KEGG ENZYME: 3.1.3.29

ENZYME: 3.1.3.29

Entry

EC 3.1.3.29                 Enzyme

Name

N-acylneuraminate-9-phosphatase;
acylneuraminate 9-phosphatase;
N-acylneuraminic acid 9-phosphate phosphatase;
N-acylneuraminic (sialic) acid 9-phosphatase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

N-acylneuraminate-9-phosphate phosphohydrolase

Reaction(IUBMB)

N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate [RN:R02597]

Reaction(KEGG)

R02597 > R01805

Substrate

N-acylneuraminate 9-phosphate [CPD:C01200];
H2O [CPD:C00001]

Product

N-acylneuraminate [CPD:C00591];
phosphate [CPD:C00009]

Comment

The enzyme, found in vertebrates, is equally active with N-acetylneuraminate 9-phosphate and N-glycoloylneuraminate 9-phosphate.

History

EC 3.1.3.29 created 1972

Pathway

ec00541

Biosynthesis of various nucleotide sugars

ec01100

Metabolic pathways

Orthology

K01097

N-acylneuraminate-9-phosphatase

Genes

HSA:	140838(NANP)

PTR:	745164(NANP)

PPS:	100987370(NANP)

GGO:	101130395(NANP)

PON:	100452305(NANP)

PPYG:

129021894(NANP)

NLE:	100605623(NANP)

HMH:	116461139(NANP)

SSYN:

129474353(NANP)

MCC:	706491(NANP)

MCF:	102129164 135965526 135965546 135965583(NANP)

MTHB:

126929868

CSAB:

103247037(NANP)

PANU:

103881046(NANP)

TGE:	112617619(NANP)

MLEU:

105534180(NANP)

RRO:	104661001(NANP)

RBB:	108522537(NANP)

TFN:	117068354(NANP)

PTEH:

111527251(NANP)

CANG:

105519002(NANP)

CJC:	100410318(NANP)

SBQ:	101047872(NANP)

CIMI:

108297901

ANAN:

105728303(NANP)

CSYR:

103271162(NANP)

MMUR:

105867030(NANP)

LCAT:

123622460

ERUF:

138400812(NANP)

PCOQ:

105818892(NANP)

OGA:	100949190(NANP)

MMU:	67311(Nanp)

MCAL:

110289363(Nanp)

MPAH:

110318710(Nanp)

RNO:	311530(Nanp)

MCOC:

116091138(Nanp)

ANU:	117704331(Nanp)

ASYL:

127686050(Nanp)

MUN:	110564574(Nanp)

CGE:	100764540(Nanp)

MAUA:

101831045

PROB:

127228848(Nanp)

PLEU:

114709546

PMAV:

102905812(Nanp)

MORG:

121460557

MFOT:

126494646

AAMP:

119805574 119815744

CNL:	130881453(Nanp)

NGI:	103735539(Nanp)

HGL:	101714663(Nanp)

CPOC:

100720176(Nanp)

CCAN:

109689891(Nanp)

DORD:

105993683(Nanp)

DSP:

122096050

DMER:

138816646(Nanp)

PLOP:

125353172

NCAR:

124977333

MMMA:

107148490

ITI:

101976373

OCU:

100341646

OPI:

101532964

OCZ:

121157043

TUP:	102473519(NANP)

GVR:

103606667

CFA:	483833 608182(NANP)

CLUD:

112642715 112668844

VVP:	112933247(NANP)

VLG:

121478955

NPO:	129507397(NANP)

AML:

100467462

UMR:

103681927

UAH:	113248364(NANP)

UAR:

123800937

ELK:

111156625

LLV:

125108434

MPUF:

101675224(NANP)

MNP:	132021670(NANP)

MLK:	131808288(NANP)

NVS:

122916437

ORO:	101362217(NANP)

EJU:	114224515(NANP)

ZCA:

113937546

MLX:	118011158(NANP)

MANO:

123851482(NANP)

NSU:

110590035

LWW:	102746574(NANP)

FCA:

101092842

PYU:

121012588

PCOO:

112869314(NANP)

PBG:

122497555

PVIV:

125162983(NANP)

LRUF:

124503738

LGF:

123579597

AJU:

106986727

PTG:	102968154(NANP)

PPAD:

109259578(NANP)

PUC:

125936179

PLEZ:

122214987

HHV:

120226609

CCRU:

144243808(NANP)

BTA:	516539(NANP)

BOM:	102265207(NANP)

BJV:	133258931(NANP)

BBUB:

102398325

BKE:	129625323(NANP)

BBIS:

104998733(NANP)

CHX:	102170886(NANP)

OAS:	114117547(NANP)

OCAN:

138437351

BTAX:

128058671(NANP)

CSUM:

138091687(NANP)

ODA:	120869152 120879866

CCAD:

122447878

MREE:

136159103(NANP)

OVR:	110148327(NANP)

SSC:	100518994(NANP)

CFR:	102515876(NANP)

CBAI:

105083191(NANP)

CDK:	105099858(NANP)

VPC:	102535569(NANP)

BACU:

103015720(NANP)

BMUS:

118881783 118891293 118895698

LVE:	103071370(NANP) 103091200

OOR:	101288226(NANP)

LALB:

132504765(NANP)

GMF:	115861575(NANP)

DDP:	132437808(NANP)

DLE:	111185026(NANP)

PCAD:

102982673

PSIU:

116740895(NANP) 116754385

PPHC:

136135258(NANP)

NASI:

112404638(NANP)

ECB:	100057290(NANP)

EPZ:	103565630(NANP)

EAI:

106826694

MYB:	102241954(NANP)

MYD:	102760298(NANP)

MMYO:

118663530

MLF:	102441233(NANP)

MDT:	132239275(NANP)

MYUM:

139014435(NANP)

PKL:

118707430

EFUS:

103285729(NANP)

MNA:	107541880(NANP)

DRO:	112319728(NANP)

SHON:

118993239

AJM:	119056776(NANP)

PDIC:

114506869

PHAS:

123815055

MMF:

118618105

PPAM:

129081791(NANP)

HAI:	109377523(NANP)

RFQ:	117015650(NANP)

PALE:

102897859(NANP)

PGIG:

120586977

PVP:	105305854(NANP)

RAY:

107499916

MJV:

108407495

TOD:	119231784(NANP)

SARA:

101539395(NANP)

SFUM:

130045405(NANP)

SETR:

126018113(NANP)

LAV:	100668640(NANP)

TMU:

101343428

ETF:	101647508 101648833

DNM:	101417938(NANP)

MDO:	100033221(NANP)

GAS:

123234795

SHR:	116420969(NANP)

AFZ:

127548410

PCW:	110209179(NANP)

TVP:

118844946

PBRV:

138151953(NANP)

MLAO:

141504347(NANP)

OAA:

100090918

TACU:

119932262

GGA:	421467(NANP)

PCOC:

116229026(NANP)

MGP:	100543041(NANP)

CJO:	107311233(NANP)

TPAI:

128080440(NANP)

LMUT:

125689923

NMEL:

110397139(NANP)

APLA:

101797319

AACU:

137853731(NANP)

OJA:	118165093(NANP)

ACYG:

106048166(NANP)

CATA:

118256373(NANP)

AFUL:

116488045(NANP)

TGU:	100222533(NANP)

LSR:	110469408(NANP)

VMC:	128804818(NANP)

VCHA:

128785176(NANP)

AIB:	137471194(NANP)

SCAN:

103821718(NANP)

PMOA:

120506927

OTC:

121335882

PRUF:

121358776

ATRC:

139591262(NANP)

MATE:

118685497(NANP)

MAEN:

136555281(NANP)

GFR:	102041889(NANP)

FAB:	101808074(NANP)

OMA:	130250639(NANP)

PHI:	102111772(NANP)

PMAJ:

107201739(NANP)

CCAE:

111926976(NANP)

CCW:

104684372

CBRC:

103624202(NANP)

ACOE:

138108007(NANP)

