KEGG   ENZYME: 3.1.3.57
Entry
EC 3.1.3.57                 Enzyme                                 
Name
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Reaction(IUBMB)
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:R03393]
Reaction(KEGG)
R03393;
(other) R03427
Substrate
1D-myo-inositol 1,4-bisphosphate [CPD:C01220];
H2O [CPD:C00001]
Product
1D-myo-inositol 4-phosphate [CPD:C03546];
phosphate [CPD:C00009]
Comment
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
History
EC 3.1.3.57 created 1989, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01107  inositol polyphosphate 1-phosphatase
K15422  3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase
Genes
HSA3628(INPP1)
PTR460106(INPP1)
PPS100967835(INPP1)
GGO101129850(INPP1)
PON100461697(INPP1)
NLE100592468(INPP1)
MCC703301(INPP1)
MCF102129084(INPP1)
CSAB103217521(INPP1)
CATY105579951(INPP1)
PANU101000049(INPP1)
TGE112635807(INPP1)
RRO104675276(INPP1)
RBB108523275 108527575(INPP1)
TFN117094721(INPP1)
PTEH111546263(INPP1)
CJC100399314(INPP1)
SBQ101034382(INPP1)
CSYR103254520(INPP1)
MMUR105877899(INPP1)
OGA100955102(INPP1)
MMU16329(Inpp1)
MCAL110297363(Inpp1)
MPAH110322195(Inpp1)
RNO316376(Inpp1)
MCOC116088401(Inpp1)
MUN110555832(Inpp1)
CGE100755639
PLEU114705100(Inpp1)
NGI103736162(Inpp1)
HGL101724306(Inpp1)
CPOC100725526(Inpp1)
DORD105993739(Inpp1)
DSP122114999(Inpp1)
NCAR124981282
OCU100357992(INPP1)
OPI101526202(INPP1)
TUP102481098(INPP1)
CFA478842(INPP1)
VVP112922928(INPP1)
VLG121480554(INPP1)
AML100473008(INPP1)
UMR103659679(INPP1)
UAH113250658(INPP1)
UAR123798142(INPP1)
ELK111140882
LLV125094908
MPUF101681848(INPP1)
ORO101376858(INPP1)
EJU114223619(INPP1)
ZCA113919578(INPP1)
MLX118012214(INPP1)
FCA101082081(INPP1)
PYU121030826(INPP1)
PBG122481570(INPP1)
PTG102951036(INPP1)
PPAD109274528(INPP1)
AJU106979728(INPP1)
HHV120233471(INPP1)
BTA281869(INPP1)
BOM102276134(INPP1)
BIU109565484(INPP1)
BBUB102416046(INPP1)
CHX102176832(INPP1)
OAS101110908(INPP1)
ODA120854041(INPP1)
CCAD122453921(INPP1)
SSC100514878(INPP1)
CFR102520689(INPP1)
CBAI105072928(INPP1)
CDK105099189(INPP1)
VPC102532377(INPP1)
BACU103020750(INPP1)
LVE103071146(INPP1)
OOR101271125(INPP1)
DLE111171662(INPP1)
PCAD102982005(INPP1)
PSIU116740704 116756993(INPP1)
ECB100054603(INPP1)
EPZ103548647(INPP1)
EAI106828805(INPP1)
MYB102245840(INPP1)
MYD102766936(INPP1)
MMYO118661461(INPP1)
MLF102435148(INPP1)
MNA107539777(INPP1)
PKL118710626(INPP1)
HAI109372960(INPP1)
DRO112308010(INPP1)
SHON118985305(INPP1)
AJM119062127(INPP1)
PDIC114495492(INPP1)
PHAS123830117(INPP1)
MMF118625103(INPP1)
RFQ117025735(INPP1)
PALE102885459(INPP1)
PGIG120587469(INPP1)
PVP105289360(INPP1)
RAY107511589(INPP1)
MJV108402009(INPP1)
TOD119256036(INPP1)
SARA101556760(INPP1)
LAV100668984(INPP1)
TMU101352306
DNM101431044(INPP1)
MDO100028793(INPP1)
GAS123242155(INPP1)
SHR100914455(INPP1)
PCW110213313(INPP1)
OAA103169187(INPP1)
