KEGG   ENZYME: 3.1.3.39
Entry
EC 3.1.3.39                 Enzyme                                 
Name
streptomycin-6-phosphatase;
streptomycin 6-phosphate phosphatase;
streptomycin 6-phosphate phosphohydrolase;
streptomycin-6-P phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
streptomycin-6-phosphate phosphohydrolase
Reaction(IUBMB)
streptomycin 6-phosphate + H2O = streptomycin + phosphate [RN:R02228]
Reaction(KEGG)
R02228
Substrate
streptomycin 6-phosphate [CPD:C01138];
H2O [CPD:C00001]
Product
streptomycin [CPD:C00413];
phosphate [CPD:C00009]
Comment
Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate.
History
EC 3.1.3.39 created 1976
Pathway
ec00521  Streptomycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04342  streptomycin-6-phosphatase
Genes
SGRSGR_5938(strK)
SRCM271_11895
SBHSBI_00130
SGUSGLAU_01170(strK)
SLDT261_3818
SRNA4G23_04371(phoA)
STRTA8713_16450
SVUB1H20_31850
SALJSMD11_2283(strK)
SKACP970_20650
SRKFGW37_22050
SRIMCP984_20395
SSUBCP968_05865 CP968_30885
SSPBCP982_40795
SCALI6J39_31655
SMOBJ7W19_21760
STRYEQG64_29890
SAOVG3H79_17330(phoA)
SCTSCAT_5710(strK)
SCYSCATT_57100
PARNNBH00_09850
 » show all
Reference
1  [PMID:4121457]
  Authors
Walker JB, Skorvaga M.
  Title
Streptomycin biosynthesis and metabolism. Phosphate transfer from dihydrostreptomycin 6-phosphate to inosamines, streptamine, and 2-deoxystreptamine.
  Journal
J Biol Chem 248:2441-6 (1973)
Reference
2  [PMID:4331203]
  Authors
Walker MS, Walker JB.
  Title
Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin-(streptidino)phosphate.
  Journal
J Biol Chem 246:7034-40 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.39
IUBMB Enzyme Nomenclature: 3.1.3.39
ExPASy - ENZYME nomenclature database: 3.1.3.39
BRENDA, the Enzyme Database: 3.1.3.39
CAS: 9055-33-8

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