KEGG   ENZYME: 3.1.3.108
Entry
EC 3.1.3.108                Enzyme                                 
Name
nocturnin;
NOCT (gene name);
nocturnin (curled);
MJ0109 (gene name);
NADP phosphatase;
NADPase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
NADPH 2'-phosphohydrolase
Reaction(IUBMB)
(1) NADPH + H2O = NADH + phosphate [RN:R12587];
(2) NADP+ + H2O = NAD+ + phosphate [RN:R00118]
Reaction(KEGG)
R00118 R12587
Substrate
NADPH [CPD:C00005];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Product
NADH [CPD:C00004];
phosphate [CPD:C00009];
NAD+ [CPD:C00003]
Comment
The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.
History
EC 3.1.3.108 created 2020
Orthology
K18764  nocturnin
Genes
HSA25819(NOCT)
PTR100611804(NOCT)
PPS100979611(NOCT)
GGO101133256(NOCT)
PON100449251(NOCT)
PPYG129034702(NOCT)
NLE100591529(NOCT)
HMH116464020(NOCT)
SSYN129481067(NOCT)
MCC100428993(NOCT)
MCF102134207(NOCT)
MTHB126954609
MNI105493258(NOCT)
CSAB103236274(NOCT)
CATY105580807(CCRN4L)
PANU100997677(NOCT)
TGE112624769(NOCT)
MLEU105543649(CCRN4L)
RRO104654345(NOCT)
RBB108536941(NOCT)
TFN117085922(NOCT)
PTEH111551937(NOCT)
CANG105513704(CCRN4L)
CJC100393251(NOCT)
SBQ101030297(CCRN4L)
CIMI108285596(NOCT)
ANAN105710737(NOCT)
CSYR103255271(NOCT)
MMUR105872360(NOCT)
LCAT123638565(NOCT)
PCOQ105818763(CCRN4L)
OGA100962419(NOCT)
MMU12457(Noct)
MCAL110291122(Noct)
MPAH110320210(Noct)
RNO310395(Noct)
MCOC116094444(Noct)
ANU117707840(Noct)
ASYL127683371(Noct)
MUN110545133(Noct)
CGE100766002(Noct)
MAUA101830083(Noct)
PROB127216289(Noct)
PLEU114695851(Noct) 114707977
MORG121452881(Noct)
MFOT126499231
AAMP119825973(Noct)
NGI103742363(Noct)
HGL101710110(Noct)
CPOC100713041(Noct)
CCAN109691470(Noct)
DORD105995684(Noct)
DSP122127151(Noct)
DMER138826833(Noct)
PLOP125341701(Noct)
NCAR124994353
MMMA107136589(Noct)
ITI101960580(Noct)
OCU100348337
OPI101518231(NOCT)
TUP102502756(NOCT)
GVR103600636(CCRN4L)
CFA483818(NOCT)
CLUD112669290(NOCT)
VVP112934917(NOCT)
VLG121493119(NOCT)
NPO129504355(NOCT)
AML100472917(NOCT)
UMR103657961(NOCT)
UAH113255683(NOCT)
UAR123793276(NOCT)
ELK111149080
LLV125093397
MPUF101692678(NOCT)
MNP132003129(NOCT)
MLK131827682(NOCT)
NVS122919185(NOCT)
ORO101365311(CCRN4L)
EJU114208164(NOCT)
ZCA113924598(NOCT)
MLX118022315(NOCT)
NSU110571230(NOCT)
LWW102737589(NOCT)
FCA101092681(NOCT)
PYU121029610(NOCT)
PCOO112858609(NOCT)
PBG122497251(NOCT)
PVIV125164343(NOCT)
LRUF124520050
LGF123592399(NOCT)
AJU106976192
PTG102965630(NOCT)
PPAD109249387(NOCT)
PUC125923702
PLEZ122217853(NOCT)
HHV120243132(NOCT)
BTA540641(NOCT)
BOM102279918(NOCT)
BIU109571342(NOCT)
BBUB102399873(NOCT)
BBIS104981272(CCRN4L)
CHX102187886(NOCT)
OAS101117790(NOCT)
BTAX128062375(NOCT) 128071342
CSUM138093684(NOCT)
ODA120870925(NOCT)
CCAD122452524(NOCT)
MREE136145943(NOCT)
OVR110147189(NOCT)
MBEZ129542657(NOCT)
SSC100513746(NOCT)
CFR102524312(NOCT)
CBAI105068704(CCRN4L)
CDK105087080(NOCT)
VPC102538495
BACU103003260(NOCT)
BMUS118895200(NOCT)
LVE103072303(CCRN4L)
OOR101283045(NOCT)
LALB132520036(NOCT)
GMF115863734(NOCT)
DDP132426168(NOCT)
DLE111164860(NOCT)