GGA107049248(INPP1)
PCOC116235214(INPP1)
MGP104916077(INPP1)
CJO107325828(INPP1)
NMEL110391102(INPP1)
AFUL116499954(INPP1)
LSR110482129(INPP1)
OTC121338760(INPP1)
PRUF121357165(INPP1)
PHI102109751(INPP1)
ETL114070097(INPP1)
FPG101914982(INPP1)
CLV102088663(INPP1)
TALA116964443(INPP1)
ACHC115350877(INPP1)
NPD112954222(INPP1)
ASN102386296(INPP1)
AMJ102571874(INPP1)
PSS102452926
CMY102940917(INPP1) 102947691
CPIC101953281(INPP1)
TST117884990(INPP1) 117888676
CABI116815202(INPP1) 116827757
MRV120374526(INPP1) 120391107
ACS100556887(inpp1)
PVT110074857(INPP1)
SUND121924194(INPP1)
PBI103053524(INPP1)
PMUR107293737(INPP1) 107300809
TSR106548583(INPP1)
PGUT117662749(INPP1)
VKO123019224(INPP1)
PMUA114592953(INPP1)
ZVI118078820(INPP1)
GJA107120900(INPP1)
XLA398838(inpp1.L)
XTR100144649(inpp1)
NPR108786717 108786723(INPP1)
RTEM120943702(INPP1)
BBUF121008241(INPP1)
BGAR122945161(INPP1)
DRE555899(si:ch211-160o17.2)
SRX107730897 107737355
SANH107683640
SGH107557551(inpp1) 107562242
CCAR109077394(inpp1) 109104896
CAUA113054901 113069252
IPU108255283(inpp1)
PHYP113537788(inpp1)
TFD113656547(inpp1)
AMEX103037924(inpp1)
EEE113588699(inpp1)
TRU101068265(inpp1)
TNGGSTEN00013621G001
NCC104954761(inpp1)
CGOB115008160(inpp1)
ELY117256325(inpp1)
PLEP121950029(inpp1)
SLUC116066658(inpp1)
ECRA117944008(inpp1)
PFLV114553800(inpp1)
GAT120835252(inpp1)
PPUG119193950(inpp1)
MSAM119886042(inpp1)
CUD121528912(inpp1)
MZE101464380(inpp1)
ONL100692058(inpp1)
OAU116329894(inpp1)
OLA101154772(inpp1)
OML112145722(inpp1)
XMA102216503(inpp1)
XCO114135867(inpp1)
XHE116711137(inpp1)
PRET103465287(inpp1)
PFOR103144301(inpp1)
PLAI106934496(inpp1)
PMEI106906103(inpp1)
GAF122834743(inpp1)
CVG107083317(inpp1)
CTUL119791830(inpp1)
GMU124856281(inpp1)
NFU107385611(inpp1)
KMR108235670(inpp1)
ALIM106513286(inpp1)
NWH119411958(inpp1)
AOCE111579734(inpp1)
CSEM103386015(inpp1)
POV109629125(inpp1)
SSEN122767990(inpp1)
HHIP117761206(inpp1)
LCF108898919(inpp1)
SDU111221493(inpp1)
SLAL111667781(inpp1)
XGL120807198(inpp1)
HCQ109522370(inpp1)
BPEC110171309(inpp1)
MALB109956047(inpp1)
SASA100306749(inpp) 106583335
OTW112215856(inpp1)
OMY110494163 110528263
OGO124003939(inpp1) 124030750
ONE115143033(inpp1)
SALP111965037 111970240
SNH120062361 120065230
ELS105017082(inpp1)
SFM108918545 108927928(inpp1)
PKI111842935(inpp1) 111854764
AANG118211820(inpp1)
LOC102690388
PSPA121309074 121323234
ARUT117400900(inpp1) 117403754 117427192
LCM102349777(INPP1)
CMK103176536(inpp1)
RTP109933224(inpp1)
BFO118423791
BBEL109472076
CIN100182945
SCLV120332331
SPU584178
APLC110973571
SKO100373112
DMEDmel_CG3028(Ipp)
DER6553381
DSE6606457
DSIDsimw501_GD18939(Dsim_GD18939)
DYADyak_GE26306
DAN6499025
DSR110186462
DPODpse_GA15747
DPE6588323
DMN108154941
DWI6649474
DGR6568376
DMODmoj_GI10045
DAZ108609143
DNV115563516
DHE111602750
DVI6629641
CCAT101448467
BOD106625225
MDE101888480
SCAC106083385
LCQ111684799
AGAAgaP_AGAP001047
