KEGG   ENZYME: 3.1.3.108
Entry
EC 3.1.3.108                Enzyme                                 
Name
nocturnin;
NOCT (gene name);
nocturnin (curled);
MJ0109 (gene name);
NADP phosphatase;
NADPase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
NADPH 2'-phosphohydrolase
Reaction(IUBMB)
(1) NADPH + H2O = NADH + phosphate [RN:R12587];
(2) NADP+ + H2O = NAD+ + phosphate [RN:R00118]
Reaction(KEGG)
R00118 R12587
Substrate
NADPH [CPD:C00005];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Product
NADH [CPD:C00004];
phosphate [CPD:C00009];
NAD+ [CPD:C00003]
Comment
The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.
History
EC 3.1.3.108 created 2020
Orthology
K18764  nocturnin
Genes
HSA25819(NOCT)
PTR100611804(NOCT)
PPS100979611(NOCT)
GGO101133256(NOCT)
PON100449251(NOCT)
NLE100591529(NOCT)
MCC100428993(NOCT)
MCF102134207(NOCT)
CSAB103236274(NOCT)
CATY105580807(CCRN4L)
PANU100997677(NOCT)
TGE112624769(NOCT)
RRO104654345(NOCT)
RBB108536941(NOCT)
TFN117085922(NOCT)
PTEH111551937(NOCT)
CJC100393251(NOCT)
SBQ101030297(CCRN4L)
CSYR103255271(NOCT)
MMUR105872360(NOCT)
OGA100962419(NOCT)
MMU12457(Noct)
MCAL110291122(Noct)
MPAH110320210(Noct)
RNO310395(Noct)
MCOC116094444(Noct)
MUN110545133(Noct)
CGE100766002(Noct)
PLEU114695851(Noct) 114707977
NGI103742363(Noct)
HGL101710110(Noct)
CPOC100713041(Noct)
CCAN109691470(Noct)
DORD105995684(Noct)
DSP122127151(Noct)
OCU100348337(NOCT)
OPI101518231(NOCT)
TUP102502756(NOCT)
CFA483818(NOCT)
VVP112934917(NOCT)
VLG121493119(NOCT)
AML100472917(NOCT)
UMR103657961(NOCT)
UAH113255683(NOCT)
UAR123793276(NOCT)
ELK111149080
LLV125093397
MPUF101692678(NOCT)
ORO101365311(CCRN4L)
EJU114208164(NOCT)
ZCA113924598(NOCT)
MLX118022315(NOCT)
FCA101092681(NOCT)
PYU121029610(NOCT)
PBG122497251(NOCT)
PTG102965630(NOCT)
PPAD109249387(NOCT)
AJU106976192(NOCT)
HHV120243132(NOCT)
BTA540641(NOCT)
BOM102279918(NOCT)
BIU109571342(NOCT)
BBUB102399873(NOCT)
CHX102187886(NOCT)
OAS101117790(NOCT)
ODA120870925(NOCT)
CCAD122452524(NOCT)
SSC100513746(NOCT)
CFR102524312(NOCT)
CBAI105068704(CCRN4L)
CDK105087080(NOCT)
VPC102538495
BACU103003260(NOCT)
LVE103072303(NOCT)
OOR101283045(CCRN4L)
DLE111164860(NOCT)
PCAD102992628(NOCT)
PSIU116753825(NOCT)
ECB100071468(NOCT)
EPZ103549003(NOCT)
EAI106837991(NOCT)
MYB102260842(NOCT)
MYD102759031(NOCT)
MMYO118651580 118658853(NOCT)
MLF102428003(NOCT)
MNA107534921(NOCT)
PKL118711607(NOCT)
HAI109394194(NOCT)
DRO112312425(NOCT)
SHON118995459(NOCT)
AJM119034879(NOCT)
PDIC114504158(NOCT)
PHAS123813997(NOCT)
MMF118615874(NOCT)
RFQ117038246(NOCT)
PALE102883027(NOCT)
PGIG120613209(NOCT)
PVP105301556(NOCT)
RAY107515347(NOCT)
MJV108407063(NOCT)
TOD119234772(NOCT)
SARA101549546(CCRN4L)
LAV100677271(NOCT)
TMU101347454
DNM101427251(NOCT)
MDO100027658(NOCT)
GAS123251016(NOCT)
SHR100930989(NOCT)
PCW110194902(NOCT)
OAA100078856(NOCT)
GGA404779(NOCT)
PCOC116226093(NOCT)
MGP100541508(NOCT)
CJO107313121(NOCT)
NMEL110399084(NOCT)
APLA101797379(NOCT)
ACYG106040962(NOCT)
AFUL116488596(NOCT)
TGU100231561(NOCT)
LSR110480519(NOCT)
SCAN103822546(NOCT)
PMOA120496055(NOCT)
OTC121339918(NOCT)