PCAD102992628(NOCT)
PSIU116753825(NOCT)
PPHC136123633(NOCT)
NASI112399817(NOCT)
ECB100071468(NOCT)
EPZ103549003(NOCT)
EAI106837991(NOCT)
MYB102260842(NOCT)
MYD102759031(NOCT)
MMYO118651580 118658853(NOCT)
MLF102428003(NOCT)
MDT132235524(NOCT)
MYUM139010574(NOCT)
PKL118711607(NOCT)
EFUS103290399(NOCT)
MNA107534921(NOCT)
DRO112312425(NOCT)
SHON118995459(NOCT)
AJM119034879(NOCT)
PDIC114504158(NOCT)
PHAS123813997(NOCT)
MMF118615874(NOCT)
PPAM129062301(NOCT)
HAI109394194(NOCT)
RFQ117038246(NOCT)
PALE102883027(NOCT)
PGIG120613209(NOCT)
PVP105301556(NOCT)
RAY107515347(NOCT)
MJV108407063(NOCT)
TOD119234772(NOCT)
SARA101549546(CCRN4L)
SFUM130042370(NOCT)
SETR126003746(NOCT)
LAV100677271(NOCT)
TMU101347454
ETF101647778(NOCT)
DNM101427251(NOCT)
MDO100027658(NOCT)
GAS123251016(NOCT)
SHR100930989(NOCT)
AFZ127540638
PCW110194902(NOCT)
TVP118833784 118854325(NOCT)
PBRV138175080(NOCT)
MLAO141517865(NOCT)
OAA100078856(NOCT)
TACU119935747(NOCT)
GGA404779(NOCT)
PCOC116226093(NOCT)
MGP100541508(NOCT)
CJO107313121(NOCT)
TPAI128084196(NOCT)
LMUT125692468(NOCT)
NMEL110399084(NOCT)
APLA101797379(NOCT)
ACYG106040962(NOCT)
CATA118250885(NOCT)
AFUL116488596(NOCT)
TGU100231561(NOCT)
LSR110480519(NOCT)
SCAN103822546(NOCT)
PMOA120496055(NOCT)
OTC121339918(NOCT)
PRUF121354684(NOCT)
ATRC139602481(NOCT)
GFR102040001(NOCT)
FAB101806807(NOCT)
OMA130252568(NOCT)
PHI102100975(NOCT)
PMAJ107198931(NOCT)
CCAE111928919(NOCT)
CCW104697280(NOCT)
CBRC103614517(NOCT)
ACOE138109390(NOCT)
ETL114058376(NOCT)
ZAB102063908(NOCT)
ZLE135446880(NOCT)
ACHL103804840(CCRN4L)
SVG106864038(NOCT)
MMEA130582142(NOCT)
HRT120753022(NOCT)
SATI136360682(NOCT)
CCIC134044645(NOCT)
FPG101917647(NOCT)
FCH102053174(NOCT)
CCRI104161150(CCRN4L)
NNT104409418(CCRN4L)
SHAB115610637(NOCT)
ACUN113479829(NOCT)
TALA104369517(NOCT)
ACHC115338678(NOCT)
HALD104312627(CCRN4L)
HLE104841761(CCRN4L)
AGEN126044800
HHAR128154647(NOCT)
GCL127015925
CSTI104563375(CCRN4L)
LDI104349266(CCRN4L)
MNB103780478(CCRN4L)
DPUB104296870(CCRN4L)
PPUS135178777(NOCT)
AVIT104279765(CCRN4L)
BRHI104493236(CCRN4L)
EGZ104135809(NOCT)
NNI104015978(CCRN4L)
PCRI104032285(CCRN4L)
PCAO104043146(CCRN4L)
PADL103920979(CCRN4L)
AFOR103908037(NOCT)
FGA104071983(CCRN4L)
GSTE104263383(CCRN4L)
CBOY140652561(NOCT)
CLV102088785(NOCT)
CNIC135988175(NOCT)
MUI104540965(CCRN4L)
PGUU104463899(CCRN4L)
PLET104615944(CCRN4L)
EHS104509053(CCRN4L)
CMAC104483879(CCRN4L)
CUCA104066442(NOCT)
TEO104377144(CCRN4L)
BREG104640636(CCRN4L)
OHA104336715(CCRN4L)
ACAR104530792(NOCT)
CPEA104398832(CCRN4L)
CVF104292758(CCRN4L)
RTD128909748(NOCT)
CRID134515814(NOCT)
AAM106491891(NOCT)
AROW112965417(NOCT)
NPD112950172(NOCT)
TGT104577902(CCRN4L)
DNE112986740(NOCT)
SCAM104153488(CCRN4L)
ASN102373172(NOCT)
AMJ102567362(NOCT)
CPOO109309613(NOCT)
GGN109301160(NOCT)
PSS102451508(NOCT)
CMY102939146(NOCT)
DCC119854597(NOCT)
CPIC101936301(NOCT)
TST117878109(NOCT)
CABI116838879(NOCT)
MRV120406199(NOCT)
ACS100556517(noct)
ASAO132776850(NOCT)
PVT110073655(NOCT)
SUND121930735(NOCT)
PBI103058940(NOCT)
PMUR107293158(NOCT)
CTIG120308385(NOCT)
TSR106545270(NOCT)
