KEGG   ENZYME: 3.1.3.66
Entry
EC 3.1.3.66                 Enzyme                                 
Name
phosphatidylinositol-3,4-bisphosphate 4-phosphatase;
inositol-3,4-bisphosphate 4-phosphatase;
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase;
phosphoinositide 4-phosphatase;
inositol polyphosphate 4-phosphatase;
inositol polyphosphate 4-phosphatase type II
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate [RN:R07299]
Reaction(KEGG)
R07299;
(other) R04372 R10950
Substrate
1-phosphatidyl-myo-inositol 3,4-bisphosphate;
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 3-phosphate [CPD:C04549];
phosphate [CPD:C00009]
Comment
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
History
EC 3.1.3.66 created 1992, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01109  inositol polyphosphate-4-phosphatase
Genes
HSA3631(INPP4A) 8821(INPP4B)
PTR461514(INPP4B) 470448(INPP4A)
PPS100968284(INPP4A) 100989263(INPP4B)
GGO101142456(INPP4A) 101144077(INPP4B)
PON100174369(INPP4B) 100454992(INPP4A)
NLE100592186(INPP4A) 100599079(INPP4B)
MCC699738(INPP4B) 707986(INPP4A)
MCF101865720(INPP4B) 102139378(INPP4A)
CSAB103236308(INPP4B) 103241097(INPP4A)
CATY105580825(INPP4B) 105583693(INPP4A)
PANU101007295(INPP4B) 101009927(INPP4A)
TGE112604909(INPP4A) 112625108(INPP4B)
RRO104661477(INPP4A) 104670159(INPP4B)
RBB108526763(INPP4B) 108529486(INPP4A)
TFN117085960(INPP4B) 117099619(INPP4A)
PTEH111542207(INPP4A) 111551909(INPP4B)
CJC100396234(INPP4A) 100408233(INPP4B)
SBQ101038514(INPP4A) 101043111(INPP4B)
CSYR103263131(INPP4B) 103268471(INPP4A)
MMUR105881868(INPP4B) 105883669(INPP4A)
OGA100948620(INPP4B) 100953691(INPP4A)
MMU234515(Inpp4b) 269180(Inpp4a)
MCAL110299691(Inpp4b) 110300411(Inpp4a)
MPAH110321244(Inpp4a) 110337280(Inpp4b)
RNO116699(Inpp4b) 80849(Inpp4a)
MCOC116069649(Inpp4b) 116088316(Inpp4a)
MUN110545446(Inpp4a)
CGE100767245(Inpp4a) 100771589(Inpp4b)
PLEU114690783(Inpp4a) 114701625(Inpp4b)
NGI103742385(Inpp4b) 103744153(Inpp4a)
HGL101718534(Inpp4a) 101719238(Inpp4b)
CPOC100727592(Inpp4a) 100731049(Inpp4b)
CCAN109687366(Inpp4b) 109694386(Inpp4a)
DORD105988275(Inpp4a) 105995705(Inpp4b)
DSP122121289(Inpp4a) 122127120(Inpp4b)
OCU100340475(INPP4A) 100348588(INPP4B)
OPI101523532(INPP4B) 101534162(INPP4A)
TUP102471411(INPP4A) 102477229(INPP4B)
CFA474563(INPP4A) 476072(INPP4B)
VVP112915174(INPP4A) 112934936(INPP4B)
VLG121490612(INPP4A) 121492825(INPP4B)
AML100482175(INPP4A) 100484540(INPP4B)
UMR103657978(INPP4B) 103671184(INPP4A)
UAH113246757(INPP4A) 113255708(INPP4B)
UAR123776040(INPP4A) 123793255(INPP4B)
ELK111149029 111155844
LLV125093429 125108758
MPUF101677091(INPP4A) 101679328(INPP4B)
ORO101375367(INPP4A) 101380415(INPP4B)
EJU114208271(INPP4B) 114209790(INPP4A)
ZCA113924814(INPP4B) 113937212(INPP4A)
MLX118008223(INPP4A) 118022290(INPP4B)
FCA101088920(INPP4A) 101089005(INPP4B)
