KEGG ENZYME: 3.1.2.27

ENZYME: 3.1.2.27

Entry

EC 3.1.2.27                 Enzyme

Name

choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2

Class

Hydrolases;
Acting on ester bonds;
Thioester hydrolases

Sysname

choloyl-CoA hydrolase

Reaction(IUBMB)

choloyl-CoA + H2O = cholate + CoA [RN:R07296]

Reaction(KEGG)

R07296;
(other) R03974

Substrate

choloyl-CoA [CPD:C01794];
H2O [CPD:C00001]

Product

cholate [CPD:C00695];
CoA [CPD:C00010]

Comment

Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].

History

EC 3.1.2.27 created 2005

Pathway

ec00120

Primary bile acid biosynthesis

ec01100

Metabolic pathways

Orthology

K11992

acyl-CoA thioesterase 8

Genes

HSA:	10005(ACOT8)

PTR:	458288(ACOT8)

PPS:	100968654(ACOT8)

GGO:	101153013(ACOT8)

PON:	100173249(ACOT8)

NLE:	100583641(ACOT8)

MCC:	717238(ACOT8)

MCF:	102141803(ACOT8)

MTHB:

126963847

CSAB:

103245242(ACOT8)

CATY:

105588492(ACOT8)

PANU:

101008538(ACOT8)

TGE:	112632694(ACOT8)

RRO:	104678827(ACOT8)

RBB:	108533338(ACOT8)

TFN:	117068850(ACOT8)

PTEH:

111530022(ACOT8)

CANG:

105502422(ACOT8)

CJC:	100412346(ACOT8)

SBQ:	101031716(ACOT8)

CSYR:

103260276(ACOT8)

MMUR:

105859259(ACOT8)

LCAT:

123622172(ACOT8)

PCOQ:

105807181(ACOT8)

OGA:	100965931(ACOT8)

MMU:	170789(Acot8)

MCAL:

110289264(Acot8)

MPAH:

110318159(Acot8)

RNO:	170588(Acot8)

MCOC:

116091377(Acot8)

MUN:	110549372(Acot8)

CGE:

100761464

MAUA:

101831444(Acot8)

PLEU:

114692624(Acot8)

MORG:

121460241(Acot8)

MFOT:

126506885

AAMP:

119814211(Acot8)

NGI:	103737941(Acot8)

HGL:	101723404(Acot8)

CPOC:

100728225(Acot8)

CCAN:

109689267(Acot8)

DORD:

105981706(Acot8)

DSP:	122120244(Acot8)

NCAR:

124975916

OCU:

100338853

OPI:	101531181(ACOT8)

TUP:	102482443(ACOT8)

GVR:	103589583(ACOT8)

CFA:	477247(ACOT8)

CLUD:

112674049(ACOT8)

VVP:	112931856(ACOT8)

VLG:	121478146(ACOT8)

AML:	100473659(ACOT8)

UMR:	103669711(ACOT8)

UAH:	113258662(ACOT8)

UAR:	123797075(ACOT8)

ELK:

111141409

LLV:

125108322

MPUF:

101680439(ACOT8)

ORO:	101377976(ACOT8)

EJU:	114223172(ACOT8)

ZCA:	113937027(ACOT8)

MLX:	118011542(ACOT8)

NSU:	110579302(ACOT8)

LWW:	102732856(ACOT8)

FCA:	101086550(ACOT8)

PYU:	121012110(ACOT8)

PBG:	122467335(ACOT8)

LRUF:

124503241

PTG:	102970206(ACOT8)

PPAD:

109272355(ACOT8)

AJU:	106968968(ACOT8)

HHV:	120243280(ACOT8)

BTA:	504360(ACOT8)

BOM:	102271157(ACOT8)

BIU:	109567496(ACOT8)

BBUB:

102409800(ACOT8)

BBIS:

104985041(ACOT8)

CHX:	102180774(ACOT8)

OAS:	101115474(ACOT8)