PGUT117680128(NOCT)
PCAE139320216(NOCT)
APRI131202970(NOCT)
PTEX113434721(NOCT)
NSS113412908(NOCT)
VKO123023763(NOCT)
PMUA114604123(NOCT)
PRAF128421086(NOCT)
ZVI118083410(NOCT)
HCG128328518(NOCT)
GJA107110787(NOCT)
STOW125440398(NOCT)
EMC129336741(NOCT)
XLA378568(noct.L) 734309(noct.S)
XTR549285(noct)
NPR108787519(NOCT)
RTEM120919058(NOCT)
ACAT141111722(NOCT)
BBUF120989975(NOCT)
BGAR122943301(NOCT)
DTC141086238(NOCT)
PWL138301719(NOCT)
MUO115461700(NOCT)
GSH117357962(NOCT)
DRE568973(noctb) 572044(nocta)
SRX107714224 107742507 107756481(noct)
SANH107676528 107680657 107692596 107702303
SGH107550850(noct) 107562977 107563986 107601501
CCAR109045774 109075089 109079183 109101575 109102500
CAUA113044314 113091093 113114064
CGIB127948694 127970881 128027532
PTET122352499(noctb) 122357557(nocta)
LROH127166104(noctb) 127176027(nocta)
GRF141288475(nocta) 141336649(noctb)
OMC131549294(noctb) 131553811(nocta)
PPRM120460783(nocta) 120481331(noctb)
RKG130071398(noctb) 130089758(nocta)
MAMB125258890(nocta) 125272488(noctb)
CIDE127509561 127525632
CERY137021888(nocta) 137033162(noctb)
MASI127412676 127417760 127443400 127445407
TROS130553649(noctb) 130563809(nocta)
TDW130412926(noctb) 130437825(nocta)
MANU129422882(nocta) 129444845(noctb)
PDAB135735833(noctb) 135759232(nocta)
IPU108268604(nocta)
IFU128611948(nocta)
PHYP113542743(noct)
SMEO124385831(nocta)
TFD113645990(nocta)
TVC132855531(nocta)
CGAR128532209(nocta)
NGRA132890435(nocta)
TRN134319408(nocta)
AMEX103024657(nocta)
CMAO118806990(nocta)
EEE113581505(noct)
CHAR105906267(nocta) 105908471(noctb)
SPIL134065105(noctb) 134068749(nocta)
TRU101067716 101074895
TFS130527329 130531180(nocta)
TNGGSTEN00023219G001 GSTEN00026635G001
LCO104922934(noct) 104938899
NCC104959560 104966628
TBEN117482054 117485366(nocta)
CGOB115013792 115015035(noct)
PGEO117447582 117454208(nocta)
GACU117560284 117561811(nocta)
EMAC134859547(nocta) 134864511
ELY117255743 117261177(nocta)
EFO125886576 125894363(nocta)
PLEP121941963(noctb) 121947728(nocta)
SLUC116039580 116042198(nocta)
ECRA117951223(nocta) 117955006(noctb)
ESP116669841(noct) 116695867
PFLV114562853(noct) 114565677
GAT120817933(nocta) 120825114
PPUG119211376(nocta) 119217668
AFB129095468(noctb) 129117103(nocta)
CLUM117735243 117737444(nocta)
PSWI130189616 130209214(nocta)
CANA137792502 137793022(noctb)
CVE137875173(nocta) 137890561(noctb)
MSAM119884055 119888743(nocta) 119899704
SCHU122873910 122879935(nocta)
CUD121508649 121516664(nocta)
SPUL138598160(nocta) 138604805(noctb)
LMIX132980814 132982507(nocta)
ALAT119008016(nocta) 119027483
ASTR137600112(noctb) 137603078(nocta)
MZE101478528(noct)
ONL100690381(noct)
OAU116331504(noctb)
OLA101157593(noct)
OML112153354 112157020
CSAI133446587(noctb) 133447283(nocta)
XMA102226828 102237197
XCO114145157 114153060(noct)
XHE116714362 116719974
PRET103463886 103471162(noct)
PFOR103132691 103154723(noct)
PLAI106946193 106963244(noct)
PMEI106905149 106931160
GAF122836546(nocta)
PPRL129353840(nocta) 129367065(noctb)
CVG107093243 107097348
CTUL119773479(nocta) 119786952
GMU124859873(nocta) 124868318
