KEGG ENZYME: 3.1.3.106

ENZYME: 3.1.3.106

Entry

EC 3.1.3.106                Enzyme

Name

2-lysophosphatidate phosphatase;
1-acyl-sn-glycerol 3-phosphatase;
CPC3 (gene name);
PHM8 (gene name)

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

1-acyl-sn-glycerol 3-phosphate phosphohydrolase

Reaction(IUBMB)

a 1-acyl-sn-glycerol 3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate [RN:R11527]

Reaction(KEGG)

R11527

Substrate

1-acyl-sn-glycerol 3-phosphate [CPD:C00681];
H2O [CPD:C00001]

Product

1-acyl-sn-glycerol;
phosphate [CPD:C00009]

Comment

The enzyme has been studied from the plants Arachis hypogaea (peanut) and Arabidopsis thaliana (thale cress) and from the yeast Saccharomyces cerevisiae. The enzyme from yeast, but not from the plants, requires Mg2+.

History

EC 3.1.3.106 created 2019

Pathway

ec00561

Glycerolipid metabolism

ec01100

Metabolic pathways

Orthology

K23736

2-lysophosphatidate phosphatase

K23737

2-lysophosphatidate phosphatase

Genes

ATH:	AT3G03520(NPC3)

ALY:

9318364

CRB:

17891215

CSAT:

104744444 104763975 104787501

EUS:	EUTSA_v10020514mg

BRP:

103855165

BNA:	106431248 125587701

BOE:

106343659

RSZ:	108859072 108863372

THJ:

104827241

CPAP:

110825949

SCE:	YER037W(PHM8)

SEUB:

DI49_1436

SPAO:

SPAR_E01080

» show all

Reference

1 [PMID:11891254]

Authors

Shekar S, Tumaney AW, Rao TJ, Rajasekharan R

Title

Isolation of lysophosphatidic acid phosphatase from developing peanut cotyledons.

Journal

Plant Physiol 128:988-96 (2002)
DOI:10.1104/pp.010654

Reference

2 [PMID:18234677]

Authors

Reddy VS, Singh AK, Rajasekharan R

Title

The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase.

Journal

J Biol Chem 283:8846-54 (2008)
DOI:10.1074/jbc.M706752200

Sequence

[sce:YER037W]

Reference

3 [PMID:20045079]

Authors

Reddy VS, Rao DK, Rajasekharan R

Title

Functional characterization of lysophosphatidic acid phosphatase from Arabidopsis thaliana.

Journal

Biochim Biophys Acta 1801:455-61 (2010)
DOI:10.1016/j.bbalip.2009.12.005

Sequence

[ath:AT3G03520]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.3.106

IUBMB Enzyme Nomenclature:

3.1.3.106

ExPASy - ENZYME nomenclature database:

3.1.3.106

BRENDA, the Enzyme Database:

3.1.3.106

DBGET integrated database retrieval system