KEGG   ENZYME: 3.1.3.103Help
Entry
EC 3.1.3.103                Enzyme                                 

Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase;
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphohydrolase
Reaction(IUBMB)
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + phosphate [RN:R11440]
Reaction(KEGG)
Substrate
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate;
H2O [CPD:C00001]
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate;
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 3.1.3.103 created 2016
Orthology
K21055  3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase
Genes
BTH: BT_1713
BTHO: Btheta7330_01303
BCEL: BcellWH2_03094
BVS: BARVI_00425
SHT: KO02_22670
CAMU: CA2015_3636
ASL: Aeqsu_2922
Taxonomy
Reference
1  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1713]
Reference
2  [PMID:18986982]
  Authors
Lu Z, Wang L, Dunaway-Mariano D, Allen KN
  Title
Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.
  Journal
J Biol Chem 284:1224-33 (2009)
DOI:10.1074/jbc.M807056200
  Sequence
[bth:BT_1713]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.103
IUBMB Enzyme Nomenclature: 3.1.3.103
ExPASy - ENZYME nomenclature database: 3.1.3.103
BRENDA, the Enzyme Database: 3.1.3.103

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