NFU107389498(noct) 107396430
KMR108245508 108249656(nocta)
ALIM106511359 106511585 106524622(noct)
NWH119409150(nocta) 119422687
AOCE111572374(nocta) 111585149(noctb)
EJA138208123 138211188
BFRE138629794 138632315(noctb)
MCEP125004132 125008415(nocta)
CSEM103384260(noct)
POV109624667 109627218
SSEN122762066(noctb) 122778975
SSOE131467520(noctb) 131473107
HHIP117765493 117769693(nocta)
HSP118098124 118112237(nocta)
PPLT128437564 128446256(nocta)
SMAU118312003 118319286
LCF108895516(nocta) 108900154
SDU111229271 111230402(noct)
SLAL111663590(noct) 111666744
XGL120784882(nocta) 120800067
HCQ109514429(noct) 109527505
SSCV125968450(noctb)
SBIA133506132(noctb)
PEE133404024(noctb) 133408029(nocta)
PTAO133476513(noctb) 133484482
BPEC110155793 110175173(noct)
ENY140349541 140377217(noctb)
MALB109957867 109966424(noct)
BSPL114862797 114864915(nocta)
SJO128362586(nocta) 128370701
SSCO133985774(nocta) 133990377(noctb)
GMH115540540(noct) 115552643
SASA106596388 106597766 106604687 106610553
STRU115172215 115182600 115182606
OTW112220937(nocta) 112244497 112255690
OMY110488807(nocta) 110497191 110497192
OGO123993401(nocta) 124023194 124023344
ONE115126566 115130688
OKI109864774(noct) 109887460 116352827
OKE118377976(nocta) 127925236
OMM135526386
OCLA139366272 139419137 139419725 139419726 139419728 139419731
SALP111965719 111967170 112078726
SNH120041083 120048106(nocta)
CCLU121536531 121542552
ELS105020852 105029048
OEP134032614(nocta) 134033819(noctb)
SFM108925729 108930757
PKI111853054
AANG118228032 118231012
AROT135254413 135259692
CCOG133131735 133135896
LOC102682701(noct)
PSPA121325246 121330605
ARUT117408755 117420930
PSEX120527823(nocta)
LCM102349012(NOCT)
CMK103181305
RTP109932243
CPLA122539350(nocta)
HOC132833315
LERI129701956(nocta)
HAKA140726387
PMRN116944946(NOCT)
LRJ133341818(NOCT)
BFO118420286
BBEL109467894
SCLV120329053
SPU591893
AJJ139979369
APLC110988644
ARUN117293861
AAMU139936561
AFIL140160839
AJC117112949
SKO100368766
PFLL139131660
DMEDmel_CG31299(cu)
DER26527069
DSE116801625
DSIDsimw501_GD26876(Dsim_GD26876)
DYADyak_GE27400
DAN6499531
DSR110188135
DPO4803139
DPE113567256
DMN108156775
DWI26528816
DGR116805427
DMODmoj_GI25727
DAZ108621833
DNV108659911
DHE111600242
CCAT101460917
RZE108373523
TDA119668788 119672624
MDE101887281
LCQ111674873
CVJ135953404(cu)
GFS119631833
ECOE129946143
CLON129610210
HIS119647579
AGA1279310
ACOZ120959966
AARA120904983
AMER121595200
ASTE118509089
AMAP126564403
AFUN125760850
AMOU128301157
AMRS128715627
AALI118460707
ACOS131266604
AAG5570471
AALB109398703 109404878
ASUA134212636
CQUCpipJ_CPIJ011434
CPII120420797
CNS116351978
BCOO119073735
LLL129793620
PPAP129804903
DSM124404757
NPT124211984
NFB124176761
NLO107222528
NVG124298306
AROA105692539
TCA663596
TMOL138137958(cu)
DPA109539469
ESIM136415554(cu)
EFOR136344563(cu)
AGRG126739490
ATD109598810
AGB108917458
LDC111512182
DVV114329802
NVL108556280
APLN108741418
PPYR116181069
OTU111413373
CFEL113363253
CCRN123296750
API100161460
DNX107170974
AGS114122020
RMD113560517
ACOO126832801 126832802 126835819 126840514 126840680 126840735 126846771
