KEGG   ENZYME: 3.1.2.1
Entry
EC 3.1.2.1                  Enzyme                                 
Name
acetyl-CoA hydrolase;
acetyl-CoA deacylase;
acetyl-CoA acylase;
acetyl coenzyme A hydrolase;
acetyl coenzyme A deacylase;
acetyl coenzyme A acylase;
acetyl-CoA thiol esterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
acetyl-CoA hydrolase
Reaction(IUBMB)
acetyl-CoA + H2O = CoA + acetate [RN:R00227]
Reaction(KEGG)
R00227
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
acetate [CPD:C00033]
History
EC 3.1.2.1 created 1961
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K01067  acetyl-CoA hydrolase
Genes
HSA: 134526(ACOT12)
PTR: 461769(ACOT12)
PPS: 100970341(ACOT12)
GGO: 101152146(ACOT12)
PON: 100438971(ACOT12)
NLE: 100598208(ACOT12)
HMH: 116471044(ACOT12)
MCC: 711665(ACOT12)
MCF: 102142119(ACOT12)
MTHB: 126957582
MNI: 105475057(ACOT12)
CSAB: 103223934(ACOT12)
CATY: 105599135(ACOT12)
PANU: 101004670(ACOT12)
TGE: 112626400(ACOT12)
MLEU: 105550615(ACOT12)
RRO: 104680192(ACOT12)
RBB: 108528919(ACOT12)
TFN: 117064963(ACOT12)
PTEH: 111544509(ACOT12)
CANG: 105506269(ACOT12)
CJC: 100391176(ACOT12)
SBQ: 101041377(ACOT12)
CIMI: 108288692(ACOT12)
CSYR: 103256160(ACOT12)
MMUR: 105882202(ACOT12)
LCAT: 123648070(ACOT12)
PCOQ: 105826489(ACOT12)
OGA: 100952911(ACOT12)
MMU: 74156(Acot12)
MCAL: 110307632(Acot12)
MPAH: 110328781(Acot12)
RNO: 170570(Acot12)
MCOC: 116083947(Acot12)
ANU: 117700534(Acot12)
MUN: 110566047(Acot12)
CGE: 100752768(Acot12)
MAUA: 101834949(Acot12)
PROB: 127221057(Acot12)
PLEU: 114708044(Acot12)
MORG: 121455808(Acot12)
MFOT: 126508494
AAMP: 119808983(Acot12)
NGI: 103750264(Acot12)
HGL: 101703913(Acot12)
CPOC: 100729776(Acot12)
CCAN: 109682295(Acot12)
DORD: 105985401(Acot12)
DSP: 122117156(Acot12)
PLOP: 125340113(Acot12)
NCAR: 124987086
OCU: 100338318 127482676
OPI: 101522047(ACOT12)
TUP: 102476138(ACOT12)
GVR: 103585603(ACOT12)
CFA: 488925(ACOT12)
CLUD: 112653855(ACOT12)
VVP: 112915585(ACOT12)
VLG: 121489896(ACOT12)
NPO: 129521004(ACOT12)
AML: 100476121(ACOT12)
UMR: 103681503(ACOT12)
UAH: 113254979(ACOT12)
UAR: 123791521(ACOT12)
ELK: 111148302
LLV: 125101077
MPUF: 101681932(ACOT12)
NVS: 122918030(ACOT12)
ORO: 101382166(ACOT12)
EJU: 114217625(ACOT12)
ZCA: 113928716(ACOT12)
MLX: 118016954(ACOT12)
NSU: 110589198(ACOT12)
LWW: 102735840(ACOT12)
FCA: 101091423(ACOT12)
PYU: 121013736(ACOT12)
PCOO: 112861363(ACOT12)
PBG: 122490434(ACOT12)
LRUF: 124518597
PTG: 102960516(ACOT12)
PPAD: 109274913(ACOT12)
PUC: 125935788
AJU: 106967948
HHV: 120222314(ACOT12)
BTA: 525155(ACOT12)