PRUF121354684(NOCT)
GFR102040001(NOCT)
FAB101806807(NOCT)
PHI102100975(NOCT)
PMAJ107198931(NOCT)
CCAE111928919(NOCT)
CCW104697280(NOCT)
ETL114058376(NOCT)
ZAB102063908(NOCT)
FPG101917647(NOCT)
FCH102053174(NOCT)
CLV102088785(NOCT)
EGZ104135809(CCRN4L)
NNI104015978(CCRN4L)
ACUN113479829(NOCT)
TALA104369517(NOCT)
PADL103920979(CCRN4L)
ACHC115338678(NOCT)
AAM106491891(NOCT)
AROW112965417(NOCT)
NPD112950172(NOCT)
DNE112986740(NOCT)
ASN102373172(NOCT)
AMJ102567362(NOCT)
CPOO109309613(NOCT)
GGN109301160(NOCT)
PSS102451508(NOCT)
CMY102939146(NOCT)
CPIC101936301(NOCT)
TST117878109(NOCT)
CABI116838879(NOCT)
MRV120406199(NOCT)
ACS100556517(noct)
PVT110073655(NOCT)
SUND121930735(NOCT)
PBI103058940(NOCT)
PMUR107293158(NOCT)
TSR106545270(NOCT)
PGUT117680128(NOCT)
VKO123023763(NOCT)
PMUA114604123(NOCT)
ZVI118083410(NOCT)
GJA107110787(NOCT)
XLA378568(noct.L) 734309(noct.S)
XTR549285(noct)
NPR108787519(NOCT)
RTEM120919058(NOCT)
BBUF120989975(NOCT)
BGAR122943301(NOCT)
DRE568973(noctb) 572044(nocta)
SRX107714224 107742507 107756481(noct)
SANH107676528 107680657 107692596 107702303
SGH107550850(noct) 107562977 107563986 107601501
CCAR109045774 109079183 109102500
CAUA113044314 113091093 113114064
IPU108268604(nocta)
PHYP113542743(noct)
SMEO124385831(nocta)
AMEX103024657(noct)
EEE113581505(noct)
TRU101067716 101074895
TNGGSTEN00023219G001 GSTEN00026635G001
LCO104922934(noct) 104938899
NCC104959560 104966628
CGOB115013792 115015035(noct)
ELY117255743 117261177(nocta)
PLEP121941963(noctb) 121947728(nocta)
SLUC116039580 116042198(nocta)
ECRA117951223(nocta) 117955006(noctb)
PFLV114562853(noct) 114565677
GAT120817933(nocta) 120825114
PPUG119211376(nocta) 119217668
MSAM119884055 119888743(nocta) 119899704
CUD121508649 121516664(nocta)
MZE101478528(noct)
ONL100690381(noct)
OAU116331504(noctb)
OLA101157593(noct)
OML112153354 112157020
XMA102226828 102237197
XCO114145157 114153060(noct)
XHE116714362 116719974
PRET103463886 103471162(noct)
PFOR103132691 103154723(noct)
PLAI106946193 106963244(noct)
PMEI106905149 106931160
GAF122836546(nocta)
CVG107093243 107097348
CTUL119773479(nocta) 119786952
GMU124859873(nocta) 124868318
NFU107389498(noct) 107396430
KMR108245508 108249656(nocta)
ALIM106511359 106511585 106524622(noct)
NWH119409150(nocta) 119422687
AOCE111572374(noct) 111585149
CSEM103384260(noct)
POV109624667 109627218
SSEN122762066(noctb) 122778975
HHIP117765493 117769693(nocta)
LCF108895516(noct) 108900154
SDU111229271 111230402(noct)
SLAL111663590(noct) 111666744
XGL120784882(nocta) 120800067
HCQ109514429(noct) 109527505
BPEC110155793 110175173(noct)
MALB109957867 109966424(noct)
SASA106596388 106597766 106604687 106610553
OTW112220937(nocta) 112244497 112255690
OMY110488807(nocta) 110497191 110497192
OGO123993401(nocta) 124023194 124023344
ONE115126566 115130688
SALP111965719 111967170 112078726
SNH120041083 120048106(nocta)
ELS105020852 105029048
SFM108925729 108930757
PKI111853054
AANG118228032 118231012
LOC102682701(noct)
PSPA121325246 121330605
ARUT117408755 117420930
LCM102349012(NOCT)
CMK103181305
