EC                 Enzyme                                 

multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
Acting on ester bonds;
Phosphoric-monoester hydrolases
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
R07584 > R07583;
(other) R03434
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
EC created 1992, modified 2002
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase
HSA: 9562(MINPP1)
PTR: 450579(MINPP1)
PPS: 100980933(MINPP1)
GGO: 101144263(MINPP1)
PON: 100173135(MINPP1)
NLE: 100602225(MINPP1)
MCC: 704362(MINPP1)
MCF: 101925472(MINPP1)
CSAB: 103216204(MINPP1)
CATY: 105587179(MINPP1)
PANU: 101012993(MINPP1)
RRO: 104675164(MINPP1)
RBB: 108527546(MINPP1)
TFN: 117086018(MINPP1)
PTEH: 111551309(MINPP1)
CJC: 100391750(MINPP1)
MMUR: 105870306(MINPP1)
MMU: 17330(Minpp1)
MCAL: 110285877(Minpp1)
MPAH: 110323978(Minpp1)
RNO: 29688(Minpp1)
MCOC: 116095796 116103741(Minpp1)
MUN: 110562929(Minpp1)
CGE: 100766430(Minpp1)
NGI: 103738050(Minpp1)
HGL: 101711589(Minpp1)
CPOC: 100716660(Minpp1)
CCAN: 109681827(Minpp1)
OCU: 100350561 100358192(MINPP1)
OPI: 101524790(MINPP1)
TUP: 102484201(MINPP1)
CFA: 486462(MINPP1)
VVP: 112931957(MINPP1)
VLG: 121475661(MINPP1)
AML: 100468979(MINPP1)
UMR: 103661917(MINPP1)
UAH: 113258980(MINPP1)
ORO: 101367977(MINPP1)
ELK: 111144977
MPUF: 101692752(MINPP1)
EJU: 114210314(MINPP1)
MLX: 118012967(MINPP1)
FCA: 101091150(MINPP1)
PYU: 121016563(MINPP1)
PBG: 122492666(MINPP1)
PTG: 102971475(MINPP1)
PPAD: 109255399(MINPP1)
AJU: 106980974(MINPP1)
HHV: 120235962(MINPP1)
BTA: 541067(MINPP1)
BOM: 102266889(MINPP1)
BIU: 109553098(MINPP1)
BBUB: 102403735(MINPP1)
CHX: 102187288(MINPP1)
OAS: 101118833(MINPP1)
ODA: 120873780(MINPP1)
CCAD: 122446201(MINPP1)
SSC: 100152243(MINPP1)
CFR: 102522901(MINPP1)
CBAI: 105081865(MINPP1)
CDK: 105088961(MINPP1)
BACU: 103015775(MINPP1)
LVE: 103073572(MINPP1)
OOR: 101278048(MINPP1)
DLE: 111172535(MINPP1)
PCAD: 102981370(MINPP1)
PSIU: 116741817(MINPP1)
ECB: 100062448(MINPP1)
EPZ: 103549844(MINPP1)
EAI: 106845893(MINPP1)
MYB: 102256717(MINPP1)
MYD: 102754386(MINPP1)
MMYO: 118670003(MINPP1)
MLF: 102429829(MINPP1)
MNA: 107543261(MINPP1)
PKL: 118719255(MINPP1)
HAI: 109387537(MINPP1)
DRO: 112307316(MINPP1)
SHON: 118987934(MINPP1)
AJM: 119057723(MINPP1)
PDIC: 114496574(MINPP1)
MMF: 118632317(MINPP1)
RFQ: 117036242(MINPP1)
PALE: 102882782(MINPP1)
PGIG: 120609362(MINPP1)
RAY: 107501766(MINPP1)
MJV: 108404755(MINPP1)
TOD: 119233710(MINPP1)
LAV: 100661711(MINPP1)
TMU: 101353457
MDO: 100022488(MINPP1)
GAS: 123236541(MINPP1) 123247903
SHR: 100924973(MINPP1)
PCW: 110199940(MINPP1)
OAA: 100681694(MINPP1)
GGA: 395356(MINPP1)
PCOC: 116234765(MINPP1)
MGP: 100540797(MINPP1)
CJO: 107315617(MINPP1)
NMEL: 110390504(MINPP1)
APLA: 101798501(MINPP1)
ACYG: 106030215(MINPP1)
TGU: 100225117(MINPP1)
LSR: 110474022(MINPP1)
SCAN: 103814225(MINPP1)
PMOA: 120499702(MINPP1)
OTC: 121336132(MINPP1)
PRUF: 121356682(MINPP1)
GFR: 102040581(MINPP1)
FAB: 101807959(MINPP1)
PHI: 102106327(MINPP1)
PMAJ: 107207068(MINPP1)
CCAE: 111931623(MINPP1)
CCW: 104695103(MINPP1)
ETL: 114069298(MINPP1)
FPG: 101912524(MINPP1)
FCH: 102050541(MINPP1)
CLV: 102099022(MINPP1)
EGZ: 104125133(MINPP1)
NNI: 104013518(MINPP1)
ACUN: 113481831(MINPP1)
PADL: 103924285(MINPP1)
AAM: 106489037(MINPP1)
AROW: 112973345(MINPP1)
NPD: 112948436(MINPP1)
DNE: 112981621(MINPP1)