BOM: 102273943(ACOT12)
BIU: 109562293(ACOT12)
BBUB: 102390801(ACOT12)
BBIS: 105005393(ACOT12)
CHX: 102172148(ACOT12)
OAS: 101118188(ACOT12)
BTAX: 128051582(ACOT12)
ODA: 120863324(ACOT12)
CCAD: 122439571(ACOT12)
SSC: 100738062(ACOT12)
CFR: 102509429(ACOT12)
CBAI: 105064330(ACOT12)
CDK: 105084844(ACOT12)
VPC: 102529794(ACOT12)
BACU: 102999602(ACOT12)
LVE: 103069255(ACOT12)
OOR: 101285482(ACOT12)
DLE: 111184738(ACOT12)
PCAD: 102986121(ACOT12)
PSIU: 116750862(ACOT12)
NASI: 112406737(ACOT12)
ECB: 100073251(ACOT12)
EPZ: 103549612(ACOT12)
EAI: 106841156(ACOT12)
MYB: 102255432(ACOT12)
MYD: 102756728(ACOT12)
MMYO: 118656711(ACOT12)
MLF: 102419129(ACOT12)
MNA: 107535082(ACOT12)
PKL: 118702935(ACOT12)
HAI: 109388132(ACOT12)
DRO: 112307478(ACOT12)
SHON: 118977307(ACOT12)
AJM: 119059586(ACOT12)
PDIC: 114510948(ACOT12)
PHAS: 123824528(ACOT12)
MMF: 118642443(ACOT12)
RFQ: 117024718(ACOT12)
PALE: 102888499(ACOT12)
PGIG: 120612585(ACOT12)
PVP: 105304674(ACOT12)
MJV: 108407043(ACOT12)
TOD: 119260987(ACOT12)
SARA: 101543838(ACOT12)
TMU: 101357788
ETF: 101644675(ACOT12)
DNM: 101437381(ACOT12)
MDO: 100015770(ACOT12)
GAS: 123236514(ACOT12)
SHR: 100919572(ACOT12)
AFZ: 127559237
PCW: 110222640(ACOT12)
OAA: 100081254(ACOT12)
GGA: 431627(ACOT12)
PCOC: 116235329(ACOT12)
MGP: 104915280(ACOT12)
CJO: 107306526(ACOT12)
TPAI: 128089274(ACOT12)
NMEL: 110389622(ACOT12)
APLA: 101791825(ACOT12)
ACYG: 106042718(ACOT12)
AFUL: 116501225(ACOT12)
TGU: 100219385(ACOT12)
LSR: 110482520(ACOT12)
SCAN: 103823057(ACOT12)
PMOA: 120496155(ACOT12)
OTC: 121347777(ACOT12)
PRUF: 121351283(ACOT12)
GFR: 102035411(ACOT12)
FAB: 101810335(ACOT12)
PHI: 102112382(ACOT12)
PMAJ: 107216375(ACOT12)
CCAE: 111941640(ACOT12)
CCW: 104695825(ACOT12)
CBRC: 103613260(ACOT12)
ETL: 114056129(ACOT12)
ZAB: 102061972(ACOT12)
SVG: 106861538(ACOT12)
FPG: 101924947(ACOT12)
FCH: 102059422(ACOT12)
CLV: 102092439(ACOT12)
EGZ: 104128353(ACOT12)
NNI: 104022999(ACOT12)
PLET: 104626682(ACOT12)
PCRI: 104027095
PCAO: 104046198(ACOT12)
ACUN: 113490327(ACOT12)
TALA: 104362994(ACOT12)
PADL: 103923438(ACOT12)
AFOR: 103900359(ACOT12)
ACHC: 115336815(ACOT12)
HALD: 104312186
HLE: 104838378(ACOT12)
AGEN: 126036511
GCL: 127027217
CCRI: 104164326(ACOT12)
CSTI: 104560214
CMAC: 104481913(ACOT12)
MUI: 104543030(ACOT12)
BREG: 104638202(ACOT12)
FGA: 104081085(ACOT12)
GSTE: 104252979(ACOT12)
LDI: 104349529(ACOT12)
MNB: 103768267(ACOT12)
OHA: 104335504(ACOT12)
NNT: 104405564(ACOT12)
SHAB: 115600863(ACOT12)
DPUB: 104309376(ACOT12)
PGUU: 104465968(ACOT12)
ACAR: 104526695
