KEGG   ENZYME: 3.1.2.27
Entry
EC 3.1.2.27                 Enzyme                                 
Name
choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
choloyl-CoA hydrolase
Reaction(IUBMB)
choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Reaction(KEGG)
R07296;
(other) R03974
Substrate
choloyl-CoA [CPD:C01794];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
CoA [CPD:C00010]
Comment
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].
History
EC 3.1.2.27 created 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K11992  acyl-CoA thioesterase 8
Genes
HSA10005(ACOT8)
PTR458288(ACOT8)
PPS100968654(ACOT8)
GGO101153013(ACOT8)
PON100173249(ACOT8)
NLE100583641(ACOT8)
MCC717238(ACOT8)
MCF102141803(ACOT8)
MTHB126963847
CSAB103245242(ACOT8)
CATY105588492(ACOT8)
PANU101008538(ACOT8)
TGE112632694(ACOT8)
RRO104678827(ACOT8)
RBB108533338(ACOT8)
TFN117068850(ACOT8)
PTEH111530022(ACOT8)
CANG105502422(ACOT8)
CJC100412346(ACOT8)
SBQ101031716(ACOT8)
CSYR103260276(ACOT8)
MMUR105859259(ACOT8)
LCAT123622172(ACOT8)
PCOQ105807181(ACOT8)
OGA100965931(ACOT8)
MMU170789(Acot8)
MCAL110289264(Acot8)
MPAH110318159(Acot8)
RNO170588(Acot8)
MCOC116091377(Acot8)
MUN110549372(Acot8)
CGE100761464
MAUA101831444(Acot8)
PLEU114692624(Acot8)
MORG121460241(Acot8)
MFOT126506885
AAMP119814211(Acot8)
NGI103737941(Acot8)
HGL101723404(Acot8)
CPOC100728225(Acot8)
CCAN109689267(Acot8)
DORD105981706(Acot8)
DSP122120244(Acot8)
NCAR124975916
OCU100338853
OPI101531181(ACOT8)
TUP102482443(ACOT8)
GVR103589583(ACOT8)
CFA477247(ACOT8)
CLUD112674049(ACOT8)
VVP112931856(ACOT8)
VLG121478146(ACOT8)
AML100473659(ACOT8)
UMR103669711(ACOT8)
UAH113258662(ACOT8)
UAR123797075(ACOT8)
ELK111141409
LLV125108322
MPUF101680439(ACOT8)
ORO101377976(ACOT8)
EJU114223172(ACOT8)
ZCA113937027(ACOT8)
MLX118011542(ACOT8)
NSU110579302(ACOT8)
LWW102732856(ACOT8)
FCA101086550(ACOT8)
PYU121012110(ACOT8)
PBG122467335(ACOT8)
LRUF124503241
PTG102970206(ACOT8)
PPAD109272355(ACOT8)
AJU106968968(ACOT8)
HHV120243280(ACOT8)
BTA504360(ACOT8)
BOM102271157(ACOT8)
BIU109567496(ACOT8)
BBUB102409800(ACOT8)
BBIS104985041(ACOT8)
CHX102180774(ACOT8)
OAS101115474(ACOT8)
ODA120869518(ACOT8)
CCAD122448646(ACOT8)
SSC100157173(ACOT8)
CFR102506493(ACOT8)
CBAI105071895(ACOT8)
CDK105087835(ACOT8)
VPC102531597(ACOT8)
BACU103019412(ACOT8)
LVE103089157(ACOT8)
OOR101275178(ACOT8)
DLE111170154(ACOT8)
PCAD102996587(ACOT8)
PSIU116739730(ACOT8)
ECB100056378(ACOT8)
EPZ103551928(ACOT8)
EAI106843034(ACOT8)
MYB102256663(ACOT8)
MYD102767910(ACOT8)
MMYO118662629(ACOT8)
MLF102421081(ACOT8)
MNA107530904(ACOT8)
PKL118708367(ACOT8)
HAI109379967(ACOT8)
DRO112304033(ACOT8)
SHON118985546(ACOT8)
AJM119063322(ACOT8)
PDIC114506673(ACOT8)
PHAS123815348(ACOT8)
MMF118618280(ACOT8)
RFQ117015874(ACOT8)
PALE102886033(ACOT8)
PGIG120603730(ACOT8)
PVP105298202(ACOT8)
