| Entry |
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| Name |
sucrose-phosphate phosphatase;
sucrose 6-phosphate hydrolase;
sucrose-phosphate hydrolase;
sucrose-phosphate phosphohydrolase;
sucrose-6-phosphatase;
sucrose phosphatase;
sucrose-6-phosphate phosphatase;
SPP
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
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| Sysname |
sucrose-6F-phosphate phosphohydrolase
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| Reaction(IUBMB) |
sucrose 6F-phosphate + H2O = sucrose + phosphate [RN: R00805 R06211]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Mg2+ for maximal activity [2]. This is the final step in the sucrose-biosynthesis pathway. The enzyme is highly specific for sucrose 6-phosphate, with fructose 6-phosphate unable to act as a substrate [2]. Belongs in the haloacid dehydrogenase (HAD) superfamily. The F of sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
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| History |
EC 3.1.3.24 created 1972, modified 2008
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| Pathway |
| ec00500 | Starch and sucrose metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Hawker JS, Hatch MD. |
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| Title |
A specific sucrose phosphatase from plant tissues. |
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| Journal |
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| Reference |
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| Authors |
Lunn JE, Ashton AR, Hatch MD, Heldt HW |
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| Title |
Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lunn JE, MacRae E |
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| Title |
New complexities in the synthesis of sucrose. |
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| Journal |
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| Reference |
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| Authors |
Fieulaine S, Lunn JE, Borel F, Ferrer JL |
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| Title |
The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.3.24 |
| ExPASy - ENZYME nomenclature database: | 3.1.3.24 |
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