KEGG   ENZYME: 3.1.3.56
Entry
EC 3.1.3.56                 Enzyme                                 

Name
inositol-polyphosphate 5-phosphatase;
type I inositol-polyphosphate phosphatase;
inositol trisphosphate phosphomonoesterase;
InsP3/Ins(1,3,4,5)P4 5-phosphatase;
inosine triphosphatase;
D-myo-inositol 1,4,5-triphosphate 5-phosphatase;
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase;
L-myo-inositol 1,4,5-trisphosphate-monoesterase;
inositol phosphate 5-phosphomonoesterase;
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase;
Ins(1,4,5)P3 5-phosphatase;
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase;
inositol 1,4,5-trisphosphate phosphatase;
inositol polyphosphate-5-phosphatase;
myo-inositol-1,4,5-trisphosphate 5-phosphatase;
inositol-1,4,5-trisphosphate 5-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
Reaction(IUBMB)
(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate [RN:R03394];
(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430]
Reaction(KEGG)
R03394 R03430
Substrate
D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
H2O [CPD:C00001];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272]
Product
myo-inositol 1,4-bisphosphate [CPD:C01220];
phosphate [CPD:C00009];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243]
Comment
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
History
EC 3.1.3.56 created 1989, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01106  inositol polyphosphate 5-phosphatase INPP5A
K24221  type I inositol polyphosphate 5-phosphatase IP5P1/2
K24222  inositol polyphosphate 5-phosphatase INPP5J/K
Genes
HSA: 27124(INPP5J) 3632(INPP5A) 51763(INPP5K)
PTR: 454410(INPP5K) 458767(INPP5J) 747128(INPP5A)
PPS: 100976910(INPP5K) 100980932(INPP5J) 100995871(INPP5A)
GGO: 101124081(INPP5K) 101127025(INPP5J) 101137047(INPP5A)
PON: 100440857(INPP5A) 100457320(INPP5J)
NLE: 100585101(INPP5J) 100587560(INPP5A) 100601583(INPP5K)
MCC: 718308(INPP5J) 719508(INPP5A) 721222(INPP5K)
MCF: 101867263(INPP5K) 102124549(INPP5A) 102139212(INPP5J)
CSAB: 103216744(INPP5A) 103223181(INPP5J) 103242115(INPP5K)
RRO: 104660350(INPP5J) 104670313(INPP5K) 104677635(INPP5A)
RBB: 108524657(INPP5K) 108527617(INPP5J) 108543386(INPP5A)
CJC: 100387531(INPP5A) 100395276(INPP5J) 100399558(INPP5K)
SBQ: 101034783(INPP5J) 101037105(INPP5A) 101041430(INPP5K)
MMU: 170835(Inpp5j) 19062(Inpp5k) 212111(Inpp5a)
MCAL: 110298346(Inpp5a) 110304984(Inpp5j) 110305558(Inpp5k)
MPAH: 110320177(Inpp5a) 110330530(Inpp5j) 110331673(Inpp5k)
RNO: 171088(Inpp5j) 287533(Inpp5k) 365382(Inpp5a)
MUN: 110549016(Inpp5a) 110557671(Inpp5j) 110564981(Inpp5k)
CGE: 100760037(Inpp5a) 100761777(Inpp5j) 100764873(Inpp5k)
NGI: 103725829(Inpp5a) 103730507(Inpp5k) 103740431(Inpp5j)
HGL: 101704617(Inpp5a) 101719531(Inpp5k) 101726724(Inpp5j)