PSS: 102458605(MINPP1)
CMY: 102941827(MINPP1)
CPIC: 101932598(MINPP1)
TST: 117879812(MINPP1)
CABI: 116818985(MINPP1)
MRV: 120369205(MINPP1)
ACS: 100555619(minpp1)
PVT: 110083113(MINPP1) 110083124
SUND: 121925894(MINPP1)
PBI: 103064022(MINPP1)
PMUR: 107285106(MINPP1)
TSR: 106551602(MINPP1)
PGUT: 117670640(MINPP1)
VKO: 123018463(MINPP1)
PMUA: 114597276(MINPP1)
ZVI: 118096383(MINPP1)
GJA: 107120017(MINPP1)
XLA: 108696047(minpp1.L) 108697356(minpp1.S)
XTR: 100493648(minpp1)
NPR: 108794027(MINPP1)
DRE: 394075(minpp1b) 561891(minpp1a)
IPU: 108269684 108273659(minpp1)
PHYP: 113527108(minpp1) 113547731
EEE: 113579496(minpp1) 113591888
NCC: 104956666(minpp1)
SLUC: 116055165 116059242(minpp1b)
GAT: 120819649 120820469(minpp1a)
PPUG: 119213180 119213978(minpp1a)
OML: 112162089(minpp1a) 118597846(minpp1b)
GAF: 122822905(minpp1b) 122842976(minpp1a)
CTUL: 119790840 119790872(minpp1a) 119792861(minpp1b)
NFU: 107376031 107387490(minpp1)
KMR: 108242898 108251380(minpp1b)
ALIM: 106513483 106528196(minpp1)
POV: 109632753
SSEN: 122759393(minpp1b) 122781461(minpp1a)
HHIP: 117753044(minpp1b) 117775612 117775613
XGL: 120794537(minpp1b) 120796379(minpp1a)
ELS: 105006245(minpp1) 105010648
SFM: 108939677(minpp1)
PKI: 111853700(minpp1)
AANG: 118218022 118221659(minpp1b)
LOC: 102685596(minpp1)
PSPA: 121325690(minpp1b)
LCM: 102349601(MINPP1) 102355063
CMK: 103180855(minpp1b)
RTP: 109911866(minpp1)
BFO: 118412093
BBEL: 109481336
DME: Dmel_CG4123(Mipp1) Dmel_CG4317(Mipp2)
DSI: Dsimw501_GD12462(Dsim_GD12462) Dsimw501_GD16214(Dsim_GD16214)
DAN: 6493392
DNV: 108652406
DHE: 111596480
SCAC: 106087349
FEX: 115245494
PGC: 109860814
PCF: 106783586
PFUC: 122520664
VPS: 122636939
AGB: 108912760
DSV: 119453325
DPTE: 113799142
SDM: 118185378
PCAN: 112557841
BGT: 106058145
GAE: 121379899
CRG: 105336484
OBI: 106879508
OSN: 115225400
EGL: EGR_04276
AQU: 109582726
ATH: AT1G09870
ALY: 9328594
CRB: 17896695
CPAP: 110819153
CIT: 102615443
PVY: 116106184
TCC: 18585803
GAB: 108484036
DZI: 111298017
EGR: 104455913
GMX: 100812135(PAP02) 100815749
VRA: 106776102
VAR: 108343523
VUN: 114188689
CCAJ: 109809735
APRC: 113849463
CAM: 101507608
LJA: Lj0g3v0197689.1(Lj0g3v0197689.1) Lj0g3v0197689.2(Lj0g3v0197689.2)
ADU: 107471196
FVE: 101314222
RCN: 112179772
PPER: 18785898
PMUM: 103332825
PAVI: 110749720
PDUL: 117619714
MDM: 103417780
PXB: 103937111
ZJU: 107413891
MNT: 21390348
BHJ: 120081561
MCHA: 111015966
RCU: 8272082
PALZ: 118055917
JRE: 108983886
QLO: 115955878
CANN: 107871120
INI: 109154998
ITR: 116019989
SIND: 105160857
OEU: 111390935
EGT: 105977634
HAN: 110872695
ECAD: 122605897
CCAV: 112524542
DCR: 108210743
BVG: 104905971
SOE: 110781869
NNU: 104597681
NCOL: 116263272
OSA: 4334577
DOSA: Os03t0818100-01(Os03g0818100)
OBR: 102712072
BDI: 100831816
ATS: 109744068
SBI: 8057380
ZMA: 100282868
SITA: 101772807
PHAI: 112875216
PDA: 103708852
EGU: 105033642
MUS: 103984406
DCT: 110101297
PEQ: 110029458
MNG: MNEG_3694
DFA: DFA_01730
EHI: EHI_059910(101.t00003)
FLN: FLA_2532
 » show all
1  [PMID:2786415]
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
Biochem J 259:931-3 (1989)
2  [PMID:9359836]
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
Biochem J 328 ( Pt 1):75-81 (1997)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 116958-30-6

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