ETL:	114065178(NANP)

ZAB:	102064626(NANP)

ZLE:	135445759(NANP)

ACHL:

103806190(NANP)

SVG:	106853400(NANP)

MMEA:

130588840(NANP)

HRT:	120749974(NANP)

SATI:

136359347(NANP)

CFAI:

136286712(NANP)

CCIC:

134042095(NANP)

FPG:	101910761(NANP)

FCH:	102051704(NANP)

FRS:

119156075

CCRI:

104162041(NANP)

NNT:	104407055(NANP)

SHAB:

115613972(NANP)

ACUN:

113478693(NANP)

ANOC:

141956376(NANP)

SURA:

141941132(NANP)

TALA:

104355713

ACHC:

115350105

HALD:

104312989(NANP)

HLE:	104840342(NANP)

AGEN:

126051776

HHAR:

128149875(NANP)

BBUT:

142038079(NANP)

GCL:

127015115

CSTI:

104550140(NANP)

LDI:	104340327(NANP)

MNB:	103773335(NANP)

DPUB:

104310307(NANP)

PPUS:

135183575(NANP)

IIN:	128979311(NANP)

AVIT:

104273994(NANP)

BRHI:

104494280(NANP)

EGZ:

104124113

NNI:	104018709(NANP)

PCRI:

104024483(NANP)

PCAO:

104045723(NANP)

PARX:

142055389(NANP)

PADL:

103922880(NANP)

AFOR:

103902732(NANP)

FGA:	104079523(NANP)

CBOR:

142080741(NANP)

GSTE:

104256209(NANP)

CBOY:

140649416(NANP)

MAME:

142407060(NANP)

CLV:	102085571(NANP)

CNIC:

135987219(NANP)

MUI:	104541203(NANP)

PGUU:

104458085(NANP)

PLET:

104614087(NANP)

EHS:	104513551(NANP)

CMAC:

104473375(NANP)

CUCA:

104057919(NANP)

PCUR:

138718175(NANP)

TEO:	104381899(NANP)

BREG:

104640064(NANP)

GAME:

129204890(NANP)

OHA:	104329307(NANP)

ACAR:

104527445(NANP)

CPEA:

104394946(NANP)

CVF:	104282309(NANP)

RTD:	128907646(NANP)

CRID:

134512925(NANP)

LMIC:

141740726(NANP)

NARQ:

141479565(NANP)

AAM:	106485424(NANP)

AROW:

112973406(NANP)

NPD:	112957547(NANP)

TGT:	104576066(NANP)

DNE:	112984649(NANP)

SCAM:

104151676(NANP)

ASN:	102376523(NANP)

AMJ:	102560484(NANP)

CPOO:

109319891(NANP)

GGN:	109304741(NANP)

PSS:	102450434(NANP)

CIZ:	142010254(NANP)

CMY:

102933873

CCAY:

125633813

LKP:	140909338(NANP)

NDS:	141984128(NANP)

DCC:

119853658

CPIC:

101940927

TST:	117874621(NANP)

CABI:

116822554(NANP)

MRV:

120400197

ACS:	100556235(nanp)

ASAO:

132761264(NANP)

PVT:	110083931(NANP)

SUND:

121936867

PBI:	103059839(NANP)

PMUR:

107287482(NANP)

CTIG:

120312079

TSR:	106557403(NANP)

PGUT:

117671887(NANP)

PCAE:

139321507(NANP)

APRI:

131188822(NANP)

PTEX:

113433133(NANP)

NSS:	113420595(NANP)

VKO:

123035751

PMUA:

114594495(NANP)

PRAF:

128410933(NANP)

ZVI:	118081806(NANP)

HCG:	128347965(NANP)

GJA:	107125446 107125745(NANP)

EMC:	129334375(NANP)

XLA:	414493(nanp.L)

XTR:	549940(nanp)

NPR:	108801139(NANP)

RTEM:

120937674

ACAT:

141140643(NANP)

PADS:

140329269(NANP)

BBUF:

120997348

BGAR:

122935279

DTC:	141063451(NANP)

PWL:	138296178(NANP)

MUO:	115465044(NANP)

GSH:	117356389(NANP)

DRE:	553795(nanP)

SRX:	107719206 107736515

SANH:

107665564 107676393

SGH:	107549144 107586073

CCAR:

109084911 109084918

CAUA:

113069995 113092406 113112443

CGIB:

127970249 128025955

PTET:

122356736

LROH:

127174922(nanp)

GRF:	141326460(nanp)

OMC:	131552231(nanp)

PPRM:

120468565

RKG:	130106367(nanp)

MAMB:

125277246

CIDE:

127525470

CERY:

137020265(nanp)

MASI:

127411875 127414421

TROS:

130559397(nanp)

TDW:	130431935(nanp)

MANU:

129415697(nanp)

PDAB:

135786595(nanp)

IPU:

108263708

IFU:	128605892(nanp)

PHYP:

113544573(nanp)

SMEO:

124376215

TFD:

113661084

TVC:	132847482(nanp)

CGAR:

128528972(nanp)

NGRA:

132889592(nanp)

TRN:	134314602(nanp)

AMEX:

103036320

CMAO:

118810625

EEE:	113579924(nanp)

CHAR:

122131878

SPIL:

134063862(nanp)

ASAD:

121685037

TRU:	101072969 115248707

TFS:	130534134(nanp)

TNG:	GSTEN00003817G001

LCO:	104921917(nanp)

NCC:	104950808(nanp)

TBEN:

117475707(nanp)

CGOB:

115020169(nanp)

PGEO:

117460030(nanp)

GACU:

117551253(nanp)

EMAC:

134859091(nanp)

ELY:	117248584(nanp)

EFO:

125903695

PLEP:

121954662

SLUC:

116047874

ECRA:

117960962(nanp)

ESP:	116705356(nanp)

PFLV:

114572243(nanp)

GAT:

120820401

PPUG:

119214182(nanp)

AFB:	129092623(nanp)

CLUM:

117744499(nanp)

PSWI:

130207150(nanp)

CANA:

137780141(nanp)

CVE:	137877959(nanp)

MSAM:

119917265

SCHU:

122884823

EARM:

139294058(nanp)

CUD:

121510761

SPUL:

138588529(nanp)

LMIX:

132975892(nanp)

HTC:	141795318(nanp)

ALAT:

119033693

ASTR:

137603545(nanp)

PKLU:

139210741(nanp)

MZE:	101486709(nanp)

ONL:	100705305(nanp)

OAU:

116318760

OLA:	101159461(nanp)

OML:

112140816

CSAI:

133463491(nanp)

XMA:	102222058(nanp)

XCO:	114137461(nanp)

XHE:	116713443(nanp)

PRET:

103477102(nanp)

PFOR:

103148257(nanp)

PLAI:

106951801(nanp)

PMEI:

106920955(nanp)

GAF:

122842253

PPRL:

129352637(nanp)

CVG:	107088310(nanp)

CTUL:

119782915

GMU:

124859450

NFU:	107375516(nanp)

KMR:

108247169

ALIM:

106525584(nanp)

NWH:

119410815

AOCE:

111586655(nanp)

EJA:	138195615(nanp)

BFRE:

138615987(nanp)

MCEP:

125019235

CSEM:

103387494(nanp)

POV:	109634921(nanp)

SSEN:

122782038

SSOE:

131473784(nanp)

HHIP:

117775629(nanp)

HSP:

118119186

PPLT:

128453682(nanp)

SMAU:

118283459

LCF:

108886283

SDU:	111220631(nanp)

SLAL:

111669529(nanp)

XGL:

120796511

HCQ:	109523020(nanp)

SSCV:

125978239(nanp)

SBIA:

133509918(nanp)

PEE:	133409649(nanp)

PTAO:

133485925(nanp)

BPEC:

110168523(nanp)

ENY:	140351643(nanp)

MALB:

109961560(nanp)

BSPL:

114842027(nanp)

SJO:	128372901(nanp)