RAY107514587(ACOT8)
MJV108392911(ACOT8)
TOD119236001(ACOT8)
SARA101537867(ACOT8)
LAV100662846(ACOT8)
TMU101348063
ETF101655607(ACOT8)
DNM101430308(ACOT8)
MDO100021873(ACOT8)
GAS123237285(ACOT8)
SHR100932746(ACOT8)
PCW110193672(ACOT8)
OAA114806147(ACOT8)
GGA419303(ACOT8)
PCOC116225686(ACOT8)
MGP104914099(ACOT8)
CJO107323042(ACOT8)
NMEL110408373(ACOT8)
APLA101799658(ACOT8)
AFUL116495637(ACOT8)
TGU100226822(ACOT8)
LSR110479811(ACOT8)
SCAN103818819(ACOT8)
PMOA120497811(ACOT8)
OTC121343744(ACOT8)
PRUF121359677(ACOT8)
GFR102041910(ACOT8)
FAB101812723(ACOT8)
PHI102113815(ACOT8)
PMAJ107213229(ACOT8)
CCAE111945659(ACOT8)
CCW104687856(ACOT8)
CBRC103617359(ACOT8)
ETL114063020(ACOT8)
ZAB102069111(ACOT8)
ACHL103797652(ACOT8)
FPG101912113(ACOT8)
FCH102046223(ACOT8)
CLV102088484(ACOT8)
EGZ104127963(ACOT8)
NNI104018336(ACOT8)
PLET104624498(ACOT8)
PCRI104025211(ACOT8)
PCAO104039868(ACOT8)
ACUN113487671(ACOT8)
TALA116962521(ACOT8)
PADL103916207(ACOT8)
AFOR103899134(ACOT8)
ACHC115339650(ACOT8)
HLE104833153(ACOT8)
AGEN126045394
GCL127023511
CCRI104155488(ACOT8)
CSTI104561154(ACOT8)
FGA104070180(ACOT8)
GSTE104263491(ACOT8)
DPUB104301469(ACOT8) 104303686
CPEA104385556(ACOT8)
AVIT104268624
CVF104293964(ACOT8)
CUCA104060844(ACOT8)
TEO104373164(ACOT8)
AAM106497599(ACOT8)
AROW112974738(ACOT8)
NPD112949527(ACOT8)
TGT104566758(ACOT8)
DNE112994571(ACOT8)
SCAM104140407(ACOT8)
ASN102374940(ACOT8)
AMJ109282370(ACOT8)
CPOO109313118(ACOT8)
GGN109292476(ACOT8)
PSS102459959(ACOT8)
CMY102946356(ACOT8)
CPIC101938495(ACOT8)
TST117885666(ACOT8)
CABI116831197(ACOT8)
MRV120379742(ACOT8)
ACS100554009(acot8)
PVT110086215(ACOT8)
SUND121928202(ACOT8)
PBI103055025(ACOT8)
PMUR107298443(ACOT8)
CTIG120307548(ACOT8)
TSR106540329(ACOT8)
PGUT117669613(ACOT8)
PMUA114599885(ACOT8)
ZVI118089065(ACOT8)
GJA107111365(ACOT8)
STOW125433863(ACOT8)
XLA108702736(acot8.S)
XTR100495154(acot8)
NPR108793375(ACOT8)
RTEM120918582(ACOT8)
BBUF121003199(ACOT8)
BGAR122940126(ACOT8)
DRE450052(acot8)
SRX107722006 107730625
SANH107670930
SGH107551324(acot8)
CCAR109081237(acot8)
CAUA113054961(acot8)
PPRM120473404(acot8)
MAMB125256785(acot8)
IPU108254895(acot8)
PHYP113537819(acot8)
TFD113647842(acot8)
AMEX103036772(acot8)
EEE113572378(acot8)
TRU101074147(acot8)
TNGGSTEN00014144G001
LCO104936755(acot8)
NCC104967028(acot8)
CGOB115008355(acot8)
ELY117256975(acot8)
EFO125886861(acot8)
PLEP121950338(acot8)
SLUC116037096(acot8)
ECRA117942829(acot8)
ESP116687352(acot8)
PFLV114554325(acot8)
GAT120835511(acot8)
PPUG119194178(acot8)
MSAM119886519(acot8)
CUD121507009(acot8)
ALAT119020976(acot8)
MZE101476913(acot8)
ONL100712267(acot8)
OAU116327003(acot8)
OLA101168035(acot8)
OML112144512(acot8)
XMA102229258(acot8)
XCO114135809(acot8)
XHE116711120(acot8)
PRET103465408(acot8)
PFOR103144076 103144077
PLAI106938527(acot8)
PMEI106910883 106911348
GAF122833756(acot8)
