR:	110482520(ACOT12)

SCAN:

103823057(ACOT12)

PMOA:

120496155(ACOT12)

OTC:	121347777(ACOT12)

PRUF:

121351283(ACOT12)

ATRC:

139604083(ACOT12)

GFR:	102035411(ACOT12)

FAB:	101810335(ACOT12)

OMA:	130265054(ACOT12)

PHI:	102112382(ACOT12)

PMAJ:

107216375(ACOT12)

CCAE:

111941640(ACOT12)

CCW:	104695825(ACOT12)

CBRC:

103613260(ACOT12)

ACOE:

138103652(ACOT12)

ETL:	114056129(ACOT12)

ZAB:	102061972(ACOT12)

ZLE:	135459496(ACOT12)

SVG:	106861538(ACOT12)

MMEA:

130583972(ACOT12)

HRT:	120765352(ACOT12)

SATI:

136373912(ACOT12)

CCIC:

134056556(ACOT12)

FPG:	101924947(ACOT12)

FCH:	102059422(ACOT12)

CCRI:

104164326(ACOT12)

NNT:	104405564(ACOT12)

SHAB:

115600863(ACOT12)

ACUN:

113490327(ACOT12)

TALA:

104362994(ACOT12)

ACHC:

115336815(ACOT12)

HALD:

104312186

HLE:	104838378(ACOT12)

AGEN:

126036511

HHAR:

128136733(ACOT12)

GCL:

127027217

CSTI:

104560214

LDI:	104349529(ACOT12)

MNB:	103768267(ACOT12)

DPUB:

104309376(ACOT12)

PPUS:

135173415(ACOT12)

AVIT:

104269672(ACOT12)

BRHI:

104499524(ACOT12)

EGZ:	104128353(ACOT12)

NNI:	104022999(ACOT12)

PCRI:

104027095

PCAO:

104046198(ACOT12)

PADL:

103923438(ACOT12)

AFOR:

103900359(ACOT12)

FGA:	104081085(ACOT12)

GSTE:

104252979(ACOT12)

CBOY:

140651338(ACOT12)

CLV:	102092439(ACOT12)

CNIC:

136002134(ACOT12)

MUI:	104543030(ACOT12)

PGUU:

104465968(ACOT12)

PLET:

104626682(ACOT12)

CMAC:

104481913(ACOT12)

TEO:

104381518

BREG:

104638202(ACOT12)

OHA:	104335504(ACOT12)

ACAR:

104526695

CPEA:

104398313(ACOT12)

CVF:	104288130(ACOT12)

RTD:	128902942(ACOT12)

CRID:

134508275(ACOT12)

AROW:

112968328(ACOT12)

NPD:	112946777(ACOT12)

TGT:	104573352(ACOT12)

DNE:	112983658(ACOT12)

SCAM:

104152902(ACOT12)

ASN:	102379080(ACOT12)

AMJ:	102570778(ACOT12)

CPOO:

109308072(ACOT12)

GGN:	109298053(ACOT12)

PSS:	102459479(ACOT12)

CMY:	102944174(ACOT12)

CCAY:

125636611(ACOT12)

DCC:	119855765(ACOT12)

CPIC:

101931735(ACOT12)

TST:	117879436(ACOT12)

CABI:

116819787

MRV:	120407403(ACOT12)

ACS:	100554997(acot12)

ASAO:

132767111(ACOT12)

PVT:	110077334(ACOT12)

SUND:

121921120(ACOT12)

PBI:	103061492(ACOT12)

PMUR:

107286315(ACOT12)

CTIG:

120297757(ACOT12)

TSR:	106551901(ACOT12)

PGUT:

117679346(ACOT12)

PCAE:

139311367(ACOT12)

APRI:

131190731(ACOT12)

PTEX:

113448049(ACOT12)

NSS:	113414852(ACOT12)

PMUA:

114606537(ACOT12)

PRAF:

128423736(ACOT12)

ZVI:	118076846(ACOT12)

HCG:	128346452(ACOT12)

GJA:	107120563(ACOT12)

STOW:

125436198(ACOT12)

EMC:	129334280(ACOT12)

XLA:	444535(acot12.L)

XTR:	100170471(acot12)

NPR:	108787611(ACOT12)

RTEM:

120930456(ACOT12)

ACAT:

141135600(ACOT12)

BBUF:

120992492(ACOT12)

BGAR:

122935753(ACOT12)

DTC:	141095700(ACOT12)

PWL:	138285076(ACOT12)

MUO:	115463114(ACOT12)

GSH:	117350200(ACOT12)

DRE:	100536873(acot12)

SRX:	107758641(acot12)

SANH:

107658612(acot12)

SGH:

107588978

CCAR:

109071741

CAUA:

113054589(acot12)

CGIB:

128020735

PTET:

