KEGG   ENZYME: 3.1.3.26
Entry
EC 3.1.3.26                 Enzyme                                 
Name
4-phytase;
6-phytase (name based on 1L-numbering system and not 1D-numbering);
phytase;
phytate 6-phosphatase;
myo-inositol-hexakisphosphate 6-phosphohydrolase (name based on 1L-numbering system and not 1D-numbering)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
myo-inositol-hexakisphosphate 4-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate [RN:R03372]
Reaction(KEGG)
R03372
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
1D-myo-inositol 1,2,3,5,6-pentakisphosphate [CPD:C04579];
phosphate [CPD:C00009]
History
EC 3.1.3.26 created 1972, modified 1976, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01093  4-phytase / acid phosphatase
Genes
ECO: b0980(appA)
ECJ: JW0963(appA)
ECD: ECDH10B_1050(appA)
EBW: BWG_0832(appA)
ECOK: ECMDS42_0832(appA)
ECE: Z1397(appA)
ECS: ECs_1136(appA)
ECF: ECH74115_1216(appA)
ETW: ECSP_1149(appA)
ELX: CDCO157_1101
EOI: ECO111_1091(appA)
EOJ: ECO26_1535(appA)
EOH: ECO103_1025(appA)
ECOO: ECRM13514_1157(appA)
ECOH: ECRM13516_1086(appA)
ESL: O3K_16440
ESO: O3O_08855
ESM: O3M_16415
ECK: EC55989_1088(appA)
ECG: E2348C_0965(appA)
EOK: G2583_1215(appA)
ELR: ECO55CA74_05935
ELH: ETEC_1049
ECW: EcE24377A_1096(appA)
EUN: UMNK88_1135
ECP: ECP_0985
ENA: ECNA114_1060(appA)
ECOS: EC958_1185(appA)
ECV: APECO1_84(appA)
ECOA: APECO78_08890
ECX: EcHS_A1089(appA)
ECM: EcSMS35_2136(appA)
ECY: ECSE_1042
ECR: ECIAI1_1021(appA)
ECQ: ECED1_1064(appA)
EUM: ECUMN_1170(appA)
ECT: ECIAI39_2166(appA)
EOC: CE10_1008(appA)
EBR: ECB_00983(appA)
EBL: ECD_00983(appA)
EBE: B21_00990(appA)
EBD: ECBD_2614
ECI: UTI89_C1049(appA)
EIH: ECOK1_1042(appA)
ECZ: ECS88_1002(appA)
ECC: c1121(appA)
ELO: EC042_1065(appA)
ELN: NRG857_04465
ESE: ECSF_0894
ECL: EcolC_2616
EKO: EKO11_2850
EKF: KO11_17825(appA)
EAB: ECABU_c10140(appA)
EDH: EcDH1_2663
EDJ: ECDH1ME8569_0932(appA)
ELU: UM146_12675
ELW: ECW_m1091(appA)
ELL: WFL_05315(appA)
ELC: i14_1025(appA)
ELD: i02_1025(appA)
ELP: P12B_c0967(appA)
ELF: LF82_0100(appA)
ECOL: LY180_05140
ECOI: ECOPMV1_01011(appA_1)
ECOJ: P423_05380
EFE: EFER_3043
EAL: EAKF1_ch0429c(appA)
EMA: C1192_07320
ESZ: FEM44_19790
SFL: SF0982(appA)
SFX: S1048(appA)
SFV: SFV_0989(appA)
SFE: SFxv_1064(appA)
SFN: SFy_1341
SFS: SFyv_1383
SFT: NCTC1_01020(appA_1)
SSN: SSON_0987(appA)
SBO: SBO_2250(appA)
SBC: SbBS512_E2335(appA)
SDY: SDY_0956(appA)
SDZ: Asd1617_01201
SHQ: A0259_09025
ENR: H650_02130
ESA: ESA_02095
CSK: ES15_2251(appA)
CSZ: CSSP291_09965
CSJ: CSK29544_03387
CSI: P262_03255
CUI: AFK65_08545
CTU: CTU_18700(appA)
KPN: KPN_00628
KPU: KP1_1578
KPM: KPHS_14650
KPP: A79E_3612
KPH: KPNIH24_21485
