KEGG   ENZYME: 3.1.2.2Help
Entry
EC 3.1.2.2                  Enzyme                                 

Name
palmitoyl-CoA hydrolase;
long-chain fatty-acyl-CoA hydrolase;
palmitoyl coenzyme A hydrolase;
palmitoyl thioesterase;
palmitoyl coenzyme A hydrolase;
palmitoyl-CoA deacylase;
palmityl thioesterase;
palmityl-CoA deacylase;
fatty acyl thioesterase I;
palmityl thioesterase I
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
palmitoyl-CoA hydrolase
Reaction(IUBMB)
palmitoyl-CoA + H2O = CoA + palmitate [RN:R01274]
Reaction(KEGG)
Substrate
palmitoyl-CoA [CPD:C00154];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
palmitate [CPD:C00249]
Comment
Also hydrolyses CoA thioesters of other long-chain fatty acids.
History
EC 3.1.2.2 created 1961
Pathway
ec00062  Fatty acid elongation
ec01040  Biosynthesis of unsaturated fatty acids
ec01110  Biosynthesis of secondary metabolites
Orthology
K00659  bile acid-CoA:amino acid N-acyltransferase
K01068  acyl-coenzyme A thioesterase 1/2/4
K16339  acyl-coenzyme A thioesterase THEM4
K17360  acyl-coenzyme A thioesterase 7
K22554  acyl-coenzyme A thioesterase THEM5
Genes
HSA: 10965(ACOT2) 11332(ACOT7) 117145(THEM4) 122970(ACOT4) 284486(THEM5) 570(BAAT) 641371(ACOT1)
PTR: 100609278 453017(ACOT2) 453018(ACOT4) 457304(THEM5) 457305(THEM4) 472997 745616(ACOT7)
PPS: 100971608(ACOT2) 100972861 100973111(ACOT4) 100977829(ACOT7) 100978366 100981869(THEM4) 100983203(THEM5) 100992429(BAAT)
GGO: 101126562(ACOT7) 101139031(ACOT2) 101139248(THEM5) 101139653(ACOT4) 101140183(BAAT) 101140561(THEM4) 101140727 101148764 109025257
PON: 100173009(ACOT7) 100431907(BAAT) 100440874(THEM4) 100441238(THEM5) 100442699 100443692(ACOT4) 100444412(ACOT2)
NLE: 100581694(ACOT7) 100591490 100591629 100598200(BAAT) 100600007(THEM5) 100600341(THEM4) 100600674(ACOT2) 100601709(ACOT4)
MCC: 100429419(BAAT) 100430689(THEM5) 697011(ACOT2) 697131(ACOT4) 703288(ACOT7) 711796(THEM4)
MCF: 101866731(ACOT7) 101925489(ACOT2) 102116302(THEM5) 102120236 102132073(BAAT) 102144834(ACOT4) 102145205(THEM4) 107127621
CSAB: 103219118(BAAT) 103224017 103225695(ACOT7) 103229305(ACOT4) 103229306 103246191
RRO: 104657575(ACOT7) 104659239 104662094 104670797(BAAT) 104677548 104677549(ACOT4) 104679127 104681026(THEM4) 104681027(THEM5)
RBB: 108517951(ACOT7) 108522286 108533212(THEM4) 108533222(THEM5) 108534984(ACOT4) 108536227 108537176(BAAT)
CJC: 100390157(ACOT7) 100393740(THEM5) 100394190 100396712(BAAT) 100400243(THEM4) 100404918(ACOT4) 100409427
MMU: 12012(Baat) 171210(Acot2) 171281(Acot3) 171282(Acot4) 217698(Acot5) 26897(Acot1) 66198(Them5) 70025(Acot7) 75778(Them4)
RNO: 192272(Acot2) 26759(Acot7) 29725(Baat) 314304(Acot3) 361992(Them4) 361993(Them5) 503049(Acot5) 50559(Acot1) 681337(Acot4)
TUP: 102472797 102473647(BAAT) 102478970(ACOT7) 102482524(THEM4) 102482962(THEM5) 102487858 102497766 102502559(ACOT4) 102502991(ACOT2)
CFA: 479589(ACOT7) 481635 490770 490771(ACOT4) 608399(THEM5) 609163(THEM4)
AML: 100469263(ACOT7) 100471932(THEM4) 100476252(BAAT) 100478713(ACOT2) 100479468 100481250(THEM5) 105235582(ACOT4)
BTA: 511033(ACOT2) 511431(ACOT4) 512541 514788(ACOT7) 525765(THEM5) 530653 785383(ACOT2) 786798(BAAT) 787270(THEM4)
CFR: 102507666(THEM4) 102507701(ACOT2) 102508662(THEM5) 102517012(ACOT7) 102523415(BAAT)