CCAN: 109682597(Inpp5k) 109696904(Inpp5j) 109698635(Inpp5a)
OCU: 100338012(INPP5J) 100358289(INPP5K) 103347071
TUP: 102474778(INPP5J) 102485414(INPP5A) 102490192(INPP5K)
CFA: 403937(INPP5A) 480647(INPP5K) 486360(INPP5J)
VVP: 112909845(INPP5J) 112928852(INPP5A) 112933092(INPP5K)
AML: 100465896(INPP5A) 100467068(INPP5K) 100479313(INPP5J)
UMR: 103658509(INPP5A) 103667174(INPP5K) 103681118(INPP5J)
UAH: 113245051(INPP5J) 113252083(INPP5A) 113269114(INPP5K)
ORO: 101367060(INPP5J) 101368492(INPP5A) 101385393(INPP5K)
FCA: 101083037(INPP5A) 101085842(INPP5K) 101095688(INPP5J)
PTG: 102951376(INPP5J) 102951654(INPP5A) 102971559(INPP5K)
PPAD: 109253608(INPP5J) 109255154(INPP5K) 109256690(INPP5A)
AJU: 106983189(INPP5K) 106983314(INPP5J) 113600366(INPP5A)
BTA: 514123(INPP5K) 514307(INPP5J) 615232(INPP5A)
BOM: 102279605(INPP5K) 102284010(INPP5J) 102285484(INPP5A)
BIU: 109571558(INPP5J) 109574139(INPP5K) 109579046(INPP5A)
BBUB: 102395746(INPP5K) 102402973(INPP5A) 102407829(INPP5J)
CHX: 102171365(INPP5J) 102177657(INPP5K) 102181924(INPP5A)
OAS: 101103674(INPP5J) 101110014(INPP5A) 101115806(INPP5K)
SSC: 100462756(INPP5K) 100510987(INPP5J) 100512501(INPP5A)
CFR: 102510594(INPP5A) 102521192(INPP5K) 102521406(INPP5J)
CDK: 105088121(INPP5K) 105099429(INPP5J) 105104581(INPP5A)
BACU: 103000099(INPP5K) 103017049(INPP5J) 103018455(INPP5A)
LVE: 103086449(INPP5K) 103088886(INPP5A) 103089080(INPP5J)
OOR: 101274395(INPP5J) 101278141(INPP5A) 101282708(INPP5K)
DLE: 111162792(INPP5J) 111172172(INPP5A) 111186008(INPP5K)
PCAD: 102981168(INPP5K) 102988800(INPP5J) 102996894(INPP5A)
ECB: 100051027(INPP5A) 100058547(INPP5J) 100072370(INPP5K)
EPZ: 103547528(INPP5K) 103554530(INPP5A) 103566939(INPP5J)
EAI: 106821965(INPP5K) 106826923(INPP5J) 106841072(INPP5A)
MYB: 102251847(INPP5K) 102256211(INPP5J) 102256550(INPP5A)
MYD: 102759392(INPP5K) 102770814(INPP5A) 102770954(INPP5J)
MNA: 107526175(INPP5J) 107532111(INPP5A) 107535610(INPP5K)
HAI: 109383019(INPP5J) 109383559(INPP5A) 109386898(INPP5K)
DRO: 112300235(INPP5A) 112308492(INPP5K) 112310387(INPP5J)
PALE: 102886374(INPP5K) 102886411(INPP5A) 102894864(INPP5J)
RAY: 107507726(INPP5K) 107517147(INPP5A) 107520983(INPP5J)
MJV: 108386409(INPP5J) 108394545(INPP5K) 108396822(INPP5A)
LAV: 100655016(INPP5A) 100656050(INPP5J) 100663160(INPP5K)
MDO: 100028528(INPP5J) 100619651(INPP5K) 107650382(INPP5A)
SHR: 100916010(INPP5J) 100927613(INPP5K)
PCW: 110198691(INPP5A) 110215268(INPP5J) 110222149(INPP5K)
OAA: 100075999(INPP5J) 100089552(INPP5K) 100093027(INPP5A)
GGA: 416996(INPP5J) 423973(INPP5A) 771549(INPP5K)
MGP: 100538550(INPP5K) 100546269(INPP5J) 100548603
CJO: 107316265(INPP5A) 107321387(INPP5J) 107322425(INPP5K)
NMEL: 110399478(INPP5A) 110406222(INPP5J) 110407618(INPP5K)
