KEGG   ENZYME: 3.1.3.101Help
Entry
EC 3.1.3.101                Enzyme                                 

Name
validoxylamine A 7'-phosphate phosphatase;
vldH (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
validoxylamine-A 7'-phosphate phosphohydrolase
Reaction(IUBMB)
validoxylamine A 7'-phosphate + H2O = validoxylamine A + phosphate [RN:R11240]
Reaction(KEGG)
Substrate
validoxylamine A 7'-phosphate [CPD:C21219];
H2O [CPD:C00001]
Product
validoxylamine A [CPD:C17700];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 3.1.3.101 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20437  validoxylamine A 7'-phosphate phosphatase
Genes
SHY: SHJG_0271
SHO: SHJGH_0105
Taxonomy
Reference
1  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T.
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.101
IUBMB Enzyme Nomenclature: 3.1.3.101
ExPASy - ENZYME nomenclature database: 3.1.3.101
BRENDA, the Enzyme Database: 3.1.3.101

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