Entry
Name
2-aminobenzoylacetyl-CoA thioesterase;
pqsE (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
(2-aminobenzoyl)acetyl-CoA hydrolase
Reaction(IUBMB)
(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA [RN:
R11542 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ).
History
EC 3.1.2.32 created 2016
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K20257 2-aminobenzoylacetyl-CoA thioesterase
Genes
PAEB : NCGM1900_1668(pqsE)
DALK : DSCA_14130 DSCA_25720
DGI : Desgi_1436 Desgi_3231
STED : SPTER_30530(gloB_2)
» show all
Taxonomy
Reference
Authors
Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Haussler S, Blankenfeldt W
Title
Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
Journal
Sequence
Reference
Authors
Drees SL, Fetzner S
Title
PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.32
ExPASy - ENZYME nomenclature database: 3.1.2.32