KEGG   ENZYME: 3.1.2.1
Entry
EC 3.1.2.1                  Enzyme                                 
Name
acetyl-CoA hydrolase;
acetyl-CoA deacylase;
acetyl-CoA acylase;
acetyl coenzyme A hydrolase;
acetyl coenzyme A deacylase;
acetyl coenzyme A acylase;
acetyl-CoA thiol esterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
acetyl-CoA hydrolase
Reaction(IUBMB)
acetyl-CoA + H2O = CoA + acetate [RN:R00227]
Reaction(KEGG)
R00227
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
acetate [CPD:C00033]
History
EC 3.1.2.1 created 1961
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K01067  acetyl-CoA hydrolase
Genes
HSA134526(ACOT12)
PTR461769(ACOT12)
PPS100970341(ACOT12)
GGO101152146(ACOT12)
PON100438971(ACOT12)
NLE100598208(ACOT12)
MCC711665(ACOT12)
MCF102142119(ACOT12)
CSAB103223934(ACOT12)
CATY105599135(ACOT12)
PANU101004670(ACOT12)
TGE112626400(ACOT12)
RRO104680192(ACOT12)
RBB108528919(ACOT12)
TFN117064963(ACOT12)
PTEH111544509(ACOT12)
CJC100391176(ACOT12)
SBQ101041377(ACOT12)
CSYR103256160(ACOT12)
MMUR105882202(ACOT12)
LCAT123648070(ACOT12)
OGA100952911(ACOT12)
MMU74156(Acot12)
MCAL110307632(Acot12)
MPAH110328781(Acot12)
RNO170570(Acot12)
MCOC116083947(Acot12)
MUN110566047(Acot12)
CGE100752768(Acot12)
MAUA101834949(Acot12)
PLEU114708044(Acot12)
MORG121455808(Acot12)
AAMP119808983(Acot12)
NGI103750264(Acot12)
HGL101703913(Acot12)
CPOC100729776(Acot12)
CCAN109682295(Acot12)
DORD105985401(Acot12)
DSP122117156(Acot12)
NCAR124987086
OCU100338318(ACOT12)
OPI101522047(ACOT12)
TUP102476138(ACOT12)
CFA488925(ACOT12)
CLUD112653855(ACOT12)
VVP112915585(ACOT12)
VLG121489896(ACOT12)
AML100476121(ACOT12)
UMR103681503(ACOT12)
UAH113254979(ACOT12)
UAR123791521(ACOT12)
ELK111148302
LLV125101077
MPUF101681932(ACOT12)
ORO101382166(ACOT12)
EJU114217625(ACOT12)
ZCA113928716(ACOT12)
MLX118016954(ACOT12)
FCA101091423(ACOT12)
PYU121013736(ACOT12)
PBG122490434(ACOT12)
PTG102960516(ACOT12)
PPAD109274913(ACOT12)
AJU106967948(ACOT12)
HHV120222314(ACOT12)
BTA525155(ACOT12)
BOM102273943(ACOT12)
BIU109562293(ACOT12)
BBUB102390801(ACOT12)
CHX102172148(ACOT12)
OAS101118188(ACOT12)
ODA120863324(ACOT12)
CCAD122439571(ACOT12)
SSC100738062(ACOT12)
CFR102509429(ACOT12)
CBAI105064330(ACOT12)
CDK105084844(ACOT12)
VPC102529794(ACOT12)
BACU102999602(ACOT12)
LVE103069255(ACOT12)
OOR101285482(ACOT12)
DLE111184738(ACOT12)
PCAD102986121(ACOT12)
PSIU116750862(ACOT12)
ECB100073251(ACOT12)
EPZ103549612(ACOT12)
EAI106841156(ACOT12)
MYB102255432(ACOT12)
MYD102756728(ACOT12)
MMYO118656711(ACOT12)
MLF102419129(ACOT12)
MNA107535082(ACOT12)
PKL118702935(ACOT12)