CVG107093191(acot8)
CTUL119785997(acot8)
GMU124856638(acot8)
NFU107385835(acot8)
KMR108251003(acot8)
ALIM106528518(acot8)
AOCE111562665(acot8)
CSEM103386342(acot8)
POV109629039(acot8)
SSEN122768297(acot8)
HHIP117760955(acot8)
HSP118105251(acot8)
LCF108886572
SDU111221847(acot8)
SLAL111668590(acot8)
XGL120807021(acot8)
HCQ109521623(acot8)
BPEC110154578(acot8)
MALB109956138(acot8)
BSPL114856256(acot8)
SASA100380377(acot8)
STRU115207230(acot8)
OTW112239375(acot8)
OMY110494851(acot8)
OGO124003447(acot8)
ONE115124767(acot8)
SALP112072437(acot8)
SNH120037213(acot8)
CCLU121575384(acot8)
ELS105010097(acot8)
SFM108923421(acot8)
PKI111840975(acot8)
AANG118210526(acot8)
LOC102689344(acot8)
PSPA121297965 121319410
ARUT117429194 117434926
PSEX120514560(acot8)
LCM102353321(ACOT8)
CMK103191249(acot8)
RTP109933390(acot8)
SPU589369
APLC110973614 110973634
SKO102804197
CELCELE_F25E2.3(F25E2.3)
CBRCBG_08110 CBG_24030
NAINECAME_01234
TSPTsp_08781 Tsp_10152
HROHELRODRAFT_177007
LGILOTGIDRAFT_149477 LOTGIDRAFT_229801
PCAN112553245
BGT106051927
GAE121388485
HRF124137954 124137956
HRJ124287001 124287035
CRG105345904
MYI110443770
PMAX117328530 117337054
MMER123549209
OBI106884441
OSN115217550 115217917
LAK106169050
TADTRIADDRAFT_24642 TRIADDRAFT_50197 TRIADDRAFT_55623 TRIADDRAFT_55625
YLIYALI0F14729g
MTMMYCTH_2297376
CTHRCTHT_0014910
SSCKSPSK_06467 SPSK_06504
FGRFGSG_08585
FPUFPSE_06466
FOXFOXG_03400 FOXG_17358
TRETRIREDRAFT_119875
TRRM419DRAFT_101852
MAJMAA_09089
CMTCCM_03161
CFJCFIO01_06873
ELAUCREL1_6024
PFYPFICI_10668
BFUBCIN_09g01530(Bctes1)
PSCOLY89DRAFT_693556
PCSPc22g07280
PNOSNOG_02275
PTEPTT_02801
BZECOCCADRAFT_31937
BSCCOCSADRAFT_34794
BORCOCMIDRAFT_92275
AALTCC77DRAFT_1032569
FFUCLAFUR5_00383
BCOMBAUCODRAFT_126390
NPAUCRNP2_8326
PCOPHACADRAFT_247055
HIRHETIRDRAFT_437983
ADLAURDEDRAFT_179219
FMEFOMMEDRAFT_121626
LBCLACBIDRAFT_301765
CCICC1G_04423
ABPAGABI1DRAFT32971(AGABI1DRAFT_32971)
ABVAGABI2DRAFT189998(AGABI2DRAFT_189998)
MRRMoror_224
MOREE1B28_000923
SCMSCHCO_02612570(SCHCODRAFT_02612570)
SLASERLADRAFT_476615
WICJ056_000829
PFPPFL1_03649
MLRMELLADRAFT_72857
TCR504149.55
 » show all
Reference
1  [PMID:11673457]
  Authors
Hunt MC, Solaas K, Kase BF, Alexson SE.
  Title
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
  Journal
J Biol Chem 277:1128-38 (2002)
DOI:10.1074/jbc.M106458200
  Sequence
[mmu:170789]
Reference
2  [PMID:10817395]
  Authors
Solaas K, Sletta RJ, Soreide O, Kase BF.
  Title
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.
  Journal
Scand J Clin Lab Invest 60:91-102 (2000)
DOI:10.1080/00365510050184903
Reference
3  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.27
IUBMB Enzyme Nomenclature: 3.1.2.27
ExPASy - ENZYME nomenclature database: 3.1.2.27
BRENDA, the Enzyme Database: 3.1.2.27

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