KEGG   ENZYME: 3.1.3.103
Entry
EC 3.1.3.103                Enzyme                                 
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase;
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphohydrolase
Reaction(IUBMB)
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + phosphate [RN:R11440]
Reaction(KEGG)
R11440
Substrate
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:C21383];
H2O [CPD:C00001]
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:C20934];
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 3.1.3.103 created 2016
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K21055  3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase
Genes
HSHNHP194022_04600
BPAAK7I13_00560
SBUSpiBuddy_2424
BTHBT_1713
BTHOBtheta7330_01303 Btheta7330_02993
BCELBcellWH2_03094
BISDXK01_006205
BEGINE88_01922
BSTEK6V31_10245
BVSBARVI_00425
SHTKO02_22670
CAMUCA2015_3636
FAZM0M57_00270
ASLAeqsu_2922
AICJK629_04870
SMISLDL76_16000
MGELG5B37_10200
SINHLS482_08945
FBEFF125_10320
PTANCRYO30217_01042
 » show all
Reference
1  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1713]
Reference
2  [PMID:18986982]
  Authors
Lu Z, Wang L, Dunaway-Mariano D, Allen KN
  Title
Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.
  Journal
J Biol Chem 284:1224-33 (2009)
DOI:10.1074/jbc.M807056200
  Sequence
[bth:BT_1713]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.103
IUBMB Enzyme Nomenclature: 3.1.3.103
ExPASy - ENZYME nomenclature database: 3.1.3.103
BRENDA, the Enzyme Database: 3.1.3.103

DBGET integrated database retrieval system