HAI109388132(ACOT12)
DRO112307478(ACOT12)
SHON118977307(ACOT12)
AJM119059586(ACOT12)
PDIC114510948(ACOT12)
PHAS123824528(ACOT12)
MMF118642443(ACOT12)
RFQ117024718(ACOT12)
PALE102888499(ACOT12)
PGIG120612585(ACOT12)
PVP105304674(ACOT12)
MJV108407043(ACOT12)
TOD119260987(ACOT12)
SARA101543838(ACOT12)
TMU101357788
DNM101437381(ACOT12)
MDO100015770(ACOT12)
GAS123236514(ACOT12)
SHR100919572(ACOT12)
PCW110222640(ACOT12)
OAA100081254(ACOT12)
GGA431627(ACOT12)
PCOC116235329(ACOT12)
MGP104915280(ACOT12)
CJO107306526(ACOT12)
NMEL110389622(ACOT12)
APLA101791825(ACOT12)
ACYG106042718(ACOT12)
AFUL116501225(ACOT12)
TGU100219385(ACOT12)
LSR110482520(ACOT12)
SCAN103823057(ACOT12)
PMOA120496155(ACOT12)
OTC121347777(ACOT12)
PRUF121351283(ACOT12)
GFR102035411(ACOT12)
FAB101810335(ACOT12)
PHI102112382(ACOT12)
PMAJ107216375(ACOT12)
CCAE111941640(ACOT12)
CCW104695825(ACOT12)
CBRC103613260(ACOT12)
ETL114056129(ACOT12)
ZAB102061972(ACOT12)
FPG101924947(ACOT12)
FCH102059422(ACOT12)
CLV102092439(ACOT12)
EGZ104128353(ACOT12)
NNI104022999(ACOT12)
PLET104626682(ACOT12)
PCRI104027095
ACUN113490327(ACOT12)
TALA104362994(ACOT12)
PADL103923438(ACOT12)
ACHC115336815(ACOT12)
HALD104312186
CCRI104164326(ACOT12)
CSTI104560214
CMAC104481913(ACOT12)
FGA104081085(ACOT12)
GSTE104252979(ACOT12)
LDI104349529(ACOT12)
MNB103768267(ACOT12)
OHA104335504(ACOT12)
AROW112968328(ACOT12)
NPD112946777(ACOT12)
DNE112983658(ACOT12)
ASN102379080(ACOT12)
AMJ102570778(ACOT12)
CPOO109308072(ACOT12)
GGN109298053(ACOT12)
PSS102459479(ACOT12)
CMY102944174(ACOT12)
CPIC101931735(ACOT12)
TST117879436(ACOT12)
CABI116819787
MRV120407403(ACOT12)
ACS100554997(acot12)
PVT110077334(ACOT12)
SUND121921120(ACOT12)
PBI103061492(ACOT12)
PMUR107286315(ACOT12)
TSR106551901(ACOT12)
PGUT117658741 117679346(ACOT12)
PMUA114606537(ACOT12)
ZVI118076846(ACOT12)
GJA107120563(ACOT12)
STOW125436198(ACOT12)
XLA444535(acot12.L)
XTR100170471(acot12)
NPR108787611(ACOT12)
RTEM120930456(ACOT12)
BBUF120992492(ACOT12)
BGAR122935753(ACOT12)
DRE100536873(acot12)
SRX107758641(acot12)
SANH107658612(acot12)
SGH107588978
CCAR109071741(acot12)
CAUA113054589(acot12)
PPRM120482001
MAMB125262360
SASA106568307
OTW112220242
OMY110509639 110523420
OGO124049111
ONE115124688(acot12)
SALP111961784(acot12)
SNH120026391
CCLU121541525 121582667
PKI111859863(acot12)
AANG118213249
LOC102686048(acot12)
PSPA121312816
ARUT117403721 117973490
LCM102361204(ACOT12)
PXY105396710
SCEYBL015W(ACH1)
SEUBDI49_0165
SPAOSPAR_B00910
AGOAGOS_AFR020W
ERCEcym_6197
KLAKLLA0_E10561g
KMXKLMA_20042(ACH1)
LTHKLTH0H08338g
VPOKpol_1002p112
ZROZYRO0C13134g
CGRCAGL0J04268g
