KEGG   ENZYME: 3.1.3.108Help
Entry
EC 3.1.3.108                Enzyme                                 

Name
nocturnin;
NOCT (gene name);
nocturnin (curled);
MJ0109 (gene name);
NADP phosphatase;
NADPase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
NADPH 2'-phosphohydrolase
Reaction(IUBMB)
(1) NADPH + H2O = NADH + phosphate [RN:R12587];
(2) NADP+ + H2O = NAD+ + phosphate [RN:R00118]
Reaction(KEGG)
Substrate
NADPH [CPD:C00005];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Product
NADH [CPD:C00004];
phosphate [CPD:C00009];
NAD+ [CPD:C00003]
Comment
The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.
History
EC 3.1.3.108 created 2020
Orthology
K18764  nocturnin
Genes
HSA: 25819(NOCT)
PTR: 100611804(NOCT)
PPS: 100979611(NOCT)
GGO: 101133256(NOCT)
PON: 100449251(NOCT)
NLE: 100591529(NOCT)
MCC: 100428993(NOCT)
MCF: 102134207(NOCT)
CSAB: 103236274(NOCT)
RRO: 104654345(NOCT)
RBB: 108536941(NOCT)
CJC: 100393251(NOCT)
SBQ: 101030297(CCRN4L)
MMU: 12457(Noct)
MCAL: 110291122(Noct)
MPAH: 110320210(Noct)
RNO: 310395(Noct)
MUN: 110545133(Noct)
CGE: 100766002(Noct)
NGI: 103742363(Noct)
HGL: 101710110(Noct)
CCAN: 109691470(Noct)
OCU: 100348337(NOCT)
TUP: 102502756(NOCT)
CFA: 483818(NOCT)
VVP: 112934917(NOCT)
AML: 100472917(NOCT)
UMR: 103657961(NOCT)
UAH: 113255683(NOCT)
ORO: 101365311(CCRN4L)
ELK: 111149080
FCA: 101092681(NOCT)
PTG: 102965630(NOCT)
PPAD: 109249387(NOCT)
AJU: 106976192(NOCT)
BTA: 540641(NOCT)
BOM: 102279918(NOCT)
BIU: 109571342(NOCT)
BBUB: 102399873(NOCT)
CHX: 102187886(NOCT)
OAS: 101117790(NOCT)
SSC: 100513746(NOCT)
CFR: 102524312(NOCT)
CDK: 105087080(NOCT)
BACU: 103003260(NOCT)
LVE: 103072303(NOCT)
OOR: 101283045(CCRN4L)
DLE: 111164860(NOCT)
PCAD: 102992628(NOCT)
ECB: 100071468(NOCT)
EPZ: 103549003(NOCT)
EAI: 106837991(NOCT)
MYB: 102260842(NOCT)
MYD: 102759031(NOCT)
MNA: 107534921(NOCT)
HAI: 109394194(NOCT)
DRO: 112312425(NOCT)
PALE: 102883027(NOCT)
RAY: 107515347(NOCT)
MJV: 108407063(NOCT)
LAV: 100677271(NOCT)
TMU: 101347454
MDO: 100027658(NOCT)
SHR: 100930989(NOCT)
PCW: 110194902(NOCT)
OAA: 100078856(NOCT)
GGA: 404779(NOCT)
MGP: 100541508(NOCT)
CJO: 107313121(NOCT)
NMEL: 110399084(NOCT)
APLA: 101797379(NOCT)
ACYG: 106040962(NOCT)
TGU: 100231561(NOCT)
LSR: 110480519(NOCT)
SCAN: 103822546(NOCT)
GFR: 102040001(NOCT)
FAB: 101806807(NOCT)
PHI: 102100975(NOCT)
PMAJ: 107198931(NOCT)
CCAE: 111928919(NOCT)
CCW: 104697280(NOCT)
ETL: 114058376(NOCT)
FPG: 101917647(NOCT)
FCH: 102053174(NOCT)
CLV: 102088785(NOCT)
EGZ: 104135809(CCRN4L)
NNI: 104015978(CCRN4L)
ACUN: 113479829(NOCT)
PADL: 103920979(CCRN4L)
AAM: 106491891(NOCT)
ASN: 102373172(NOCT)
AMJ: 102567362(NOCT)
PSS: 102451508(NOCT)
CMY: 102939146(NOCT)
CPIC: 101936301(NOCT)
ACS: 100556517(noct)
PVT: 110073655(NOCT)
