KEGG ENZYME: 3.1.3.39

ENZYME: 3.1.3.39

Entry

EC 3.1.3.39                 Enzyme

Name

streptomycin-6-phosphatase;
streptomycin 6-phosphate phosphatase;
streptomycin 6-phosphate phosphohydrolase;
streptomycin-6-P phosphohydrolase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

streptomycin-6-phosphate phosphohydrolase

Reaction(IUBMB)

streptomycin 6-phosphate + H2O = streptomycin + phosphate [RN:R02228]

Reaction(KEGG)

R02228

Substrate

streptomycin 6-phosphate [CPD:C01138];
H2O [CPD:C00001]

Product

streptomycin [CPD:C00413];
phosphate [CPD:C00009]

Comment

Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate.

History

EC 3.1.3.39 created 1976

Pathway

ec00521

Streptomycin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K04342

streptomycin-6-phosphatase

Genes

SGR:	SGR_5938(strK)

SRC:	M271_11895

SBH:

SBI_00130

SGU:	SGLAU_01170(strK)

SLD:

T261_3818

SRN:	A4G23_04371(phoA)

STRT:

A8713_16450

SVU:	B1H20_31850

SALJ:

SMD11_2283(strK)

SKA:	CP970_20650

SRK:	FGW37_22050

SRIM:

CP984_20395

SSUB:

CP968_05865 CP968_30885

SSPB:

CP982_40795

SCAL:

I6J39_31655

SMOB:

J7W19_21760

STRY:

EQG64_29890

SAOV:

G3H79_17330(phoA)

SNIG:

HEK616_79010(phoA)

SYUN:

MOV08_03610

SOV:	QZH56_10280

SFP:	QUY26_18515(phoA)

SCT:	SCAT_5710(strK)

SCY:	SCATT_57100

KSL:	OG809_31340

PARN:

NBH00_09850

» show all

Reference

1 [PMID:4121457]

Authors

Walker JB, Skorvaga M.

Title

Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine.

Journal

J Biol Chem 248:2441-6 (1973)

Reference

2 [PMID:4331203]

Authors

Walker MS, Walker JB.

Title

Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate.

Journal

J Biol Chem 246:7034-40 (1971)

Other DBs

ExplorEnz - The Enzyme Database:

3.1.3.39

IUBMB Enzyme Nomenclature:

3.1.3.39

ExPASy - ENZYME nomenclature database:

3.1.3.39

BRENDA, the Enzyme Database:

3.1.3.39

CAS:

9055-33-8

DBGET integrated database retrieval system