KEGG   ENZYME: 3.1.3.71Help
Entry
EC 3.1.3.71                 Enzyme                                 

Name
2-phosphosulfolactate phosphatase;
(2R)-phosphosulfolactate phosphohydrolase;
ComB phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
(R)-2-phospho-3-sulfolactate phosphohydrolase
Reaction(IUBMB)
(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate [RN:R05789]
Reaction(KEGG)
Substrate
(2R)-2-phospho-3-sulfolactate;
H2O [CPD:C00001]
Product
(2R)-3-sulfolactate [CPD:C11537];
phosphate [CPD:C00009]
Comment
Requires Mg2+. The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyses a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate. This enzyme can also hydrolyse phosphate monoesters of (R)-2-hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)-2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations.
History
EC 3.1.3.71 created 2002
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K05979  2-phosphosulfolactate phosphatase
Genes
EHI: EHI_199080(87.t00023)
EDI: EDI_263600
EIV: EIN_377190
ENR: H650_23055
KSA: C813_07395
KOR: AWR26_16780
KRD: A3780_07480
SPE: Spro_2330
SRR: SerAS9_2288
SRL: SOD_c21600
SPLY: Q5A_011995(comB)
RAA: Q7S_22911
PAM: PANA_3041
PAJ: PAJ_2316
PSTW: DSJ_05315
CBS: COXBURSA331_A1552(comB)
ABO: ABO_2222
ADI: B5T_03960
APAC: S7S_01775
AXE: P40_19270
RSO: RSc1273
RSE: F504_1302
RPI: Rpic_1101
TIN: Tint_1596
DSU: Dsui_0788
DAR: Daro_4162
AZA: AZKH_0196(comB)
DMA: DMR_44220
DAS: Daes_1285
DPI: BN4_10816(comB)
PPRF: DPRO_0671(comB)
DBR: Deba_1180
PSF: PSE_4903
SSY: SLG_05240
BSU: BSU10940(yitC)
BSR: I33_1229(yitC)
BSL: A7A1_0910
BSH: BSU6051_10940(yitC)
BSUT: BSUB_01191(yitC)
BSUL: BSUA_01191(yitC)
BSUS: Q433_06180
BSS: BSUW23_05545(yitC)
BST: GYO_1400(yitC)
BSQ: B657_10940(slpH)
BSX: C663_1117(comB)
BATR: TD68_02705
BMQ: BMQ_2361
BMD: BMD_2323
BMH: BMWSH_2873(comB)
BMEG: BG04_4734
BCK: BCO26_1399(yitC)
BAG: Bcoa_3121
BCOA: BF29_415
BJS: MY9_1192
BACY: QF06_04405
BACL: BS34A_12080(yitC)
BALM: BsLM_1139
OIH: OB0681
GKA: GK1033
GTN: GTNG_0895
GGH: GHH_c09740(comB)
GEA: GARCT_01054(comB)
AAMY: GFC30_1312
HHD: HBHAL_1804(comB)
PMW: B2K_14735
PLV: ERIC2_c33010(comB)
PSWU: SY83_19305
ASOC: CB4_01292(comB)
BTS: Btus_1176
CAC: CA_C3233
CAE: SMB_G3269
CAY: CEA_G3236
CPE: CPE2556
CPF: CPF_2881(comB)
CPR: CPR_2562(comB)
CTC: CTC_00180
CBO: CBO3553
CBA: CLB_3635
CBH: CLC_3533
CBY: CLM_4046
CBL: CLK_3023
CBK: CLL_A0084
CBB: CLD_0930
CBI: CLJ_B3884
CBN: CbC4_2352
CBT: CLH_0068
CBF: CLI_3775
CBM: CBF_3741
CBE: Cbei_0040
CBZ: Cbs_0040
CBEI: LF65_00040
CKL: CKL_0138(comB)
CKR: CKR_0113
CLJ: CLJU_c41880(comB)
CSR: Cspa_c00530(comB)
CPAS: Clopa_4611
CPAT: CLPA_c37880(comB)
CPAE: CPAST_c37880(comB)
CSB: CLSA_c00560(comB)
CLT: CM240_2564(comB)
CBV: U729_1190
CSQ: CSCA_4209
CLD: CLSPO_c37370(comB)
CTYK: CTK_C29650
STH: STH1711
DRM: Dred_2444
SGY: Sgly_0670
HMO: HM1_0947(comB)
TMR: Tmar_2078
SAY: TPY_1197(comB)
TTE: TTE1972
THX: Thet_1864
TIT: Thit_1772
TKI: TKV_c18010(comB)
CHY: CHY_1042
MTA: Moth_0119
TPZ: Tph_c04500(comB)
CSC: Csac_0183
ATE: Athe_0305
TOC: Toce_0301
TTM: Tthe_0625
PUF: UFO1_0369
PFT: JBW_03234
LPIL: LIP_2832
RER: RER_56570
REY: O5Y_27015
RHB: NY08_1356
RFA: A3L23_04591(comB)
RHS: A3Q41_03679(comB)
TPR: Tpau_2411
SCO: SCO7611(SC2H2.09)
SGR: SGR_675
SGB: WQO_31825
SFA: Sfla_0337
SBH: SBI_00626
SHY: SHJG_8207
STRP: F750_6675
SFI: SFUL_5723
SALU: DC74_7672
SALL: SAZ_39580
SLV: SLIV_01260(comB)
SGU: SGLAU_31680(comB)
STRM: M444_03505
SLX: SLAV_02885(comB)