ACOZ120953248
AARA120905831
AAG110674709
AALB109405391 109413222
CQUCpipJ_CPIJ015548
CNS116338877
AME107963968
ACER108002365
ALAB122719644
BIM100748881
BBIF117210778
BVK117231168
BVAN117166507
BTER100650852
BPYO122572536
CCAL108627285
OBB114873942
MGEN117225229
NMEA116425469
CGIG122397406
SOC105201853
MPHA105830074
AEC105151247
ACEP105619421
PBAR105430157
VEM105565095
HST105190691
DQU106749393
CFO105257301
FEX115233830
LHU105678194
PGC109863506
OBO105274709
PCF106784339
PFUC122521473
VPS122627228
NVI100122810
CSOL105368207
TPRE106654473
MDL103579536
CGLO123265125
FAS105273126
DAM107035449
AGIF122852102
CCIN107264550
TCA656805
DPA109539053
SOY115891502
ATD109601500
CSET123319337
AGB108911859
LDC111516841
NVL108570021
APLN108740125
PPYR116163408
OTU111422312
BMOR101745603
BMAN114243639
MSEX115444074 119189963
DPLKGM_211277
BANY112052762
PMAC106718335
PPOT106103542
PXU106115803
PRAP110996506
ZCE119838413
HAW110374210
TNL113500690
OFU114363981
PXY105392571
API100162683 103308779
DNX107164159
AGS114119547
RMD113560581
BTAB109033272
DCI113469124
CLEC106669705
HHAL106691324
NLU111043305
FOC113209055
ZNE110831304
CSEC111864479
FCD110861442
PVM113813437
PJA122258156
PCHN125029675
HAME121854309
PCLA123763711
PTRU123502575
HAZT108683083
EAF111701600
ISCIscW_ISCW016506
DSV119442164
RSAN119387764
VDE111245697
VJA111269204
DPTE113792231
DFR124490411
CSCU111624569
PTEP107439288
SDM118196035
LGILOTGIDRAFT_225152
PCAN112563815
BGT106072619
GAE121382210
HRF124131069
CRG105347500
MYI110465129
PMAX117344194
MMER123531621
OBI106872453
OSN115216816
LAK106157083 106159956 106160005
SMMSmp_017520
OVIT265_04718
NVE5507017
ATEN116300482
ADF107348893
AMIL114953045
PDAM113675931
SPIS111341176
TADTRIADDRAFT_22251
AQU100633510 100637942
ATHAT5G09290 AT5G63980(SAL1) AT5G63990 AT5G64000(SAL2)
ALY9300956 9300957 9302658 9309460
CRB17874672 17876775 17876793 17881495
CSAT104727027 104727030 104729063 104734921 104741992 104742002 104742027 104762546 104762547 104769111
EUSEUTSA_v10004312mg EUTSA_v10004421mg EUTSA_v10004505mg EUTSA_v10013884mg
BRP103837510 103855221 103873815 103873817 103873819
BNA106347951 106347952 106347953 106347988 106347997 106348088 106348090 106348091 106357655 106366235 106366259 106382921 106382923 106405023 106438858
BOE106327641 106328745 106331533 106335719
RSZ108813390 108827480 108838580 108838778 108857639 108858775 108859126
THJ104800114 104818427 104819342
CPAP110816127
CIT102627477
PVY116140353
MINC123199195 123205585 123223973
TCC18611884
GRA105777076 105798049 105798241
GHI107888505 107888629 107892352 107896671 107914433 107931327 107957606
GAB108454499 108454552 108466233 108489423
DZI111300625 111316055
EGR104418113 104418114
GMX100796038 100817415
GSJ114412686 114421496
PVUPHAVU_002G190600g
VRA106766815
VAR108347870
VUN114175827
CCAJ109812821
APRC113857669
MTRMTR_4g094672
CAM101512228
LJALj4g3v0231940.1(Lj4g3v0231940.1) Lj4g3v0231940.2(Lj4g3v0231940.2)