APLA: 101790657(INPP5J) 101798206(INPP5K) 101804204(INPP5A)
ACYG: 106041437(INPP5K) 106047331(INPP5A) 106047485(INPP5J)
TGU: 100218210(INPP5A) 100231908(INPP5K)
LSR: 110473850(INPP5J) 110477043(INPP5A) 110482081(INPP5K)
SCAN: 103814084(INPP5A) 103817969(INPP5J) 103820107(INPP5K)
GFR: 102034127(INPP5K) 102036109(INPP5A) 102040736(INPP5J)
FAB: 101806643(INPP5K) 101810436(INPP5J) 101814745(INPP5A)
PHI: 102099529(INPP5A) 102101343(INPP5K) 102114523(INPP5J)
PMAJ: 107206908(INPP5A) 107211796(INPP5J) 107212795(INPP5K)
CCAE: 111931657(INPP5A) 111936697(INPP5J) 111937741(INPP5K)
CCW: 104691071(INPP5K) 104694952(INPP5A) 104694974(INPP5J)
ETL: 114060452(INPP5K) 114063234(INPP5J) 114067417(INPP5A)
FPG: 101918225(INPP5K) 101918251(INPP5J) 101924782(INPP5A)
FCH: 102050343(INPP5J) 102052658(INPP5K) 102054445(INPP5A)
CLV: 102088610(INPP5K) 102090809(INPP5A) 102097794(INPP5J)
EGZ: 104128277(INPP5A) 104129956(INPP5J) 104131931(INPP5K)
NNI: 104013867(INPP5A) 104015977(INPP5K) 104016328(INPP5J)
ACUN: 113481514(INPP5A) 113486145(INPP5J) 113487016(INPP5K)
PADL: 103917517 103918623(INPP5A) 103924841(INPP5K)
AAM: 106485811(INPP5A) 106487420(INPP5J) 106487707(INPP5K)
ASN: 102367974(INPP5K) 102368100 102382432(INPP5J)
AMJ: 102559502(INPP5A) 102559762(INPP5K) 102572423(INPP5J)
PSS: 102447470(INPP5A) 102451462(INPP5J) 102464080(INPP5K)
CMY: 102929515(INPP5A) 102943056(INPP5J) 102944286(INPP5K)
CPIC: 101940311(INPP5A) 101945750(INPP5J) 101948693(INPP5K)
PVT: 110079716(INPP5A) 110082915(INPP5J) 110084312(INPP5K)
PBI: 103054766(INPP5J) 103065503(INPP5K) 103066208(INPP5A)
PMUR: 107285446(INPP5J) 107289571(INPP5K)
TSR: 106547271(INPP5J) 106548666(INPP5A)
PMUA: 114585335(INPP5K) 114586515(INPP5J) 114597360(INPP5A)
GJA: 107116265(INPP5J) 107119380(INPP5K) 107123620(INPP5A)
XLA: 108696106(inpp5a.1.L) 108707052 108715295(inpp5j.L) 443677(inpp5k.L) 447532(inpp5a.1.S)
XTR: 100127685(inpp5k) 548959(inpp5a.1) 779554(inpp5j)
NPR: 108784796(INPP5A) 108786267(INPP5J) 108801652(INPP5K)
DRE: 100037338(inpp5ka) 100317089(inpp5jb) 101884388(inpp5a) 566188(inpp5kb) 569568
CVG: 107087273 107093121(inpp5a)
KMR: 108232573 108234557(inpp5jb) 108236576(inpp5l) 108236894(inpp5kb) 108246549(inpp5ka)
CSEM: 103377799 103387519(inpp5a) 103390480(inpp5j) 103395106
ELS: 105010721(inpp5a) 105014853(inpp5j) 105024103(inpp5k) 105026120 105031022
LCM: 102349479(INPP5A) 102349489(INPP5K) 102356377(INPP5J)
CMK: 103180430(inpp5a) 103180576(inpp5k) 103184062(inpp5j)
RTP: 109917655(inpp5a) 109925814(inpp5k) 109931760(inpp5j)
DME: Dmel_CG42283(5PtaseI) Dmel_CG6805(CG6805) Dmel_CG9784(CG9784)
DER: 26526597
DSE: 116801694
DSI: Dsimw501_GD18243(Dsim_GD18243) Dsimw501_GD27508(Dsim_GD27508) Dsimw501_GD27861(Dsim_GD27861)
DAN: 26515147
DSR: 110190986
DPE: 113566108
DMN: 108154075
DWI: 26529127