CPEA: 104398313(ACOT12)
AVIT: 104269672(ACOT12)
CVF: 104288130(ACOT12)
CUCA: 104057991(ACOT12)
TEO: 104381518
BRHI: 104499524(ACOT12)
AROW: 112968328(ACOT12)
NPD: 112946777(ACOT12)
TGT: 104573352(ACOT12)
DNE: 112983658(ACOT12)
SCAM: 104152902(ACOT12)
ASN: 102379080(ACOT12)
AMJ: 102570778(ACOT12)
CPOO: 109308072(ACOT12)
GGN: 109298053(ACOT12)
PSS: 102459479(ACOT12)
CMY: 102944174(ACOT12)
CPIC: 101931735(ACOT12)
TST: 117879436(ACOT12)
CABI: 116819787
MRV: 120407403(ACOT12)
ACS: 100554997(acot12)
PVT: 110077334(ACOT12)
SUND: 121921120(ACOT12)
PBI: 103061492(ACOT12)
PMUR: 107286315(ACOT12)
CTIG: 120297757(ACOT12)
TSR: 106551901(ACOT12)
PGUT: 117658741 117679346(ACOT12)
PTEX: 113448049(ACOT12)
NSS: 113414852(ACOT12)
PMUA: 114606537(ACOT12)
ZVI: 118076846(ACOT12)
HCG: 128346452(ACOT12)
GJA: 107120563(ACOT12)
STOW: 125436198(ACOT12)
XLA: 444535(acot12.L)
XTR: 100170471(acot12)
NPR: 108787611(ACOT12)
RTEM: 120930456(ACOT12)
BBUF: 120992492(ACOT12)
BGAR: 122935753(ACOT12)
DRE: 100536873(acot12)
SRX: 107758641(acot12)
SANH: 107658612(acot12)
SGH: 107588978
CCAR: 109071741(acot12)
CAUA: 113054589(acot12)
CGIB: 128020735
PTET: 122333719
LROH: 127171498
PPRM: 120482001
MAMB: 125262360
CIDE: 127521036
MASI: 127432873
CHAR: 105911606
SASA: 106568307
STRU: 115159765
OTW: 112220242
OMY: 110509639 110523420
OGO: 124049111
ONE: 115124688(acot12)
SALP: 111961784(acot12)
SNH: 120026391
CCLU: 121541525 121582667
PKI: 111859863(acot12)
AANG: 118213249
LOC: 102686048(acot12)
PSPA: 121312816
ARUT: 117403721 117973490
PSEX: 120532848
LCM: 102361204(ACOT12)
PXY: 105396710
SCE: YBL015W(ACH1)
SEUB: DI49_0165
SPAO: SPAR_B00910
AGO: AGOS_AFR020W
ERC: Ecym_6197
KLA: KLLA0_E10561g
KMX: KLMA_20042(ACH1)
LTH: KLTH0H08338g
VPO: Kpol_1002p112
ZRO: ZYRO0C13134g
CGR: CAGL0J04268g
NCS: NCAS_0B05550(NCAS0B05550)
NDI: NDAI_0B02890(NDAI0B02890)
TPF: TPHA_0C02890(TPHA0C02890)
TBL: TBLA_0E03560(TBLA0E03560)
TGB: HG536_0D02480
TDL: TDEL_0B04500(TDEL0B04500)
KAF: KAFR_0C02850(KAFR0C02850)
KNG: KNAG_0G01420(KNAG0G01420)
ZMK: HG535_0E03230
PPA: PAS_chr3_0253
DHA: DEHA2F18744g
PIC: PICST_78208(ACH1)
PGU: PGUG_02595
SPAA: SPAPADRAFT_61211
LEL: LELG_03976
CAL: CAALFM_C502000CA(ACH1)
CTP: CTRG_05320
COT: CORT_0F01790
CDU: CD36_51850
CTEN: CANTEDRAFT_113926
CLU: CLUG_02878
CLUS: A9F13_26g00176
CAUR: CJI96_0004449
SLB: AWJ20_2963(ACH1)
PKZ: C5L36_0A09950
BNN: FOA43_004748(ACH1)
BBRX: BRETT_001654(ACH1)
OPA: HPODL_04251
SLUD: SCDLUD_001585
NCR: NCU09770(acu-8)
NTE: NEUTE1DRAFT64379(NEUTE1DRAFT_64379)
SMP: SMAC_09176
PAN: PODANSg552