ADU107481633
AIP107631494
AHF112734627 112792409
LANG109362951
FVE101292053
RCN112189693
PPER18779780
PMUM103327119
PAVI110751194
PDUL117625973
MDM114826767
PXB103927135 103930420
ZJU107425623 107425654
MNT21403578
CSV101204881
CMO103485286
BHJ120072626
MCHA111005385
CMAX111478099
CMOS111453114
CPEP111803461
RCU107261021
JCU105632756
HBR110644282
MESC110628194
POP7479141 7486102
PEU105124562 105130388
PALZ118030467 118040286
JRE108996258
QSU112009029
QLO115963512
TWL120002309
VVI100244767
VRI117912858
SLY101267407
SPEN107020572
SOT102601366
CANN107851478
NTA107771952 107818321
NSY104246659
NTO104116454
NAU109225448
INI109160070 109176801
ITR116012753
SIND105178071
OEU111366828 111397064
EGT105973236
SSPL121768751 121772384
HAN110878734
ECAD122589089
LSV111882493
CCAV112515300
DCR108204352
CSIN114310174
BVG104895417
SOE110800752
CQI110681994 110695157 110697645
NNU104606715
MING122062507
TSS122669156
PSOM113346503 113356457
NCOL116266866
OSA4351685 4351686
DOSAOs12t0183200-00(Os12g0183200) Os12t0183300-01(Os12g0183300)
OBR102699826 102700102
BDI100844934
ATS109732486 109734469 109770883
TDC119287732 119300772 119330960
TAES123088055 123102908 123111085 123120050 123152343 123166325 123172930
SBI8054114 8082771
ZMA100276170 542492
SITA101764411 101764810
SVS117862843 117862844
PVIR120663760 120696887 120696890
PHAI112884814 112887766
PDA103720532
EGU105051760
MUS103976059
DCT110111209
PEQ110039533
AOF109824316
ATR18436938
SMOSELMODRAFT_234473 SELMODRAFT_97708
PPP112292558
CRECHLRE_01g030250v5
VCNVOLCADRAFT_65837
MNGMNEG_5969
CSLCOCSUDRAFT_37844
CVRCHLNCDRAFT_31694
APROF751_6258
OTAOT_ostta12g01880
BPGBathy07g02870
MISMICPUN_88595
MPPMICPUCDRAFT_52965
GSLGasu_16130
CCPCHC_T00008454001 CHC_T00008808001
DDIDDB_G0268652
DPPDICPUDRAFT_82219
DFADFA_01660
ACANACA1_328760
AAFAURANDRAFT_70779
TBRTb927.8.7170
TBGTbgDal_VIII7430
LBZLBRM_31_3290
LPANLPMP_312790
DMLDmul_17380
DLIdnl_29360
LPAVPLANPX_1320
PLMPlim_3418
PEHSpb1_00090(suhB_1)
MRIMal4_14500(hisN_1)
SACISinac_5439
CABYCabys_4010
 » show all
Reference
1  [PMID:6309146]
  Authors
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
  Title
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
  Journal
Biochem J 212:473-82 (1983)
DOI:10.1042/bj2120473
Reference
2  [PMID:3029066]
  Authors
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
  Title
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
  Journal
J Biol Chem 262:2146-9 (1987)
Reference
3  [PMID:2824473]
  Authors
Inhorn RC, Majerus PW.
  Title
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
  Journal
J Biol Chem 262:15946-52 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.57
IUBMB Enzyme Nomenclature: 3.1.3.57
ExPASy - ENZYME nomenclature database: 3.1.3.57
BRENDA, the Enzyme Database: 3.1.3.57
CAS: 111070-17-8 111694-13-4

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