ODA:	120869518(ACOT8)

CCAD:

122448646(ACOT8)

SSC:	100157173(ACOT8)

CFR:	102506493(ACOT8)

CBAI:

105071895(ACOT8)

CDK:	105087835(ACOT8)

VPC:	102531597(ACOT8)

BACU:

103019412(ACOT8)

LVE:	103089157(ACOT8)

OOR:	101275178(ACOT8)

DLE:	111170154(ACOT8)

PCAD:

102996587(ACOT8)

PSIU:

116739730(ACOT8)

ECB:	100056378(ACOT8)

EPZ:	103551928(ACOT8)

EAI:	106843034(ACOT8)

MYB:	102256663(ACOT8)

MYD:	102767910(ACOT8)

MMYO:

118662629(ACOT8)

MLF:	102421081(ACOT8)

MNA:	107530904(ACOT8)

PKL:	118708367(ACOT8)

HAI:	109379967(ACOT8)

DRO:	112304033(ACOT8)

SHON:

118985546(ACOT8)

AJM:	119063322(ACOT8)

PDIC:

114506673(ACOT8)

PHAS:

123815348(ACOT8)

MMF:	118618280(ACOT8)

RFQ:	117015874(ACOT8)

PALE:

102886033(ACOT8)

PGIG:

120603730(ACOT8)

PVP:	105298202(ACOT8)

RAY:	107514587(ACOT8)

MJV:	108392911(ACOT8)

TOD:	119236001(ACOT8)

SARA:

101537867(ACOT8)

LAV:	100662846(ACOT8)

TMU:

101348063

ETF:	101655607(ACOT8)

DNM:	101430308(ACOT8)

MDO:	100021873(ACOT8)

GAS:	123237285(ACOT8)

SHR:	100932746(ACOT8)

PCW:	110193672(ACOT8)

OAA:	114806147(ACOT8)

GGA:	419303(ACOT8)

PCOC:

116225686(ACOT8)

MGP:	104914099(ACOT8)

CJO:	107323042(ACOT8)

NMEL:

110408373(ACOT8)

APLA:

101799658(ACOT8)

AFUL:

116495637(ACOT8)

TGU:	100226822(ACOT8)

LSR:	110479811(ACOT8)

SCAN:

103818819(ACOT8)

PMOA:

120497811(ACOT8)

OTC:	121343744(ACOT8)

PRUF:

121359677(ACOT8)

GFR:	102041910(ACOT8)

FAB:	101812723(ACOT8)

PHI:	102113815(ACOT8)

PMAJ:

107213229(ACOT8)

CCAE:

111945659(ACOT8)

CCW:	104687856(ACOT8)

CBRC:

103617359(ACOT8)

ETL:	114063020(ACOT8)

ZAB:	102069111(ACOT8)

ACHL:

103797652(ACOT8)

FPG:	101912113(ACOT8)

FCH:	102046223(ACOT8)

CLV:	102088484(ACOT8)

EGZ:	104127963(ACOT8)

NNI:	104018336(ACOT8)

PLET:

104624498(ACOT8)

PCRI:

104025211(ACOT8)

PCAO:

104039868(ACOT8)

ACUN:

113487671(ACOT8)

TALA:

116962521(ACOT8)

PADL:

103916207(ACOT8)

AFOR:

103899134(ACOT8)

ACHC:

115339650(ACOT8)

HLE:	104833153(ACOT8)

AGEN:

126045394

GCL:

127023511

CCRI:

104155488(ACOT8)

CSTI:

104561154(ACOT8)

FGA:	104070180(ACOT8)

GSTE:

104263491(ACOT8)

DPUB:

104301469(ACOT8) 104303686

CPEA:

104385556(ACOT8)

AVIT:

104268624

CVF:	104293964(ACOT8)

CUCA:

104060844(ACOT8)

TEO:	104373164(ACOT8)

AAM:	106497599(ACOT8)

AROW:

112974738(ACOT8)