DVT126905951
BTAB109031372
DCI103506068
CLEC106663477
HHAL106682379(cu)
NLU111048726
HVI124370385
MQU128994633
PHUPhum_PHUM563920
FOC113204980
TPAL117653992
ZNE110827948
CSEC111871414
PAME138713139(cu)
SGRE126365928
BROR134538717
IEL124158710
HAMR139692575(cu)
FCD110856840
DPXDAPPUDRAFT_3216
DMK116917637
AFRA136038506
PJA122248849
PCHN125026195
PMOO119580337
HAME121869506
PCLA123771723
CQD128698040(cu)
PTRU123509330
ESN126983707
MNZ135198809
MRJ136833139
PORN139758486
HAZT108670333
EAF111714947
LSM121119876(cu)
TCF131877665
PPOI119108638
DSV119450253
RSAN119383299
RMP119170433
VDE111248629
VJA111265314
GOE100902263
CSCU111618187 111618189
CVS136982236(cu)
PTEP107440090
ABRU129960118
UDV129231561
SDM118182631
LPOL106458554 106474155 106475180
LGILOTGIDRAFT_95897
PVUL126829331
PCAN112560883
LSAX138969482
BGT106060053
GAE121374500 121391533
HRF124133660
HRJ124272289
HASI137272636 137273925
HCRA139450099
CRG105336378
CANU128156280
CVN111125355
OED125667268
MYI110454107
PMAX117329411
AIRR138327830
MCAF127714207
MMER123557696
RPHI132719110 132724865
DPOL127877671 127880020
MAEA128228288
OBI106875999
OSN115218557
LJP135472925
LAK106167882 106175603
SMMSmp_105040
SHXMS3_00001426(CCRN4L)
OVIT265_04013
LLON135493731
NVE5506068
EPA110243529
ATEN116289593 116293651
ADF107328558
AMIL114966105
MCAZ138016060
MFOO137999904
PDAM113680403
SPIS111337344
DGT114527765
XEN124446063
HMG105845432
HSY130653603
RES135686896
TADTRIADDRAFT_25141
PPP112287324
CRECHLRE_10g448950v5
VCNVOLCADRAFT_98156
MNGMNEG_6331
CSLCOCSUDRAFT_66649
OLUOSTLU_26290
OTAOT_ostta02g01180
BPGBathy11g03490
MISMICPUN_109024
MPPMICPUCDRAFT_42465
GSLGasu_20920
MBRMONBRDRAFT_36891
SREPTSG_04783 PTSG_07643
ACANACA1_215730 ACA1_354370
TETTTHERM_00660300 TTHERM_00825610
PTMGSPATT00021689001
SPARSPRG_11328 SPRG_19107
GTTGUITHDRAFT_143708
MFBMFUL124B02_29440
 » show all
Reference
1  [PMID:18391451]
  Authors
Kawai S, Murata K
  Title
Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).
  Journal
Biosci Biotechnol Biochem 72:919-30 (2008)
DOI:10.1271/bbb.70738
  Sequence
[mja:MJ_0109]
Reference
2  [PMID:29860338]
  Authors
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC
  Title
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
  Journal
Nucleic Acids Res 46:6257-6270 (2018)
DOI:10.1093/nar/gky412
  Sequence
[hsa:25819]
Reference
3  [PMID:30389976]
  Authors
Estrella MA, Du J, Korennykh A
  Title
Crystal Structure of Human Nocturnin Catalytic Domain.
  Journal
Sci Rep 8:16294 (2018)
DOI:10.1038/s41598-018-34615-0
  Sequence
[hsa:25819]
Reference
4  [PMID:31147539]
  Authors
Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A
  Title
The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled).
  Journal
Nat Commun 10:2367 (2019)
DOI:10.1038/s41467-019-10125-z
  Sequence
[hsa:25819]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.108
IUBMB Enzyme Nomenclature: 3.1.3.108
ExPASy - ENZYME nomenclature database: 3.1.3.108
BRENDA, the Enzyme Database: 3.1.3.108

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