KEGG ENZYME: 3.1.3.108

ENZYME: 3.1.3.108

Entry

EC 3.1.3.108                Enzyme

Name

nocturnin;
NOCT (gene name);
nocturnin (curled);
MJ0109 (gene name);
NADP phosphatase;
NADPase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

NADPH 2'-phosphohydrolase

Reaction(IUBMB)

(1) NADPH + H2O = NADH + phosphate [RN:R12587];
(2) NADP+ + H2O = NAD+ + phosphate [RN:R00118]

Reaction(KEGG)

R00118 R12587

Substrate

NADPH [CPD:C00005];
H2O [CPD:C00001];
NADP+ [CPD:C00006]

Product

NADH [CPD:C00004];
phosphate [CPD:C00009];
NAD+ [CPD:C00003]

Comment

The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.

History

EC 3.1.3.108 created 2020

Orthology

K18764

nocturnin

Genes

HSA:	25819(NOCT)

PTR:	100611804(NOCT)

PPS:	100979611(NOCT)

GGO:	101133256(NOCT)

PON:	100449251(NOCT)

NLE:	100591529(NOCT)

HMH:	116464020(NOCT)

MCC:	100428993(NOCT)

MCF:	102134207(NOCT)

MTHB:

126954609

MNI:	105493258(NOCT)

CSAB:

103236274(NOCT)

CATY:

105580807(CCRN4L)

PANU:

100997677(NOCT)

TGE:	112624769(NOCT)

MLEU:

105543649(CCRN4L)

RRO:	104654345(NOCT)

RBB:	108536941(NOCT)

TFN:	117085922(NOCT)

PTEH:

111551937(NOCT)

CANG:

105513704(CCRN4L)

CJC:	100393251(NOCT)

SBQ:	101030297(CCRN4L)

CIMI:

108285596(NOCT)

CSYR:

103255271(NOCT)

MMUR:

105872360(NOCT)

LCAT:

123638565(NOCT)

PCOQ:

105818763(CCRN4L)

OGA:	100962419(NOCT)

MMU:	12457(Noct)

MCAL:

110291122(Noct)

MPAH:

110320210(Noct)

RNO:	310395(Noct)

MCOC:

116094444(Noct)

ANU:	117707840(Noct)

MUN:	110545133(Noct)

CGE:	100766002(Noct)

MAUA:

101830083(Noct)

PROB:

127216289(Noct)

PLEU:

114695851(Noct) 114707977

MORG:

121452881(Noct)

MFOT:

126499231

AAMP:

119825973(Noct)

NGI:	103742363(Noct)

HGL:	101710110(Noct)

CPOC:

100713041(Noct)

CCAN:

109691470(Noct)

DORD:

105995684(Noct)

DSP:	122127151(Noct)

PLOP:

125341701(Noct)

NCAR:

124994353

OCU:

100348337

OPI:	101518231(NOCT)

TUP:	102502756(NOCT)

GVR:	103600636(CCRN4L)

CFA:	483818(NOCT)

CLUD:

112669290(NOCT)

VVP:	112934917(NOCT)

VLG:	121493119(NOCT)

NPO:	129504355(NOCT)

AML:	100472917(NOCT)

UMR:	103657961(NOCT)

UAH:	113255683(NOCT)

UAR:	123793276(NOCT)

ELK:

111149080

LLV:

125093397

MPUF:

101692678(NOCT)

MNP:	132003129(NOCT)

NVS:	122919185(NOCT)

ORO:	101365311(CCRN4L)

EJU:	114208164(NOCT)

ZCA:	113924598(NOCT)

MLX:	118022315(NOCT)

NSU:	110571230(NOCT)

LWW:	102737589(NOCT)

FCA:	101092681(NOCT)

PYU:	121029610(NOCT)

PCOO:

112858609(NOCT)

PBG:	122497251(NOCT)

LRUF:

124520050

PTG:	102965630(NOCT)

PPAD:

109249387(NOCT)

PUC:

125923702

AJU:

106976192

HHV:	120243132(NOCT)

BTA:	540641(NOCT)

BOM:	102279918(NOCT)

BIU:	109571342(NOCT)

BBUB:

102399873(NOCT)

BBIS:

104981272(CCRN4L)