NPD:	112949527(ACOT8)

TGT:	104566758(ACOT8)

DNE:	112994571(ACOT8)

SCAM:

104140407(ACOT8)

ASN:	102374940(ACOT8)

AMJ:	109282370(ACOT8)

CPOO:

109313118(ACOT8)

GGN:	109292476(ACOT8)

PSS:	102459959(ACOT8)

CMY:	102946356(ACOT8)

CPIC:

101938495(ACOT8)

TST:	117885666(ACOT8)

CABI:

116831197(ACOT8)

MRV:	120379742(ACOT8)

ACS:	100554009(acot8)

PVT:	110086215(ACOT8)

SUND:

121928202(ACOT8)

PBI:	103055025(ACOT8)

PMUR:

107298443(ACOT8)

CTIG:

120307548(ACOT8)

TSR:	106540329(ACOT8)

PGUT:

117669613(ACOT8)

PMUA:

114599885(ACOT8)

ZVI:	118089065(ACOT8)

GJA:	107111365(ACOT8)

STOW:

125433863(ACOT8)

XLA:	108702736(acot8.S)

XTR:	100495154(acot8)

NPR:	108793375(ACOT8)

RTEM:

120918582(ACOT8)

BBUF:

121003199(ACOT8)

BGAR:

122940126(ACOT8)

DRE:	450052(acot8)

SRX:	107722006 107730625

SANH:

107670930

SGH:	107551324(acot8)

CCAR:

109081237(acot8)

CAUA:

113054961(acot8)

PPRM:

120473404(acot8)

MAMB:

125256785(acot8)

IPU:	108254895(acot8)

PHYP:

113537819(acot8)

TFD:	113647842(acot8)

AMEX:

103036772(acot8)

EEE:	113572378(acot8)

TRU:	101074147(acot8)

TNG:	GSTEN00014144G001

LCO:	104936755(acot8)

NCC:	104967028(acot8)

CGOB:

115008355(acot8)

ELY:	117256975(acot8)

EFO:	125886861(acot8)

PLEP:

121950338(acot8)

SLUC:

116037096(acot8)

ECRA:

117942829(acot8)

ESP:	116687352(acot8)

PFLV:

114554325(acot8)

GAT:	120835511(acot8)

PPUG:

119194178(acot8)

MSAM:

119886519(acot8)

CUD:	121507009(acot8)

ALAT:

119020976(acot8)

MZE:	101476913(acot8)

ONL:	100712267(acot8)

OAU:	116327003(acot8)

OLA:	101168035(acot8)

OML:	112144512(acot8)

XMA:	102229258(acot8)

XCO:	114135809(acot8)

XHE:	116711120(acot8)

PRET:

103465408(acot8)

PFOR:

103144076 103144077

PLAI:

106938527(acot8)

PMEI:

106910883 106911348

GAF:	122833756(acot8)

CVG:	107093191(acot8)

CTUL:

119785997(acot8)

GMU:	124856638(acot8)

NFU:	107385835(acot8)

KMR:	108251003(acot8)

ALIM:

106528518(acot8)

AOCE:

111562665(acot8)

CSEM:

103386342(acot8)

POV:	109629039(acot8)

SSEN:

122768297(acot8)

HHIP:

117760955(acot8)

HSP:	118105251(acot8)

LCF:

108886572

SDU:	111221847(acot8)

SLAL:

111668590(acot8)

XGL:	120807021(acot8)

HCQ:	109521623(acot8)

BPEC:

110154578(acot8)

MALB:

109956138(acot8)

BSPL:

114856256(acot8)

SASA:

100380377(acot8)

STRU:

115207230(acot8)

OTW:	112239375(acot8)

OMY:	110494851(acot8)

OGO:	124003447(acot8)

ONE:	115124767(acot8)

SALP:

112072437(acot8)

SNH:	120037213(acot8)

CCLU:

121575384(acot8)

ELS:	105010097(acot8)

SFM:	108923421(acot8)

