KEGG   ENZYME: 3.1.2.27
Entry
EC 3.1.2.27                 Enzyme                                 
Name
choloyl-CoA hydrolase;
PTE-2 (ambiguous);
choloyl-coenzyme A thioesterase;
chenodeoxycholoyl-coenzyme A thioesterase;
peroxisomal acyl-CoA thioesterase 2
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
choloyl-CoA hydrolase
Reaction(IUBMB)
choloyl-CoA + H2O = cholate + CoA [RN:R07296]
Reaction(KEGG)
R07296;
(other) R03974
Substrate
choloyl-CoA [CPD:C01794];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
CoA [CPD:C00010]
Comment
Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].
History
EC 3.1.2.27 created 2005
Pathway
ec00120  Primary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K11992  acyl-CoA thioesterase 8
Genes
HSA10005(ACOT8)
PTR458288(ACOT8)
PPS100968654(ACOT8)
GGO101153013(ACOT8)
PON100173249(ACOT8)
NLE100583641(ACOT8)
HMH116460908
MCC717238(ACOT8)
MCF102141803(ACOT8)
MTHB126963847
MNI105496457(ACOT8)
CSAB103245242(ACOT8)
CATY105588492(ACOT8)
PANU101008538(ACOT8)
TGE112632694(ACOT8)
MLEU105542302(ACOT8)
RRO104678827(ACOT8)
RBB108533338(ACOT8)
TFN117068850(ACOT8)
PTEH111530022(ACOT8)
CANG105502422(ACOT8)
CJC100412346(ACOT8)
SBQ101031716(ACOT8)
CIMI108313038(ACOT8)
CSYR103260276(ACOT8)
MMUR105859259(ACOT8)
LCAT123622172(ACOT8)
PCOQ105807181(ACOT8)
OGA100965931(ACOT8)
MMU170789(Acot8)
MCAL110289264(Acot8)
MPAH110318159(Acot8)
RNO170588(Acot8)
MCOC116091377(Acot8)
ANU117702465(Acot8)
MUN110549372(Acot8)
CGE100761464
MAUA101831444(Acot8)
PROB127223747(Acot8)
PLEU114692624(Acot8)
MORG121460241(Acot8)
MFOT126506885
AAMP119814211(Acot8)
NGI103737941(Acot8)
HGL101723404(Acot8)
CPOC100728225(Acot8)
CCAN109689267(Acot8)
DORD105981706(Acot8)
DSP122120244(Acot8)
PLOP125353839(Acot8)
NCAR124975916
MMMA107136610(Acot8)
OCU100338853
OPI101531181(ACOT8)
TUP102482443(ACOT8)
GVR103589583(ACOT8)
CFA477247(ACOT8)
CLUD112674049(ACOT8)
VVP112931856(ACOT8)
VLG121478146(ACOT8)
NPO129495739(ACOT8)
AML100473659(ACOT8)
UMR103669711(ACOT8)
UAH113258662(ACOT8)
UAR123797075(ACOT8)
ELK111141409
LLV125108322
MPUF101680439(ACOT8)
MNP132021981(ACOT8)
MLK131807542(ACOT8)
NVS122916027(ACOT8)
ORO101377976(ACOT8)
EJU114223172(ACOT8)
ZCA113937027(ACOT8)
MLX118011542(ACOT8)
NSU110579302(ACOT8)
LWW102732856(ACOT8)
FCA101086550(ACOT8)
PYU121012110(ACOT8)
PCOO112869153(ACOT8)
PBG122467335(ACOT8)
PVIV125161545(ACOT8)
LRUF124503241
PTG102970206(ACOT8)
PPAD109272355(ACOT8)
PUC125936527
AJU106968968
HHV120243280(ACOT8)
BTA504360(ACOT8)
BOM102271157(ACOT8)
BIU109567496(ACOT8)
BBUB102409800(ACOT8)
BBIS104985041(ACOT8)
CHX102180774(ACOT8)
OAS101115474(ACOT8)
BTAX128058131(ACOT8)
ODA120869518(ACOT8)
CCAD122448646(ACOT8)
MBEZ129564211(ACOT8)
SSC100157173(ACOT8)
CFR102506493(ACOT8)
CBAI105071895(ACOT8)
CDK105087835(ACOT8)
VPC102531597(ACOT8)
BACU103019412(ACOT8)
BMUS118881754(ACOT8)
LVE103089157(ACOT8)
OOR101275178(ACOT8)
DLE111170154(ACOT8)
PCAD102996587(ACOT8)
PSIU116739730(ACOT8)
NASI112400870(ACOT8)
ECB100056378(ACOT8)
EPZ103551928(ACOT8)
EAI106843034(ACOT8)
MYB102256663(ACOT8)
MYD102767910(ACOT8)
MMYO118662629(ACOT8)
MLF102421081(ACOT8)
PKL118708367(ACOT8)
EFUS103301841(ACOT8)
MNA107530904(ACOT8)
DRO112304033(ACOT8)
SHON118985546(ACOT8)
AJM119063322(ACOT8)
PDIC114506673(ACOT8)