CDK: 105086124 105086252(ACOT4) 105086253 105086911(BAAT) 105103231(THEM5) 105103232(THEM4) 105104722(ACOT7)
BACU: 102997243(ACOT4) 102998002(ACOT7) 103002195(THEM4) 103004901(ACOT2) 103006095 103012688(THEM5) 103017253(BAAT)
LVE: 103069390(THEM5) 103071761(ACOT4) 103072862(ACOT2) 103076361(ACOT7) 103079978 103081315 103082496(BAAT) 103091662(THEM4)
OOR: 101269957(ACOT7) 101276207 101276466(ACOT4) 101284164(BAAT) 101284403 101285149(THEM4) 101287201(THEM5)
MYD: 102752282(ACOT7) 102759368(ACOT2) 102759648(ACOT4) 102762307(THEM5) 102762592(THEM4) 102764048 102764710
HAI: 109374382(THEM5) 109374393(THEM4) 109381542 109381571(ACOT4) 109392168(ACOT7) 109395040(BAAT)
PALE: 102887428(ACOT7) 102892341(BAAT) 102894686(THEM5) 102897248(THEM4) 102897591
MDO: 100019143(THEM5) 100023136(BAAT) 100024487(ACOT2) 100026645(ACOT7)
OAA: 100081588(THEM4) 100084547(ACOT7) 100091099 100091117(ACOT2)
GGA: 100858223(THEM4) 419371(ACOT7) 423222(ACOT1L) 423247(ACOT2L) 428872(ACOT4) 769879(BAAT)
XLA: 100137716(LOC100488333.L) 108696607 108697249 108699174 108699179(acot2.L) 108707337 414573(acot2.S) 443715(them4.L)
DRE: 447878(acot7) 553440(acot20) 562047(acot21) 791152(them4)
AQU: 100635222
THJ: 104814102
CPAP: 110819430
CIT: 102621834
TCC: 18614145
GRA: 105802688
LJA: Lj0g3v0161459.1(Lj0g3v0161459.1) Lj1g3v2658230.1(Lj1g3v2658230.1) Lj1g3v2658230.2(Lj1g3v2658230.2) Lj1g3v2658230.3(Lj1g3v2658230.3) Lj1g3v2658230.4(Lj1g3v2658230.4) Lj1g3v2658230.5(Lj1g3v2658230.5) Lj1g3v2658230.6(Lj1g3v2658230.6)
FVE: 101302104
PPER: 18784798
PMUM: 103331993
PAVI: 110744916
ZJU: 107404880
CSV: 101222848
CMO: 103483275
MCHA: 111016341
RCU: 8261870
JCU: 105642991
POP: 7464929
VVI: 100256759
CANN: 107839179
NSY: 104243361
NTO: 104100056
INI: 109184689
SIND: 105173170
SOE: 110789465
NNU: 104586388
OSA: 4336637
DOSA: Os04t0558400-01(Os04g0558400)
OBR: 102718259
BDI: 100842302
ATS: 109761356
ZMA: 100273486(cl483_1)
SITA: 101781418
PDA: 103722362
EGU: 105034433
PEQ: 110032560
ATR: 18423021
SCE: YJR019C(TES1)
ERC: Ecym_7379
KMX: KLMA_60086(TES1)
NCS: NCAS_0D01710(NCAS0D01710)
NDI: NDAI_0C02900(NDAI0C02900)
TPF: TPHA_0A04850(TPHA0A04850)
TDL: TDEL_0E04960(TDEL0E04960)
MGR: MGG_02999
 » show all
Taxonomy
Reference
1  [PMID:4871199]
  Authors
Barnes EM Jr, Wakil SJ.
  Title
Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase.
  Journal
J Biol Chem 243:2955-62 (1968)
Reference
2  [PMID:6116156]
  Authors
Berge RK, Farstad M.
  Title
Long-chain fatty acyl-CoA hydrolase from rat liver mitochondria.
  Journal
Methods Enzymol 71 Pt C:234-42 (1981)
Reference
3  [PMID:6115749]
  Authors
Miyazawa S, Furuta S, Hashimoto T.
  Title
Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators.
  Journal
Eur J Biochem 117:425-30 (1981)
DOI:10.1111/j.1432-1033.1981.tb06356.x
Reference
4  [PMID:13670899]
  Authors
SRERE PA, SEUBERT W, LYNEN F.
  Title
Palmityl coenzyme A deacylase.
  Journal
Biochim Biophys Acta 33:313-9 (1959)
DOI:10.1016/0006-3002(59)90118-0
Reference
5
  Authors
Yabusaki, K.K. and Ballou, C.E.
  Title
Long-chain fatty acyl-CoA thioesterases from Mycobacterium smegmatis.
  Journal
Methods Enzymol 71:242-246 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.2
IUBMB Enzyme Nomenclature: 3.1.2.2
ExPASy - ENZYME nomenclature database: 3.1.2.2
BRENDA, the Enzyme Database: 3.1.2.2
CAS: 9025-87-0

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