KPZ: KPNIH27_06790
KPV: KPNIH29_07485
KPW: KPNIH30_07515
KPY: KPNIH31_07390
KPG: KPNIH32_07620
KPC: KPNIH10_07305
KPQ: KPR0928_07215
KPT: VK055_1906(phyK)
KPO: KPN2242_01675 KPN2242_06005
KPR: KPR_3951
KPJ: N559_3698
KPI: D364_03295
KPA: KPNJ1_03953
KPS: KPNJ2_03943
KPX: PMK1_02960(agp_1)
KPB: FH42_24175
KPNE: KU54_019140
KPNU: LI86_18965
KPNK: BN49_1685 BN49_4737(appA)
KVA: Kvar_3740
KPE: KPK_3948
KPK: A593_17605
KVD: KR75_15065
KOX: KOX_14030
KOE: A225_1624
KOY: J415_23510
KOM: HR38_12765
KOK: KONIH1_07970
KQU: AVR78_11805
EAE: EAE_02525
EAR: CCG33480
KQV: B8P98_20555
KLL: BJF97_08350
KLW: DA718_20335
KAR: LGL98_18165
KGR: JJJ10_20205
ROR: RORB6_11940
RON: TE10_08950
RPLN: B1209_19645
RAO: DSD31_18475
RTG: NCTC13098_04907(agp_2)
CWE: CO701_07465
CFQ: C2U38_04960
CAF: AL524_16675
CIR: C2U53_20695
HDE: HDEF_2244(appA)
KSA: C813_02725
KRD: A3780_12010
KPSE: IP581_11955
BUF: D8682_18890
IZH: FEM41_23385
PSHI: SAMEA2665130_1541(appA_4)
EBU: CUC76_08260
YPE: YPO1648
YPK: y1810(appA)
YPH: YPC_1753
YPA: YPA_1875
YPN: YPN_1982
YPM: YP_1778(appA)
YPP: YPDSF_1799
YPG: YpAngola_A2841(appA)
YPZ: YPZ3_2046
YPT: A1122_17635
YPD: YPD4_2087
YPX: YPD8_2084
YPW: CH59_189(appA)
YPJ: CH55_223(appA)
YPV: BZ15_1903(appA)
YPL: CH46_3477(appA)
YPS: YPTB2421
YPO: BZ17_30(appA)
YPI: YpsIP31758_1622(appA)
YPY: YPK_1730
YPB: YPTS_2503
YPQ: DJ40_4145(appA)
YPU: BZ21_1712(appA)
YPR: BZ20_3780(appA)
YPC: BZ23_1998(appA)
YPF: BZ19_1789(appA)
YEN: YE2600
YEP: YE105_C1662
YEY: Y11_14891
YEL: LC20_02112
YEW: CH47_1942(appA)
YET: CH48_3266(appA)
YEF: FORC2_2576
YEE: YE5303_23821
YSI: BF17_21295
YAL: AT01_51(appA)
YFR: AW19_831(appA)
YIN: CH53_3517(appA)
YKR: CH54_831
YRO: CH64_183(appA)
YAK: ACZ76_01245
YMA: DA391_08650
YHI: D5F51_10995
YCA: F0T03_13360
YMO: HRD69_13485
SMAF: D781_3671
SRZ: AXX16_1414
SERA: Ser39006_002070
SERQ: CWC46_02070
SERM: CLM71_23710
SOF: NCTC11214_01745(appA_1)
SRHZ: FO014_10010
GQU: AWC35_02855
RBAD: H2866_12100
ECA: ECA4198
PATR: EV46_20920
PATO: GZ59_42580
PCT: PC1_3998
PCC: PCC21_039770
PWA: Pecwa_4189
PPAR: A8F97_20560
PEC: W5S_4347
PWS: A7983_06065
PPOA: BJK05_14960
PBRA: B5S52_01235
PPUJ: E2566_20310
PARI: I2D83_01305
PAQU: DMB82_0019175
PVZ: OA04_42630
PPAV: LOZ86_02330
DDD: Dda3937_01138
DZE: Dd1591_4136
DDC: Dd586_4105
DZC: W909_19900
DSO: A4U42_08550
CED: LH89_12890
DFN: CVE23_22000
DDQ: DDI_4181
DAQ: DAQ1742_00052
DIC: Dpoa569_000047
DDA: Dd703_3938
LBQ: CKQ53_08705
LPOP: I6N93_12585
EBI: EbC_09720(appa)
EGE: EM595_0941
EPE: CI789_13695
ERWI: GN242_16350 GN242_16370
PAM: PANA_0959(agp)
PLF: PANA5342_3343(phyK)
PAJ: PAJ_0285(agp)
PAQ: PAGR_g3246
PVA: Pvag_0342(phyK)
PAGG: AL522_08675
PAO: Pat9b_0907
PANT: PSNIH1_09405