PHAS123815348(ACOT8)
MMF118618280(ACOT8)
PPAM129070658(ACOT8)
HAI109379967(ACOT8)
RFQ117015874(ACOT8)
PALE102886033(ACOT8)
PGIG120603730(ACOT8)
PVP105298202(ACOT8)
RAY107514587(ACOT8)
MJV108392911
TOD119236001(ACOT8)
SARA101537867(ACOT8)
SETR126017405(ACOT8)
LAV100662846(ACOT8)
TMU101348063
ETF101655607(ACOT8)
DNM101430308(ACOT8)
MDO100021873(ACOT8)
GAS123237285(ACOT8)
SHR100932746(ACOT8)
AFZ127550769
PCW110193672(ACOT8)
OAA114806147(ACOT8)
GGA419303(ACOT8)
PCOC116225686(ACOT8)
MGP104914099(ACOT8)
CJO107323042(ACOT8)
TPAI128080879(ACOT8)
LMUT125701359(ACOT8)
NMEL110408373(ACOT8)
APLA101799658(ACOT8)
CATA118258407(ACOT8)
AFUL116495637(ACOT8)
TGU100226822(ACOT8)
LSR110479811(ACOT8)
SCAN103818819(ACOT8)
PMOA120497811(ACOT8)
OTC121343744(ACOT8)
PRUF121359677(ACOT8)
GFR102041910(ACOT8)
FAB101812723(ACOT8)
OMA130261256(ACOT8)
PHI102113815(ACOT8)
PMAJ107213229(ACOT8)
CCAE111945659(ACOT8)
CCW104687856(ACOT8)
CBRC103617359(ACOT8)
ETL114063020(ACOT8)
ZAB102069111(ACOT8)
ZLE135456454(ACOT8)
ACHL103797652(ACOT8)
SVG106861628(ACOT8)
MMEA130573501(ACOT8)
HRT120760234(ACOT8)
FPG101912113(ACOT8)
FCH102046223(ACOT8)
CLV102088484(ACOT8)
EGZ104127963(ACOT8)
NNI104018336(ACOT8)
PCRI104025211(ACOT8)
PLET104624498(ACOT8)
PCAO104039868(ACOT8)
ACUN113487671(ACOT8)
TALA116962521(ACOT8)
PADL103916207(ACOT8)
AFOR103899134(ACOT8)
ACHC115339650(ACOT8)
HLE104833153(ACOT8)
AGEN126045394
GCL127023511
CCRI104155488(ACOT8)
CSTI104561154(ACOT8)
BREG104638419(ACOT8)
FGA104070180(ACOT8)
GSTE104263491(ACOT8)
SHAB115615007(ACOT8)
DPUB104301469(ACOT8) 104303686
CPEA104385556(ACOT8)
AVIT104268624
CVF104293964(ACOT8)
RTD128916792(ACOT8)
CUCA104060844(ACOT8)
TEO104373164(ACOT8)
AAM106497599(ACOT8)
AROW112974738(ACOT8)
NPD112949527(ACOT8)
TGT104566758(ACOT8)
DNE112994571(ACOT8)
SCAM104140407(ACOT8)
ASN102374940(ACOT8)
AMJ109282370(ACOT8)
CPOO109313118(ACOT8)
GGN109292476(ACOT8)
PSS102459959(ACOT8)
CMY102946356(ACOT8)
CCAY125622162(ACOT8)
DCC119841846(ACOT8)
CPIC101938495(ACOT8)
TST117885666(ACOT8)
CABI116831197(ACOT8)
MRV120379742(ACOT8)
ACS100554009(acot8)
ASAO132772952(ACOT8)
PVT110086215(ACOT8)
SUND121928202(ACOT8)
PBI103055025(ACOT8)
PMUR107298443(ACOT8)
CTIG120307548(ACOT8)
TSR106540329(ACOT8)
PGUT117669613(ACOT8)
APRI131195812(ACOT8)
PTEX113450536(ACOT8)
NSS113427137(ACOT8)
PMUA114599885(ACOT8)
PRAF128416723(ACOT8)
ZVI118089065(ACOT8)
HCG128323735(ACOT8)
GJA107111365(ACOT8)
STOW125433863(ACOT8)
EMC129330950(ACOT8)
XLA108702736(acot8.S)
XTR100495154(acot8)
NPR108793375(ACOT8)
RTEM120918582(ACOT8)
BBUF121003199(ACOT8)
BGAR122940126(ACOT8)
MUO115476989(ACOT8)
GSH117345722(ACOT8)
DRE450052(acot8)
SRX107722006 107730625
SANH107670930
SGH107551324(acot8)
CCAR109081237(acot8)
CAUA113054961(acot8)
CGIB128022675
PTET122353690(acot8)
LROH127173232(acot8)
OMC131549586(acot8)
PPRM120473404(acot8)
RKG130086269(acot8)
MAMB125256785(acot8)
CIDE127522963
MASI127428303
TROS130571306(acot8)
TDW130410380(acot8)
MANU129428090(acot8)
IPU108254895
IFU128624953(acot8)
PHYP113537819(acot8)
TFD113647842(acot8)
TVC132838415(acot8)
TRN134301853(acot8)
AMEX103036772(acot8)
CMAO118799914(acot8)
EEE113572378(acot8)
CHAR105909841(acot8)
TRU101074147(acot8)
TFS130524564(acot8)
TNGGSTEN00014144G001
LCO104936755(acot8)
NCC104967028(acot8)