DAZ: 108620926
DNV: 108657916
DHE: 111598612
DVI: 26530829
LCQ: 111684065
AALB: 109422023
CCAL: 108632468
OBB: 114875121
MPHA: 105837420
VEM: 105568062
LHU: 105672434
OBO: 105281757
CSOL: 105361431
ATD: 109595501
BMAN: 114252973
TNL: 113498973
AGS: 114119588
RMD: 113554864
BTAB: 109031743
PVM: 113811257
TUT: 107362580
DPTE: 113797458
CSCU: 111640456
PTEP: 107447025
CEL: CELE_C09B8.1(ipp-5)
CBR: CBG14816(Cbr-ipp-5)
TSP: Tsp_10192
PCAN: 112563612
NVE: 5521410
EPA: 110234686
ADF: 107340984
AMIL: 114967761
PDAM: 113684075
SPIS: 111340331
DGT: 114516296
AQU: 100631474
ATH: AT1G34120(IP5PI) AT4G18010(IP5PII)
THJ: 104812837
CPAP: 110822208
CIT: 102607565
TCC: 18606093
GRA: 105791958
GAB: 108469916
DZI: 111276492
EGR: 104443574
GMX: 100794203
GSJ: 114393998
VRA: 106768887
VAR: 108336054
VUN: 114177796
CCAJ: 109809354
CAM: 101500068
LJA: Lj4g3v1154250.1(Lj4g3v1154250.1)
ADU: 107487571
AIP: 107642633
LANG: 109349586
FVE: 101293593
RCN: 112176759
PPER: 18776220
PMUM: 103336998
MDM: 103436928
PXB: 103960432
ZJU: 107430450
CSV: 101215556
CMO: 103490810
MCHA: 111022641
CMAX: 111500265
CMOS: 111431114
CPEP: 111810199
RCU: 8289056
JCU: 105645101
HBR: 110669388
MESC: 110602181
POP: 18094202
PEU: 105121602
QSU: 111992295
VVI: 100267737
SLY: 101257984
SPEN: 107028804
SOT: 102598120
NSY: 104213440
NTO: 104089469
NAU: 109221557
INI: 109185382
SIND: 105155946
OEU: 111389892
HAN: 110926220
LSV: 111907353
CCAV: 112528676
DCR: 108205999
SOE: 110792457
NNU: 104610404
PSOM: 113302072
OSA: 4347930
ZMA: 103632346
SITA: 101763176
PDA: 103706389
EGU: 105054920
MUS: 103998979
AOF: 109822184
ATR: 18437396
ERC: Ecym_3554
NCS: NCAS_0C03510(NCAS0C03510)
 » show all
Reference
1  [PMID:6285891]
  Authors
Downes CP, Mussat MC, Michell RH.
  Title
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
  Journal
Biochem J 203:169-77 (1982)
DOI:10.1042/bj2030169
Reference
2  [PMID:2540972]
  Authors
Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE.
  Title
Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain.
  Journal
Eur J Biochem 181:317-22 (1989)
DOI:10.1111/j.1432-1033.1989.tb14726.x
Reference
3
  Authors
Woscholski, R. and Parker, P.J.
  Title
Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
  Journal
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
Reference
4  [PMID:8198557]
  Authors
Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C
  Title
Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.
  Journal
Biochem J 300 ( Pt 1):85-90 (1994)
DOI:10.1042/bj3000085
  Sequence
[cfa:403937]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.56
IUBMB Enzyme Nomenclature: 3.1.3.56
ExPASy - ENZYME nomenclature database: 3.1.3.56
BRENDA, the Enzyme Database: 3.1.3.56
CAS: 106283-14-1

DBGET integrated database retrieval system