PAGC: BEE12_11405
PSTW: DSJ_05650
PEY: EE896_14885
PDIS: D8B20_04380 D8B20_04945
PER: LAC65_03650
TPTY: NCTC11468_02898(appA)
EIC: NT01EI_1443
ETR: ETAE_1316
ETD: ETAF_1224
ETE: ETEE_3291(appA)
ETC: ETAC_06220
EDW: QY76_13330
EDL: AAZ33_06825
EHO: A9798_10215
HAV: AT03_09325
HPAR: AL518_16440
OPO: DSM2777_09415
XCC: XCC0760(appA)
XCB: XC_3473
XCA: xcc-b100_3594
XCP: XCR_0938
XCV: XCV0590(appA) XCV0864(appA) XCV4225
XAX: XACM_0548(appA) XACM_0808 XACM_4001
XAC: XAC0557(appA) XAC0812(appA) XAC4132(appA)
XCI: XCAW_00167(appA) XCAW_03768(appA)
XCT: J151_00678 J151_00938 J151_04311
XCJ: J158_00675 J158_00935 J158_04264
XCU: J159_00675 J159_00935 J159_04260
XCN: J169_00674 J169_00934 J169_04308
XCW: J162_00674 J162_00934 J162_04266
XCR: J163_00674 J163_00934 J163_04260
XCM: J164_00674 J164_00934 J164_04261
XCF: J172_00669 J172_00929 J172_04301
XFU: XFF4834R_chr05530 XFF4834R_chr08180(appA) XFF4834R_chr40020
XAO: XAC29_02840 XAC29_04140 XAC29_20810
XOM: XOO3574(XOO3574)
XOO: XOO3792(appA)
XOP: PXO_04687
XOY: AZ54_04960
XOR: XOC_0877
XOZ: BE73_19995
XAL: XALC_2788
XSA: SB85_06825 SB85_08885 SB85_15620
XTN: FD63_15880 FD63_18170
XVE: BJD12_17075
XPE: BJD13_12650 BJD13_14080 BJD13_18375
XHR: XJ27_11295
XGA: BI317_04905
XPH: XppCFBP6546_07375(XppCFBP6546P_07375) XppCFBP6546_08950(XppCFBP6546P_08950) XppCFBP6546_13775(XppCFBP6546P_13775)
XVA: C7V42_02915 C7V42_04510
XAN: AC801_02705 AC801_04200 AC801_20520
XAR: XB05_00730 XB05_20985
XHY: FZ025_13610
XCZ: EBN15_03110
XTH: G4Q83_01245 G4Q83_02555
XEU: XSP_000818
XHD: LMG31886_31450(appA_1) LMG31886_35170(appA_2)
DCS: ISN74_19960
DTL: H8F01_03305
LRZ: BJI69_17270
LPY: FIV34_11065
PSB: Psyr_4500
PRX: HRH33_09805 HRH33_09810
PSK: U771_10000 U771_10005
PFZ: AV641_16965 AV641_16970
PLQ: AA042_16710 AA042_16715
PPSY: AOC04_14235 AOC04_14240
PPSH: G5J76_20705
PEZ: HWQ56_10970
PTAE: NCTC10697_03275(agp)
MMOB: F6R98_16485
ZPL: ZBT109_1255
ATY: A9R16_007405
CDIZ: CEDIAZO_01004(agp)
LHK: LHK_03226
DEE: HQN60_06560
PPNO: DA70_12870
PPNM: LV28_17830
PRB: X636_14000
PPUL: RO07_12025
PSPU: NA29_08045
PAPI: SG18_25920
PVE: UC34_03875
POX: MB84_08330
PFG: AB870_14950
PNR: AT302_02035 AT302_12140
PFIB: PI93_003430
OTK: C6570_10225
OFO: BRW83_1278(appA_1) BRW83_1307(appA_2)
BBAY: A4V04_07650
DFI: AXF13_09085
DPG: DESPIGER_0144
LIP: LI0436 LI0438
LIR: LAW_00452
AVI: Avi_0609
ARUI: G6M88_09665
BAPI: BBC0122_017370
AZC: AZC_4319
CCR: CC_0542
CCS: CCNA_00576(oppA)
CSE: Cseg_2456 Cseg_3136
CFH: C1707_14850
CAUF: CSW63_14990
ZMO: ZMO0061
ZMN: Za10_1128
ZMM: Zmob_0756
ZMB: ZZ6_1138
ZMI: ZCP4_1165
ZMC: A265_01156(appA)
ZMR: A254_01155(appA)
NRE: BES08_21135 BES08_24235
NOV: TQ38_024435 TQ38_025560