NCSNCAS_0B05550(NCAS0B05550)
NDINDAI_0B02890(NDAI0B02890)
TPFTPHA_0C02890(TPHA0C02890)
TBLTBLA_0E03560(TBLA0E03560)
TDLTDEL_0B04500(TDEL0B04500)
TGBHG536_0D02480
KAFKAFR_0C02850(KAFR0C02850)
KNGKNAG_0G01420(KNAG0G01420)
ZMKHG535_0E03230
PPAPAS_chr3_0253
DHADEHA2F18744g
PICPICST_78208(ACH1)
PGUPGUG_02595
SPAASPAPADRAFT_61211
LELLELG_03976
CALCAALFM_C502000CA(ACH1)
CTPCTRG_05320
COTCORT_0F01790
CDUCD36_51850
CTENCANTEDRAFT_113926
CLUCLUG_02878
CLUSA9F13_26g00176
CAURCJI97_004749
SLBAWJ20_2963(ACH1)
PKZC5L36_0A09950
BNNFOA43_004748(ACH1)
BBRXBRETT_001654(ACH1)
OPAHPODL_04251
SLUDSCDLUD_001585
NCRNCU09770(acu-8)
NTENEUTE1DRAFT64379(NEUTE1DRAFT_64379)
SMPSMAC_09176
PANPODANSg552
TTTTHITE_2124665
MTMMYCTH_2313014
MGRMGG_06609
PPEIPpBr36_06207
TMNUCRPA7_8846
SSCKSPSK_09099
FGRFGSG_08266
FPUFPSE_09544
FVRFVEG_01781
FOXFOXG_02924
NHENECHADRAFT_67022
VALVDBG_01384
VDAVDAG_07866
CFJCFIO01_02082
CHIGCH63R_11542
SAPOSAPIO_CDS6251
ELAUCREL1_10661
PFYPFICI_08653
SSLSS1G_03975
BFUBCIN_04g01780(Bcach1)
MBEMBM_05077
PSCOLY89DRAFT_700047
ANIAN1547.2
AFMAFUA_8G05580
ACTACLA_058990
NFINFIA_098300
AORAO090005000588
ANGANI_1_938144(An16g07110)
AFVAFLA_003396
ALUCAKAW2_70557A(ACH1)
ACHEACHE_31238S(ACH1)
APUUAPUU_21658A(ACH1)
PCSPc12g03130
PDPPDIP_03640
TMFPMAA_009070
TRGTRUGW13939_02280
CIMCIMG_08724
CPWCPC735_063030
UREUREG_02698
PBLPAAG_04856
PBNPADG_02597
AJEHCAG_02840
BGHBDBG_04166
PNOSNOG_05874
PTEPTT_11541
BZECOCCADRAFT_30135
BSCCOCSADRAFT_145897
BORCOCMIDRAFT_106926
ZTRMYCGRDRAFT_101405
PFJMYCFIDRAFT_53451
FFUCLAFUR5_03054
BCOMBAUCODRAFT_33876
NPAUCRNP2_9672
SPOSPAC1952.09c
ADLAURDEDRAFT_113021
LBCLACBIDRAFT_252427
CCICC1G_08888
PCUBJR316_0001544 JR316_0009903
MRRMoror_11650
MOREE1B28_011471(ACU8)
SCMSCHCO_02637680(SCHCODRAFT_02637680)
DDIDDB_G0287519
DPPDICPUDRAFT_76067
DFADFA_08685
NGRNAEGRDRAFT_38428
TVATVAG_393850
BUGBC1001_1331
BPYBphyt_5109
GEMGM21_0485 GM21_0842 GM21_3982
GEBGM18_3910
GURGura_4029
GEOGeob_0742(ato-1) Geob_2594(ato-2)
GLOGlov_0345 Glov_3013
GBNGEOBRER4_04660(ato-1_1) GEOBRER4_07930(ato-1_2) GEOBRER4_37860(ato-2)
PPDPpro_0286
DATHRM2_15970(ach1)
DINSelin_0775
DAPDacet_1280
CNICalni_0213
FSIFlexsi_1428
 » show all
Reference
1  [PMID:12999747]
  Authors
GERGELY J, HELE P, RAMAKRISHNAN CV.
  Title
Succinyl and acetyl coenzyme a deacylases.
  Journal
J Biol Chem 198:324-34 (1952)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.1
IUBMB Enzyme Nomenclature: 3.1.2.1
ExPASy - ENZYME nomenclature database: 3.1.2.1
BRENDA, the Enzyme Database: 3.1.2.1
CAS: 9027-54-7

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