KEGG   ENZYME: 3.1.3.112
Entry
EC 3.1.3.112                Enzyme                                 
Name
4'-phosphooxetanocin A phosphatase;
oxsA (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
[(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-(hydroxymethyl)oxetan-2-yl]methyl phosphate phosphohydrolase
Reaction(IUBMB)
4'-phosphooxetanocin A + H2O = oxetanocin A + phosphate [RN:R13364]
Reaction(KEGG)
R13364
Substrate
4'-phosphooxetanocin A [CPD:C22952];
H2O [CPD:C00001]
Product
oxetanocin A [CPD:C22953];
phosphate [CPD:C00009]
Comment
The enzyme can catalyse the sequential hydrolysis of tri-, di-, and mono-phosphorylated oxetanocin A compounds, releasing one molecule of inorganic phosphate at a time. The active site switches from a dinuclear to a mononuclear metal center as phosphates are eliminated from the substrate.
History
EC 3.1.3.112 created 2024
Orthology
K27843  4'-phosphooxetanocin A phosphatase
Genes
ALIC: GI364_07575(yfbR)
Reference
1  [PMID:28346939]
  Authors
Bridwell-Rabb J, Zhong A, Sun HG, Drennan CL, Liu HW.
  Title
A B(12)-dependent radical SAM enzyme involved in oxetanocin A biosynthesis.
  Journal
Nature 544:322-326 (2017)
DOI:10.1038/nature21689
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.112
IUBMB Enzyme Nomenclature: 3.1.3.112
ExPASy - ENZYME nomenclature database: 3.1.3.112
BRENDA, the Enzyme Database: 3.1.3.112

  All links  
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (2)   

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