KEGG   ENZYME: 3.1.2.32Help
Entry
EC 3.1.2.32                 Enzyme                                 

Name
2-aminobenzoylacetyl-CoA thioesterase;
pqsE (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
(2-aminobenzoyl)acetyl-CoA hydrolase
Reaction(IUBMB)
(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA [RN:R11542]
Reaction(KEGG)
Substrate
2-aminobenzoylacetyl-CoA [CPD:C21452];
H2O [CPD:C00001]
Product
2-aminobenzoylacetate [CPD:C21453];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ).
History
EC 3.1.2.32 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20257  2-aminobenzoylacetyl-CoA thioesterase
Genes
PAE: PA1000(pqsE)
PAEV: N297_1033
PAEI: N296_1033
PAU: PA14_51380(pqsE)
PAP: PSPA7_4398
PAG: PLES_43251(pqsE)
PAF: PAM18_4048(pqsE)
PNC: NCGM2_1854(pqsE)
PAEB: NCGM1900_1668(pqsE)
PDK: PADK2_20740
PAEP: PA1S_20970
PAEM: U769_20815
PAEL: T223_22095
PAEU: BN889_01052(pqsE)
PAEG: AI22_12970
PAEC: M802_1030
PAEO: M801_1033
BPS: BPSS0485
BPSE: BDL_3711
BPSM: BBQ_5711
BPSU: BBN_3885
BPSD: BBX_5548
BPK: BBK_5690
BPSH: DR55_4867
BPSA: BBU_5562
BPSO: X996_4617
BUT: X994_4135
BTQ: BTQ_5214
BTJ: BTJ_3845
BTZ: BTL_4699
BTD: BTI_4293
BTV: BTHA_5528
BTHE: BTN_4338
BTHM: BTRA_4604
BTHA: DR62_4387
BTHL: BG87_4671
BOK: DM82_4588
BOC: BG90_6004
BAM: Bamb_5767
BCON: NL30_31565
BUB: BW23_4061
BSTG: WT74_17005
BUL: BW21_3834
CCT: CC1_24010
CHZ: CHSO_1946
GAC: GACE_1202
 » show all
Taxonomy
Reference
1  [PMID:19788310]
  Authors
Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Haussler S, Blankenfeldt W
  Title
Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
  Journal
Biochemistry 48:10298-307 (2009)
DOI:10.1021/bi900123j
  Sequence
[pae:PA1000]
Reference
2  [PMID:25960261]
  Authors
Drees SL, Fetzner S
  Title
PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.
  Journal
Chem Biol 22:611-8 (2015)
DOI:10.1016/j.chembiol.2015.04.012
  Sequence
[pae:PA1000]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.32
IUBMB Enzyme Nomenclature: 3.1.2.32
ExPASy - ENZYME nomenclature database: 3.1.2.32
BRENDA, the Enzyme Database: 3.1.2.32

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