CHX:	102187886(NOCT)

OAS:	101117790(NOCT)

BTAX:

128062375(NOCT) 128071342

ODA:	120870925(NOCT)

CCAD:

122452524(NOCT)

MBEZ:

129542657(NOCT)

SSC:	100513746(NOCT)

CFR:	102524312(NOCT)

CBAI:

105068704(CCRN4L)

CDK:	105087080(NOCT)

VPC:

102538495

BACU:

103003260(NOCT)

LVE:	103072303(CCRN4L)

OOR:	101283045(NOCT)

DLE:	111164860(NOCT)

PCAD:

102992628(NOCT)

PSIU:

116753825(NOCT)

NASI:

112399817(NOCT)

ECB:	100071468(NOCT)

EPZ:	103549003(NOCT)

EAI:	106837991(NOCT)

MYB:	102260842(NOCT)

MYD:	102759031(NOCT)

MMYO:

118651580 118658853(NOCT)

MLF:	102428003(NOCT)

MNA:	107534921(NOCT)

PKL:	118711607(NOCT)

EFUS:

103290399(NOCT)

HAI:	109394194(NOCT)

DRO:	112312425(NOCT)

SHON:

118995459(NOCT)

AJM:	119034879(NOCT)

PDIC:

114504158(NOCT)

PHAS:

123813997(NOCT)

MMF:	118615874(NOCT)

RFQ:	117038246(NOCT)

PALE:

102883027(NOCT)

PGIG:

120613209(NOCT)

PVP:	105301556(NOCT)

RAY:	107515347(NOCT)

MJV:	108407063(NOCT)

TOD:	119234772(NOCT)

SARA:

101549546(CCRN4L)

LAV:	100677271(NOCT)

TMU:

101347454

ETF:	101647778(NOCT)

DNM:	101427251(NOCT)

MDO:	100027658(NOCT)

GAS:	123251016(NOCT)

SHR:	100930989(NOCT)

AFZ:

127540638

PCW:	110194902(NOCT)

OAA:	100078856(NOCT)

GGA:	404779(NOCT)

PCOC:

116226093(NOCT)

MGP:	100541508(NOCT)

CJO:	107313121(NOCT)

TPAI:

128084196(NOCT)

LMUT:

125692468(NOCT)

NMEL:

110399084(NOCT)

APLA:

101797379(NOCT)

ACYG:

106040962(NOCT)

CATA:

118250885(NOCT)

AFUL:

116488596(NOCT)

TGU:	100231561(NOCT)

LSR:	110480519(NOCT)

SCAN:

103822546(NOCT)

PMOA:

120496055(NOCT)

OTC:	121339918(NOCT)

PRUF:

121354684(NOCT)

GFR:	102040001(NOCT)

FAB:	101806807(NOCT)

OMA:	130252568(NOCT)

PHI:	102100975(NOCT)

PMAJ:

107198931(NOCT)

CCAE:

111928919(NOCT)

CCW:	104697280(NOCT)

CBRC:

103614517(NOCT)

ETL:	114058376(NOCT)

ZAB:	102063908(NOCT)

ACHL:

103804840(CCRN4L)

SVG:	106864038(NOCT)

MMEA:

130582142(NOCT)

HRT:	120753022(NOCT)

FPG:	101917647(NOCT)

FCH:	102053174(NOCT)

CLV:	102088785(NOCT)

EGZ:	104135809(CCRN4L)

NNI:	104015978(CCRN4L)

PCRI:

104032285(CCRN4L)

PLET:

104615944(CCRN4L)

EHS:	104509053(CCRN4L)

PCAO:

104043146(CCRN4L)

ACUN:

113479829(NOCT)

TALA:

104369517(NOCT)

PADL:

103920979(CCRN4L)

AFOR:

103908037(NOCT)

ACHC:

115338678(NOCT)

HALD:

104312627(CCRN4L)

HLE:	104841761(CCRN4L)

AGEN:

126044800

GCL:

127015925

CCRI:

104161150(CCRN4L)

CSTI:

104563375(CCRN4L)

CMAC:

104483879(CCRN4L)

MUI:	104540965(CCRN4L)

BREG:

104640636(CCRN4L)

FGA:	104071983(CCRN4L)

GSTE:

104263383(CCRN4L)

