KEGG   ENZYME: 3.1.3.106
Entry
EC 3.1.3.106                Enzyme                                 

Name
2-lysophosphatidate phosphatase;
1-acyl-sn-glycerol 3-phosphatase;
CPC3 (gene name);
PHM8 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-acyl-sn-glycerol 3-phosphate phosphohydrolase
Reaction(IUBMB)
a 1-acyl-sn-glycerol 3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate [RN:R11527]
Reaction(KEGG)
R11527
Substrate
1-acyl-sn-glycerol 3-phosphate [CPD:C00681];
H2O [CPD:C00001]
Product
1-acyl-sn-glycerol;
phosphate [CPD:C00009]
Comment
The enzyme has been studied from the plants Arachis hypogaea (peanut) and Arabidopsis thaliana (thale cress) and from the yeast Saccharomyces cerevisiae. The enzyme from yeast, but not from the plants, requires Mg2+.
History
EC 3.1.3.106 created 2019
Pathway
ec00561  Glycerolipid metabolism
Orthology
K23736  2-lysophosphatidate phosphatase
K23737  2-lysophosphatidate phosphatase
Genes
ATH: AT3G03520(NPC3)
ALY: 9318364
CRB: 17891215
CSAT: 104744444 104763975 104787501
EUS: EUTSA_v10020514mg
BRP: 103855165
BNA: 106431248
BOE: 106343659
RSZ: 108859072 108863372
THJ: 104827241
CPAP: 110825949
SCE: YER037W(PHM8)
 » show all
Reference
1  [PMID:11891254]
  Authors
Shekar S, Tumaney AW, Rao TJ, Rajasekharan R
  Title
Isolation of lysophosphatidic acid phosphatase from developing peanut cotyledons.
  Journal
Plant Physiol 128:988-96 (2002)
DOI:10.1104/pp.010654
Reference
2  [PMID:18234677]
  Authors
Reddy VS, Singh AK, Rajasekharan R
  Title
The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase.
  Journal
J Biol Chem 283:8846-54 (2008)
DOI:10.1074/jbc.M706752200
  Sequence
[sce:YER037W]
Reference
3  [PMID:20045079]
  Authors
Reddy VS, Rao DK, Rajasekharan R
  Title
Functional characterization of lysophosphatidic acid phosphatase from Arabidopsis thaliana.
  Journal
Biochim Biophys Acta 1801:455-61 (2010)
DOI:10.1016/j.bbalip.2009.12.005
  Sequence
[ath:AT3G03520]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.106
IUBMB Enzyme Nomenclature: 3.1.3.106
ExPASy - ENZYME nomenclature database: 3.1.3.106
BRENDA, the Enzyme Database: 3.1.3.106

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