TBEN117475401(acot8)
CGOB115008355(acot8)
PGEO117443159(acot8)
GACU117560402(acot8)
EMAC134883148(acot8)
ELY117256975(acot8)
EFO125886861(acot8)
PLEP121950338(acot8)
SLUC116037096(acot8)
ECRA117942829(acot8)
ESP116687352(acot8)
PFLV114554325(acot8)
GAT120835511(acot8)
PPUG119194178(acot8)
AFB129105886(acot8)
CLUM117731481(acot8)
PSWI130208302(acot8)
MSAM119886519(acot8)
CUD121507009(acot8)
ALAT119020976(acot8)
MZE101476913(acot8)
ONL100712267(acot8)
OAU116327003(acot8)
OLA101168035(acot8)
OML112144512(acot8)
CSAI133449574(acot8)
XMA102229258(acot8)
XCO114135809(acot8)
XHE116711120(acot8)
PRET103465408(acot8)
PFOR103144076 103144077
PLAI106938527(acot8)
PMEI106910883 106911348
GAF122833756(acot8)
PPRL129352408(acot8)
CVG107093191(acot8)
CTUL119785997(acot8)
GMU124856638(acot8)
NFU107385835(acot8)
KMR108251003(acot8)
ALIM106528518(acot8)
AOCE111562665(acot8)
CSEM103386342(acot8)
POV109629039(acot8)
SSEN122768297(acot8)
HHIP117760955(acot8)
HSP118105251(acot8)
PPLT128453178(acot8)
SMAU118309443(acot8)
LCF108886572
SDU111221847(acot8)
SLAL111668590(acot8)
XGL120807021(acot8)
HCQ109521623(acot8)
SSCV125976742
SBIA133507500(acot8)
PEE133408761(acot8)
PTAO133483736(acot8)
BPEC110154578(acot8)
MALB109956138(acot8)
BSPL114856256(acot8)
SJO128355607(acot8)
SASA100380377(acot8)
STRU115207230(acot8)
OTW112239375(acot8)
OMY110494851(acot8)
OGO124003447(acot8)
ONE115124767(acot8)
OKI109901326(acot8)
OKE118377122(acot8)
SALP112072437(acot8)
SNH120037213(acot8)
CCLU121575384(acot8)
ELS105010097(acot8)
SFM108923421(acot8)
PKI111840975(acot8)
AANG118210526(acot8)
LOC102689344(acot8)
PSPA121297965 121319410
ARUT117429194 117434926
PSEX120514560(acot8)
LCM102353321(ACOT8)
CMK103191249(acot8)
RTP109933390(acot8)
CPLA122560012(acot8)
HOC132822705(acot8)
PMRN116954235(ACOT8)
SPU589369
LPIC129273386
APLC110973614 110973634
SKO102804197
CELCELE_C37H5.13(C37H5.13) CELE_F25E2.3(F25E2.3)
CBRCBG_08110 CBG_08841 CBG_24030
CRQGCK72_019338 GCK72_022209
NAINECAME_01234
TSPTsp_08781 Tsp_10152
HROHELRODRAFT_177007
LGILOTGIDRAFT_149477 LOTGIDRAFT_229801
PVUL126816472 126816474 130010388 130010390
PCAN112553245
BGT106051927
GAE121388485
HRF124137954 124137956
HRJ124287001 124287035
CRG105345904
CVN111133015
CANU128190516
OED125679030 125679034
MYI110443770
PMAX117328530 117337054
MCAF127703289
MMER123549209
RPHI132713755 132747938
DPOL127882083 127882376
OBI106872711 106884441
OSN115217550 115217917
LJP135475459
LAK106169050
TADTRIADDRAFT_24642 TRIADDRAFT_50197 TRIADDRAFT_55623 TRIADDRAFT_55625
PSTRPst134EA_031464
 » show all
Reference
1  [PMID:11673457]
  Authors
Hunt MC, Solaas K, Kase BF, Alexson SE.
  Title
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.
  Journal
J Biol Chem 277:1128-38 (2002)
DOI:10.1074/jbc.M106458200
  Sequence
[mmu:170789]
Reference
2  [PMID:10817395]
  Authors
Solaas K, Sletta RJ, Soreide O, Kase BF.
  Title
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver.
  Journal
Scand J Clin Lab Invest 60:91-102 (2000)
DOI:10.1080/00365510050184903
Reference
3  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.27
IUBMB Enzyme Nomenclature: 3.1.2.27
ExPASy - ENZYME nomenclature database: 3.1.2.27
BRENDA, the Enzyme Database: 3.1.2.27

DBGET integrated database retrieval system