PYU121016396(INPP4A) 121029252(INPP4B)
PBG122476032(INPP4B) 122496737(INPP4A)
PTG102959803(INPP4B) 102967296(INPP4A)
PPAD109249767(INPP4B) 109272013(INPP4A)
AJU106968725(INPP4A) 106983487(INPP4B)
HHV120232055(INPP4A) 120242439(INPP4B)
BTA534793(INPP4B) 535487(INPP4A)
BOM102287496(INPP4A)
BIU109565495(INPP4A) 109571208(INPP4B)
BBUB102389203(INPP4B) 102411289(INPP4A)
CHX102180694(INPP4B) 102181043(INPP4A)
OAS101109605(INPP4A) 101112848(INPP4B)
ODA120870901(INPP4B) 120883568(INPP4A)
CCAD122441393(INPP4A) 122452129(INPP4B)
SSC100233232(INPP4A) 100511393(INPP4B)
CFR102523124(INPP4A) 102524318(INPP4B)
CBAI105068684(INPP4B) 105072193(INPP4A)
CDK105087825(INPP4B) 105099796(INPP4A)
VPC102536578(INPP4A) 102538208(INPP4B)
BACU102998108(INPP4B) 103010671(INPP4A)
LVE103074180(INPP4A) 103086012(INPP4B)
OOR101285539(INPP4A) 101286407(INPP4B)
DLE111187436(INPP4A) 111187693(INPP4B)
PCAD102989180(INPP4A) 102992579(INPP4B)
PSIU116754252(INPP4B) 116764603(INPP4A)
ECB100051038(INPP4A) 100062978(INPP4B)
EPZ103549151(INPP4B) 103559003(INPP4A)
EAI106835458(INPP4B) 106842549(INPP4A)
MYB102242129(INPP4B) 102249694(INPP4A)
MYD102757149(INPP4B) 102763551(INPP4A)
MMYO118652495(INPP4A) 118657622(INPP4B)
MLF102417001(INPP4A) 102426747(INPP4B)
MNA107532527(INPP4B)
PKL118710800(INPP4B) 118727995(INPP4A)
HAI109396934(INPP4A)
DRO112312620(INPP4B) 112315136(INPP4A)
SHON118994209(INPP4A) 118995434(INPP4B)
AJM119034884(INPP4B) 119043279(INPP4A)
PDIC114498559(INPP4A) 114503475(INPP4B)
PHAS123811116(INPP4A) 123813643(INPP4B)
MMF118630897(INPP4A) 118643716(INPP4B)
RFQ117033237(INPP4A) 117038287(INPP4B)
PALE102883721(INPP4A) 102887805(INPP4B)
PGIG120610226(INPP4A) 120613237(INPP4B)
PVP105301204(INPP4B) 105306777(INPP4A)
RAY107499261(INPP4B) 107509976(INPP4A)
MJV108396814(INPP4A)
TOD119233771(INPP4B) 119259244(INPP4A)
SARA101541344(INPP4A) 101549808(INPP4B)
LAV100663143(INPP4A) 100670266(INPP4B)
TMU101341371 101341428
DNM101413303(INPP4B) 101431517(INPP4A)
MDO100012162(INPP4A) 100026918(INPP4B)
GAS123242576(INPP4A) 123251145(INPP4B)
SHR100918022(INPP4A) 100926247(INPP4B)
PCW110210779(INPP4B) 110212755(INPP4A)
OAA100082415(INPP4B) 114816889(INPP4A)
GGA418690(INPP4A) 422454(INPP4B)
PCOC116226113(INPP4B) 116236556(INPP4A)
MGP100543360(INPP4B) 100551349(INPP4A)
CJO107307314(INPP4A) 107313162(INPP4B)
NMEL110397750(INPP4B) 110406294(INPP4A)
APLA101793148(INPP4B) 101802644(INPP4A)
ACYG106035699(INPP4A) 106046672(INPP4B)
AFUL116486655(INPP4A) 116488729(INPP4B)
TGU100224898(INPP4B) 100225656(INPP4A)
LSR110468509(INPP4B) 110479351(INPP4A)
SCAN103812345(INPP4A) 103822524(INPP4B)
PMOA120496067(INPP4B) 120504528(INPP4A)
OTC121339828(INPP4B) 121343101(INPP4A)
PRUF121350442(INPP4B) 121354053(INPP4A)
GFR102039668(INPP4B) 102043062(INPP4A)
FAB101806527(INPP4A) 101812696(INPP4B)
PHI102101814(INPP4A) 102107844(INPP4B)
PMAJ107202431(INPP4A) 107203153(INPP4B)