NOR: FA702_18675
SMAG: AN936_11405
SMAZ: LH19_12560
SPHO: C3E99_18720
STAX: MC45_02080 MC45_11915
SNJ: A7E77_13750
SMY: BJP26_19115
SPAN: AWL63_14190
SPLK: AV944_00945 AV944_08690
SPHF: DM480_08675 DM480_15510
SPAU: DRN02_015065
GOX: GOX1076 GOX1190
GOH: B932_1054
GOY: GLS_c11450(appA)
GAL: A0U94_13015
GTI: FXF46_05795
GSP: IGS75_07320
GFA: MKW11_05760
GBC: GbCGDNIH3_1410
GBS: GbCGDNIH4_1410
KEU: S101446_02698(appA)
KSC: CD178_00707(appA)
APT: APA01_03230
APW: APA42C_03230
APF: APA03_03230
APU: APA07_03230
APG: APA12_03230
APQ: APA22_03230
APX: APA26_03230
APZ: APA32_03230
APK: APA386B_1808(appA)
ASZ: ASN_1924(appA)
ASV: WG31_01590
APOM: CPF11_05710
ATO: CIW82_02435
AASC: A4S02_10975
ACET: DS739_01710
AOY: EOV40_001640
ACEK: FLP30_10775
ABG: Asbog_01039
NTN: D5366_04285
AZL: AZL_b01070
AZM: DM194_22125
AZZ: DEW08_01260
NAO: Y958_04115 Y958_13160 Y958_24860
NCB: C0V82_17515
MHAD: B586_02085
MLL: B1R94_26470
MAIC: MAIC_03690(appA)
MANY: MANY_34820(appA)
ACA: ACP_1579
GMA: AciX8_0270
GRW: FTO74_19065
TALB: FTW19_21545
ABAS: ACPOL_3731
EDA: GWR55_14565
PFER: IRI77_10650 IRI77_15290 IRI77_16660 IRI77_16665
CPOR: BED41_01000
 » show all
Reference
1  [PMID:4310376]
  Authors
Johnson LF, Tate ME.
  Title
The structure of myo-inositol pentaphosphates.
  Journal
Ann N Y Acad Sci 165:526-32 (1969)
DOI:10.1111/j.1749-6632.1970.tb56420.x
Reference
2  [PMID:13921788]
  Authors
TOMLINSON RV, BALLOU CE.
  Title
Myoinositol polyphosphate intermediates in the dephosphorylation of phytic acid by phytase.
  Journal
Biochemistry 1:166-71 (1962)
DOI:10.1021/bi00907a025
Reference
3  [PMID:4349266]
  Authors
Lim PE, Tate ME.
  Title
The phytases. II. Properties of phytase fractions F 1  and F 2  from wheat bran and the myoinositol phosphates produced by fraction F 2 .
  Journal
Biochim Biophys Acta 302:316-28 (1973)
DOI:10.1016/0005-2744(73)90160-5
Reference
4
  Authors
Cosgrove, D.J.
  Title
Inositol Phosphates: Their Chemistry, Biochemistry, and Physiology, Elsevier, Amsterdam, 1980
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.26
IUBMB Enzyme Nomenclature: 3.1.3.26
ExPASy - ENZYME nomenclature database: 3.1.3.26
BRENDA, the Enzyme Database: 3.1.3.26
CAS: 9001-89-2

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (811)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (477)   
   KEGG MGENES (177)   
   RefGene (156)   
Protein sequence (1342)   
   UniProt (600)   
   RefSeq(pep) (737)   
   PDBSTR (5)   
DNA sequence (4214)   
   RefSeq(nuc) (2599)   
   GenBank (837)   
   EMBL (778)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   InterPro (3)   
   PROSITE(DOC) (1)   
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