122333719

LROH:

127171498

GRF:	141299354(acot12)

OMC:

131548491

PPRM:

120482001

RKG:

130070264

MAMB:

125262360

CIDE:

127521036

CERY:

137028574

MASI:

127432873

TROS:

130546589

TDW:

130411463

CHAR:

105911606

SPIL:

134100909

SASA:

106568307

STRU:

115159765

OTW:

112220242

OMY:	110509639 110523420

OGO:

124049111

ONE:	115124688(acot12)

OKI:	109868824(acot12)

OKE:

118376809

OMM:

135518122

OCLA:

139387799 139408516

SALP:

111961784(acot12)

SNH:

120026391

CCLU:

121541525 121582667

OEP:

134038640

PKI:	111859863(acot12)

AANG:

118213249

AROT:

135239276

CCOG:

133142340

LOC:	102686048(acot12)

PSPA:

121312816

ARUT:

117403721 117973490

PSEX:

120532848

LCM:	102361204(ACOT12)

SCE:	YBL015W(ACH1)

SEUB:

DI49_0165

SPAO:

SPAR_B00910

AGO:	AGOS_AFR020W

ERC:

Ecym_6197

KLA:	KLLA0_E10561g

KMX:	KLMA_20042(ACH1)

LTH:	KLTH0H08338g

VPO:	Kpol_1002p112

ZRO:	ZYRO0C13134g

CGR:	2889653(GVI51_J04103)

NCS:	NCAS_0B05550(NCAS0B05550)

NDI:	NDAI_0B02890(NDAI0B02890)

TPF:	TPHA_0C02890(TPHA0C02890)

TBL:	TBLA_0E03560(TBLA0E03560)

TGB:	HG536_0D02480

TDL:	TDEL_0B04500(TDEL0B04500)

KAF:	KAFR_0C02850(KAFR0C02850)

KNG:	KNAG_0G01420(KNAG0G01420)

ZMK:	HG535_0E03230

SLUD:

SCDLUD_001585

DHA:	DEHA2F18744g

PIC:	PICST_78208(ACH1)

PGU:	PGUG_02595

SPAA:

SPAPADRAFT_61211

LEL:	PVL30_004796(ACH1)

LBG:	92210698(LODBEIA_P55020)

CAL:	CAALFM_C502000CA(ACH1)

CTP:	CTRG_05320

COT:	CORT_0F01790

CDU:	CD36_51850

CTEN:

18247184(ACH1)

CLU:	CLUG_02878

CLUS:

A9F13_26g00176

CAUR:

CJI96_0004449

ASAU:

88173862(PUMCH_002798)

PPA:	PAS_chr3_0253

PKZ:	C5L36_0A09950

BNN:	FOA43_004748(ACH1)

BBRX:

BRETT_001654(ACH1)

OPA:	HPODL_04251

SLB:	AWJ20_2963(ACH1)

NCR:	NCU09770(acu-8)

NTE:	NEUTE1DRAFT64379(NEUTE1DRAFT_64379)

SMP:	10802122(SMAC4_09176)

PAN:	PODANSg552

PBEL:

QC761_310910(ACH1)

PPSD:

QC762_310910(ACH1)

PPSP:

QC763_310910(ACH1)

PPSA:

QC764_310910(ACH1)

TTT:	THITE_2124665

MTM:	MYCTH_2313014

RTHE:

98128332(VTJ83DRAFT_6923)

MGR:

MGG_06609

PPEI:

PpBr36_06207

PGRI:

PgNI_01147

TMN:	UCRPA7_8846

SSCK:

SPSK_09099

FGR:	FGSG_08266

FPU:	FPSE_09544

FPOA:

FPOAC1_004331(ACU8)

FVN:	FVRRES_04847

FVR:	FVEG_01781

FOX:	FOXG_02924

NHE:	NECHADRAFT_67022

FFC:	NCS54_00360900

FKR:	NCS57_00366100

FMU:	J7337_008143(ACU8)

VAL:	VDBG_01384

VDA:	VDAG_07866

CFJ:	CFIO01_02082

CLUP:

CLUP02_12121

CHIG:

CH63R_11542

CDET:

87946288(CDEST_09786)

SAPO:

SAPIO_CDS6251

ELA:	UCREL1_10661

PFY:	PFICI_08653

SSL:	SS1G_03975

BFU:	BCIN_04g01780(Bcach1)

MBE:

MBM_05077

PSCO:

LY89DRAFT_700047

GLZ:	GLAREA_08985

ANI:	ANIA_01547

AFM:	AFUA_8G05580

ACT:	ACLA_058990

NFI:	NFIA_098300

AOR:	AO090005000588

ANG:	An16g07110

AFV:	AFLA_003396

ALUC:

AKAW2_70557A(ACH1)

ACHE:

ACHE_31238S(ACH1)

APUU:

APUU_21658A(ACH1)

PCS:	N7525_002157

PDP:	PDIP_03640

POU:	POX_h09772

TMF:	EYB26_009407

TRG:	TRUGW13939_02280

CIM:	CIMG_08724

CPW:	9696070(ACH1_1)

URE:	UREG_02698

PBL:	PAAG_04856

PBN:	PADG_02597

AJE:	HCAG_02840

BGH:	BDBG_04166

PNO:	SNOG_05874

PTE:

PTT_11541

PTRR:

6343502(PtrM4_123150)

BZE:	COCCADRAFT_30135

BSC:	COCSADRAFT_145897

BOR:	COCMIDRAFT_106926

ADAC:

96086177(ACET3X_005855)

ARAB:

EKO05_0000812

ZTR:	MYCGRDRAFT_101405

PFJ:	MYCFIDRAFT_53451

FFU:	CLAFUR5_03054

CBET:

CB0940_03647

BCOM:

BAUCODRAFT_33876

NPA:	UCRNP2_9672

SPO:	2542515(ach1)

SOM:	SOMG_00227 SOMG_03490(ach1)

ADL:	AURDEDRAFT_113021

LBC:	LACBIDRAFT_252427

CCI:	CC1G_08888

PCUB:

JR316_0001544 JR316_0009903

MRR:	Moror_11650

E1B28_011471(ACU8)

SCM:	SCHCO_02637680(SCHCODRAFT_02637680)

RIE:	OCT59_021996

DDI:	DDB_G0287519

DPP:	DICPUDRAFT_76067

DFA:

DFA_08685

NGR:	NAEGRDRAFT_38428

TVA:	4773241(TVAGG3_0279550)

GSU:	GSU0174(ato-2) GSU0490(ato-1)

GSK:	KN400_0148(ato-2) KN400_0477(ato-1)

GME:	Gmet_1125 Gmet_1730(ato-2) Gmet_3044(ato-1)

GPI:	GPICK_04620 GPICK_10040 GPICK_13940

GAO:	A2G06_15590

GBZ:	JZM60_03300 JZM60_14870

GEM:	GM21_0485 GM21_0842 GM21_3982

GEB:

GM18_3910

GEF:	FO488_00065 FO488_04760

GEV:	GSVR_00590(ato-1)

GEC:	GEO60473_30550 GEO60473_33830

GUR:	Gura_1337 Gura_4029

GEO:	Geob_0513(ato-3) Geob_0742(ato-1) Geob_2594(ato-2)

GLO:	Glov_0345 Glov_3013

TAMM:

GEAMG1_2441

GBM:	Gbem_0468(ato-1) Gbem_0795(ato-3) Gbem_3897(ato-4)

GBN:	GEOBRER4_04660(ato-1_1) GEOBRER4_07930(ato-1_2) GEOBRER4_37860(ato-2)

GER:	KP004_01545 KP004_18680

GSUB:

KP001_13935 KP001_17560

GNT:	KP003_01200 KP003_18685

GPL:	M1B72_01095 M1B72_19400

GSB:	GSUB_04000

GHC:	L9S41_06215

PCA:	Pcar_2384(ato)

PACE:

A6070_03410

PEF:	A7E78_12615

PPD:

Ppro_0286

DEU:

DBW_2512

DVE:	DESUT3_29580(ato-2)

DEP:	AOP6_1047(ato-1) AOP6_1757(ato-2)

DES:	DSOUD_2347(ato-2)

DAT:	HRM2_15970(ach1)

DHG:	EYB58_06025 EYB58_17850

DIN:	Selin_0775

DAP:	Dacet_1280

GTL:	EP073_07170

CNI:	Calni_0213

FSI:	Flexsi_1428

» show all

Reference

1 [PMID:12999747]

Authors

GERGELY J, HELE P, RAMAKRISHNAN CV.

Title

Succinyl and acetyl coenzyme a deacylases.

Journal

J Biol Chem 198:324-34 (1952)

Other DBs

ExplorEnz - The Enzyme Database:

3.1.2.1

IUBMB Enzyme Nomenclature:

3.1.2.1

ExPASy - ENZYME nomenclature database:

3.1.2.1

BRENDA, the Enzyme Database:

3.1.2.1

CAS:

9027-54-7

All links

Gene (186)   
   MGENES (67)   
   RefGene (119)   
Protein sequence (2676)   
   UniProt (2584)   
   SWISS-PROT (31)   
   RefSeq(pep) (50)   
   PDBSTR (11)   
DNA sequence (636)   
   RefSeq(nuc) (82)   
   GenBank (274)   
   EMBL (280)   
3D Structure (5)   
   PDB (5)   
Protein domain (26)   
   InterPro (24)   
   Pfam (2)   
All databases (3529)   

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