LDI:	104349266(CCRN4L)

MNB:	103780478(CCRN4L)

OHA:	104336715(CCRN4L)

NNT:	104409418(CCRN4L)

SHAB:

115610637(NOCT)

DPUB:

104296870(CCRN4L)

PGUU:

104463899(CCRN4L)

ACAR:

104530792(NOCT)

CPEA:

104398832(CCRN4L)

AVIT:

104279765(CCRN4L)

CVF:	104292758(CCRN4L)

RTD:	128909748(NOCT)

CUCA:

104066442(CCRN4L)

TEO:	104377144(CCRN4L)

BRHI:

104493236(CCRN4L)

AAM:	106491891(NOCT)

AROW:

112965417(NOCT)

NPD:	112950172(NOCT)

TGT:	104577902(CCRN4L)

DNE:	112986740(NOCT)

SCAM:

104153488(CCRN4L)

ASN:	102373172(NOCT)

AMJ:	102567362(NOCT)

CPOO:

109309613(NOCT)

GGN:	109301160(NOCT)

PSS:	102451508(NOCT)

CMY:	102939146(NOCT)

DCC:	119854597(NOCT)

CPIC:

101936301(NOCT)

TST:	117878109(NOCT)

CABI:

116838879(NOCT)

MRV:	120406199(NOCT)

ACS:	100556517(noct)

PVT:	110073655(NOCT)

SUND:

121930735(NOCT)

PBI:	103058940(NOCT)

PMUR:

107293158(NOCT)

CTIG:

120308385(NOCT)

TSR:	106545270(NOCT)

PGUT:

117680128(NOCT)

APRI:

131202970(NOCT)

PTEX:

113434721(NOCT)

NSS:	113412908(NOCT)

VKO:	123023763(NOCT)

PMUA:

114604123(NOCT)

PRAF:

128421086(NOCT)

ZVI:	118083410(NOCT)

HCG:	128328518(NOCT)

GJA:	107110787(NOCT)

STOW:

125440398(NOCT)

EMC:	129336741(NOCT)

XLA:	378568(noct.L) 734309(noct.S)

XTR:	549285(noct)

NPR:	108787519(NOCT)

RTEM:

120919058(NOCT)

BBUF:

120989975(NOCT)

BGAR:

122943301(NOCT)

MUO:	115461700(NOCT)

GSH:	117357962(NOCT)

DRE:	568973(noctb) 572044(nocta)

SRX:	107714224 107742507 107756481(noct)

SANH:

107676528 107680657 107692596 107702303

SGH:	107550850(noct) 107562977 107563986 107601501

CCAR:

109045774 109079183 109102500

CAUA:

113044314 113091093 113114064

CGIB:

127948694 127970881 128027532

PTET:

122352499(noctb) 122357557(nocta)

LROH:

127166104(noctb) 127176027(nocta)

OMC:	131549294(noctb) 131553811(nocta)

PPRM:

120460783(nocta) 120481331(noctb)

MAMB:

125258890(nocta) 125272488(noctb)

CIDE:

127509561 127525632

MASI:

127412676 127417760 127443400 127445407

TROS:

130553649(noctb) 130563809(nocta)

MANU:

129422882(nocta) 129444845(noctb)

IPU:	108268604(nocta)

IFU:	128611948(nocta)

PHYP:

113542743(noct)

SMEO:

124385831(nocta)

TFD:	113645990(nocta)

AMEX:

103024657(noct)

CMAO:

118806990(nocta)

EEE:	113581505(noct)

CHAR:

105906267(nocta) 105908471(noctb)

TRU:	101067716 101074895

TFS:	130527329 130531180(nocta)

TNG:	GSTEN00023219G001 GSTEN00026635G001

LCO:	104922934(noct) 104938899

NCC:	104959560 104966628

CGOB:

115013792 115015035(noct)

ELY:	117255743 117261177(nocta)

EFO:	125886576 125894363(nocta)

PLEP:

121941963(noctb) 121947728(nocta)

SLUC:

116039580 116042198(nocta)

ECRA:

117951223(nocta) 117955006(noctb)

ESP:	116669841(noct) 116695867

PFLV:

114562853(noct) 114565677

GAT:	120817933(nocta) 120825114

PPUG:

119211376(nocta) 119217668

AFB:	129095468(noctb) 129117103(nocta)

CLUM:

117735243 117737444(nocta)

MSAM:

119884055 119888743(nocta) 119899704

SCHU:

122873910 122879935(nocta)

CUD:	121508649 121516664(nocta)

ALAT:

119008016(nocta) 119027483

MZE:	101478528(noct)

ONL:	100690381(noct)

OAU:	116331504(noctb)

OLA:	101157593(noct)

OML:	112153354 112157020

XMA:	102226828 102237197

XCO:	114145157 114153060(noct)

XHE:	116714362 116719974

PRET:

103463886 103471162(noct)

PFOR:

103132691 103154723(noct)

PLAI:

106946193 106963244(noct)

PMEI:

106905149 106931160

GAF:	122836546(nocta)

CVG:	107093243 107097348

CTUL:

119773479(nocta) 119786952

GMU:	124859873(nocta) 124868318

NFU:	107389498(noct) 107396430

KMR:	108245508 108249656(nocta)

ALIM:

106511359 106511585 106524622(noct)

NWH:	119409150(nocta) 119422687

AOCE:

111572374(noct) 111585149

MCEP:

125004132 125008415(nocta)

CSEM:

103384260(noct)

POV:	109624667 109627218

SSEN:

122762066(noctb) 122778975

HHIP:

117765493 117769693(nocta)

HSP:	118098124 118112237(nocta)

LCF:	108895516(nocta) 108900154

SDU:	111229271 111230402(noct)

SLAL:

111663590(noct) 111666744

XGL:	120784882(nocta) 120800067

HCQ:	109514429(noct) 109527505

SSCV:

125968450

BPEC:

110155793 110175173(noct)

MALB:

109957867 109966424(noct)

BSPL:

114862797 114864915(nocta)

SASA:

106596388 106597766 106604687 106610553

STRU:

115172215 115182600 115182606

OTW:	112220937(nocta) 112244497 112255690

OMY:	110488807(nocta) 110497191 110497192

OGO:	123993401(nocta) 124023194 124023344

ONE:	115126566 115130688

OKI:	109864774(noct) 109887460 116352827

OKE:	118377976(nocta) 127925236

SALP:

111965719 111967170 112078726

SNH:	120041083 120048106(nocta)

CCLU:

121536531 121542552

ELS:	105020852 105029048

SFM:	108925729 108930757

PKI:

111853054

AANG:

118228032 118231012

LOC:	102682701(noct)

PSPA:

121325246 121330605

ARUT:

117408755 117420930

PSEX:

120527823(nocta)

LCM:	102349012(NOCT)

CMK:

103181305

RTP:	109932243(noct)

CPLA:

122539350(nocta)

LERI:

129701956(nocta)

BFO:

118420286

BBEL:

109467894

SCLV:

120329053

SPU:

591893

APLC:

110988644

AJC:

117112949

SKO:

100368766

DME:	Dmel_CG31299(cu)

DER:

26527069

DSE:

116801625

DSI:	Dsimw501_GD26876(Dsim_GD26876)

DYA:	Dyak_GE27400

DAN:

6499531

DSR:

110188135

DPO:

4803139

DPE:

113567256

DMN:

108156775

DWI:

26528816

DGR:

116805427

DMO:	Dmoj_GI25727

DAZ:

108621833

DNV:

108659911

DHE:

111600242

CCAT:

101460917

RZE:

108373523

TDA:	119668788 119672624

MDE:

101887281

LCQ:

111674873

ECOE:

129946143

HIS:

119647579

AGA:	AgaP_AGAP009893

ACOZ:

120959966

AARA:

120904983

AMER:

121595200

ASTE:

118509089

AFUN:

125760850

AALI:

118460707

AAG:

5570471

AALB:

109398703 109404878

CQU:	CpipJ_CPIJ011434

CPII:

120420797

CNS:

116351978

BCOO:

119073735

DSM:

124404757

NPT:

124211984

NFB:

124176761

NLO:

107222528

NVG:

124298306

TCA:

663596

DPA:

109539469

AGRG:

126739490

ATD:

109598810

AGB:

108917458

LDC:

111512182

NVL:

108556280

APLN:

108741418

PPYR:

116181069

OTU:

111413373

CFEL:

113363253

CCRN:

123296750

API:

100161460

DNX:

107170974

AGS:

114122020

RMD:

113560517

ACOO:

126832801 126832802 126835819 126840514 126840680 126840735 126846771

BTAB:

109031372

DCI:

103506068

CLEC:

106663477

HHAL:

106682379

NLU:

111048726

HVI:

124370385

PHU:	Phum_PHUM563920

FOC:

113204980

TPAL:

117653992

ZNE:

110827948

CSEC:

111871414

SGRE:

126365928

IEL:

124158710

FCD:

110856840

DPX:	DAPPUDRAFT_3216

DMK:

116917637

PVM:

113816919

PJA:

122248849

PCHN:

125026195

PMOO:

119580337

HAME:

121869506

PCLA:

123771723

CQD:

128698040

PTRU:

123509330

ESN:

126983707

HAZT:

108670333

EAF:

111714947

LSM:

121119876

PPOI:

119108638

DSV:

119450253

RSAN:

119383299

RMP:

119170433

VDE:

111248629

VJA:

111265314

CSCU:

111618187 111618189

PTEP:

107440090

UDV:

129231561

SDM:

118182631

LPOL:

106458554 106474155 106475180

LGI:	LOTGIDRAFT_95897

PCAN:

112560883

BGT:

106060053

GAE:	121374500 121391533

HRF:

124133660

HRJ:

124272289

CRG:

105336378

CVN:

111125355

CANU:

128156280

OED:	125667268 125682441

MYI:

110454107

PMAX:

117329411

MCAF:

127714207

MMER:

123557696

DPOL:

127877671 127880020

OBI:

106875999

OSN:

115218557

LAK:	106167882 106175603

SMM:	Smp_105040

SHX:	MS3_00001426(CCRN4L)

OVI:	T265_04013

NVE:

5506068

EPA:

110243529

ATEN:

116289593 116293651

ADF:

107328558

AMIL:

114966105

PDAM:

113680403

SPIS:

111337344

DGT:

114527765

XEN:

124446063

HMG:

105845432

HSY:

130653603

TAD:	TRIADDRAFT_25141

PPP:

112287324

CRE:	CHLRE_10g448950v5

VCN:	VOLCADRAFT_98156

MNG:

MNEG_6331

CSL:	COCSUDRAFT_66649

OLU:	OSTLU_26290

OTA:	OT_ostta02g01180

BPG:	Bathy11g03490

MIS:	MICPUN_109024

MPP:	MICPUCDRAFT_42465

GSL:	Gasu_20920

MBR:	MONBRDRAFT_36891

SRE:	PTSG_04783 PTSG_07643

ACAN:

ACA1_215730 ACA1_338400 ACA1_354370

TET:	TTHERM_00660300 TTHERM_00825610

PTM:	GSPATT00021689001

SPAR:

SPRG_11328 SPRG_19107

GTT:	GUITHDRAFT_143708

MFB:	MFUL124B02_29440

» show all

Reference

1 [PMID:18391451]

Authors

Kawai S, Murata K

Title

Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).

Journal

Biosci Biotechnol Biochem 72:919-30 (2008)
DOI:10.1271/bbb.70738

Sequence

[mja:MJ_0109]

Reference

2 [PMID:29860338]

Authors

Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC

Title

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.

Journal

Nucleic Acids Res 46:6257-6270 (2018)
DOI:10.1093/nar/gky412

Sequence

[hsa:25819]

Reference

3 [PMID:30389976]

Authors

Estrella MA, Du J, Korennykh A

Title

Crystal Structure of Human Nocturnin Catalytic Domain.

Journal

Sci Rep 8:16294 (2018)
DOI:10.1038/s41598-018-34615-0

Sequence

[hsa:25819]

Reference

4 [PMID:31147539]

Authors

Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A

Title

The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled).

Journal

Nat Commun 10:2367 (2019)
DOI:10.1038/s41467-019-10125-z

Sequence

[hsa:25819]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.3.108

IUBMB Enzyme Nomenclature:

3.1.3.108

ExPASy - ENZYME nomenclature database:

3.1.3.108

BRENDA, the Enzyme Database:

3.1.3.108

DBGET integrated database retrieval system