Entry
Name
choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
choloyl-CoA hydrolase
Reaction(IUBMB)
choloyl-CoA + H2O = cholate + CoA [RN:
R07296 ]
Reaction(KEGG)
Substrate
Product
Comment
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].
History
EC 3.1.2.27 created 2005
Pathway
ec00120 Primary bile acid biosynthesis
Orthology
K11992 acyl-CoA thioesterase 8
Genes
DPUB : 104301469(ACOT8) 104303686
PFOR : 103144076 103144077
PMEI : 106910883 106911348
PSPA : 121297965 121319410
ARUT : 117429194 117434926
APLC : 110973614 110973634
CEL : CELE_F25E2.3(F25E2.3)
LGI : LOTGIDRAFT_149477 LOTGIDRAFT_229801
PMAX : 117328530 117337054
TAD : TRIADDRAFT_24642 TRIADDRAFT_50197 TRIADDRAFT_55623 TRIADDRAFT_55625
SSCK : SPSK_06467 SPSK_06504
FOX : FOXG_03400 FOXG_17358
BFU : BCIN_09g01530(Bctes1)
ABP : AGABI1DRAFT32971(AGABI1DRAFT_32971)
ABV : AGABI2DRAFT189998(AGABI2DRAFT_189998)
SCM : SCHCO_02612570(SCHCODRAFT_02612570)
» show all
Taxonomy
Reference
Authors
Hunt MC, Solaas K, Kase BF, Alexson SE.
Title
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
Journal
Sequence
Reference
Authors
Solaas K, Sletta RJ, Soreide O, Kase BF.
Title
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.
Journal
Reference
Authors
Russell DW
Title
The enzymes, regulation, and genetics of bile acid synthesis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.27
ExPASy - ENZYME nomenclature database: 3.1.2.27