CCAE111928895(INPP4B) 111946176(INPP4A)
CCW104686042(INPP4A) 104697266(INPP4B)
ETL114058374(INPP4B) 114071010(INPP4A)
ZAB102062539(INPP4B) 102074714(INPP4A)
FPG101918767(INPP4A) 101920565(INPP4B)
FCH102045868(INPP4B) 102052619(INPP4A)
CLV102083531(INPP4B) 102098823(INPP4A)
EGZ104125227(INPP4A) 104130577(INPP4B)
NNI104015954(INPP4B) 104019323(INPP4A)
ACUN113486022(INPP4A) 113490472(INPP4B)
TALA104359549(INPP4A) 104368028(INPP4B)
PADL103916588(INPP4A) 103920894(INPP4B)
ACHC115334512(INPP4A) 115342271(INPP4B)
AAM106491884(INPP4B) 106494014(INPP4A)
AROW112967856(INPP4A) 112977286(INPP4B)
NPD112944237(INPP4A) 112950127(INPP4B)
DNE112985004(INPP4A) 112986714(INPP4B)
ASN102370491(INPP4B) 102374238(INPP4A)
AMJ102564333(INPP4A) 102575449(INPP4B)
CPOO109306176(INPP4A) 109309631(INPP4B)
GGN109301180(INPP4B) 109302773(INPP4A)
PSS102454053(INPP4B) 102462079(INPP4A)
CMY102930596(INPP4B) 102947983(INPP4A)
CPIC101948633(INPP4B) 101948721(INPP4A)
TST117870690(INPP4A) 117877831(INPP4B)
CABI116818231(INPP4B) 116839534(INPP4A)
MRV120388085(INPP4A) 120405879(INPP4B)
ACS100551799(inpp4a) 100567592(inpp4b)
PVT110073639(INPP4B) 110087729(INPP4A)
SUND121925694(INPP4A) 121932059(INPP4B)
PBI103059907(INPP4A) 103061669(INPP4B)
PMUR107288553(INPP4B) 107301415(INPP4A)
TSR106543449(INPP4A) 106550730(INPP4B)
PGUT117654561(INPP4B) 117673746(INPP4A)
VKO123023746(INPP4B) 123025035(INPP4A)
PMUA114596364(INPP4A) 114603723(INPP4B)
ZVI118084330(INPP4B) 118084736(INPP4A)
GJA107110418(INPP4A) 107115930(INPP4B)
XLA108699497 108704365 108709723(inpp4a.S) 734645(inpp4a.L)
XTR100496097(inpp4b) 780177(inpp4a)
NPR108792572(INPP4A) 108792603(INPP4B)
RTEM120919307(INPP4B) 120926427(INPP4A)
BBUF120990000(INPP4B) 120995729(INPP4A)
BGAR122933401(INPP4A) 122943117(INPP4B)
DRE560006(inpp4b) 792527(inpp4ab)
SRX107705620 107730018 107748537
SANH107657998 107660104 107688837
SGH107566790 107596323 107598548(inpp4b)
CCAR109057119 109057125 109093063(inpp4b)
CAUA113044069 113050763 113060923 113093899 113097576
IPU108263114(inpp4b) 108273053(inpp4ab)
PHYP113538268 113546078(inpp4b)
SMEO124376675(inpp4b)
AMEX103021329(inpp4b) 103041993
EEE113591760(inpp4b)
TRU101078785(inpp4b)
LCO104917900(inpp4b) 104929099
CGOB115008530(inpp4b) 115026638(inpp4a)
ELY117246316 117251396(inpp4aa) 117255563(inpp4b)
PLEP121941650(inpp4b) 121948839(inpp4aa)
SLUC116034382(inpp4b) 116046088(inpp4aa)
ECRA117953343(inpp4aa) 117956396(inpp4b)
PFLV114563969(inpp4a) 114570331(inpp4b) 114573908
GAT120824701(inpp4b) 120833987(inpp4aa)
PPUG119218445(inpp4b) 119228978(inpp4aa)
MSAM119898871(inpp4b) 119904285(inpp4aa) 119905067 119912986
CUD121504672 121508160(inpp4b) 121522253(inpp4aa)
ONL100711770(inpp4b)
OAU116316018(inpp4aa) 116327533 116330028(inpp4b) 116332929
OLA101173511(inpp4a) 105354450(inpp4b)
OML112137641(inpp4b) 112155101(inpp4aa)
XMA102230891(inpp4b)
XCO114143861(inpp4b)
