Entry
Name
nocturnin;
NOCT (gene name);
nocturnin (curled);
MJ0109 (gene name);
NADP phosphatase;
NADPase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
NADPH 2'-phosphohydrolase
Reaction(IUBMB)
(1) NADPH + H2O = NADH + phosphate [RN:
R12587 ];
(2) NADP+ + H2O = NAD+ + phosphate [RN:
R00118 ]
Reaction(KEGG)
Substrate
Product
Comment
The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC
2.7.1.23 ) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.
History
EC 3.1.3.108 created 2020
Orthology
Genes
PLEU : 114695851(Noct) 114707977
BTAX : 128062375(NOCT) 128071342
MMYO : 118651580 118658853(NOCT)
XLA : 378568(noct.L) 734309(noct.S)
DRE : 568973(noctb) 572044(nocta)
SRX : 107714224 107742507 107756481(noct)
SANH : 107676528 107680657 107692596 107702303
SGH : 107550850(noct) 107562977 107563986 107601501
CCAR : 109045774 109079183 109102500
CAUA : 113044314 113091093 113114064
CGIB : 127948694 127970881 128027532
PTET : 122352499(noctb) 122357557(nocta)
LROH : 127166104(noctb) 127176027(nocta)
OMC : 131549294(noctb) 131553811(nocta)
PPRM : 120460783(nocta) 120481331(noctb)
MAMB : 125258890(nocta) 125272488(noctb)
CIDE : 127509561 127525632
MASI : 127412676 127417760 127443400 127445407
TROS : 130553649(noctb) 130563809(nocta)
MANU : 129422882(nocta) 129444845(noctb)
CHAR : 105906267(nocta) 105908471(noctb)
TFS : 130527329 130531180(nocta)
TNG : GSTEN00023219G001 GSTEN00026635G001
LCO : 104922934(noct) 104938899
CGOB : 115013792 115015035(noct)
ELY : 117255743 117261177(nocta)
EFO : 125886576 125894363(nocta)
PLEP : 121941963(noctb) 121947728(nocta)
SLUC : 116039580 116042198(nocta)
ECRA : 117951223(nocta) 117955006(noctb)
ESP : 116669841(noct) 116695867
PFLV : 114562853(noct) 114565677
GAT : 120817933(nocta) 120825114
PPUG : 119211376(nocta) 119217668
AFB : 129095468(noctb) 129117103(nocta)
CLUM : 117735243 117737444(nocta)
MSAM : 119884055 119888743(nocta) 119899704
SCHU : 122873910 122879935(nocta)
CUD : 121508649 121516664(nocta)
ALAT : 119008016(nocta) 119027483
XCO : 114145157 114153060(noct)
PRET : 103463886 103471162(noct)
PFOR : 103132691 103154723(noct)
PLAI : 106946193 106963244(noct)
PMEI : 106905149 106931160
CTUL : 119773479(nocta) 119786952
GMU : 124859873(nocta) 124868318
NFU : 107389498(noct) 107396430
KMR : 108245508 108249656(nocta)
ALIM : 106511359 106511585 106524622(noct)
NWH : 119409150(nocta) 119422687
AOCE : 111572374(noct) 111585149
MCEP : 125004132 125008415(nocta)
SSEN : 122762066(noctb) 122778975
HHIP : 117765493 117769693(nocta)
HSP : 118098124 118112237(nocta)
LCF : 108895516(nocta) 108900154
SDU : 111229271 111230402(noct)
SLAL : 111663590(noct) 111666744
XGL : 120784882(nocta) 120800067
HCQ : 109514429(noct) 109527505
BPEC : 110155793 110175173(noct)
MALB : 109957867 109966424(noct)
BSPL : 114862797 114864915(nocta)
SASA : 106596388 106597766 106604687 106610553
STRU : 115172215 115182600 115182606
OTW : 112220937(nocta) 112244497 112255690
OMY : 110488807(nocta) 110497191 110497192
OGO : 123993401(nocta) 124023194 124023344
OKI : 109864774(noct) 109887460 116352827
OKE : 118377976(nocta) 127925236
SALP : 111965719 111967170 112078726
SNH : 120041083 120048106(nocta)
CCLU : 121536531 121542552
AANG : 118228032 118231012
PSPA : 121325246 121330605
ARUT : 117408755 117420930
DSI : Dsimw501_GD26876(Dsim_GD26876)
AALB : 109398703 109404878
ACOO : 126832801 126832802 126835819 126840514 126840680 126840735 126846771
CSCU : 111618187 111618189
LPOL : 106458554 106474155 106475180
DPOL : 127877671 127880020
SHX : MS3_00001426(CCRN4L)
ATEN : 116289593 116293651
SRE : PTSG_04783 PTSG_07643
ACAN : ACA1_215730 ACA1_338400 ACA1_354370
TET : TTHERM_00660300 TTHERM_00825610
SPAR : SPRG_11328 SPRG_19107
» show all
Taxonomy
Reference
Authors
Kawai S, Murata K
Title
Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).
Journal
Sequence
Reference
Authors
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC
Title
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Journal
Sequence
Reference
Authors
Estrella MA, Du J, Korennykh A
Title
Crystal Structure of Human Nocturnin Catalytic Domain.
Journal
Sequence
Reference
Authors
Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A
Title
The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.1.3.108