KSK: KSE_47990
ART: Arth_3752
ACH: Achl_3486
BCV: Bcav_1964
LMOI: VV02_15560
CFI: Celf_2187
NDK: I601_3277
FAL: FRAAL3693
AOI: AORI_1927(comB)
SESP: BN6_13470
KAL: KALB_1538
ACTI: UA75_07950
ACAD: UA74_07970
ALL: CRK55376
SAQ: Sare_0160
MIL: ML5_0198
ASE: ACPL_6502
ACTN: L083_6026
ACTS: ACWT_6371
SNA: Snas_6128
SYN: slr1718
SYY: SYNGTS_1332(comB)
SYT: SYNGTI_1332(comB)
SYS: SYNPCCN_1331(comB)
SYQ: SYNPCCP_1331(comB)
SYJ: D082_32420(comB)
SYW: SYNW1007
SYC: syc1521_c
SYG: sync_1547(comB)
SYR: SynRCC307_1155(comB)
SYX: SynWH7803_1034(comB)
SYP: SYNPCC7002_A1835(comB)
CYA: CYA_0651(comB)
CYB: CYB_0287(comB)
SYNR: KR49_03260
SYND: KR52_10970
TEL: tll0403
THN: NK55_06840(comB)
CYI: CBM981_0719(comB)
LET: O77CONTIG1_00275(comB_1) O77CONTIG1_00276(comB_2)
HHG: XM38_021410(comB)
PMA: Pro_1046
PMM: PMM0614
PMT: PMT_0396
PRC: EW14_0659
PRM: EW15_0713
AMR: AM1_1366(comB) AM1_C0085(comB)
MAR: MAE_16000
MPK: VL20_4627
CYL: AA637_15005(comB)
CYT: cce_1018
TER: Tery_1206
GVI: gll2974
GLJ: GKIL_1587(comB)
ANA: all2568
AVA: Ava_0497
NAZ: Aazo_3763
RCA: Rcas_0704
HAU: Haur_1570
ATM: ANT_22710
DRA: DR_1400
DGE: Dgeo_1318
TTH: TT_C1073
TTJ: TTHA1438
TSC: TSC_c05480(comB)
TAQ: TO73_0631
MRB: Mrub_2128
TTR: Tter_2178
PNL: PNK_1113(comB)
PUV: PUV_09820(comB)
RBA: RB12002
PSL: Psta_4363
PLM: Plim_1320
PLS: VT03_09445(comB)
PLH: VT85_09760(comB)
FMR: Fuma_03608(comB)
TTF: THTE_2442
IPA: Isop_3258
SACI: Sinac_5012
PBOR: BSF38_05395(comB)
TAI: Taci_0539
TLI: Tlie_1649
GAU: GAU_1922(comB)
GBA: J421_3532
PGI: PG_0013
PGN: PGN_0011
PMUC: ING2E5A_3057(comB)
DORI: FH5T_10360
BLQ: L21SP5_03537(comB)
SRU: SRU_1618
SRM: SRM_01818(comB)
RMR: Rmar_1805
CPI: Cpin_0597
FLN: FLA_5684
PHE: Phep_0407
MUC: MuYL_1548
MGOT: MgSA37_01398(comB)
CHU: CHU_2823
DFE: Dfer_4549
SLI: Slin_4415
LBY: Lbys_2736
FAE: FAES_0026
PSEZ: HME7025_00123(comB)
HSW: Hsw_3148
FLM: MY04_1840
MPW: MPR_1215
CTS: Ctha_0508
IAL: IALB_0648
MRO: MROS_1728
TMA: TM0797
TMW: THMA_0816
TMQ: THMB_0816
TMX: THMC_0816
TPT: Tpet_0131
TRQ: TRQ2_0129
TNA: CTN_1781
TNP: Tnap_0132
TLE: Tlet_0995
TME: Tmel_0377
TAF: THA_762
THER: Y592_03295
FNO: Fnod_0473
PMO: Pmob_0044
DTN: DTL3_0932
KOL: Kole_1930
CABY: Cabys_2474(comB)
MOX: DAMO_0949(comB)
MJA: MJ_1140
MMP: MMP0161(comB)
MMD: GYY_00825
MAE: Maeo_1002
MVO: Mvol_1551
MPD: MCP_2564(comB)
MEZ: Mtc_0038(comB)
RCI: RCIX630(comB)
MTH: MTH_1182
MMG: MTBMA_c15590(comB)
METC: MTCT_1075
MWO: MWSIV6_1574(comB)
METE: tca_01138(comB)
MST: Msp_0286(comB1) Msp_0973(comB2)
MSI: Msm_1023
MRU: mru_1949(comB)
MEB: Abm4_1535(comB)
MMIL: sm9_2035(comB)
MEYE: TL18_09360
MOL: YLM1_1399
METH: MBMB1_1701(comB)
MFC: BRM9_0953(comB)
MCUB: MCBB_1999(comB)
MFV: Mfer_1236
MKA: MK0138(comB)
HHB: Hhub_4195
HHI: HAH_4426
HTI: HTIA_1449
HVO: HVO_B0180
HME: HFX_0565
TAC: Ta1432
TVO: TVG0100132(TVG0100132)
PTO: PTO0436
FAI: FAD_1621
CDIV: CPM_0200
BARC: AOA65_0816(comB)
LOKI: Lokiarch_04810(comB)
 » show all
Taxonomy
Reference
1  [PMID:11589710]
  Authors
Graham DE, Graupner M, Xu H, White RH.
  Title
Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. A member of a new class of Mg(2+)-dependent acid phosphatases.
  Journal
Eur J Biochem 268:5176-88 (2001)
DOI:10.1046/j.0014-2956.2001.02451.x
  Sequence
[mja:MJ_1140]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.71
IUBMB Enzyme Nomenclature: 3.1.3.71
ExPASy - ENZYME nomenclature database: 3.1.3.71
BRENDA, the Enzyme Database: 3.1.3.71
CAS: 409095-18-7

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