KEGG   ENZYME: 3.1.3.101
Entry
EC 3.1.3.101                Enzyme                                 
Name
validoxylamine A 7'-phosphate phosphatase;
vldH (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
validoxylamine-A 7'-phosphate phosphohydrolase
Reaction(IUBMB)
validoxylamine A 7'-phosphate + H2O = validoxylamine A + phosphate [RN:R11240]
Reaction(KEGG)
R11240
Substrate
validoxylamine A 7'-phosphate [CPD:C21219];
H2O [CPD:C00001]
Product
validoxylamine A [CPD:C17700];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 3.1.3.101 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20437  validoxylamine A 7'-phosphate phosphatase
Genes
SLATJ4854_04865
SHYSHJG_0271
SHOSHJGH_0105
SNQCP978_00045
SCYGS1361_37275
SPEUCGZ69_02110
SHKJ2N69_30930
SDDD9753_08360
GYUFE374_05670
NOQLN652_08445
THAONI17_015255
AGRAAGRA3207_002910
 » show all
Reference
1  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.101
IUBMB Enzyme Nomenclature: 3.1.3.101
ExPASy - ENZYME nomenclature database: 3.1.3.101
BRENDA, the Enzyme Database: 3.1.3.101

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