KEGG   ENZYME: 3.1.3.52
Entry
EC 3.1.3.52                 Enzyme                                 
Name
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase;
branched-chain oxo-acid dehydrogenase phosphatase;
branched-chain 2-keto acid dehydrogenase phosphatase;
branched-chain alpha-keto acid dehydrogenase phosphatase;
BCKDH (ambiguous);
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase;
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphate phosphohydrolase
Reaction(IUBMB)
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O = [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate
Reaction(KEGG)
(other) R03515
Substrate
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate [CPD:C01308];
H2O [CPD:C00001]
Product
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] [CPD:C04726];
phosphate [CPD:C00009]
Comment
A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. Simultaneously dephosphorylates and activates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), that has been inactivated by phosphorylation.
History
EC 3.1.3.52 created 1986
Reference
1  [PMID:6307746]
  Authors
Fatania HR, Patston PA, Randle PJ.
  Title
Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase.
  Journal
FEBS Lett 158:234-8 (1983)
DOI:10.1016/0014-5793(83)80585-7
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr Top Cell Regul 27:41-9 (1985)
DOI:10.1016/b978-0-12-152827-0.50011-6
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.52
IUBMB Enzyme Nomenclature: 3.1.3.52
ExPASy - ENZYME nomenclature database: 3.1.3.52
BRENDA, the Enzyme Database: 3.1.3.52
CAS: 87244-20-0 88086-29-7

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (244)   
   UniProt (234)   
   SWISS-PROT (5)   
   RefSeq(pep) (5)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (4)   
   InterPro (4)   
All databases (260)   

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