SSCO:

133992092(nanp)

TTY:	137196708(nanp)

GMH:	115560154(nanp)

SASA:

106604799(nanp)

STRU:

115153033(nanp)

OTW:

112250040

OMY:

110502296

OGO:

124037182

ONE:	115112719(nanp)

OKI:	109899067(nanp)

OKE:	118401788(nanp)

OMM:	135512458(nanp)

OCLA:

139381748

SALP:

111978206(nanp)

SNH:

120045591

SFON:

129853323(nanp)

CCLU:

121569075

ELS:	105029713(nanp)

OEP:	134022419(nanp)

SFM:	108925845(nanp)

PKI:	111849594(nanp)

AANG:

118218396(nanp)

AROT:

135244622(nanp)

CCOG:

133118579(nanp)

LOC:	102695418(nanp)

PSPA:

121315254

ARUT:

117402227(nanp)

PSEX:

120516490

LCM:	102347112(NANP)

CMK:

103178930

RTP:

109915235

CPLA:

122548481

CPUN:

140457502(nanp)

HOC:	132831038(nanp)

SCAU:

119967061

LERI:

129697620(nanp)

HAKA:

140733118(nanp)

PMRN:

116947806(NANP)

LRJ:	133341349(NANP)

BFO:

118421189

BBEL:

109483709

SCLV:

120348437

SPU:

582852

LVG:

121417958

APLC:

110979302

ARUN:

117294457

AAMU:

139948554

AFIL:

140153345 140153361

AJC:

117123904

SKO:

100368795

PFLL:

139150466

DME:	Dmel_CG15771(CG15771)

DER:

6550841

DSE:

6612363

DSI:	Dsimw501_GD16749(Dsim_GD16749)

DYA:	Dyak_GE16428

DAN:

6503496

DSR:

110183047

DPO:

4814309

DPE:

6596886

DMN:

108152020

DWI:

6648677

DGR:

6565866

DMO:	Dmoj_GI16391

DAZ:

108618587

DNV:

108657310

DHE:

111592843

DVI:

6633682

CCAT:

101451032

BOD:

106614408

BDR:

105228805

RZE:	108372759 108382452

AOQ:

129238573

ALUD:

128857972

TDA:

119671836

MDE:

101898061

SCAC:

106093350

LCQ:

111676922

LSQ:

119616030

CVJ:

135958770

ECOE:

129939812

CLON:

129607067

HIS:

119652576

AGA:

3291013

ACOZ:

120951263

AARA:

120897179

AMER:

121590562

ASTE:

118517617

AMAP:

126558561

AFUN:

125760812

AMOU:

128299542

AMRS:

128718094

ANIL:

128722167

AALI:

118457927

ADAR:

125947975

ACOS:

131261207

AAG:

5576134

AALB:

109412789

CQU:	CpipJ_CPIJ008694

CNS:

116345077

BCOO:

119067189

LLL:

129792609

PPAP:

129805897

AME:

552430

ACER:

107997786

ALAB:

122715086

ADR:

102676755

AFLR:

100869008

BIM:

100748175

BBIF:

117205078

BVK:

117231041

BVAN:

117166227

BHUN:

126871766

BTER:

100645078

BAFF:

126921924

BPYO:

122567342

BPAS:

132913058

FVI:

122527517

CCAL:

108627053

OBB:

114877387

OLG:

117603070

MGEN:

117219206

NMEA:

116433074

CGIG:

122399139

SOC:

105204844

MPHA:

105827793

AEC:

105150576

ACEP:

105620191

ACOC:

108692586

MZT:

108727285

CCOA:

108778085

TCZ:

108757861

TSEP:

108748935

PBAR:

105426588

VEM:

105561235

COBS:

139108087

TLN:

139822147

TAME:

143906563

HST:

105191991

DQU:

106747444

CFO:

105257744

FEX:

115236002

LHU:

105674238

PGC:

109860798

OBO:

105275767

PCF:

106786016

VPS:

122633106

VCRB:

124428026

VVE:

124952924

NVI:

100114567

TPRE:

106652293

LHT:

122512740

LBD:

127287532

MDL:

103578673

CGLO:

123267712

CTYP:

141530388

FAS:

105270710

AGIF:

122855777

CINS:

118065342

VCAN:

122409724

CCIN:

107274984

DSM:

124414112

NPT:

124223004

NFB:

124186607

NLO:

107220601

NVG:

124309064

AROA:

105693954

TCA:

664523

TMOL:

138122858

DPA:

109536856

ESIM:

136419674

EFOR:

136341428

SOY:

115887983

AGRG:

126750738

ATD:

109609653

CSET:

123308745

HAXR:

123680894

AGB:

108911514

LDC:

111511063

DVV:

114333468

NVL:

108562670

APLN:

108743175

PPYR:

116164423

OTU:

111422773

BMOR:

101736830

BMAN:

114249335

MSEX:

115451106 119189137 119191552 119191577

DPL:	KGM_204154

BANY:

112051376

MJU:

123874789

NIQ:

126776018

VCD:

124538394

MCIX:

123662324

PMAC:

106721633

BPHI:

137920097

ZCE:

119828822

CCRC:

123699995

LSIN:

126967472

AAGE:

121726181

HAW:

110378594

HZE:

124640478

TNL:

113498930

SLIU:

111350178

OFU:

114363507

ONU:

135080684

ATRA:

106136137 132902388

GMW:

113519728

ECLR:

140742841

PXY:

105398463

PGW:

126374804

LGLY:

125232419

CSTB:

134748662

CFUM:

141432714

CFEL:

113382483 113386789

BTAB:

109031197

DCI:

103510176

NLU:

111044544

LDA:

142325635

HVI:

124352848

MQU:

128983627

FOC:

113216687

TPAL:

117640423

BROR:

134530042

IEL:

124168002

HAMR:

139698926

FCD:

110859166

DPX:	DAPPUDRAFT_49839

PORN:

139754985

CSCU:

111641541

CVS:

136983634

PTEP:

107455633

ABRU:

129981879

UDV:	129227732 129228438

LPOL:

106459938

NVE:

5520856

EPA:

110250578

ATEN:

116304516

PDAM:

113670649

SPIS:

111318976

HMG:

100205578

HSY:

130656196

CCLM:

134180365

NCOL:

116261997

ATR:

18432282

CJF:

131057169

SMO:	SELMODRAFT_444867

PPP:

112274287

CSL:	COCSUDRAFT_45884

CVR:	CHLNCDRAFT_145434

APRO:

F751_3181

OLU:	OSTLU_92236

BPG:	Bathy06g05120

FPOA:

FPOAC1_009762

FMU:	J7337_000130

CHIG:

CH63R_00077

EHX:	EMIHUDRAFT_208925

» show all

Reference

1 [PMID:14235556]

Authors

JOURDIAN GW, SWANSON AL, WATSON D, ROSEMAN S.

Title

ISOLATION OF SIALIC ACID 9-PHOSPHATASE FROM HUMAN ERYTHROCYTES.

Journal

J Biol Chem 239:PC2714-6 (1964)

Reference

Authors

Jourdian GW, Swanson A, Watson D, Roseman S.

Title

N-Acylneuraminic (sialic) acid 9-phosphatase.

Journal

Methods Enzymol 8:205-208 (1966)

Reference

3 [PMID:16237198]

Authors

Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E

Title

Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.

Journal

Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050

Other DBs

ExplorEnz - The Enzyme Database:

3.1.3.29

IUBMB Enzyme Nomenclature:

3.1.3.29

ExPASy - ENZYME nomenclature database:

3.1.3.29

BRENDA, the Enzyme Database:

3.1.3.29

CAS:	37288-13-4

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Protein sequence (148)   
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   RefSeq(pep) (7)   
   PDBSTR (6)   
DNA sequence (40)   
   RefSeq(nuc) (7)   
   GenBank (19)   
   EMBL (14)   
3D Structure (3)   
   PDB (3)   
All databases (571)   

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