PKI:	111840975(acot8)

AANG:

118210526(acot8)

LOC:	102689344(acot8)

PSPA:

121297965 121319410

ARUT:

117429194 117434926

PSEX:

120514560(acot8)

LCM:	102353321(ACOT8)

CMK:	103191249(acot8)

RTP:	109933390(acot8)

SPU:

589369

APLC:

110973614 110973634

SKO:

102804197

CEL:	CELE_F25E2.3(F25E2.3)

CBR:	CBG_08110 CBG_24030

NAI:	NECAME_01234

TSP:	Tsp_08781 Tsp_10152

HRO:	HELRODRAFT_177007

LGI:	LOTGIDRAFT_149477 LOTGIDRAFT_229801

PCAN:

112553245

BGT:

106051927

GAE:

121388485

HRF:	124137954 124137956

HRJ:	124287001 124287035

CRG:

105345904

MYI:

110443770

PMAX:

117328530 117337054

MMER:

123549209

OBI:

106884441

OSN:	115217550 115217917

LAK:

106169050

TAD:	TRIADDRAFT_24642 TRIADDRAFT_50197 TRIADDRAFT_55623 TRIADDRAFT_55625

YLI:	YALI0F14729g

MTM:	MYCTH_2297376

CTHR:

CTHT_0014910

SSCK:

SPSK_06467 SPSK_06504

FGR:	FGSG_08585

FPU:	FPSE_06466

FOX:	FOXG_03400 FOXG_17358

TRE:	TRIREDRAFT_119875

TRR:	M419DRAFT_101852

MAJ:

MAA_09089

CMT:

CCM_03161

CFJ:	CFIO01_06873

ELA:	UCREL1_6024

PFY:	PFICI_10668

BFU:	BCIN_09g01530(Bctes1)

PSCO:

LY89DRAFT_693556

PCS:	Pc22g07280

PNO:	SNOG_02275

PTE:

PTT_02801

BZE:	COCCADRAFT_31937

BSC:	COCSADRAFT_34794

BOR:	COCMIDRAFT_92275

AALT:

CC77DRAFT_1032569

FFU:	CLAFUR5_00383

BCOM:

BAUCODRAFT_126390

NPA:	UCRNP2_8326

PCO:	PHACADRAFT_247055

HIR:	HETIRDRAFT_437983

ADL:	AURDEDRAFT_179219

FME:	FOMMEDRAFT_121626

LBC:	LACBIDRAFT_301765

CCI:	CC1G_04423

ABP:	AGABI1DRAFT32971(AGABI1DRAFT_32971)

ABV:	AGABI2DRAFT189998(AGABI2DRAFT_189998)

MRR:

Moror_224

E1B28_000923

SCM:	SCHCO_02612570(SCHCODRAFT_02612570)

SLA:	SERLADRAFT_476615

WIC:	J056_000829

PFP:	PFL1_03649

MLR:	MELLADRAFT_72857

TCR:

504149.55

» show all

Reference

1 [PMID:11673457]

Authors

Hunt MC, Solaas K, Kase BF, Alexson SE.

Title

Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.

Journal

J Biol Chem 277:1128-38 (2002)
DOI:10.1074/jbc.M106458200

Sequence

[mmu:170789]

Reference

2 [PMID:10817395]

Authors

Solaas K, Sletta RJ, Soreide O, Kase BF.

Title

Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.

Journal

Scand J Clin Lab Invest 60:91-102 (2000)
DOI:10.1080/00365510050184903

Reference

3 [PMID:12543708]

Authors

Russell DW

Title

The enzymes, regulation, and genetics of bile acid synthesis.

Journal

Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712

Other DBs

ExplorEnz - The Enzyme Database:

3.1.2.27

IUBMB Enzyme Nomenclature:

3.1.2.27

ExPASy - ENZYME nomenclature database:

3.1.2.27

BRENDA, the Enzyme Database:

3.1.2.27

DBGET integrated database retrieval system