PBI: 103058940(NOCT)
PMUR: 107293158(NOCT)
TSR: 106545270(NOCT)
PMUA: 114604123(NOCT)
GJA: 107110787(NOCT)
XLA: 378568(noct.L) 734309(noct.S)
XTR: 549285(noct)
NPR: 108787519(NOCT)
DRE: 568973(noctb) 572044(nocta)
IPU: 108268604(noct)
PHYP: 113542743(noct)
AMEX: 103024657(noct)
EEE: 113581505(noct)
LCO: 104922934(noct) 104938899
MZE: 101478528(noct)
ONL: 100690381(noct)
OLA: 101157593(noct)
XCO: 114145157 114153060(noct)
PRET: 103463886 103471162(noct)
NFU: 107389498(noct) 107396430
AOCE: 111572374(noct) 111585149
CSEM: 103384260(noct)
LCF: 108895516(noct) 108900154
SDU: 111229271 111230402(noct)
SLAL: 111663590(noct) 111666744
HCQ: 109514429(noct) 109527505
BPEC: 110155793 110175173(noct)
MALB: 109957867 109966424(noct)
PKI: 111853054
LCM: 102349012(NOCT)
CMK: 103181305(noct)
RTP: 109932243(noct)
SPU: 591893
APLC: 110988644
SKO: 100368766
DME: Dmel_CG31299(cu)
DER: 26527069
DSE: 116801625
DSI: Dsimw501_GD26876(Dsim_GD26876)
DAN: 6499531
DSR: 110188135
DPE: 113567256
DMN: 108156775
DWI: 26528816
DAZ: 108621833
DNV: 108659911
DHE: 111600242
MDE: 101887281
LCQ: 111674873
AAG: 5570471
TCA: 663596
DPA: 109539469
ATD: 109598810
NVL: 108556280
API: 100161460
DNX: 107170974
AGS: 114122020
RMD: 113560517
BTAB: 109031372
CLEC: 106663477
ZNE: 110827948
FCD: 110856840
PVM: 113816919
PTEP: 107440090
PCAN: 112560883
CRG: 105336378
MYI: 110454107
OBI: 106875999
SHX: MS3_06304
NVE: 5506068
EPA: 110243529
ADF: 107328558
AMIL: 114966105
PDAM: 113680403
SPIS: 111337344
DGT: 114527765
HMG: 105845432
PPP: 112287324
MNG: MNEG_6331
 » show all
Taxonomy
Reference
1  [PMID:18391451]
  Authors
Kawai S, Murata K
  Title
Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).
  Journal
Biosci Biotechnol Biochem 72:919-30 (2008)
DOI:10.1271/bbb.70738
  Sequence
[mja:MJ_0109]
Reference
2  [PMID:29860338]
  Authors
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC
  Title
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
  Journal
Nucleic Acids Res 46:6257-6270 (2018)
DOI:10.1093/nar/gky412
  Sequence
[hsa:25819]
Reference
3  [PMID:30389976]
  Authors
Estrella MA, Du J, Korennykh A
  Title
Crystal Structure of Human Nocturnin Catalytic Domain.
  Journal
Sci Rep 8:16294 (2018)
DOI:10.1038/s41598-018-34615-0
  Sequence
[hsa:25819]
Reference
4  [PMID:31147539]
  Authors
Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A
  Title
The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled).
  Journal
Nat Commun 10:2367 (2019)
DOI:10.1038/s41467-019-10125-z
  Sequence
[hsa:25819]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.108
IUBMB Enzyme Nomenclature: 3.1.3.108
ExPASy - ENZYME nomenclature database: 3.1.3.108
BRENDA, the Enzyme Database: 3.1.3.108

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