RTP109932243(noct)
BFO118420286
BBEL109467894
SCLV120329053
SPU591893
APLC110988644
SKO100368766
DMEDmel_CG31299(cu)
DER26527069
DSE116801625
DSIDsimw501_GD26876(Dsim_GD26876)
DYADyak_GE27400
DAN6499531
DSR110188135
DPODpse_GA16160
DPE113567256
DMN108156775
DWI26528816
DGR116805427
DMODmoj_GI25727
DAZ108621833
DNV108659911
DHE111600242
CCAT101460917
MDE101887281
LCQ111674873
AGAAgaP_AGAP009893
ACOZ120959966
AARA120904983
AAG5570471
AALB109398703 109404878
CQUCpipJ_CPIJ011434
CPII120420797
CNS116351978
TCA663596
DPA109539469
ATD109598810
AGB108917458
LDC111512182
NVL108556280
APLN108741418
PPYR116181069
OTU111413373
API100161460
DNX107170974
AGS114122020
RMD113560517
BTAB109031372
DCI103506068
CLEC106663477
HHAL106682379
NLU111048726
PHUPhum_PHUM563920
FOC113204980
ZNE110827948
CSEC111871414
FCD110856840
DPXDAPPUDRAFT_3216
DMK116917637
PVM113816919
PJA122248849
HAME121869506
PCLA123771723
PTRU123509330
HAZT108670333
EAF111714947
ISCIscW_ISCW023719
DSV119450253
RSAN119383299
RMP119170433
VDE111248629
VJA111265314
CSCU111618187 111618189
PTEP107440090
SDM118182631
LGILOTGIDRAFT_95897
PCAN112560883
BGT106060053
GAE121374500 121391533
HRF124133660
HRJ124272289
CRG105336378
MYI110454107
PMAX117329411
MMER123557696
OBI106875999
OSN115218557
LAK106167882 106175603
SMMSmp_105040
SHXMS3_0014066
OVIT265_04013
NVE5506068
EPA110243529
ATEN116289593 116293651
ADF107328558
AMIL114966105
PDAM113680403
SPIS111337344
DGT114527765
XEN124446063
HMG105845432
TADTRIADDRAFT_25141
PPP112287324
CRECHLRE_10g448950v5
VCNVOLCADRAFT_98156
MNGMNEG_6331
CSLCOCSUDRAFT_66649
OLUOSTLU_26290
OTAOT_ostta02g01180
BPGBathy11g03490
MISMICPUN_109024
MPPMICPUCDRAFT_42465
GSLGasu_20920
MBRMONBRDRAFT_36891
SREPTSG_04783 PTSG_07643
ACANACA1_215730 ACA1_338400 ACA1_354370
TETTTHERM_00660300 TTHERM_00825610
PTMGSPATT00021689001
SPARSPRG_11328 SPRG_19107
GTTGUITHDRAFT_143708
MFBMFUL124B02_29440
 » show all
Reference
1  [PMID:18391451]
  Authors
Kawai S, Murata K
  Title
Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).
  Journal
Biosci Biotechnol Biochem 72:919-30 (2008)
DOI:10.1271/bbb.70738
  Sequence
[mja:MJ_0109]
Reference
2  [PMID:29860338]
  Authors
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC
  Title
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
  Journal
Nucleic Acids Res 46:6257-6270 (2018)
DOI:10.1093/nar/gky412
  Sequence
[hsa:25819]
Reference
3  [PMID:30389976]
  Authors
Estrella MA, Du J, Korennykh A
  Title
Crystal Structure of Human Nocturnin Catalytic Domain.
  Journal
Sci Rep 8:16294 (2018)
DOI:10.1038/s41598-018-34615-0
  Sequence
[hsa:25819]
Reference
4  [PMID:31147539]
  Authors
Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A
  Title
The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled).
  Journal
Nat Commun 10:2367 (2019)
DOI:10.1038/s41467-019-10125-z
  Sequence
[hsa:25819]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.108
IUBMB Enzyme Nomenclature: 3.1.3.108
ExPASy - ENZYME nomenclature database: 3.1.3.108
BRENDA, the Enzyme Database: 3.1.3.108

DBGET integrated database retrieval system