XHE116720422(inpp4b) 116723036(inpp4a)
PRET103471125(inpp4b)
PFOR103140351(inpp4a) 103144825(inpp4b)
PLAI106948786(inpp4a) 106949372(inpp4b)
PMEI106926707 106928904(inpp4a)
GAF122829133(inpp4b) 122840073(inpp4aa)
CVG107082794(inpp4b)
CTUL119773894(inpp4b) 119786356(inpp4aa)
GMU124868435(inpp4b) 124871820(inpp4aa)
NFU107389437(inpp4b)
KMR108231661(inpp4b)
NWH119419236(inpp4aa)
AOCE111568836(inpp4b)
CSEM103383335(inpp4b) 103389601
POV109638366(inpp4b)
SSEN122759267(inpp4aa) 122771265(inpp4b)
HHIP117754394(inpp4aa) 117765365(inpp4b)
LCF108893085(inpp4b)
SDU111216559(inpp4b)
SLAL111653596(inpp4b)
XGL120797232 120797970 120800821(inpp4b) 120801225(inpp4aa)
MALB109955537(inpp4b) 109960502
SASA106574620 106602354 106610235
OTW112234711 112237419 112266371
OMY110495689 110498435 110498640 110501314(inpp4aa) 110518889 110528761
OGO124001345 124008432 124012699 124044360
ONE115117107
SALP111953317
SNH120034789 120034790 120040983 120051389
ELS105019823 105020950(inpp4b)
SFM108920556 108924462 108933221
PKI111837311(inpp4b)
AANG118213588(inpp4aa) 118224397 118231840(inpp4b)
LOC102686262(inpp4b) 102695688(inpp4a)
PSPA121297058(inpp4b) 121320501 121321015 121327918
ARUT117406148 117406629(inpp4aa) 117409344(inpp4b) 117421560
LCM102348021(INPP4B) 102360654(INPP4A)
CMK103177132
BFO118418806
BBEL109467946
CIN100180081
SCLV120341656
SPU579262
DMEDmel_CG42271(CG42271)
DER6550101
DSE6618515
DSIDsimw501_GD15857(Dsim_GD15857)
DYADyak_GE16121
DSR110180629
DPODpse_GA25798
DPE6597251
DMN108160542
DWI6649348
DGR6565334
CCAT101458989
BOD106624717
SCAC106082697
AGAAgaP_AGAP000124
ACOZ120951435
AARA120905997
AAG5572787
AALB109422061
CQUCpipJ_CPIJ018996
CPII120432249
CNS116343882
SOY115889869
AGB108910133
LDC111518085
APLN108740740
PPYR116173230
OTU111426837
BMOR101743706
DFR124498744
LAK106161392
HMG100202677 105845283
 » show all
Reference
1  [PMID:2546770]
  Authors
Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS.
  Title
Evidence for at least four different inositol bisphosphatases in bovine brain.
  Journal
Eur J Biochem 183:169-72 (1989)
DOI:10.1111/j.1432-1033.1989.tb14909.x
Reference
2  [PMID:7608176]
  Authors
Norris FA, Auethavekiat V, Majerus PW
  Title
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
  Journal
J Biol Chem 270:16128-33 (1995)
DOI:10.1074/jbc.270.27.16128
  Sequence
[hsa:3631] [rno:80849]
Reference
3  [PMID:9295334]
  Authors
Norris FA, Atkins RC, Majerus PW.
  Title
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
  Journal
J Biol Chem 272:23859-64 (1997)
DOI:10.1074/jbc.272.38.23859
  Sequence
[hsa:3631 8821] [rno:116699]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.66
IUBMB Enzyme Nomenclature: 3.1.3.66
ExPASy - ENZYME nomenclature database: 3.1.3.66
BRENDA, the Enzyme Database: 3.1.3.66
CAS: 123644-80-4

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