TTT: THITE_2124665
MTM: MYCTH_2313014
MGR: MGG_06609
PPEI: PpBr36_06207
TMN: UCRPA7_8846
SSCK: SPSK_09099
FGR: FGSG_08266
FPU: FPSE_09544
FVR: FVEG_01781
FOX: FOXG_02924
NHE: NECHADRAFT_67022
VAL: VDBG_01384
VDA: VDAG_07866
CFJ: CFIO01_02082
CLUP: CLUP02_12121
CHIG: CH63R_11542
SAPO: SAPIO_CDS6251
ELA: UCREL1_10661
PFY: PFICI_08653
SSL: SS1G_03975
BFU: BCIN_04g01780(Bcach1)
MBE: MBM_05077
PSCO: LY89DRAFT_700047
GLZ: GLAREA_08985
ANI: AN1547.2
AFM: AFUA_8G05580
ACT: ACLA_058990
NFI: NFIA_098300
AOR: AO090005000588
ANG: ANI_1_938144(An16g07110)
AFV: AFLA_003396
ALUC: AKAW2_70557A(ACH1)
ACHE: ACHE_31238S(ACH1)
APUU: APUU_21658A(ACH1)
PCS: Pc12g03130
PDP: PDIP_03640
TMF: EYB26_009407
TRG: TRUGW13939_02280
CIM: CIMG_08724
CPW: CPC735_063030
URE: UREG_02698
PBL: PAAG_04856
PBN: PADG_02597
AJE: HCAG_02840
BGH: BDBG_04166
PNO: SNOG_05874
PTE: PTT_11541
BZE: COCCADRAFT_30135
BSC: COCSADRAFT_145897
BOR: COCMIDRAFT_106926
ZTR: MYCGRDRAFT_101405
PFJ: MYCFIDRAFT_53451
FFU: CLAFUR5_03054
BCOM: BAUCODRAFT_33876
NPA: UCRNP2_9672
SPO: SPAC1952.09c
ADL: AURDEDRAFT_113021
LBC: LACBIDRAFT_252427
CCI: CC1G_08888
PCUB: JR316_0001544 JR316_0009903
MRR: Moror_11650
MORE: E1B28_011471(ACU8)
SCM: SCHCO_02637680(SCHCODRAFT_02637680)
DDI: DDB_G0287519
DPP: DICPUDRAFT_76067
DFA: DFA_08685
NGR: NAEGRDRAFT_38428
TVA: TVAG_2v0279550
GEM: GM21_0485 GM21_0842 GM21_3982
GEB: GM18_3910
GUR: Gura_4029
GEO: Geob_0742(ato-1) Geob_2594(ato-2)
GLO: Glov_0345 Glov_3013
GBN: GEOBRER4_04660(ato-1_1) GEOBRER4_07930(ato-1_2) GEOBRER4_37860(ato-2)
PPD: Ppro_0286
DAT: HRM2_15970(ach1)
DIN: Selin_0775
DAP: Dacet_1280
CNI: Calni_0213
FSI: Flexsi_1428
 » show all
Reference
1  [PMID:12999747]
  Authors
GERGELY J, HELE P, RAMAKRISHNAN CV.
  Title
Succinyl and acetyl coenzyme a deacylases.
  Journal
J Biol Chem 198:324-34 (1952)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.1
IUBMB Enzyme Nomenclature: 3.1.2.1
ExPASy - ENZYME nomenclature database: 3.1.2.1
BRENDA, the Enzyme Database: 3.1.2.1
CAS: 9027-54-7

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (553)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (403)   
   KEGG MGENES (30)   
   RefGene (119)   
Protein sequence (2230)   
   UniProt (2146)   
   SWISS-PROT (31)   
   RefSeq(pep) (42)   
   PDBSTR (11)   
DNA sequence (614)   
   RefSeq(nuc) (67)   
   GenBank (270)   
   EMBL (277)   
3D Structure (5)   
   PDB (5)   
Protein domain (24)   
   InterPro (22)   
   Pfam (2)   
All databases (3437)   

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